PT1716145E - Di-hidrotetrabenazinas e composições farmacológicas que as contêm - Google Patents
Di-hidrotetrabenazinas e composições farmacológicas que as contêm Download PDFInfo
- Publication number
- PT1716145E PT1716145E PT05708289T PT05708289T PT1716145E PT 1716145 E PT1716145 E PT 1716145E PT 05708289 T PT05708289 T PT 05708289T PT 05708289 T PT05708289 T PT 05708289T PT 1716145 E PT1716145 E PT 1716145E
- Authority
- PT
- Portugal
- Prior art keywords
- pharmaceutical compositions
- compositions containing
- dihydrotetrabenazine
- dihydrotetrabenazines
- novel isomers
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- WEQLWGNDNRARGE-DJIMGWMZSA-N (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol Chemical class C1CN2C[C@@H](CC(C)C)[C@H](O)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-DJIMGWMZSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010058504 Ballismus Diseases 0.000 abstract 1
- 206010008748 Chorea Diseases 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- 208000023105 Huntington disease Diseases 0.000 abstract 1
- 208000000269 Hyperkinesis Diseases 0.000 abstract 1
- 206010043118 Tardive Dyskinesia Diseases 0.000 abstract 1
- 208000000323 Tourette Syndrome Diseases 0.000 abstract 1
- 208000016620 Tourette disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54353104P | 2004-02-11 | 2004-02-11 | |
| GB0403037A GB2410947B (en) | 2004-02-11 | 2004-02-11 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1716145E true PT1716145E (pt) | 2008-11-14 |
Family
ID=32011732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05708289T PT1716145E (pt) | 2004-02-11 | 2005-02-11 | Di-hidrotetrabenazinas e composições farmacológicas que as contêm |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20080108645A1 (pt) |
| EP (1) | EP1716145B1 (pt) |
| JP (1) | JP2007522193A (pt) |
| CN (1) | CN100591680C (pt) |
| AT (1) | ATE406370T1 (pt) |
| AU (1) | AU2005213525B2 (pt) |
| CA (1) | CA2555815A1 (pt) |
| CY (1) | CY1108592T1 (pt) |
| DE (1) | DE602005009327D1 (pt) |
| DK (1) | DK1716145T3 (pt) |
| ES (1) | ES2313292T3 (pt) |
| GB (1) | GB2410947B (pt) |
| HK (1) | HK1098138A1 (pt) |
| HR (1) | HRP20080564T3 (pt) |
| MX (1) | MXPA06009164A (pt) |
| NZ (1) | NZ549105A (pt) |
| PL (1) | PL1716145T3 (pt) |
| PT (1) | PT1716145E (pt) |
| RS (1) | RS50660B (pt) |
| RU (1) | RU2365590C2 (pt) |
| SI (1) | SI1716145T1 (pt) |
| WO (1) | WO2005077946A1 (pt) |
| ZA (1) | ZA200607425B (pt) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843590B1 (fr) | 2002-08-14 | 2007-10-05 | Prestwick Scient Capital Inc | Derives de l'acide r(+)-2-amino-3-hydroxypropanoique a action glycinergique |
| GB0514501D0 (en) | 2005-07-14 | 2005-08-24 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| RU2407743C2 (ru) * | 2005-08-06 | 2010-12-27 | Байовейл Лэборетериз Интернешнл (Барбадос) Срл | Фармацевтические соединения |
| MX2008014064A (es) * | 2006-05-02 | 2009-06-12 | Univ Pennsylvania | Derivados radiomarcados de dihidrotetrabenazina y su uso como agentes de diagnostico por imagenes. |
| EP2081929B1 (en) | 2006-11-08 | 2013-01-09 | Neurocrine Biosciences, Inc. | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto |
| US7897770B2 (en) | 2007-10-25 | 2011-03-01 | General Electric Company | Fluorinated dihydrotetrabenazine ether imaging agents and probes |
| US7897769B2 (en) | 2007-10-25 | 2011-03-01 | General Electric Company | Intermediates for fluorinated dihydrotetrabenazine ether imaging agents and probes |
| WO2009055520A2 (en) * | 2007-10-25 | 2009-04-30 | General Electric Company | Fluorinated dihydrotetrabenazine ether imaging agents and probes |
| GB0721669D0 (en) * | 2007-11-02 | 2007-12-12 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US7910738B2 (en) | 2007-11-29 | 2011-03-22 | General Electric Company | Intermediates for alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
| US7902364B2 (en) | 2007-11-29 | 2011-03-08 | General Electric Company | Alpha-fluoroalkyl tetrabenazine and dihydrotetrabenazine imaging agents and probes |
| US8053578B2 (en) | 2007-11-29 | 2011-11-08 | General Electric Company | Alpha-fluoroalkyl dihydrotetrabenazine imaging agents and probes |
| US8013161B1 (en) | 2007-12-07 | 2011-09-06 | General Electric Company | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes |
| CN101889013B (zh) * | 2007-12-07 | 2014-09-03 | 通用电气公司 | 作为成像剂和探针的氟烷基丁苯那嗪甲醇化合物 |
| US7919622B2 (en) | 2007-12-07 | 2011-04-05 | Kande Kankanamalage Dayarathna Amarasinghe | Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| US20120208773A1 (en) * | 2008-08-12 | 2012-08-16 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenazine |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463451A (en) | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| WO2010044981A2 (en) * | 2008-09-18 | 2010-04-22 | Auspex Pharmaceutical ,Inc. | Benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| CA2771539A1 (en) | 2009-08-12 | 2011-02-17 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenzine |
| CN103003275A (zh) * | 2010-06-01 | 2013-03-27 | 奥斯拜客斯制药有限公司 | Vmat2的苯并喹啉酮抑制剂 |
| CN102285984B (zh) * | 2010-11-25 | 2012-10-10 | 江苏威凯尔医药科技有限公司 | (2R,3R,11bR)-二氢丁苯那嗪及相关化合物的制备方法 |
| US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
| JP6362601B2 (ja) | 2012-09-18 | 2018-07-25 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 小胞モノアミン輸送体２の重水素化ベンゾキノリン阻害剤の製剤薬物動態 |
| JP2016506957A (ja) * | 2013-01-31 | 2016-03-07 | オースペックス・ファーマシューティカルズ・インコーポレイテッドＡｕｓｐｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｖｍａｔ２のベンゾキノロン阻害剤 |
| MX369956B (es) | 2013-12-03 | 2019-11-27 | Auspex Pharmaceuticals Inc | Metodos para preparar compuestos de benzoquinolina. |
| EA201691512A1 (ru) | 2014-01-27 | 2017-01-30 | Оспекс Фармасьютикалз, Инк. | Бензохинолиновые ингибиторы везикулярного переносчика моноамина 2 |
| CA2938581C (en) * | 2014-02-07 | 2023-02-28 | Neurocrine Biosciences, Inc. | Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof |
| WO2015120110A2 (en) | 2014-02-07 | 2015-08-13 | Auspex Pharmaceuticals, Inc. | Novel pharmaceutical formulations |
| MX2017011459A (es) | 2015-03-06 | 2018-04-24 | Auspex Pharmaceuticals Inc | Metodos para el tratamiento de trastornos del movimiento involuntario anormal. |
| CN113713108A (zh) * | 2015-06-23 | 2021-11-30 | 纽罗克里生物科学有限公司 | 用于治疗神经学疾病或病症的vmat2抑制剂 |
| CA3002074A1 (en) | 2015-10-30 | 2017-05-04 | Neurocrine Biosciences, Inc. | Valbenazine salts and polymorphs thereof |
| JP6869988B2 (ja) | 2015-12-23 | 2021-05-12 | ニューロクライン バイオサイエンシーズ，インコーポレイテッド | （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法 |
| TW202345829A (zh) | 2016-12-02 | 2023-12-01 | 美商紐羅克里生物科學有限公司 | 戊苯那嗪（valbenazine）於治療精神***症或情感性精神***症之用途 |
| CN110769826A (zh) | 2017-01-27 | 2020-02-07 | 纽罗克里生物科学有限公司 | 施用某些vmat2抑制剂的方法 |
| WO2018164996A1 (en) | 2017-03-06 | 2018-09-13 | Neurocrine Biosciences, Inc. | Dosing regimen for valbenazine |
| JP7250692B2 (ja) * | 2017-04-01 | 2023-04-03 | アデプティオ ファーマシューティカルズ リミテッド | 運動障害の治療における使用のためのジヒドロテトラベナジン |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| RU2771164C2 (ru) * | 2017-04-01 | 2022-04-27 | Адептио Фармасьютикалз Лимитед | (+)-альфа-дигидротетрабеназин для использования при лечении двигательного расстройства |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| US20200179352A1 (en) | 2017-04-26 | 2020-06-11 | Neurocrine Biosciences, Inc. | Use of valbenazine for treating levodopa-induced dyskinesia |
| CN107089980B (zh) * | 2017-05-11 | 2019-08-30 | 合肥工业大学 | 一种手性苯并[a]喹嗪-2-酮类化合物及其不对称催化合成方法 |
| EP3684333A2 (en) | 2017-09-21 | 2020-07-29 | Neurocrine Biosciences, Inc. | High dosage valbenazine formulation and compositions, methods, and kits related thereto |
| AU2017435893B2 (en) * | 2017-10-10 | 2023-06-29 | Neurocrine Biosciences, Inc | Methods for the administration of certain VMAT2 inhibitors |
| US10993941B2 (en) | 2017-10-10 | 2021-05-04 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| EP3806856A1 (en) | 2018-06-14 | 2021-04-21 | Neurocrine Biosciences, Inc. | Vmat2 inhibitor compounds, compositions, and methods relating thereto |
| BR112021000019A2 (pt) | 2018-08-15 | 2021-04-06 | Neurocrine Biosciences Inc. | Métodos para administração de certos inibidores de vmat2 |
| US10940141B1 (en) | 2019-08-23 | 2021-03-09 | Neurocrine Biosciences, Inc. | Methods for the administration of certain VMAT2 inhibitors |
| EP4168409A1 (en) | 2021-03-22 | 2023-04-26 | Neurocrine Biosciences, Inc. | Vmat2 inhibitors and methods of use |
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| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
-
2004
- 2004-02-11 GB GB0403037A patent/GB2410947B/en not_active Expired - Fee Related
-
2005
- 2005-02-11 RU RU2006132329/04A patent/RU2365590C2/ru not_active IP Right Cessation
- 2005-02-11 JP JP2006552683A patent/JP2007522193A/ja active Pending
- 2005-02-11 AT AT05708289T patent/ATE406370T1/de active
- 2005-02-11 NZ NZ549105A patent/NZ549105A/en not_active IP Right Cessation
- 2005-02-11 PT PT05708289T patent/PT1716145E/pt unknown
- 2005-02-11 US US10/597,803 patent/US20080108645A1/en not_active Abandoned
- 2005-02-11 CA CA002555815A patent/CA2555815A1/en not_active Abandoned
- 2005-02-11 PL PL05708289T patent/PL1716145T3/pl unknown
- 2005-02-11 SI SI200530470T patent/SI1716145T1/sl unknown
- 2005-02-11 WO PCT/GB2005/000464 patent/WO2005077946A1/en active Application Filing
- 2005-02-11 ZA ZA200607425A patent/ZA200607425B/xx unknown
- 2005-02-11 RS RSP-2008/0550A patent/RS50660B/sr unknown
- 2005-02-11 EP EP05708289A patent/EP1716145B1/en active Active
- 2005-02-11 ES ES05708289T patent/ES2313292T3/es active Active
- 2005-02-11 DE DE602005009327T patent/DE602005009327D1/de active Active
- 2005-02-11 MX MXPA06009164A patent/MXPA06009164A/es active IP Right Grant
- 2005-02-11 CN CN200580012044A patent/CN100591680C/zh not_active Expired - Fee Related
- 2005-02-11 DK DK05708289T patent/DK1716145T3/da active
- 2005-02-11 AU AU2005213525A patent/AU2005213525B2/en not_active Ceased
-
2007
- 2007-04-25 HK HK07104428.7A patent/HK1098138A1/xx not_active IP Right Cessation
-
2008
- 2008-11-06 HR HR20080564T patent/HRP20080564T3/xx unknown
- 2008-11-26 CY CY20081101360T patent/CY1108592T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2410947B (en) | 2008-09-17 |
| ATE406370T1 (de) | 2008-09-15 |
| EP1716145A1 (en) | 2006-11-02 |
| DE602005009327D1 (de) | 2008-10-09 |
| CN100591680C (zh) | 2010-02-24 |
| ZA200607425B (en) | 2008-02-27 |
| HK1098138A1 (en) | 2007-07-13 |
| CA2555815A1 (en) | 2005-08-25 |
| HRP20080564T3 (en) | 2009-02-28 |
| WO2005077946A1 (en) | 2005-08-25 |
| AU2005213525B2 (en) | 2011-01-06 |
| MXPA06009164A (es) | 2007-01-26 |
| NZ549105A (en) | 2009-04-30 |
| RU2365590C2 (ru) | 2009-08-27 |
| RS50660B (sr) | 2010-06-30 |
| GB0403037D0 (en) | 2004-03-17 |
| RU2006132329A (ru) | 2008-03-20 |
| CN1980924A (zh) | 2007-06-13 |
| EP1716145B1 (en) | 2008-08-27 |
| GB2410947A (en) | 2005-08-17 |
| ES2313292T3 (es) | 2009-03-01 |
| SI1716145T1 (sl) | 2009-02-28 |
| DK1716145T3 (da) | 2008-11-10 |
| US20080108645A1 (en) | 2008-05-08 |
| AU2005213525A1 (en) | 2005-08-25 |
| CY1108592T1 (el) | 2014-04-09 |
| PL1716145T3 (pl) | 2009-04-30 |
| JP2007522193A (ja) | 2007-08-09 |
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