PT1278761E - Modulacao da estimulacao imunitaria mediada por oligonucleotidos de cpg, por modificacao posicional de nucleosidos - Google Patents

Modulacao da estimulacao imunitaria mediada por oligonucleotidos de cpg, por modificacao posicional de nucleosidos

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Publication number
PT1278761E
PT1278761E PT01930870T PT01930870T PT1278761E PT 1278761 E PT1278761 E PT 1278761E PT 01930870 T PT01930870 T PT 01930870T PT 01930870 T PT01930870 T PT 01930870T PT 1278761 E PT1278761 E PT 1278761E
Authority
PT
Portugal
Prior art keywords
cpg
nucleosidos
olgonucleotides
immunitary
modulation
Prior art date
Application number
PT01930870T
Other languages
English (en)
Inventor
Sudhir Agrawal
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of PT1278761E publication Critical patent/PT1278761E/pt

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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
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    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
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    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/33Chemical structure of the base
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PT01930870T 2000-05-01 2001-04-30 Modulacao da estimulacao imunitaria mediada por oligonucleotidos de cpg, por modificacao posicional de nucleosidos PT1278761E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20157800P 2000-05-01 2000-05-01

Publications (1)

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PT1278761E true PT1278761E (pt) 2005-08-31

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Country Status (12)

Country Link
US (3) US7115579B2 (pt)
EP (1) EP1278761B1 (pt)
JP (1) JP2003531915A (pt)
KR (1) KR100875003B1 (pt)
AT (1) ATE292638T1 (pt)
AU (2) AU2001257366B2 (pt)
CA (1) CA2407942A1 (pt)
DE (1) DE60109916T2 (pt)
DK (1) DK1278761T3 (pt)
ES (1) ES2238044T3 (pt)
PT (1) PT1278761E (pt)
WO (1) WO2001083503A2 (pt)

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AU5736601A (en) 2001-11-12
US20020132995A1 (en) 2002-09-19
US20060142556A1 (en) 2006-06-29
DK1278761T3 (da) 2005-08-08
CA2407942A1 (en) 2001-11-08
ATE292638T1 (de) 2005-04-15
EP1278761B1 (en) 2005-04-06
DE60109916T2 (de) 2006-01-19
ES2238044T3 (es) 2005-08-16
EP1278761A2 (en) 2003-01-29
JP2003531915A (ja) 2003-10-28
US20110059067A1 (en) 2011-03-10
WO2001083503A3 (en) 2002-07-18
AU2001257366B2 (en) 2006-03-16
WO2001083503A2 (en) 2001-11-08
US7115579B2 (en) 2006-10-03
KR100875003B1 (ko) 2008-12-19
DE60109916D1 (de) 2005-05-12
KR20030032943A (ko) 2003-04-26

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