PT2758060T - Moduladores de ror gama para o tratamento de complicações de diabetes ii - Google Patents
Moduladores de ror gama para o tratamento de complicações de diabetes iiInfo
- Publication number
- PT2758060T PT2758060T PT127594661T PT12759466T PT2758060T PT 2758060 T PT2758060 T PT 2758060T PT 127594661 T PT127594661 T PT 127594661T PT 12759466 T PT12759466 T PT 12759466T PT 2758060 T PT2758060 T PT 2758060T
- Authority
- PT
- Portugal
- Prior art keywords
- complications
- treating diabetes
- ror gamma
- gamma modulators
- modulators
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11007610 | 2011-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2758060T true PT2758060T (pt) | 2018-01-24 |
Family
ID=46852019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127594661T PT2758060T (pt) | 2011-09-19 | 2012-09-18 | Moduladores de ror gama para o tratamento de complicações de diabetes ii |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9777036B2 (pt) |
| EP (1) | EP2758060B1 (pt) |
| JP (2) | JP2014526494A (pt) |
| KR (1) | KR102020923B1 (pt) |
| CN (1) | CN103957919B (pt) |
| AU (1) | AU2012311599B2 (pt) |
| BR (1) | BR112014003704A2 (pt) |
| DK (1) | DK2758060T3 (pt) |
| ES (1) | ES2659455T3 (pt) |
| NO (1) | NO2758060T3 (pt) |
| PL (1) | PL2758060T3 (pt) |
| PT (1) | PT2758060T (pt) |
| RU (1) | RU2658013C2 (pt) |
| WO (1) | WO2013041519A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2847198B1 (en) | 2012-05-08 | 2016-12-14 | Lycera Corporation | Tetrahydro[1,8]naphthyridine sulfonamide and related compounds for use as agonists of ror-gamma and the treatment of disease |
| PE20150229A1 (es) | 2012-05-31 | 2015-03-02 | Phenex Pharmaceuticals Ag | Tiazoles sustituidos por carboxamida o sulfonamida y derivados relacionados como moduladores para el receptor nuclear huerfano rory |
| JO3215B1 (ar) | 2012-08-09 | 2018-03-08 | Phenex Pharmaceuticals Ag | حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy |
| EP2781217A1 (en) * | 2013-03-18 | 2014-09-24 | ETH Zurich | ROR gamma modulators |
| CN105531274A (zh) * | 2013-09-11 | 2016-04-27 | 豪夫迈·罗氏有限公司 | 作为RORc调节剂的酮-咪唑并吡啶衍生物 |
| CA2934378C (en) * | 2013-12-19 | 2022-03-22 | Merck Patent Gmbh | Tetrahydro-tetrazolo[1 ,5-a]pyrazines as ror-gamma inhibitors |
| AU2015222917A1 (en) | 2014-02-27 | 2016-09-15 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| WO2015171558A2 (en) | 2014-05-05 | 2015-11-12 | Lycera Corporation | BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATEMENT OF DISEASE |
| EP3140291A4 (en) | 2014-05-05 | 2018-01-10 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| AU2016257997A1 (en) | 2015-05-05 | 2017-11-09 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| US10611740B2 (en) | 2015-06-11 | 2020-04-07 | Lycera Corporation | Aryl dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| CN110139652B (zh) * | 2016-10-27 | 2022-10-11 | 爱思凯利尔生物科学私人有限责任公司 | ROR-γ调节剂 |
| EP3662076A2 (en) | 2017-08-03 | 2020-06-10 | Vio Chemicals AG | Method for preparing bile acid compound via enzymatic catalysis |
| CN109912676B (zh) * | 2019-03-07 | 2021-08-27 | 上海科骊科生物技术有限公司 | 一种3β-熊去氧胆酸的制备方法 |
| WO2022233398A1 (en) | 2021-05-04 | 2022-11-10 | Kostner Pharma Gmbh | COMPOUNDS FOR REDUCING LIPOPROTEIN(a) |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07126283A (ja) * | 1993-09-03 | 1995-05-16 | Kunio Tsuji | 胆汁アルコール |
| AU723663C (en) * | 1995-06-07 | 2001-11-01 | Magainin Pharmaceuticals, Inc. | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds |
| AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| JP2000026300A (ja) | 1998-07-02 | 2000-01-25 | Pola Chem Ind Inc | 血管内皮細胞保護医薬組成物 |
| DE60013417T2 (de) * | 1999-03-26 | 2005-09-15 | City Of Hope, Duarte | Verfahren zum screenen von fxr-rezeptormodulatoren |
| CA2386474A1 (en) | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Melanin concentrating hormone antagonist |
| WO2001021169A1 (fr) | 1999-09-20 | 2001-03-29 | Takeda Chemical Industries, Ltd. | Antagonistes de l'hormone de concentration de la melanine |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| KR100848344B1 (ko) * | 2000-02-04 | 2008-07-25 | 유서홍 | 담즙산 함유 청정 수용액 제형의 제조 |
| CN100393703C (zh) | 2000-03-14 | 2008-06-11 | 埃科特莱茵药品有限公司 | 1,2,3,4-四氢异喹啉的衍生物 |
| PT1289955E (pt) | 2000-06-16 | 2005-08-31 | Smithkline Beecham Plc | Piperidinas para utilizacao como antagonistas dos receptores da orexina |
| WO2002051232A2 (en) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Novel benzazepines and related heterocyclic derivatives |
| CA2488535C (en) | 2002-06-19 | 2012-02-07 | Karo Bio Ab | Glucocorticoid receptor ligands for the treatment of metabolic disorders |
| US20090074895A1 (en) * | 2005-05-02 | 2009-03-19 | Vanadis Bioscience Ltd | Composition and uses thereof |
| CN101679476B (zh) * | 2007-01-19 | 2014-05-07 | 英特塞普特医药品公司 | 23取代的胆汁酸作为tgr5调节剂及其使用方法 |
| JPWO2009011420A1 (ja) * | 2007-07-18 | 2010-09-24 | 田辺三菱製薬株式会社 | ２型糖尿病の治療薬 |
| US20110263546A1 (en) | 2008-02-26 | 2011-10-27 | Renxue Wang | Polyhydroxylated Bile Acids for Treatment of Biliary Disorders |
| SG178562A1 (en) * | 2009-08-25 | 2012-03-29 | Victor Ling | Polyhydroxylated bile acids for treatment of biliary disorders |
-
2012
- 2012-09-18 WO PCT/EP2012/068332 patent/WO2013041519A1/en active Application Filing
- 2012-09-18 ES ES12759466.1T patent/ES2659455T3/es active Active
- 2012-09-18 EP EP12759466.1A patent/EP2758060B1/en active Active
- 2012-09-18 RU RU2014115796A patent/RU2658013C2/ru not_active IP Right Cessation
- 2012-09-18 CN CN201280045611.7A patent/CN103957919B/zh not_active Expired - Fee Related
- 2012-09-18 BR BR112014003704A patent/BR112014003704A2/pt not_active Application Discontinuation
- 2012-09-18 KR KR1020147010403A patent/KR102020923B1/ko active IP Right Grant
- 2012-09-18 DK DK12759466.1T patent/DK2758060T3/en active
- 2012-09-18 PL PL12759466T patent/PL2758060T3/pl unknown
- 2012-09-18 JP JP2014530269A patent/JP2014526494A/ja active Pending
- 2012-09-18 AU AU2012311599A patent/AU2012311599B2/en not_active Ceased
- 2012-09-18 PT PT127594661T patent/PT2758060T/pt unknown
- 2012-09-18 NO NO12759466A patent/NO2758060T3/no unknown
- 2012-09-18 US US14/345,597 patent/US9777036B2/en active Active
-
2017
- 2017-07-28 JP JP2017146926A patent/JP6439206B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2758060B1 (en) | 2017-11-29 |
| US9777036B2 (en) | 2017-10-03 |
| WO2013041519A1 (en) | 2013-03-28 |
| JP2014526494A (ja) | 2014-10-06 |
| KR20140079416A (ko) | 2014-06-26 |
| NO2758060T3 (pt) | 2018-04-28 |
| DK2758060T3 (en) | 2018-03-05 |
| US20140343023A1 (en) | 2014-11-20 |
| ES2659455T3 (es) | 2018-03-15 |
| CN103957919A (zh) | 2014-07-30 |
| AU2012311599A1 (en) | 2014-02-20 |
| CN103957919B (zh) | 2018-10-16 |
| WO2013041519A9 (en) | 2013-06-27 |
| NZ620485A (en) | 2016-04-29 |
| BR112014003704A2 (pt) | 2017-03-07 |
| KR102020923B1 (ko) | 2019-09-11 |
| EP2758060A1 (en) | 2014-07-30 |
| RU2014115796A (ru) | 2015-10-27 |
| JP2018024651A (ja) | 2018-02-15 |
| PL2758060T3 (pl) | 2018-04-30 |
| RU2658013C2 (ru) | 2018-06-19 |
| JP6439206B2 (ja) | 2018-12-19 |
| AU2012311599B2 (en) | 2017-07-06 |
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