PT1041991E - Tetraciclinas não antibacterianas para o tratamento de esclerose múltipla - Google Patents
Tetraciclinas não antibacterianas para o tratamento de esclerose múltipla Download PDFInfo
- Publication number
- PT1041991E PT1041991E PT98964764T PT98964764T PT1041991E PT 1041991 E PT1041991 E PT 1041991E PT 98964764 T PT98964764 T PT 98964764T PT 98964764 T PT98964764 T PT 98964764T PT 1041991 E PT1041991 E PT 1041991E
- Authority
- PT
- Portugal
- Prior art keywords
- tetracyclins
- treatment
- multiple sclerosis
- tnfalpha
- chemically modified
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6826897P | 1997-12-19 | 1997-12-19 | |
PCT/US1998/026870 WO1999030720A1 (en) | 1997-12-19 | 1998-12-17 | Method for inhibiting cyclooxygenase-2 and tumor necrosis factor alpha |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1041991E true PT1041991E (pt) | 2008-10-03 |
Family
ID=22081491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98964764T PT1041991E (pt) | 1997-12-19 | 1998-12-17 | Tetraciclinas não antibacterianas para o tratamento de esclerose múltipla |
Country Status (11)
Country | Link |
---|---|
US (1) | US6319910B1 (pt) |
EP (1) | EP1041991B1 (pt) |
JP (1) | JP4733266B2 (pt) |
AT (1) | ATE399013T1 (pt) |
AU (1) | AU2001599A (pt) |
CA (1) | CA2316972C (pt) |
DE (1) | DE69839649D1 (pt) |
DK (1) | DK1041991T3 (pt) |
ES (1) | ES2310018T3 (pt) |
PT (1) | PT1041991E (pt) |
WO (1) | WO1999030720A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7811990B2 (en) * | 1998-09-25 | 2010-10-12 | Sciaticon Ab | Soluble cytokine receptors TNF-α blocking antibodies for treating spinal disorders mediated by nucleus pulposus |
US7115557B2 (en) * | 1998-09-25 | 2006-10-03 | Sciaticon Ab | Use of certain drugs for treating nerve root injury |
SE9803710L (sv) * | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
US7906481B2 (en) * | 1998-09-25 | 2011-03-15 | Sciaticon Ab | Specific TNF-A inhibitors for treating spinal disorders mediated by nucleous pulposus |
US6506740B1 (en) | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
US6946453B2 (en) | 1998-11-18 | 2005-09-20 | Collagenex Pharmaceuticals, Inc. | 4-dedimethylaminotracycline derivatives |
CA2396593A1 (en) * | 2000-01-28 | 2001-08-02 | Merck & Co., Inc. | Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug |
US20020131954A1 (en) * | 2000-05-02 | 2002-09-19 | Tobinick Edward L. | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
US20040033938A1 (en) * | 2000-09-12 | 2004-02-19 | Britten Nancy J. | Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis |
CA2444899C (en) * | 2001-04-24 | 2011-06-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
EP2332548A1 (en) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of stroke |
KR101025400B1 (ko) * | 2002-03-21 | 2011-03-28 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
WO2004038000A2 (en) * | 2002-10-24 | 2004-05-06 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate rna |
EP2277504A1 (en) * | 2002-10-24 | 2011-01-26 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
US20080153894A1 (en) * | 2002-12-19 | 2008-06-26 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis |
WO2006036655A2 (en) * | 2004-09-22 | 2006-04-06 | Research Foundation Of State University Of New York | Use of low dose chemically modified tetracyclines to reduce inflammatory mediators |
GB0518558D0 (en) * | 2005-09-12 | 2005-10-19 | Givaudan Sa | Improvements in or related to organic compounds |
WO2007098099A2 (en) * | 2006-02-16 | 2007-08-30 | Discogen, Llc | Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor |
WO2008047340A1 (en) * | 2006-10-19 | 2008-04-24 | Mor Research Applications Ltd. | Combined therapies of antipsychotic drugs and tetracyclines in the treatment of psychiatric disorders |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704383A (en) * | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
US5308839A (en) * | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
JP3016587B2 (ja) * | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
JPH0454160A (ja) * | 1990-06-21 | 1992-02-21 | Kuraray Co Ltd | テトラサイクリン誘導体 |
US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
JPH04178359A (ja) * | 1990-07-01 | 1992-06-25 | Kuraray Co Ltd | テトラサイクリン誘導体 |
US5223248A (en) | 1991-02-11 | 1993-06-29 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing antiplaque properties |
US5258371A (en) * | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
DK0599397T3 (da) * | 1992-11-17 | 1996-09-16 | Univ New York State Res Found | Tetracycliner, herunder non-mikrobielle, kemisk-modificerede tetracycliner, inhiberer overdreven collagentværbinding ved diabetes |
JPH0782153A (ja) * | 1993-07-20 | 1995-03-28 | Sumio Arai | エンドトキシン中和剤 |
JP2676093B2 (ja) * | 1994-12-05 | 1997-11-12 | ザ リサーチ ファンデーション オブ ステート ユニバーシティ オブ ニューヨーク | 動物飼料組成物 |
JPH08268907A (ja) * | 1995-03-31 | 1996-10-15 | Sunstar Inc | 歯周組織再生促進剤 |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
US5837696A (en) * | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
-
1998
- 1998-12-17 AU AU20015/99A patent/AU2001599A/en not_active Abandoned
- 1998-12-17 WO PCT/US1998/026870 patent/WO1999030720A1/en active Application Filing
- 1998-12-17 US US09/213,149 patent/US6319910B1/en not_active Expired - Lifetime
- 1998-12-17 CA CA002316972A patent/CA2316972C/en not_active Expired - Fee Related
- 1998-12-17 EP EP98964764A patent/EP1041991B1/en not_active Expired - Lifetime
- 1998-12-17 DK DK98964764T patent/DK1041991T3/da active
- 1998-12-17 JP JP2000538702A patent/JP4733266B2/ja not_active Expired - Fee Related
- 1998-12-17 PT PT98964764T patent/PT1041991E/pt unknown
- 1998-12-17 ES ES98964764T patent/ES2310018T3/es not_active Expired - Lifetime
- 1998-12-17 DE DE69839649T patent/DE69839649D1/de not_active Expired - Lifetime
- 1998-12-17 AT AT98964764T patent/ATE399013T1/de active
Also Published As
Publication number | Publication date |
---|---|
WO1999030720A9 (en) | 1999-10-07 |
CA2316972A1 (en) | 1999-06-24 |
AU2001599A (en) | 1999-07-05 |
EP1041991B1 (en) | 2008-06-25 |
WO1999030720A8 (en) | 1999-09-02 |
JP4733266B2 (ja) | 2011-07-27 |
WO1999030720A1 (en) | 1999-06-24 |
JP2002508327A (ja) | 2002-03-19 |
ES2310018T3 (es) | 2008-12-16 |
CA2316972C (en) | 2009-02-24 |
DK1041991T3 (da) | 2008-07-28 |
US6319910B1 (en) | 2001-11-20 |
EP1041991A1 (en) | 2000-10-11 |
ATE399013T1 (de) | 2008-07-15 |
EP1041991A4 (en) | 2002-08-21 |
DE69839649D1 (de) | 2008-08-07 |
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