PT2099780E - Compostos de 2-alquilo-indazol para o tratamento de certas desordens relacionadas com o snc - Google Patents

Compostos de 2-alquilo-indazol para o tratamento de certas desordens relacionadas com o snc

Info

Publication number
PT2099780E
PT2099780E PT78466737T PT07846673T PT2099780E PT 2099780 E PT2099780 E PT 2099780E PT 78466737 T PT78466737 T PT 78466737T PT 07846673 T PT07846673 T PT 07846673T PT 2099780 E PT2099780 E PT 2099780E
Authority
PT
Portugal
Prior art keywords
alkyl
treatment
related disorders
indazole compounds
certain cns
Prior art date
Application number
PT78466737T
Other languages
English (en)
Inventor
Lorenzo Polenzani
Nicola Cazzolla
Guido Furlotti
Maria Alessandra Alisi
Caterina Maugeri
Original Assignee
Acraf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acraf filed Critical Acraf
Publication of PT2099780E publication Critical patent/PT2099780E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
PT78466737T 2006-11-22 2007-11-19 Compostos de 2-alquilo-indazol para o tratamento de certas desordens relacionadas com o snc PT2099780E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002230A ITMI20062230A1 (it) 2006-11-22 2006-11-22 Composto 2-alchil-indazolico procedimento per preparalo e composizione farmaceutica che lo comprende

Publications (1)

Publication Number Publication Date
PT2099780E true PT2099780E (pt) 2013-03-11

Family

ID=38474157

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78466737T PT2099780E (pt) 2006-11-22 2007-11-19 Compostos de 2-alquilo-indazol para o tratamento de certas desordens relacionadas com o snc

Country Status (23)

Country Link
US (1) US8507528B2 (pt)
EP (1) EP2099780B1 (pt)
JP (1) JP5551443B2 (pt)
KR (1) KR101471987B1 (pt)
CN (1) CN101558057B (pt)
AR (1) AR063881A1 (pt)
AU (1) AU2007323368B2 (pt)
BR (1) BRPI0718976A2 (pt)
CA (1) CA2668205C (pt)
DK (1) DK2099780T3 (pt)
EA (1) EA019217B1 (pt)
ES (1) ES2401199T3 (pt)
GE (1) GEP20125414B (pt)
HK (1) HK1129112A1 (pt)
IL (1) IL198432A (pt)
IT (1) ITMI20062230A1 (pt)
MX (1) MX2009005250A (pt)
PL (1) PL2099780T3 (pt)
PT (1) PT2099780E (pt)
SG (1) SG176504A1 (pt)
SI (1) SI2099780T1 (pt)
UA (1) UA98311C2 (pt)
WO (1) WO2008061688A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011238054B2 (en) * 2010-04-08 2016-06-23 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. Tricyclic indazole compound, method of preparation and pharmaceutical composition containing it
DK2686303T3 (en) 2011-03-18 2016-03-29 Bayer Ip Gmbh N- (3-carbamoylphenyl) -1 H -pyrazole-5-carboxamide derivatives and their use for controlling animal pests

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4436913A (en) * 1980-09-05 1984-03-13 Siegfried Aktiengesellschaft 1H- and 2H- indazole derivatives
GB8623142D0 (en) * 1986-09-26 1986-10-29 Beecham Group Plc Compounds
DE3687080T2 (de) * 1985-04-27 1993-03-25 Beecham Group Plc Azabicyclononyl-indazol-carboxamid mit 5-ht-antagonistischer wirkung.
JPH02215779A (ja) * 1989-02-14 1990-08-28 Kuraray Co Ltd カルボン酸アミド誘導体類及びその医薬用途
US5246947A (en) * 1991-09-23 1993-09-21 Hoechst-Roussel Pharmaceuticals Incorporated Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
AU4949293A (en) 1992-08-28 1994-03-29 Ciba-Geigy Ag Indazole derivatives
JPH08277287A (ja) 1995-02-09 1996-10-22 Mitsubishi Chem Corp インダゾール類およびその用途
US5945434A (en) * 1995-05-31 1999-08-31 Nisshin Flour Milling Co., Ltd. Indazole derivatives having monocyclic amine
IT1291569B1 (it) * 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
US6218390B1 (en) * 1998-12-17 2001-04-17 Synaptic Pharmaceutical Corporation Morpholinone and morpholine derivatives and uses thereof
AU2003286180B2 (en) 2002-12-02 2009-11-12 F. Hoffmann-La Roche Ag Indazole derivatives as CRF antagonists
ITMI20030972A1 (it) 2003-05-15 2004-11-16 Acraf Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende.
ITMI20031468A1 (it) 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
FR2857966A1 (fr) * 2003-07-24 2005-01-28 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
WO2005061483A2 (en) * 2003-12-23 2005-07-07 Bio-Medisinsk Innovasjon As Modulators of peripheral 5-ht receptors
MXPA06007692A (es) * 2004-01-05 2007-01-26 Astrazeneca Ab Heterociclos sustituidos y usos de los mismos.
PE20060417A1 (es) * 2004-08-03 2006-06-13 Wyeth Corp Indazoles como moduladores de lxrs
TW200621237A (en) * 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
PE20061130A1 (es) * 2004-11-19 2007-01-05 Arena Pharm Inc Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a
WO2008054748A2 (en) * 2006-10-31 2008-05-08 Arena Pharmaceuticals, Inc. Indazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto

Also Published As

Publication number Publication date
HK1129112A1 (en) 2009-11-20
AU2007323368B2 (en) 2013-02-07
PL2099780T3 (pl) 2013-05-31
KR101471987B1 (ko) 2014-12-12
SI2099780T1 (sl) 2013-03-29
US20100056573A1 (en) 2010-03-04
CA2668205C (en) 2014-10-21
JP2010510265A (ja) 2010-04-02
CN101558057A (zh) 2009-10-14
US8507528B2 (en) 2013-08-13
JP5551443B2 (ja) 2014-07-16
WO2008061688A1 (en) 2008-05-29
EA200970496A1 (ru) 2009-10-30
BRPI0718976A2 (pt) 2014-02-04
IL198432A (en) 2013-03-24
EP2099780B1 (en) 2013-01-09
GEP20125414B (en) 2012-03-12
EP2099780A1 (en) 2009-09-16
AU2007323368A1 (en) 2008-05-29
SG176504A1 (en) 2011-12-29
UA98311C2 (ru) 2012-05-10
EA019217B1 (ru) 2014-02-28
ITMI20062230A1 (it) 2008-05-23
MX2009005250A (es) 2009-05-28
CA2668205A1 (en) 2008-05-29
ES2401199T3 (es) 2013-04-17
KR20090089880A (ko) 2009-08-24
CN101558057B (zh) 2013-05-01
IL198432A0 (en) 2010-02-17
AR063881A1 (es) 2009-02-25
DK2099780T3 (da) 2013-04-15

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