PT1076558E - 2-fenil-1-¬4-(2-aminoetoxi)-benzil|-indole em combinacao com estrogenios - Google Patents

2-fenil-1-¬4-(2-aminoetoxi)-benzil|-indole em combinacao com estrogenios

Info

Publication number
PT1076558E
PT1076558E PT99921834T PT99921834T PT1076558E PT 1076558 E PT1076558 E PT 1076558E PT 99921834 T PT99921834 T PT 99921834T PT 99921834 T PT99921834 T PT 99921834T PT 1076558 E PT1076558 E PT 1076558E
Authority
PT
Portugal
Prior art keywords
estrogenes
aminoethyl
indole
benzyl
phenyl
Prior art date
Application number
PT99921834T
Other languages
English (en)
Inventor
James Harrison Pickar
Barry Samuel Komm
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22151320&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1076558(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PT1076558E publication Critical patent/PT1076558E/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
PT99921834T 1998-05-15 1999-05-11 2-fenil-1-¬4-(2-aminoetoxi)-benzil|-indole em combinacao com estrogenios PT1076558E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7956198A 1998-05-15 1998-05-15

Publications (1)

Publication Number Publication Date
PT1076558E true PT1076558E (pt) 2003-11-28

Family

ID=22151320

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99921834T PT1076558E (pt) 1998-05-15 1999-05-11 2-fenil-1-¬4-(2-aminoetoxi)-benzil|-indole em combinacao com estrogenios

Country Status (42)

Country Link
EP (1) EP1076558B1 (pt)
JP (3) JP2002515431A (pt)
KR (1) KR100620772B1 (pt)
CN (1) CN1230163C (pt)
AP (1) AP1424A (pt)
AR (1) AR020074A1 (pt)
AT (1) ATE245026T1 (pt)
AU (1) AU760378B2 (pt)
BE (1) BE2015C026I2 (pt)
BG (1) BG64783B1 (pt)
BR (1) BR9911040A (pt)
CA (1) CA2329530A1 (pt)
CU (1) CU23241B7 (pt)
CY (1) CY2015020I1 (pt)
CZ (1) CZ299334B6 (pt)
DE (1) DE69909616T2 (pt)
DK (1) DK1076558T3 (pt)
EA (1) EA005932B1 (pt)
EE (1) EE04262B1 (pt)
ES (1) ES2203131T3 (pt)
FR (1) FR15C0035I2 (pt)
GE (1) GEP20033079B (pt)
HK (1) HK1031691A1 (pt)
HR (1) HRP20000778B1 (pt)
HU (2) HU226587B1 (pt)
ID (1) ID26890A (pt)
IL (1) IL139130A (pt)
IN (1) IN192220B (pt)
LT (1) LTC1076558I2 (pt)
LU (1) LU92699I2 (pt)
NO (2) NO328129B1 (pt)
NZ (1) NZ508200A (pt)
OA (1) OA11552A (pt)
PL (1) PL194750B1 (pt)
PT (1) PT1076558E (pt)
SI (1) SI1076558T1 (pt)
SK (1) SK284666B6 (pt)
TR (1) TR200003377T2 (pt)
TW (1) TW565554B (pt)
UA (1) UA66861C2 (pt)
WO (1) WO1999059581A1 (pt)
ZA (1) ZA200006959B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1076558B1 (en) * 1998-05-15 2003-07-16 Wyeth 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
HU230543B1 (hu) 1999-07-06 2016-11-28 Endorecherche, Inc. Inzulinrezisztencia kezelésére és/vagy megakadályozására szolgáló gyógyszerkészítmények
US20020013327A1 (en) * 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
AU2001271781A1 (en) * 2000-07-06 2002-01-21 Wyeth Use of substituted indole compounds for treating sphincter incontinence
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AU2001271784A1 (en) * 2000-07-06 2002-01-21 Wyeth Therapy for prosthesis-related bone degeneration
EP1359940A2 (en) * 2000-07-06 2003-11-12 Wyeth Combinations of statins, estrogenic agents and optionally estrogens
WO2002003976A2 (en) * 2000-07-06 2002-01-17 Wyeth Combinations of bisphosphonates, estrogenic agents and optionally estrogens
DE10117441A1 (de) * 2001-04-03 2002-10-10 Schering Ag 1-Indolylderivate, deren Verwendung zur Herstellung von Arzneimitteln, ein Verfahren zur Herstellung der 1-Indolylderivate sowie 1-Indolylderivate enthaltende pharmzeutische Präparate
WO2003011282A1 (en) 2001-07-31 2003-02-13 Pfizer Products Inc. Pharmaceutical compositions, kits and methods comprising combinations of estrogen agonists/antagonists, estrogens and progestins
KR100470274B1 (ko) 2002-11-08 2005-02-05 진 장 덮개층을 이용한 비정질 물질의 상 변화 방법
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
FR2880625B1 (fr) * 2005-01-07 2007-03-09 Sanofi Aventis Sa Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
HUE025471T2 (hu) 2008-04-16 2016-03-29 Karobio Ab Új ösztrogén receptor ligandumok
AR072297A1 (es) * 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
GB201113538D0 (en) 2011-08-04 2011-09-21 Karobio Ab Novel estrogen receptor ligands
CN102690225B (zh) * 2012-04-11 2014-12-24 南京友杰医药科技有限公司 巴多昔芬的合成方法
CN103709090A (zh) * 2014-01-16 2014-04-09 江苏万特制药有限公司 醋酸巴多昔芬的制备方法及其关键中间体
CN103739540B (zh) * 2014-01-20 2016-05-04 华润赛科药业有限责任公司 一种醋酸巴多昔芬中间体的制备方法
CN105669518B (zh) * 2014-12-04 2019-06-04 上海医药集团股份有限公司 醋酸巴多昔芬及其a晶型的制备方法
SG11202005513TA (en) * 2017-12-15 2020-07-29 Bristol Myers Squibb Co Substituted indole ether compounds
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
CN115380026B (zh) * 2020-03-17 2023-11-07 南京明德新药研发有限公司 蛋白降解调节剂与其使用方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729999A (en) * 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
EP0639567A1 (en) * 1992-05-08 1995-02-22 Otsuka Pharmaceutical Factory, Inc. Indole derivative
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
GB9326332D0 (en) * 1993-12-23 1994-02-23 Karo Bio Indole derivatives
DE4426625A1 (de) * 1994-07-27 1996-03-14 Schering Ag 2-Phenylindole, Verfahren zu deren Herstellung, diese enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
SK281737B6 (sk) * 1996-04-19 2001-07-10 American Home Products Corporation 2-fenylindolové zlúčeniny, farmaceutický prostriedok s ich obsahom a ich použitie
TW397821B (en) * 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
AU3620597A (en) * 1996-07-09 1998-02-02 Smithkline Beecham Laboratoires Pharmaceutiques Indole derivatives for the treatment of osteoporosis
US5672609A (en) * 1996-07-18 1997-09-30 Eli Lilly And Company Pyridine compounds, intermediates compositions and methods of use
CA2306343C (en) * 1997-10-15 2010-08-03 American Home Products Corporation Novel aryloxy-alkyl-dialkylamines
AU1197299A (en) * 1997-10-28 1999-05-17 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
ID24568A (id) * 1997-11-06 2000-07-27 American Home Prod Kontrasepsi oral yang mengandung anti-estrogen plus progestin
EP1076558B1 (en) * 1998-05-15 2003-07-16 Wyeth 2-phenyl-1-[-(2-aminoethoxy)-benzyl -indole in combination with estrogens

Also Published As

Publication number Publication date
FR15C0035I1 (pt) 2015-06-26
AU760378B2 (en) 2003-05-15
SI1076558T1 (en) 2003-10-31
DE69909616D1 (de) 2003-08-21
CZ20004254A3 (cs) 2001-12-12
JP2014159472A (ja) 2014-09-04
NO328129B1 (no) 2009-12-14
BG104930A (en) 2001-07-31
EP1076558B1 (en) 2003-07-16
CY2015020I1 (el) 2020-05-29
EE200000652A (et) 2002-04-15
HU226587B1 (en) 2009-04-28
ZA200006959B (en) 2001-11-27
JP5607871B2 (ja) 2014-10-15
WO1999059581A1 (en) 1999-11-25
LTC1076558I2 (lt) 2016-11-10
EA005932B1 (ru) 2005-08-25
HUS1500023I1 (hu) 2017-03-28
JP5872624B2 (ja) 2016-03-01
HK1031691A1 (en) 2001-06-22
PL194750B1 (pl) 2007-06-29
EP1076558A1 (en) 2001-02-21
NO2015015I1 (no) 2015-06-02
DK1076558T3 (da) 2003-11-03
KR20010043641A (ko) 2001-05-25
NO20005770L (no) 2001-01-12
CN1230163C (zh) 2005-12-07
HRP20000778A2 (en) 2001-06-30
TR200003377T2 (tr) 2001-03-21
IL139130A0 (en) 2001-11-25
FR15C0035I2 (fr) 2015-08-28
ID26890A (id) 2001-02-15
SK17202000A3 (sk) 2001-07-10
TW565554B (en) 2003-12-11
CU23241B7 (es) 2007-10-17
CN1326347A (zh) 2001-12-12
HUP0103096A3 (en) 2002-11-28
ES2203131T3 (es) 2004-04-01
AU3894499A (en) 1999-12-06
BR9911040A (pt) 2001-02-13
PL345268A1 (en) 2001-12-03
BE2015C026I2 (en) 2018-08-24
JP2002515431A (ja) 2002-05-28
HRP20000778B1 (en) 2004-10-31
AP2000001970A0 (en) 2000-12-31
JP2009019042A (ja) 2009-01-29
EA200001193A1 (ru) 2001-12-24
SK284666B6 (sk) 2005-08-04
AP1424A (en) 2005-06-06
CA2329530A1 (en) 1999-11-25
UA66861C2 (uk) 2004-06-15
IL139130A (en) 2005-11-20
GEP20033079B (en) 2003-10-27
NO20005770D0 (no) 2000-11-14
ATE245026T1 (de) 2003-08-15
HUP0103096A2 (hu) 2002-05-29
NZ508200A (en) 2003-09-26
EE04262B1 (et) 2004-04-15
AR020074A1 (es) 2002-04-10
OA11552A (en) 2004-06-07
CZ299334B6 (cs) 2008-06-25
NO2015015I2 (no) 2015-06-02
BG64783B1 (bg) 2006-04-28
LU92699I2 (fr) 2015-06-24
DE69909616T2 (de) 2004-06-17
IN192220B (pt) 2004-03-20
KR100620772B1 (ko) 2006-09-13

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