PT1265860E - Compostos amidino uteis como inibidores de sintase de oxido nitrico - Google Patents

Compostos amidino uteis como inibidores de sintase de oxido nitrico

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Publication number
PT1265860E
PT1265860E PT01922636T PT01922636T PT1265860E PT 1265860 E PT1265860 E PT 1265860E PT 01922636 T PT01922636 T PT 01922636T PT 01922636 T PT01922636 T PT 01922636T PT 1265860 E PT1265860 E PT 1265860E
Authority
PT
Portugal
Prior art keywords
uteis
nitric oxide
oxide synthase
synthase inhibitors
amidine compounds
Prior art date
Application number
PT01922636T
Other languages
English (en)
Inventor
Mahima Trivedi
Timothy J Hagen
Alok K Awasthi
Sofya Tsymbalov
Webber Ronald Keith
Arija A Bergmanis
Richard C Durley
Scott S Ganser
Ann E Hallinan
Donald W Hansen
Brian S Hickory
Alan E Moormann
Barnett S Pitzele
Michelle A Promo
Richard R Schartman
Jeffrey S Snyder
W Gary Phillips
Richard Vonder Embse
Gopichand Yalamanchili
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of PT1265860E publication Critical patent/PT1265860E/pt

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    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/071,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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    • CCHEMISTRY; METALLURGY
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    • C07C323/57Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
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    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D277/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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PT01922636T 2000-03-24 2001-03-23 Compostos amidino uteis como inibidores de sintase de oxido nitrico PT1265860E (pt)

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US6586474B2 (en) 2003-07-01
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US20030199701A1 (en) 2003-10-23
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DE60116067D1 (de) 2006-01-26
US7102013B2 (en) 2006-09-05
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