PT2217572E - Moduladores de isoquinolina de transportadores de cassete de ligação a atp - Google Patents

Moduladores de isoquinolina de transportadores de cassete de ligação a atp Download PDF

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Publication number
PT2217572E
PT2217572E PT08849242T PT08849242T PT2217572E PT 2217572 E PT2217572 E PT 2217572E PT 08849242 T PT08849242 T PT 08849242T PT 08849242 T PT08849242 T PT 08849242T PT 2217572 E PT2217572 E PT 2217572E
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PT
Portugal
Prior art keywords
isoquinoline
atp
modulators
binding cassette
cassette transporters
Prior art date
Application number
PT08849242T
Other languages
English (en)
Inventor
Mark Miller
Peter D J Grootenhuis
Brian Bear
Jinglan Zhou
Sara Hadida Ruah
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of PT2217572E publication Critical patent/PT2217572E/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Diabetes (AREA)
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  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
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  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
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  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
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PT08849242T 2007-11-16 2008-11-14 Moduladores de isoquinolina de transportadores de cassete de ligação a atp PT2217572E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98855907P 2007-11-16 2007-11-16

Publications (1)

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PT2217572E true PT2217572E (pt) 2014-02-17

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Application Number Title Priority Date Filing Date
PT08849242T PT2217572E (pt) 2007-11-16 2008-11-14 Moduladores de isoquinolina de transportadores de cassete de ligação a atp
PT121813703T PT2578571E (pt) 2007-11-16 2008-11-14 Moduladores de transportadores de atp-binding cassette

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PT121813703T PT2578571E (pt) 2007-11-16 2008-11-14 Moduladores de transportadores de atp-binding cassette

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US (4) US8507524B2 (pt)
EP (3) EP2578571B1 (pt)
JP (3) JP5646338B2 (pt)
CN (2) CN101952254B (pt)
AU (1) AU2008322616B2 (pt)
CA (1) CA2705562C (pt)
CY (1) CY1115318T1 (pt)
DK (2) DK2578571T3 (pt)
ES (3) ES2658064T3 (pt)
HK (3) HK1148006A1 (pt)
HR (2) HRP20140103T1 (pt)
HU (1) HUE026334T2 (pt)
NZ (2) NZ585980A (pt)
PL (2) PL2578571T3 (pt)
PT (2) PT2217572E (pt)
SI (2) SI2217572T1 (pt)
WO (1) WO2009064959A1 (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
RU2006111093A (ru) 2003-09-06 2007-10-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы атр-связывающих кассетных транспортеров
ZA200604578B (en) * 2003-11-14 2008-05-28 Vertex Pharma Thiazoles and oxazoles.useful as modulators of ATP Binding cassette transporters
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
MXPA06008606A (es) * 2004-01-30 2007-04-13 Vertex Pharma Moduladores de transportadores con casete de union a atp.
CN101891680B (zh) 2004-06-24 2014-10-29 沃泰克斯药物股份有限公司 Atp-结合***转运蛋白的调控剂
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AU2013270681A1 (en) 2012-06-08 2014-12-18 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of CFTR -mediated disorders
WO2014014841A1 (en) 2012-07-16 2014-01-23 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
CA2890106C (en) 2012-11-02 2022-08-02 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of cftr mediated diseases
US20140221424A1 (en) 2013-01-30 2014-08-07 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for use in the treatment of cystic fibrosis
BR112016023422A8 (pt) 2014-04-15 2021-07-20 Vertex Pharma dispersão seca por spray, composição farmacêutica e seus usos, kit e comprimido
EP3203840B1 (en) 2014-10-06 2020-08-05 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CA2963945C (en) 2014-10-07 2023-01-10 Vertex Pharmaceuticals Incorporated Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator

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US20130296364A1 (en) 2013-11-07
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US20090143381A1 (en) 2009-06-04
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WO2009064959A1 (en) 2009-05-22
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US20140206689A1 (en) 2014-07-24
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