PT1458888E - Métodos para tratar a psicose e a esquizofrenia baseados em polimorfismos no gene do cntf - Google Patents

Métodos para tratar a psicose e a esquizofrenia baseados em polimorfismos no gene do cntf Download PDF

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Publication number
PT1458888E
PT1458888E PT02791794T PT02791794T PT1458888E PT 1458888 E PT1458888 E PT 1458888E PT 02791794 T PT02791794 T PT 02791794T PT 02791794 T PT02791794 T PT 02791794T PT 1458888 E PT1458888 E PT 1458888E
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PT
Portugal
Prior art keywords
polymorphisms
methods
cntf gene
treating psychosis
schizophrenia based
Prior art date
Application number
PT02791794T
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English (en)
Inventor
Sridhar Kudaravalli
Mihael Hristos Polymeropoulos
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT1458888E publication Critical patent/PT1458888E/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/30—Psychoses; Psychiatry
    • G01N2800/302—Schizophrenia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT02791794T 2001-12-10 2002-12-09 Métodos para tratar a psicose e a esquizofrenia baseados em polimorfismos no gene do cntf PT1458888E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33983501P 2001-12-10 2001-12-10

Publications (1)

Publication Number Publication Date
PT1458888E true PT1458888E (pt) 2011-06-01

Family

ID=23330814

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02791794T PT1458888E (pt) 2001-12-10 2002-12-09 Métodos para tratar a psicose e a esquizofrenia baseados em polimorfismos no gene do cntf

Country Status (16)

Country Link
US (3) US20050059006A1 (pt)
EP (1) EP1458888B1 (pt)
JP (2) JP2005512576A (pt)
CN (1) CN1612941B (pt)
AT (1) ATE503845T1 (pt)
AU (1) AU2002358110A1 (pt)
BR (1) BRPI0214821B8 (pt)
CA (1) CA2468972A1 (pt)
CY (1) CY1111594T1 (pt)
DE (1) DE60239634D1 (pt)
DK (1) DK1458888T3 (pt)
ES (1) ES2364037T3 (pt)
HK (1) HK1069413A1 (pt)
PT (1) PT1458888E (pt)
SI (1) SI1458888T1 (pt)
WO (1) WO2003054226A2 (pt)

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JP5535914B2 (ja) * 2007-09-10 2014-07-02 ヴァンダ ファーマシューティカルズ インコーポレイテッド Ｓｎｐ遺伝子型に基づく抗精神病薬治療
ES2483366T3 (es) 2007-12-13 2014-08-06 Vanda Pharmaceuticals Inc. Método y composición para el tratamiento de una afección mediada por el receptor de serotonina
BRPI0820993A2 (pt) 2007-12-13 2017-05-09 Vanda Pharmaceuticals Inc método e composição para tratar uma condição mediada por alfa adrenoceptor
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US9057104B2 (en) 2009-05-15 2015-06-16 Vanda Pharmaceuticals, Inc. Antipsychotic treatment based on DRD2 or ANKK1 SNP genotype
EP3345603B1 (en) 2012-03-14 2019-12-18 Vanda Pharmaceuticals Inc. Iloperidone metabolite for use in the treatment of psychiatric disorders
US10877498B2 (en) * 2017-10-27 2020-12-29 Brasscraft Manufacturing Company Excess flow and thermal valve
CN112771619A (zh) * 2018-08-28 2021-05-07 皇家飞利浦有限公司 用于评估基因组比对基础的方法
US11214827B2 (en) * 2018-08-30 2022-01-04 Vanda Pharmaceuticals Inc. Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone
EP3959340A1 (en) * 2019-04-24 2022-03-02 Institut National de la Santé et de la Recherche Médicale (INSERM) Method for predicting the response of antipsychotic drugs
CN110184345B (zh) * 2019-07-11 2020-05-05 南京先声医学检验有限公司 用于检测精神及神经类疾病用药相关snp位点的引物组、应用、产品及方法
CN111187829A (zh) * 2020-02-24 2020-05-22 内蒙古医科大学 Lp基因启动子区甲基化检测引物与检测方法及其应用

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Also Published As

Publication number Publication date
US8460867B2 (en) 2013-06-11
CN1612941B (zh) 2011-11-16
BRPI0214821B8 (pt) 2021-07-27
WO2003054226A3 (en) 2004-04-01
CY1111594T1 (el) 2015-10-07
US20090239908A1 (en) 2009-09-24
ATE503845T1 (de) 2011-04-15
WO2003054226A2 (en) 2003-07-03
AU2002358110A1 (en) 2003-07-09
DE60239634D1 (de) 2011-05-12
JP2005512576A (ja) 2005-05-12
EP1458888B1 (en) 2011-03-30
EP1458888A2 (en) 2004-09-22
DK1458888T3 (da) 2011-06-20
BRPI0214821B1 (pt) 2015-07-07
ES2364037T3 (es) 2011-08-23
JP2011006422A (ja) 2011-01-13
CA2468972A1 (en) 2003-07-03
JP5785697B2 (ja) 2015-09-30
US20050059006A1 (en) 2005-03-17
CN1612941A (zh) 2005-05-04
AU2002358110A8 (en) 2003-07-09
HK1069413A1 (en) 2005-05-20
US20080027106A1 (en) 2008-01-31
BR0214821A (pt) 2004-11-03
SI1458888T1 (sl) 2011-07-29

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