PT1753723E - Derivados de quinolina substituída como inibidores de quinesina mitótica - Google Patents
Derivados de quinolina substituída como inibidores de quinesina mitótica Download PDFInfo
- Publication number
- PT1753723E PT1753723E PT05752901T PT05752901T PT1753723E PT 1753723 E PT1753723 E PT 1753723E PT 05752901 T PT05752901 T PT 05752901T PT 05752901 T PT05752901 T PT 05752901T PT 1753723 E PT1753723 E PT 1753723E
- Authority
- PT
- Portugal
- Prior art keywords
- substituted quinoline
- quinoline derivatives
- mitotic kinesin
- kinesin inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57312004P | 2004-05-21 | 2004-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1753723E true PT1753723E (pt) | 2008-11-19 |
Family
ID=34970815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT05752901T PT1753723E (pt) | 2004-05-21 | 2005-05-19 | Derivados de quinolina substituída como inibidores de quinesina mitótica |
Country Status (19)
Country | Link |
---|---|
US (2) | US7452996B2 (pt) |
EP (1) | EP1753723B1 (pt) |
JP (1) | JP2008502721A (pt) |
CN (1) | CN1956960A (pt) |
AT (1) | ATE404536T1 (pt) |
AU (1) | AU2005245492A1 (pt) |
BR (1) | BRPI0511433A (pt) |
CA (1) | CA2564215A1 (pt) |
DE (1) | DE602005008953D1 (pt) |
DK (1) | DK1753723T3 (pt) |
ES (1) | ES2311992T3 (pt) |
HR (1) | HRP20080493T3 (pt) |
MX (1) | MXPA06011958A (pt) |
PL (1) | PL1753723T3 (pt) |
PT (1) | PT1753723E (pt) |
RS (1) | RS50670B (pt) |
RU (1) | RU2385867C2 (pt) |
SI (1) | SI1753723T1 (pt) |
WO (1) | WO2005113507A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE404536T1 (de) * | 2004-05-21 | 2008-08-15 | Novartis Vaccines & Diagnostic | Substituierte chinolinderivate als inhibitoren von mitotischem kinesin |
KR20070046176A (ko) | 2004-08-18 | 2007-05-02 | 아스트라제네카 아베 | 특정 융합 피리미돈의 거울상이성질체 및 이의 암 치료 및예방에 있어서의 용도 |
US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
PL1965823T3 (pl) * | 2005-11-04 | 2017-08-31 | Glaxosmithkline Llc | Sposoby podawania środków hipoglikemicznych |
US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
US8129358B2 (en) * | 2006-11-13 | 2012-03-06 | Novartis Ag | Substituted pyrazole and triazole compounds as KSP inhibitors |
KR20090097210A (ko) * | 2007-01-05 | 2009-09-15 | 노파르티스 아게 | 키네신 방추체 단백질 (eg-5) 억제제로서의 이미다졸 유도체 |
FR2940289B1 (fr) * | 2008-12-23 | 2014-09-12 | Biopharmed | Derives de la classe des hydroxyquinoleines aminees pour le traitement du cancer du pancreas |
EA201201404A1 (ru) * | 2010-04-15 | 2013-04-30 | Новартис Аг | Триазолы как ингибиторы кбв (кинезин-белок веретена) |
CN103153970A (zh) * | 2010-04-15 | 2013-06-12 | 诺瓦提斯公司 | 作为ksp抑制剂的*唑和噻唑化合物 |
US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
RU2486175C2 (ru) * | 2011-09-12 | 2013-06-27 | Закрытое Акционерное Общество "Фарм-Синтез" | Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений |
US9458161B1 (en) | 2011-11-03 | 2016-10-04 | Vanderblit University | TSPO ligands for cancer imaging and treatment |
RU2617392C2 (ru) * | 2012-08-13 | 2017-04-24 | Эррэй Биофарма Инк. | Применение arry-520 для лечения рака у пациентов с низким уровнем акг |
MX2017001980A (es) | 2014-08-28 | 2017-05-04 | Eisai R&D Man Co Ltd | Derivado de quinolina muy puro y metodo para su produccion. |
BR112017017428A2 (pt) | 2015-02-25 | 2018-04-03 | Eisai R&D Management Co., Ltd. | ?método para supressão do amargor de derivado de quinolina? |
KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
JP6757959B2 (ja) | 2015-06-16 | 2020-09-23 | 株式会社 PRISM BioLab | 抗がん剤 |
SG10201913215YA (en) * | 2015-08-19 | 2020-02-27 | Eisai R&D Man Co Ltd | Therapeutic agent for biliary tract cancer |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6172087B1 (en) * | 1998-06-03 | 2001-01-09 | Gpi Nil Holding, Inc. | N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses |
JP2002541146A (ja) | 1999-04-02 | 2002-12-03 | ニューロゲン コーポレイション | アリールおよびヘテロアリール融合のアミノアルキル−イミダゾール誘導体および糖尿病薬としてのその使用 |
MXPA02004162A (es) | 1999-10-27 | 2003-08-20 | Cytokinetics Inc | Metodo y composiciones que utilizan quinazolinonas. |
US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
AU2001296799A1 (en) | 2000-10-06 | 2002-04-15 | Neurogen Corporation | Benzimidazole and indole derivatives as crf receptor modulators |
EA007538B1 (ru) | 2000-12-11 | 2006-10-27 | Туларик Инк. | Антагонисты cxcr3 |
US6992082B2 (en) | 2001-01-19 | 2006-01-31 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
US20040132830A1 (en) | 2001-01-19 | 2004-07-08 | Finer Jeffrey T | Triphenylmethane kinesin inhibitors |
US7060705B2 (en) | 2001-11-07 | 2006-06-13 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
US6753428B2 (en) | 2001-11-20 | 2004-06-22 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
EP1481077B1 (en) | 2001-12-06 | 2009-11-04 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
US7262186B2 (en) | 2001-12-06 | 2007-08-28 | Merck & Co., Inc. | Substituted pyrazolo[3,4-d] pyrimidinones as a mitotic kinesin inhibitor |
EP1465896A4 (en) | 2001-12-06 | 2006-01-11 | Merck & Co Inc | MITOTIC INHIBITORS OF KINESIN |
JP4597519B2 (ja) | 2001-12-06 | 2010-12-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 有糸***キネシン阻害薬 |
WO2003049678A2 (en) | 2001-12-06 | 2003-06-19 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
EP1465888A2 (en) | 2002-01-10 | 2004-10-13 | Neurogen Corporation | Melanin concentrating hormone receptor ligands: substituted benzoimidazole analogues |
AU2003213092A1 (en) | 2002-02-15 | 2003-09-09 | Smithkline Beecham Corporation | Syntheses of quinazolinones |
CA2478068C (en) | 2002-03-08 | 2011-02-08 | Merck & Co., Inc. | Dihydropyrazole compounds useful for treating or preventing cancer |
BR0309278A (pt) | 2002-04-17 | 2005-04-26 | Cytokinetics Inc | Composto, composição, métodos para modular a atividade da cinesina ksp, para inibir a ksp, para o tratamento de uma doença proliferativa celular, e, uso de um composto |
CA2485148A1 (en) | 2002-05-09 | 2003-11-20 | Cytokinetics, Inc. | Pyrimidinone compounds, compositions and methods |
AU2003270015A1 (en) | 2002-05-09 | 2003-12-02 | Cytokinetics, Inc. | Compounds, compositions, and methods |
CA2483627A1 (en) | 2002-05-23 | 2003-12-04 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
AU2003265242A1 (en) | 2002-05-23 | 2003-12-22 | Cytokinetics, Inc. | Compounds, compositions, and methods |
CA2486215A1 (en) | 2002-06-14 | 2003-12-24 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
AU2003245453B2 (en) | 2002-06-14 | 2008-08-14 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
EP1556357A4 (en) | 2002-06-14 | 2006-09-13 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
EP1551962A4 (en) | 2002-07-08 | 2007-08-01 | Merck & Co Inc | MITOTIC KINESIN BINDING CENTER |
US6949538B2 (en) | 2002-07-17 | 2005-09-27 | Cytokinetics, Inc. | Compounds, compositions, and methods |
AU2003256805A1 (en) | 2002-07-23 | 2004-02-09 | Cytokinetics, Inc. | Compounds compositions and methods |
EP1539180A4 (en) | 2002-08-21 | 2006-08-30 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
WO2004024086A2 (en) | 2002-09-13 | 2004-03-25 | Cytokinetics, Inc. | Compounds, compositions and methods |
ATE404536T1 (de) * | 2004-05-21 | 2008-08-15 | Novartis Vaccines & Diagnostic | Substituierte chinolinderivate als inhibitoren von mitotischem kinesin |
-
2005
- 2005-05-19 AT AT05752901T patent/ATE404536T1/de not_active IP Right Cessation
- 2005-05-19 BR BRPI0511433-0A patent/BRPI0511433A/pt not_active IP Right Cessation
- 2005-05-19 JP JP2007527522A patent/JP2008502721A/ja active Pending
- 2005-05-19 US US11/133,509 patent/US7452996B2/en not_active Expired - Fee Related
- 2005-05-19 DK DK05752901T patent/DK1753723T3/da active
- 2005-05-19 DE DE602005008953T patent/DE602005008953D1/de active Active
- 2005-05-19 CA CA002564215A patent/CA2564215A1/en not_active Abandoned
- 2005-05-19 RS RSP-2008/0534A patent/RS50670B/sr unknown
- 2005-05-19 SI SI200530384T patent/SI1753723T1/sl unknown
- 2005-05-19 PL PL05752901T patent/PL1753723T3/pl unknown
- 2005-05-19 ES ES05752901T patent/ES2311992T3/es active Active
- 2005-05-19 CN CNA2005800164405A patent/CN1956960A/zh active Pending
- 2005-05-19 RU RU2006145336/04A patent/RU2385867C2/ru not_active IP Right Cessation
- 2005-05-19 MX MXPA06011958A patent/MXPA06011958A/es active IP Right Grant
- 2005-05-19 EP EP05752901A patent/EP1753723B1/en active Active
- 2005-05-19 WO PCT/US2005/017961 patent/WO2005113507A1/en active Application Filing
- 2005-05-19 PT PT05752901T patent/PT1753723E/pt unknown
- 2005-05-19 AU AU2005245492A patent/AU2005245492A1/en not_active Abandoned
-
2008
- 2008-09-30 US US12/242,360 patent/US20090028858A1/en not_active Abandoned
- 2008-10-01 HR HR20080493T patent/HRP20080493T3/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES2311992T3 (es) | 2009-02-16 |
CN1956960A (zh) | 2007-05-02 |
US20050261337A1 (en) | 2005-11-24 |
BRPI0511433A (pt) | 2007-12-11 |
PL1753723T3 (pl) | 2009-01-30 |
RS50670B (sr) | 2010-06-30 |
SI1753723T1 (sl) | 2009-04-30 |
EP1753723B1 (en) | 2008-08-13 |
EP1753723A1 (en) | 2007-02-21 |
RU2006145336A (ru) | 2008-06-27 |
AU2005245492A1 (en) | 2005-12-01 |
US7452996B2 (en) | 2008-11-18 |
MXPA06011958A (es) | 2006-12-15 |
CA2564215A1 (en) | 2005-12-01 |
HRP20080493T3 (en) | 2009-02-28 |
WO2005113507A1 (en) | 2005-12-01 |
DK1753723T3 (da) | 2008-10-20 |
ATE404536T1 (de) | 2008-08-15 |
RU2385867C2 (ru) | 2010-04-10 |
DE602005008953D1 (de) | 2008-09-25 |
JP2008502721A (ja) | 2008-01-31 |
US20090028858A1 (en) | 2009-01-29 |
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