PT1305296E - Derivados de pirimidina, substituídos na posição 5, de análogos de nucleósidos bloqueados sob o ponto de vista da estrutura - Google Patents
Derivados de pirimidina, substituídos na posição 5, de análogos de nucleósidos bloqueados sob o ponto de vista da estrutura Download PDFInfo
- Publication number
- PT1305296E PT1305296E PT01957228T PT01957228T PT1305296E PT 1305296 E PT1305296 E PT 1305296E PT 01957228 T PT01957228 T PT 01957228T PT 01957228 T PT01957228 T PT 01957228T PT 1305296 E PT1305296 E PT 1305296E
- Authority
- PT
- Portugal
- Prior art keywords
- nucleoside analogues
- pyrimidine derivatives
- substituted pyrimidine
- locked nucleoside
- conformationally locked
- Prior art date
Links
- -1 5-substituted pyrimidine Chemical class 0.000 title abstract 2
- 229940127073 nucleoside analogue Drugs 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- 241000700584 Simplexvirus Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000845 uracil-1-yl group Chemical group [*]N1C(=O)N([H])C(=O)C([H])=C1[H] 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000000847 cytosin-1-yl group Chemical group [*]N1C(=O)N=C(N([H])[H])C([H])=C1[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22093400P | 2000-07-26 | 2000-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1305296E true PT1305296E (pt) | 2009-11-16 |
Family
ID=22825624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01957228T PT1305296E (pt) | 2000-07-26 | 2001-07-24 | Derivados de pirimidina, substituídos na posição 5, de análogos de nucleósidos bloqueados sob o ponto de vista da estrutura |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7009050B2 (pt) |
| EP (1) | EP1305296B9 (pt) |
| AT (1) | ATE442360T1 (pt) |
| AU (2) | AU7899301A (pt) |
| CA (1) | CA2417251C (pt) |
| CY (1) | CY1109592T1 (pt) |
| DE (1) | DE60139875D1 (pt) |
| DK (1) | DK1305296T3 (pt) |
| ES (1) | ES2332580T3 (pt) |
| PT (1) | PT1305296E (pt) |
| WO (1) | WO2002008204A2 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001051490A1 (en) * | 2000-01-14 | 2001-07-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methanocarba cycloalkyl nucleoside analogues |
| WO2006091905A1 (en) * | 2005-02-25 | 2006-08-31 | Gilead Sciences, Inc. | Bicyclo (3.1.0) hexane derivatives as antiviral compounds |
| WO2006128159A2 (en) | 2005-05-25 | 2006-11-30 | The Goverment Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | North-2'-deoxy-methanocarbathymidines as antiviral agents against poxviruses |
| WO2011068978A1 (en) | 2009-12-02 | 2011-06-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives and dendrimer conjugates thereof |
| EP3119789B1 (en) | 2014-03-17 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom |
| US9675632B2 (en) | 2014-08-26 | 2017-06-13 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| BR112019020780A2 (pt) | 2017-04-07 | 2020-04-28 | Enanta Pharm Inc | processo para preparação de derivados de ácido biliar de carbamato de sulfonila |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3481945B2 (ja) * | 1993-09-24 | 2003-12-22 | ザ ガヴァメント オブ ザ ユナイテッド ステイツ オブ アメリカ、レプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマンサーヴィスィズ | コンホメーションが固定されたヌクレオシド類縁体 |
| US5840728A (en) | 1996-08-07 | 1998-11-24 | United States Of America As Represented By The Department Of Health And Human Services | Conformationally locked nucleoside analogs as antiherpetic agents |
| AU6766496A (en) * | 1996-08-07 | 1998-02-25 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Conformationally locked nucleoside analogs as antiherpetic agents |
-
2001
- 2001-07-24 AU AU7899301A patent/AU7899301A/xx active Pending
- 2001-07-24 EP EP01957228A patent/EP1305296B9/en not_active Expired - Lifetime
- 2001-07-24 ES ES01957228T patent/ES2332580T3/es not_active Expired - Lifetime
- 2001-07-24 WO PCT/US2001/023246 patent/WO2002008204A2/en active Application Filing
- 2001-07-24 AU AU2001278993A patent/AU2001278993B2/en not_active Expired
- 2001-07-24 PT PT01957228T patent/PT1305296E/pt unknown
- 2001-07-24 CA CA2417251A patent/CA2417251C/en not_active Expired - Lifetime
- 2001-07-24 DK DK01957228T patent/DK1305296T3/da active
- 2001-07-24 DE DE60139875T patent/DE60139875D1/de not_active Expired - Lifetime
- 2001-07-24 AT AT01957228T patent/ATE442360T1/de active
-
2003
- 2003-01-15 US US10/346,762 patent/US7009050B2/en not_active Expired - Lifetime
-
2009
- 2009-11-09 CY CY20091101159T patent/CY1109592T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1305296T3 (da) | 2009-12-14 |
| WO2002008204A3 (en) | 2002-05-16 |
| AU7899301A (en) | 2002-02-05 |
| EP1305296B1 (en) | 2009-09-09 |
| ATE442360T1 (de) | 2009-09-15 |
| CY1109592T1 (el) | 2014-08-13 |
| WO2002008204A2 (en) | 2002-01-31 |
| ES2332580T3 (es) | 2010-02-09 |
| US7009050B2 (en) | 2006-03-07 |
| CA2417251C (en) | 2012-11-13 |
| EP1305296B9 (en) | 2010-04-07 |
| US20050282837A1 (en) | 2005-12-22 |
| AU2001278993B2 (en) | 2006-08-31 |
| DE60139875D1 (de) | 2009-10-22 |
| EP1305296A2 (en) | 2003-05-02 |
| CA2417251A1 (en) | 2002-01-31 |
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