BR9917495A - Derivados o ácido betulìnico tendo atividade antiangiogênica, processos para produzir tais derivados e sua utilização para o tratamento de antiogênese associada a tumores - Google Patents

Derivados o ácido betulìnico tendo atividade antiangiogênica, processos para produzir tais derivados e sua utilização para o tratamento de antiogênese associada a tumores

Info

Publication number
BR9917495A
BR9917495A BR9917495-2A BR9917495A BR9917495A BR 9917495 A BR9917495 A BR 9917495A BR 9917495 A BR9917495 A BR 9917495A BR 9917495 A BR9917495 A BR 9917495A
Authority
BR
Brazil
Prior art keywords
derivatives
processes
antiogenesis
tumor
produce
Prior art date
Application number
BR9917495-2A
Other languages
English (en)
Inventor
Manu Jaggi
Sunder Ramadoss
Praveen Rajendran
Mahammed Jamshed Ahme Siddiqui
Original Assignee
Dabur Res Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dabur Res Foundation filed Critical Dabur Res Foundation
Publication of BR9917495A publication Critical patent/BR9917495A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"DERIVADOS O áCIDO BETULìNICO TENDO ATIVIDADE ANTIANGIOGêNICA, PROCESSOS PARA PRODUZIR TAIS DERIVADOS E SUA UTILIZAçãO PARA O TRATAMENTO DE ANTIOGêNESE ASSOCIADA A TUMORES". A invenção se refere a novos derivados do ácido betulínico tendo atividade antiangiogênica, processos para produzir tais derivados e sua utilização para tratamento de angiogênese associada a tumor.
BR9917495-2A 1999-09-09 1999-09-09 Derivados o ácido betulìnico tendo atividade antiangiogênica, processos para produzir tais derivados e sua utilização para o tratamento de antiogênese associada a tumores BR9917495A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN1999/000043 WO2001018029A1 (en) 1999-09-09 1999-09-09 Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis

Publications (1)

Publication Number Publication Date
BR9917495A true BR9917495A (pt) 2002-06-11

Family

ID=11076668

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9917495-2A BR9917495A (pt) 1999-09-09 1999-09-09 Derivados o ácido betulìnico tendo atividade antiangiogênica, processos para produzir tais derivados e sua utilização para o tratamento de antiogênese associada a tumores

Country Status (11)

Country Link
EP (1) EP1218402B1 (pt)
JP (1) JP2003508543A (pt)
KR (1) KR100618100B1 (pt)
CN (1) CN1152046C (pt)
AT (1) ATE267837T1 (pt)
AU (1) AU780148B2 (pt)
BR (1) BR9917495A (pt)
CA (1) CA2384433C (pt)
DE (1) DE69917684T2 (pt)
ES (1) ES2224735T3 (pt)
WO (1) WO2001018029A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1594885B8 (de) 2003-02-11 2009-03-25 Novelix Pharmaceuticals, Inc. Medikament zur wachstumsinhibierung von tumoren
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
GB0604535D0 (en) 2006-03-07 2006-04-12 Sndv Sprl Betulonic acid derivatives
CZ2008528A3 (cs) * 2008-09-01 2009-11-18 Univerzita Karlova v Praze, Prírodovedecká fakulta Deriváty triterpenoidu pro lécbu nádorových onemocnení a farmaceutická kompozice je obsahující
KR101061911B1 (ko) * 2009-04-01 2011-09-02 주식회사 페라온 페길레이션된 베튤린 유도체 및 그를 포함하는 화장료 조성물
CN102603858B (zh) * 2012-03-02 2014-07-02 东北林业大学 桦木醇的含氮杂环衍生物、制备方法及用途
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
CN104910239B (zh) * 2014-03-14 2018-12-07 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
CN109517022B (zh) 2017-09-18 2022-09-13 中国科学院上海药物研究所 五环三萜类化合物及其制备方法、药物组合物和用途
CN109700760B (zh) * 2019-03-07 2021-04-06 南京中医药大学 一种白桦脂酸纳米混悬剂及其制备方法
WO2022007765A1 (zh) * 2020-07-07 2022-01-13 中国科学院上海药物研究所 一类五环三萜类碳苷化合物及其制备方法和用途
CN113135974B (zh) * 2021-03-24 2022-05-06 广东工业大学 白桦脂醇衍生物及其在制备抗肿瘤药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1415601A (en) * 1973-03-14 1975-11-26 Biorex Laboratories Ltd Dihydrobetulinic acid derivatives
JPS6417431A (en) * 1987-07-13 1989-01-20 Nec Corp Manufacture of semiconductor integrated circuit device
JP2694048B2 (ja) * 1991-05-09 1997-12-24 日立建機株式会社 建設機械の油圧駆動装置
FR2683531B1 (fr) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5869535A (en) * 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) * 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor

Also Published As

Publication number Publication date
AU2000100A (en) 2001-04-10
KR100618100B1 (ko) 2006-08-29
EP1218402A1 (en) 2002-07-03
JP2003508543A (ja) 2003-03-04
ATE267837T1 (de) 2004-06-15
EP1218402B1 (en) 2004-05-26
CN1373769A (zh) 2002-10-09
KR20020092908A (ko) 2002-12-12
CN1152046C (zh) 2004-06-02
CA2384433A1 (en) 2001-03-15
ES2224735T3 (es) 2005-03-01
AU780148B2 (en) 2005-03-03
WO2001018029A1 (en) 2001-03-15
DE69917684D1 (de) 2004-07-01
CA2384433C (en) 2007-10-23
DE69917684T2 (de) 2005-07-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 9A. ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DE RPI 1999 DE 28/04/2009.