PT2417106T - Processo para preparação de sais de pirrolidínio - Google Patents

Processo para preparação de sais de pirrolidínio

Info

Publication number
PT2417106T
PT2417106T PT107131930T PT10713193T PT2417106T PT 2417106 T PT2417106 T PT 2417106T PT 107131930 T PT107131930 T PT 107131930T PT 10713193 T PT10713193 T PT 10713193T PT 2417106 T PT2417106 T PT 2417106T
Authority
PT
Portugal
Prior art keywords
preparing
pyrrolidinium salts
pyrrolidinium
salts
preparing pyrrolidinium
Prior art date
Application number
PT107131930T
Other languages
English (en)
Inventor
Allmendinger Thomas
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42200985&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2417106(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2417106T publication Critical patent/PT2417106T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12Oxygen or sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT107131930T 2009-04-09 2010-04-07 Processo para preparação de sais de pirrolidínio PT2417106T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16797709P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
PT2417106T true PT2417106T (pt) 2017-02-13

Family

ID=42200985

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107131930T PT2417106T (pt) 2009-04-09 2010-04-07 Processo para preparação de sais de pirrolidínio

Country Status (14)

Country Link
US (1) US20120022127A1 (pt)
EP (1) EP2417106B1 (pt)
JP (2) JP5902612B2 (pt)
KR (1) KR101290893B1 (pt)
CN (1) CN102388021B (pt)
AU (1) AU2010233772B2 (pt)
BR (1) BRPI1016083A8 (pt)
CA (1) CA2758100C (pt)
ES (1) ES2617680T3 (pt)
MX (1) MX344153B (pt)
PL (1) PL2417106T3 (pt)
PT (1) PT2417106T (pt)
RU (1) RU2554878C2 (pt)
WO (1) WO2010115937A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2580195B1 (en) * 2010-06-14 2014-12-03 Chiesi Farmaceutici S.p.A. Crystal form of glycopyrronium chloride
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN105026369A (zh) * 2013-02-28 2015-11-04 德米拉股份有限公司 格隆铵盐
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
CN103553996B (zh) * 2013-11-13 2016-01-20 北京三泉医药技术有限公司 抗胆碱药物组合物
CN103819384A (zh) * 2013-12-05 2014-05-28 广东嘉博制药有限公司 一种格隆溴铵的制备方法
US9926270B2 (en) 2014-08-20 2018-03-27 Dermira, Inc. Process for production of glycopyrronium tosylate
JP6502501B2 (ja) 2014-09-09 2019-04-17 ベクトゥラ・リミテッド グリコピロレートを含む製剤、方法、及び装置
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
EP3494106B1 (en) 2016-08-02 2022-07-20 Journey Medical Corporation Processes for making, and methods of using, glycopyrronium compounds
CN107915666A (zh) * 2016-10-09 2018-04-17 四川海思科制药有限公司 一种格隆溴铵化合物
US10954191B2 (en) 2017-03-12 2021-03-23 Sol-Gel Technologies Ltd. Process for the preparation of glycopyrrolate tosylate
WO2019021290A1 (en) 2017-07-27 2019-01-31 Sol-Gel Technologies Ltd PROCESS FOR THE PREPARATION OF GLYCOPYRROLATE TOSYLATE
WO2020148777A1 (en) * 2019-01-14 2020-07-23 Neon Laboratories Limited Process for preparation of glycopyrrolate intermediate
CN111349036B (zh) * 2020-03-13 2022-03-08 安徽恒星制药有限公司 一种格隆溴铵的替代物及其制备方法和医药用途
WO2022079194A1 (en) 2020-10-14 2022-04-21 Pcas Process for the production of glycopyrronium tosylate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2956062A (en) 1959-02-26 1960-10-11 Robins Co Inc A H Esters of amino alcohols
DE2046659A1 (pt) 1970-01-28 1972-03-23
FR2081497B1 (pt) * 1970-02-09 1974-08-02 Sandoz Sa
IT1016489B (it) 1974-03-18 1977-05-30 Isf Spa Inalatore
ATE193455T1 (de) 1995-12-07 2000-06-15 Jago Pharma Ag Inhalator zur mehrfachen dosisweisen abgabe eines pharmakologischen trockenpulvers
NZ331361A (en) 1996-02-21 2000-01-28 Schering Corp Powder inhaler including swirl means for changing the flow direction of the powder and chimney means for reversing the flow direction
US6613795B2 (en) * 1996-11-11 2003-09-02 Christian Noe Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
ES2206021B1 (es) * 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.
AT412088B (de) * 2002-12-18 2004-09-27 Pharmacon Forschung & Beratung Gmbh Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere
ES2239546B1 (es) 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0504463D0 (en) * 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
US7399861B2 (en) 2005-11-10 2008-07-15 Bodor Nicholas S Soft anticholinergic esters
GB0525254D0 (en) * 2005-12-12 2006-01-18 Jagotec Ag Powder compositions for inhalation
AP2008004537A0 (en) 2005-12-30 2008-08-31 Ranbaxy Lab Ltd Muscarinic receptor antagonists
GB0613161D0 (en) 2006-06-30 2006-08-09 Novartis Ag Organic Compounds

Also Published As

Publication number Publication date
CA2758100C (en) 2017-08-29
BRPI1016083A2 (pt) 2016-05-10
KR20120013370A (ko) 2012-02-14
RU2554878C2 (ru) 2015-06-27
WO2010115937A1 (en) 2010-10-14
AU2010233772A1 (en) 2011-10-06
AU2010233772B2 (en) 2014-04-24
RU2011145051A (ru) 2013-05-20
CN102388021A (zh) 2012-03-21
JP2015007081A (ja) 2015-01-15
JP2012523390A (ja) 2012-10-04
MX2011010657A (es) 2011-10-21
BRPI1016083A8 (pt) 2017-10-10
JP5902612B2 (ja) 2016-04-13
PL2417106T3 (pl) 2017-05-31
CA2758100A1 (en) 2010-10-14
CN102388021B (zh) 2015-02-18
KR101290893B1 (ko) 2013-07-29
MX344153B (es) 2016-12-07
EP2417106B1 (en) 2016-11-30
EP2417106A1 (en) 2012-02-15
US20120022127A1 (en) 2012-01-26
ES2617680T3 (es) 2017-06-19

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