DE60109916D1 - Modulation von oligonukleotid cpg-vermittelter immunstimulation durch modifikation der nucleoside - Google Patents

Modulation von oligonukleotid cpg-vermittelter immunstimulation durch modifikation der nucleoside

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Publication number
DE60109916D1
DE60109916D1 DE60109916T DE60109916T DE60109916D1 DE 60109916 D1 DE60109916 D1 DE 60109916D1 DE 60109916 T DE60109916 T DE 60109916T DE 60109916 T DE60109916 T DE 60109916T DE 60109916 D1 DE60109916 D1 DE 60109916D1
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Prior art keywords
nucleosides
modulation
modification
mediated immunostimulation
oligonucleotide cpg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60109916T
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English (en)
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DE60109916T2 (de
Inventor
Sudhir Agrawal
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Aceragen Inc
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Hybridon Inc
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Publication of DE60109916D1 publication Critical patent/DE60109916D1/de
Publication of DE60109916T2 publication Critical patent/DE60109916T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G

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DE60109916T 2000-05-01 2001-04-30 MODULATION EINER OLIGONUKLEOTID- CpG-VERMITTELTEN IMMUNSTIMULATION DURCH POSITIONELLE MODIFIKATION VON NUKLEOSIDEN Expired - Lifetime DE60109916T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20157800P 2000-05-01 2000-05-01
US201578P 2000-05-01
PCT/US2001/013682 WO2001083503A2 (en) 2000-05-01 2001-04-30 MODULATION OF OLIGONUCLEOTIDE CpG-MEDIATED IMMUNE STIMULATION BY POSITIONAL MODIFICATION OF NUCLEOSIDES

Publications (2)

Publication Number Publication Date
DE60109916D1 true DE60109916D1 (de) 2005-05-12
DE60109916T2 DE60109916T2 (de) 2006-01-19

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DE60109916T Expired - Lifetime DE60109916T2 (de) 2000-05-01 2001-04-30 MODULATION EINER OLIGONUKLEOTID- CpG-VERMITTELTEN IMMUNSTIMULATION DURCH POSITIONELLE MODIFIKATION VON NUKLEOSIDEN

Country Status (12)

Country Link
US (3) US7115579B2 (de)
EP (1) EP1278761B1 (de)
JP (1) JP2003531915A (de)
KR (1) KR100875003B1 (de)
AT (1) ATE292638T1 (de)
AU (2) AU5736601A (de)
CA (1) CA2407942A1 (de)
DE (1) DE60109916T2 (de)
DK (1) DK1278761T3 (de)
ES (1) ES2238044T3 (de)
PT (1) PT1278761E (de)
WO (1) WO2001083503A2 (de)

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ATE292638T1 (de) 2005-04-15
KR100875003B1 (ko) 2008-12-19
DE60109916T2 (de) 2006-01-19
EP1278761B1 (de) 2005-04-06
KR20030032943A (ko) 2003-04-26
EP1278761A2 (de) 2003-01-29
US20110059067A1 (en) 2011-03-10
ES2238044T3 (es) 2005-08-16
DK1278761T3 (da) 2005-08-08
AU5736601A (en) 2001-11-12
CA2407942A1 (en) 2001-11-08
JP2003531915A (ja) 2003-10-28
US20020132995A1 (en) 2002-09-19
US20060142556A1 (en) 2006-06-29
US7115579B2 (en) 2006-10-03
WO2001083503A2 (en) 2001-11-08
AU2001257366B2 (en) 2006-03-16
WO2001083503A3 (en) 2002-07-18
PT1278761E (pt) 2005-08-31

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