PT1154986E - Processo para a preparacao de iopamidol - Google Patents

Processo para a preparacao de iopamidol

Info

Publication number: PT1154986E
Authority: PT; Portugal
Prior art keywords: preparation; iopamidol; contrast agents; ionic contrast; purifying
Prior art date: 1999-02-26

Application number

PT00911908T

Other languages

English (en)

Inventor

Ashok V Bhatia

Steven A Chamberlin

Keith A Drengler

John J Hufnagel

Richard A Lorenzini

Xiu C Wang

Original Assignee

Bracco Imaging Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-26

Filing date

2000-02-23

Publication date

2004-09-30

2000-02-23 Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa

2004-09-30 Publication of PT1154986E publication Critical patent/PT1154986E/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

PT00911908T 1999-02-26 2000-02-23 Processo para a preparacao de iopamidol PT1154986E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/257,690 US6803485B2 (en)	1999-02-26	1999-02-26	Process for the preparation of iopamidol

Publications (1)

Publication Number	Publication Date
PT1154986E true PT1154986E (pt)	2004-09-30

Family

ID=22977346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT00911908T PT1154986E (pt)	1999-02-26	2000-02-23	Processo para a preparacao de iopamidol

Country Status (10)

Country	Link
US (4)	US6803485B2 (pt)
EP (1)	EP1154986B1 (pt)
JP (1)	JP4540233B2 (pt)
AT (1)	ATE268749T1 (pt)
CA (1)	CA2364819C (pt)
DE (1)	DE60011396T2 (pt)
DK (1)	DK1154986T3 (pt)
ES (1)	ES2220429T3 (pt)
PT (1)	PT1154986E (pt)
WO (1)	WO2000050385A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol
IT1319671B1 (it)	2000-12-01	2003-10-23	Bracco Spa	Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
GB0123013D0 (en) *	2001-09-25	2001-11-14	Upperton Ltd	Improvements relating to imaging contrast agents
US20040054162A1 (en) *	2001-10-30	2004-03-18	Hanna Michelle M.	Molecular detection systems utilizing reiterative oligonucleotide synthesis
NO20055643D0 (no) *	2005-11-29	2005-11-29	Amersham Health As	Preparation of lodixanol
US8907193B2 (en) *	2007-02-20	2014-12-09	Ubisoft Entertainment	Instrument game system and method
WO2009091758A1 (en)	2008-01-14	2009-07-23	Mallinckrodt Inc.	Process for the preparation of iosimenol
US20110021824A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Adsorptive purification method for iodixanol
WO2012136813A2 (en)	2011-04-07	2012-10-11	Universitetet I Oslo	Agents for medical radar diagnosis
PT105770B (pt) *	2011-06-24	2013-07-08	Hovione Farmaciencia S A	Novo intermediário e seu uso na preparação de agente de contrate triiodado
CN103382160B (zh) *	2012-05-02	2017-10-27	上海海神化学生物科技有限公司	碘帕醇的合成及其合成中间体的制备
PL3066071T3 (pl) *	2013-11-05	2018-09-28	Bracco Imaging S.P.A	Sposób otrzymywania jopamidolu
CN105017062B (zh) *	2014-04-18	2018-11-20	沈阳中海生物技术开发有限公司	制备碘普罗胺的新方法
CN104098484A (zh) *	2014-07-21	2014-10-15	杭州杜易科技有限公司	一种碘帕醇的制备方法
CN106831480B (zh) *	2015-12-07	2019-01-15	北京大学	基于碘帕醇脂质衍生物的造影剂及其制备方法与用途
SG11202003537TA (en)	2017-11-16	2020-05-28	Persica Pharmaceuticals Ltd	Linezolid formulations
KR20220139775A (ko)	2021-04-08	2022-10-17	한양대학교 에리카산학협력단	이오파미돌의 제조방법
CN115010617B (zh) *	2022-07-11	2024-06-11	安徽普利药业有限公司	一种碘帕醇的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (pt) *	1974-12-13	1978-12-29	Savac Ag
IT1193211B (it)	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
FR2541676A1 (fr)	1983-02-25	1984-08-31	Guerbet Sa	Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant
US4997983A (en) *	1990-01-31	1991-03-05	Mallinckrodt, Inc.	Process for production of ioversol
US5204005A (en)	1990-02-26	1993-04-20	Mallinckrodt, Inc.	Reversed phase chromatographic process
US5527926A (en)	1990-11-26	1996-06-18	Bracco International B.V.	Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
IT1248741B (it)	1991-02-26	1995-01-26	Bracco Spa	Processo di concentrazione e di purificazione di composti organici
US5256393A (en)	1991-04-16	1993-10-26	Mallinckrodt Medical, Inc.	Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
CA2068089C (en)	1991-05-31	2003-09-16	Ramachandran S. Ranganathan	Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
US5177261A (en)	1991-07-22	1993-01-05	Mallinckrodt Medical, Inc.	Synthesis of ioversol using chloroacetyl chloride
IT1256163B (it)	1992-10-27	1995-11-29	Zambon Spa	Processo per la preparazione di un intermedio della sintesi organica
IT1256162B (it)	1992-10-27	1995-11-29	Zambon Spa	Processo per la preparazione di un intermedio della sintesi organica
US5396003A (en) *	1993-05-27	1995-03-07	Mallinckrodt Medical Pmc	Recovery and purification of 1,1,2-trichloroethane for reuse in the production of ioversol
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the formation of infamidol
IT1274027B (it)	1994-03-03	1997-07-14	Zambon Spa	Processo per la preparazione e purificazione di mezzi di contrasto iodurati
US5371278A (en)	1994-03-25	1994-12-06	Mallinckrodt Medical Pmc	Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
IT1286522B1 (it) *	1996-12-04	1998-07-15	Dibra Spa	Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol

1999
- 1999-02-26 US US09/257,690 patent/US6803485B2/en not_active Expired - Lifetime
2000
- 2000-02-23 EP EP20000911908 patent/EP1154986B1/en not_active Expired - Lifetime
- 2000-02-23 DK DK00911908T patent/DK1154986T3/da active
- 2000-02-23 PT PT00911908T patent/PT1154986E/pt unknown
- 2000-02-23 AT AT00911908T patent/ATE268749T1/de active
- 2000-02-23 DE DE60011396T patent/DE60011396T2/de not_active Expired - Lifetime
- 2000-02-23 WO PCT/US2000/004511 patent/WO2000050385A1/en active IP Right Grant
- 2000-02-23 CA CA002364819A patent/CA2364819C/en not_active Expired - Lifetime
- 2000-02-23 ES ES00911908T patent/ES2220429T3/es not_active Expired - Lifetime
- 2000-02-23 JP JP2000600969A patent/JP4540233B2/ja not_active Expired - Lifetime
2004
- 2004-06-16 US US10/869,519 patent/US6875887B2/en not_active Expired - Lifetime
2005
- 2005-02-24 US US11/064,779 patent/US7115778B2/en not_active Expired - Lifetime
2006
- 2006-08-16 US US11/464,981 patent/US7282607B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1154986A1 (en)	2001-11-21
US7115778B2 (en)	2006-10-03
US20050192465A1 (en)	2005-09-01
DE60011396D1 (de)	2004-07-15
CA2364819A1 (en)	2000-08-31
US20040236150A1 (en)	2004-11-25
JP4540233B2 (ja)	2010-09-08
US7282607B2 (en)	2007-10-16
JP2002537371A (ja)	2002-11-05
CA2364819C (en)	2008-12-02
DK1154986T3 (da)	2004-10-18
DE60011396T2 (de)	2005-06-23
EP1154986B1 (en)	2004-06-09
US6875887B2 (en)	2005-04-05
US6803485B2 (en)	2004-10-12
ATE268749T1 (de)	2004-06-15
US20010056206A1 (en)	2001-12-27
ES2220429T3 (es)	2004-12-16
WO2000050385A1 (en)	2000-08-31
US20070078281A1 (en)	2007-04-05

Publication	Publication Date	Title
PT1154986E (pt)	2004-09-30	Processo para a preparacao de iopamidol
BR9909844A (pt)	2001-04-03	Processo para sintetizar um composto, e, composto.
BR9914293A (pt)	2001-10-16	Processo para a purificação de 1,3-propanodiol
BR0012774B1 (pt)	2011-03-22	processo para preparação de poliamida.
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BR9812837A (pt)	2000-08-08	Processo para fazer um composto, e, composto
BR0211391B1 (pt)	2013-05-14	processo para preparaÇço de 4-aminodifenilaminas.
BR0310115B1 (pt)	2013-04-30	processo para preparaÇço de dinitrilas de Ácido fenilmalânico.
BR0213561B1 (pt)	2013-04-16	processo para a preparaÇço de amidas de Ácido 2-halopiridincarboxÍlico.
IT1313009B1 (it)	2002-05-29	Processo per la rigenerazione di catalizzatori zeolitici.
ATE247630T1 (de)	2003-09-15	Verfahren zur herstellung von n,n'-bis,2,3- dihydroxypropyl)-5-((hydroxyacetyl)methylamino) 2,4,6-triiodo-1,3-benzenedicarboxamide
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BR9808664A (pt)	2000-07-11	Processo para preparar eprosartan
PT1203000E (pt)	2003-09-30	Processo para producao de fosfonometilglicina
IT1274675B (it)	1997-07-24	Processo per la preparazione di 2- ammino-1,3-propandiolo
PT1339703E (pt)	2004-08-31	Processo para a preparacao de paclitaxel
BR0006843A (pt)	2001-07-03	Dispositivo de embreagem
ATE277924T1 (de)	2004-10-15	Aryl-8-azabicyclo(3.2.1)octanes für die behandlung von depression
PT1159296E (pt)	2004-10-29	Processo para o fabrico do ciclo-(asp-dphe-nmeval-arggly)
BR0008566B1 (pt)	2011-03-22	processo para cristalização de n-(4-trifluormetilfenil)-5-metil-isoxazol-4-carboxami da.
DK1200387T3 (da)	2004-07-19	Fremgangsmåde til den cis-selektive katalytiske hydrogenering af cyclohexylidenaminer
DE60227652D1 (de)	2008-08-28	Verfahren für die herstellung von hydroxyethylaminen
BR0011559A (pt)	2002-02-26	Processo para a preparação de derivados de 10, 11-metano benzossuberano