DK1305296T3 - 5-substituerede pyrimidinderivater af konformationsfastlagte nucleosidanaloge - Google Patents
5-substituerede pyrimidinderivater af konformationsfastlagte nucleosidanalogeInfo
- Publication number
- DK1305296T3 DK1305296T3 DK01957228T DK01957228T DK1305296T3 DK 1305296 T3 DK1305296 T3 DK 1305296T3 DK 01957228 T DK01957228 T DK 01957228T DK 01957228 T DK01957228 T DK 01957228T DK 1305296 T3 DK1305296 T3 DK 1305296T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleoside analogues
- pyrimidine derivatives
- substituted pyrimidine
- conformationally
- determined
- Prior art date
Links
- -1 5-substituted pyrimidine Chemical class 0.000 title abstract 2
- 229940127073 nucleoside analogue Drugs 0.000 title abstract 2
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- 241000700584 Simplexvirus Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000845 uracil-1-yl group Chemical group [*]N1C(=O)N([H])C(=O)C([H])=C1[H] 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000000847 cytosin-1-yl group Chemical group [*]N1C(=O)N=C(N([H])[H])C([H])=C1[H] 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22093400P | 2000-07-26 | 2000-07-26 | |
| PCT/US2001/023246 WO2002008204A2 (en) | 2000-07-26 | 2001-07-24 | 5-substituted pyrimidine derivatives of conformationally locked nucleoside analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1305296T3 true DK1305296T3 (da) | 2009-12-14 |
Family
ID=22825624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK01957228T DK1305296T3 (da) | 2000-07-26 | 2001-07-24 | 5-substituerede pyrimidinderivater af konformationsfastlagte nucleosidanaloge |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7009050B2 (da) |
| EP (1) | EP1305296B9 (da) |
| AT (1) | ATE442360T1 (da) |
| AU (2) | AU7899301A (da) |
| CA (1) | CA2417251C (da) |
| CY (1) | CY1109592T1 (da) |
| DE (1) | DE60139875D1 (da) |
| DK (1) | DK1305296T3 (da) |
| ES (1) | ES2332580T3 (da) |
| PT (1) | PT1305296E (da) |
| WO (1) | WO2002008204A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001230913B2 (en) * | 2000-01-14 | 2005-06-30 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Methanocarba cycloalkyl nucleoside analogues |
| WO2006091905A1 (en) * | 2005-02-25 | 2006-08-31 | Gilead Sciences, Inc. | Bicyclo (3.1.0) hexane derivatives as antiviral compounds |
| EP1898935B1 (en) | 2005-05-25 | 2012-09-19 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | North-2'-deoxy-methanocarbathymidines as antiviral agents against poxviruses |
| WO2011068978A1 (en) | 2009-12-02 | 2011-06-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methanocarba adenosine derivatives and dendrimer conjugates thereof |
| WO2015142910A1 (en) | 2014-03-17 | 2015-09-24 | Isis Pharmaceuticals, Inc. | Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom |
| WO2016033164A1 (en) * | 2014-08-26 | 2016-03-03 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
| US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
| WO2018187804A1 (en) | 2017-04-07 | 2018-10-11 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE160340T1 (de) | 1993-09-24 | 1997-12-15 | Us Health | Konformationell festgelegte nukleosidanaloge |
| AU6766496A (en) * | 1996-08-07 | 1998-02-25 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Conformationally locked nucleoside analogs as antiherpetic agents |
| US5840728A (en) | 1996-08-07 | 1998-11-24 | United States Of America As Represented By The Department Of Health And Human Services | Conformationally locked nucleoside analogs as antiherpetic agents |
-
2001
- 2001-07-24 DK DK01957228T patent/DK1305296T3/da active
- 2001-07-24 AU AU7899301A patent/AU7899301A/xx active Pending
- 2001-07-24 WO PCT/US2001/023246 patent/WO2002008204A2/en active Application Filing
- 2001-07-24 ES ES01957228T patent/ES2332580T3/es not_active Expired - Lifetime
- 2001-07-24 AU AU2001278993A patent/AU2001278993B2/en not_active Expired
- 2001-07-24 CA CA2417251A patent/CA2417251C/en not_active Expired - Lifetime
- 2001-07-24 EP EP01957228A patent/EP1305296B9/en not_active Expired - Lifetime
- 2001-07-24 DE DE60139875T patent/DE60139875D1/de not_active Expired - Lifetime
- 2001-07-24 AT AT01957228T patent/ATE442360T1/de active
- 2001-07-24 PT PT01957228T patent/PT1305296E/pt unknown
-
2003
- 2003-01-15 US US10/346,762 patent/US7009050B2/en not_active Expired - Lifetime
-
2009
- 2009-11-09 CY CY20091101159T patent/CY1109592T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1305296B1 (en) | 2009-09-09 |
| CY1109592T1 (el) | 2014-08-13 |
| ES2332580T3 (es) | 2010-02-09 |
| PT1305296E (pt) | 2009-11-16 |
| US7009050B2 (en) | 2006-03-07 |
| WO2002008204A2 (en) | 2002-01-31 |
| CA2417251C (en) | 2012-11-13 |
| AU2001278993B2 (en) | 2006-08-31 |
| AU7899301A (en) | 2002-02-05 |
| CA2417251A1 (en) | 2002-01-31 |
| DE60139875D1 (de) | 2009-10-22 |
| US20050282837A1 (en) | 2005-12-22 |
| EP1305296B9 (en) | 2010-04-07 |
| EP1305296A2 (en) | 2003-05-02 |
| WO2002008204A3 (en) | 2002-05-16 |
| ATE442360T1 (de) | 2009-09-15 |
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