PT2790687T - Moduladores de trpc4 para uso no tratamento ou prevenção da dor - Google Patents

Moduladores de trpc4 para uso no tratamento ou prevenção da dor

Info

Publication number
PT2790687T
PT2790687T PT12806318T PT12806318T PT2790687T PT 2790687 T PT2790687 T PT 2790687T PT 12806318 T PT12806318 T PT 12806318T PT 12806318 T PT12806318 T PT 12806318T PT 2790687 T PT2790687 T PT 2790687T
Authority
PT
Portugal
Prior art keywords
trpc4
modulators
pain
prevention
treatment
Prior art date
Application number
PT12806318T
Other languages
English (en)
Inventor
M Ostertag Eric
Stuart Crawford John
Original Assignee
Poseida Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poseida Therapeutics Inc filed Critical Poseida Therapeutics Inc
Publication of PT2790687T publication Critical patent/PT2790687T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT12806318T 2011-12-16 2012-12-14 Moduladores de trpc4 para uso no tratamento ou prevenção da dor PT2790687T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161576619P 2011-12-16 2011-12-16

Publications (1)

Publication Number Publication Date
PT2790687T true PT2790687T (pt) 2018-11-13

Family

ID=47430150

Family Applications (1)

Application Number Title Priority Date Filing Date
PT12806318T PT2790687T (pt) 2011-12-16 2012-12-14 Moduladores de trpc4 para uso no tratamento ou prevenção da dor

Country Status (17)

Country Link
US (2) US10131634B2 (pt)
EP (2) EP3485889B1 (pt)
JP (3) JP2015500345A (pt)
AU (2) AU2012352083B2 (pt)
CA (1) CA2859283C (pt)
CY (1) CY1121293T1 (pt)
DK (1) DK2790687T3 (pt)
ES (1) ES2692546T3 (pt)
HR (1) HRP20181746T1 (pt)
HU (1) HUE041294T2 (pt)
LT (1) LT2790687T (pt)
PL (1) PL2790687T3 (pt)
PT (1) PT2790687T (pt)
RS (1) RS57919B1 (pt)
SI (1) SI2790687T1 (pt)
TR (1) TR201815535T4 (pt)
WO (1) WO2013090722A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012352083B2 (en) * 2011-12-16 2018-01-04 Transposagen Biopharmaceuticals, Inc. TRPC4 modulators for use in the treatment or prevention of pain
US20220204477A1 (en) * 2019-04-11 2022-06-30 Teijin Pharma Limited Benzimidazole derivatives and their uses

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
ATE196548T1 (de) 1991-05-10 2000-10-15 Genentech Inc Auswählen von agonisten und antagonisten von liganden
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5656449A (en) * 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
DE69638269D1 (de) 1995-06-14 2010-11-18 Univ California Hochaffine humane antikörper gegen tumorantigene
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
DK0974111T3 (da) 1997-04-11 2003-04-22 California Inst Of Techn Apparat og metode til automatiseret design af proteiner
US6403312B1 (en) 1998-10-16 2002-06-11 Xencor Protein design automatic for protein libraries
AU4802500A (en) * 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
US7375125B2 (en) * 1999-08-04 2008-05-20 Ore Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
WO2001025277A1 (en) 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
US20020072101A1 (en) 2000-01-21 2002-06-13 Gaughan Glen T. Novel human nucleic acid molecules and polypeptides encoding cation channels
JP2005506037A (ja) 2000-12-01 2005-03-03 ブリストル−マイヤーズ スクイブ カンパニー 脊髄および脳で発現される新規なヒトイオンチャンネルをコードする新規なヒト核酸分子およびポリペプチド
AU2002316150A1 (en) 2001-05-22 2002-12-03 Bristol-Myers Squibb Company Polynucleotide encoding a novel trp channel family member, trp-plik2, and splice variants thereof
WO2003024899A2 (en) * 2001-09-17 2003-03-27 Bristol-Myers Squibb Company CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE)
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
WO2003057843A2 (en) * 2001-12-31 2003-07-17 Algos Therapeutics, Inc. Methods and materials for modulating trpc4
WO2003060400A1 (fr) * 2002-01-15 2003-07-24 Kabushiki Kaisha Toshiba Refrigerateur muni d'un systeme d'alerte pour signaler une fuite d'agent refrigerant
WO2004039463A1 (ja) * 2002-10-31 2004-05-13 Kunihiro Tamura グラヴィティ ルールを実感するゴルフクラブ
US7256200B2 (en) 2003-02-10 2007-08-14 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Method and composition for potentiating an oplate analgesic
KR100561646B1 (ko) * 2003-10-23 2006-03-20 엘지.필립스 엘시디 주식회사 표시 소자용 박막 트랜지스터 기판 및 그 제조 방법
WO2005087742A1 (en) * 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
WO2005089206A2 (en) 2004-03-13 2005-09-29 Irm Llc Modulators of ion channel trpa1
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017932A1 (de) * 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
US20090325975A1 (en) 2005-07-15 2009-12-31 Helmut H Buschmann Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
EP2044027A2 (en) * 2006-07-03 2009-04-08 Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg Fused bicyclic compounds interacting with the histamine h4 receptor
GB0615136D0 (en) 2006-07-29 2006-09-06 Univ Edinburgh Induction of analgesia in neuropathic pain
US20090131302A1 (en) 2007-04-11 2009-05-21 Pasricha Pankaj J Transient receptor potential vanilloid 1 and uses thereof
EP2171615A2 (en) * 2007-06-27 2010-04-07 Dolby Laboratories Licensing Corporation Incremental construction of search tree with signature pointers for identification of multimedia content
EP2203411B1 (en) 2007-09-20 2016-01-06 Ramot at Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
US8084616B2 (en) 2007-10-24 2011-12-27 Abbott Laboratories TRPV1 antagonists
US7998993B2 (en) 2007-10-25 2011-08-16 Abbott Laboratories TRPV1 antagonists
KR20090047637A (ko) 2007-11-08 2009-05-13 재단법인서울대학교산학협력재단 커큐민 또는 이의 약학적으로 허용가능한 염을유효성분으로 함유하는 통증 예방 및 치료용 조성물
GEP20125707B (en) 2007-12-18 2012-12-10 Glenmark Pharmaceuticals Sa Chromane derivatives as trpv3 modulators
WO2009086303A2 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2010070804A1 (ja) * 2008-12-19 2010-06-24 パナソニック株式会社 画像検索装置及び画像検索方法
US20120151609A1 (en) * 2009-08-20 2012-06-14 Ostertag Eric M Genetically Modified Rat Models for Pain
EP2467398B1 (en) 2009-08-20 2019-10-09 Poseida Therapeutics, Inc. Trpc4 inhibitors and uses thereof
DE102009046649A1 (de) 2009-11-12 2011-05-19 Robert Bosch Gmbh Klimakompressor für ein Fahrzeug, Fahrzeug
JP2013526546A (ja) * 2010-05-13 2013-06-24 アムジエン・インコーポレーテツド Pde10阻害剤としてのヘテロアリ−ルオキシヘテロシクリル化合物
AU2012352083B2 (en) * 2011-12-16 2018-01-04 Transposagen Biopharmaceuticals, Inc. TRPC4 modulators for use in the treatment or prevention of pain

Also Published As

Publication number Publication date
JP6534716B2 (ja) 2019-06-26
JP6858808B2 (ja) 2021-04-14
HRP20181746T1 (hr) 2018-12-28
DK2790687T3 (en) 2018-11-19
RS57919B1 (sr) 2019-01-31
US20190135759A1 (en) 2019-05-09
EP3485889B1 (en) 2023-09-06
AU2018202172A1 (en) 2018-04-26
ES2692546T3 (es) 2018-12-04
HUE041294T2 (hu) 2019-05-28
EP2790687B1 (en) 2018-08-29
CA2859283A1 (en) 2013-06-20
WO2013090722A1 (en) 2013-06-20
TR201815535T4 (tr) 2018-11-21
LT2790687T (lt) 2018-12-10
JP2018030875A (ja) 2018-03-01
EP3485889A1 (en) 2019-05-22
AU2012352083B2 (en) 2018-01-04
CY1121293T1 (el) 2020-05-29
AU2018202172B2 (en) 2019-12-19
US10131634B2 (en) 2018-11-20
SI2790687T1 (sl) 2019-01-31
JP2019135271A (ja) 2019-08-15
US20140329856A1 (en) 2014-11-06
AU2012352083A1 (en) 2014-07-17
EP2790687A1 (en) 2014-10-22
JP2015500345A (ja) 2015-01-05
PL2790687T3 (pl) 2019-03-29
CA2859283C (en) 2021-03-09

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