PT1033978E - Sistema terapeutico transdermico compreendendo um agonista d2 para o tratamento do sindroma de parkinson e processo para a sua producao - Google Patents
Sistema terapeutico transdermico compreendendo um agonista d2 para o tratamento do sindroma de parkinson e processo para a sua producaoInfo
- Publication number
- PT1033978E PT1033978E PT99910359T PT99910359T PT1033978E PT 1033978 E PT1033978 E PT 1033978E PT 99910359 T PT99910359 T PT 99910359T PT 99910359 T PT99910359 T PT 99910359T PT 1033978 E PT1033978 E PT 1033978E
- Authority
- PT
- Portugal
- Prior art keywords
- agonist
- treatment
- production
- therapeutic system
- parkinson syndrome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19814084A DE19814084B4 (de) | 1998-03-30 | 1998-03-30 | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1033978E true PT1033978E (pt) | 2002-06-28 |
Family
ID=7862904
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99910359T PT1033978E (pt) | 1998-03-30 | 1999-03-18 | Sistema terapeutico transdermico compreendendo um agonista d2 para o tratamento do sindroma de parkinson e processo para a sua producao |
Country Status (31)
Country | Link |
---|---|
US (4) | US6884434B1 (pt) |
EP (1) | EP1033978B1 (pt) |
JP (1) | JP3984785B2 (pt) |
KR (1) | KR100432276B1 (pt) |
CN (1) | CN1142773C (pt) |
AR (1) | AR014778A1 (pt) |
AT (1) | ATE210973T1 (pt) |
AU (1) | AU746856B2 (pt) |
BR (1) | BRPI9909313B8 (pt) |
CA (1) | CA2326630C (pt) |
CZ (1) | CZ297889B6 (pt) |
DE (4) | DE19814084B4 (pt) |
DK (1) | DK1033978T3 (pt) |
ES (1) | ES2170573T3 (pt) |
FR (1) | FR06C0025I2 (pt) |
HK (1) | HK1031196A1 (pt) |
HU (1) | HU226733B1 (pt) |
ID (1) | ID26646A (pt) |
IL (1) | IL138722A (pt) |
LU (1) | LU91269I2 (pt) |
MY (1) | MY119660A (pt) |
NL (1) | NL300236I2 (pt) |
NO (3) | NO325766B1 (pt) |
NZ (1) | NZ507066A (pt) |
PL (1) | PL193074B1 (pt) |
PT (1) | PT1033978E (pt) |
SK (1) | SK284618B6 (pt) |
TR (1) | TR200002829T2 (pt) |
TW (1) | TW579299B (pt) |
WO (1) | WO1999049852A1 (pt) |
ZA (1) | ZA200005261B (pt) |
Families Citing this family (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE19918106A1 (de) | 1999-04-22 | 2000-10-26 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern |
HU229085B1 (en) | 1999-07-02 | 2013-07-29 | Lohmann Therapie Syst Lts | Microreservoir system on the basis of polysiloxanes and ambiphilic solvents |
CZ295031B6 (cs) * | 1999-11-29 | 2005-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermální terapeutické systémy se zlepšenou stabilitou a způsob jejich výroby |
DE10054713C2 (de) * | 1999-11-29 | 2002-07-18 | Lohmann Therapie Syst Lts | Transdermale Therapeutische Systeme mit verbesserter Stabilität und ein Verfahren zu ihrer Herstellung |
DE10012908B4 (de) * | 2000-03-16 | 2005-03-17 | Lts Lohmann Therapie-Systeme Ag | Stabilisierte übersättigte transdermale therapeutische Matrixsysteme und Verfahren zu ihrer Herstellung |
AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
US6306403B1 (en) * | 2000-06-14 | 2001-10-23 | Allergan Sales, Inc. | Method for treating parkinson's disease with a botulinum toxin |
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
AU2005242160B2 (en) * | 2000-10-12 | 2009-02-26 | Lts Lohmann Therapie-Systeme Ag | Improved transdermal therapeutic system for the treatment of parkinson's disease |
DK1256339T3 (da) | 2001-05-08 | 2004-02-09 | Sanol Arznei Schwarz Gmbh | Transdermalt terapeutisk system for opnåelse af høje plasmaniveauer af rotigotin i behandlingen af Parkinsons sygdom |
DE60100595T2 (de) * | 2001-05-08 | 2004-06-24 | Lts Lohmann Therapie-Systeme Ag | Verbessertes transdermales therapeutisches System zur Behandlung von Morbus Parkinson |
US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
DE10137082A1 (de) * | 2001-07-28 | 2003-02-13 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
DE10141652B4 (de) * | 2001-08-24 | 2011-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System auf der Basis von Polyacrylat-Haftklebern ohne funktionelle Gruppen und seine Verwendung |
DE10159745A1 (de) | 2001-12-05 | 2003-07-03 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit verbessertem Langzeittragekomfort |
US20060263419A1 (en) * | 2002-03-12 | 2006-11-23 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
DE10220230A1 (de) * | 2002-05-06 | 2003-11-27 | Sanol Arznei Schwarz Gmbh | Verwendung von Rotigotine zur Behandlung des Restless Leg Syndroms |
US20040048779A1 (en) * | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
EP1386605A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system for the administration of rotigotine |
US8246979B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
EP1386604A1 (en) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Improved transdermal delivery system |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
DE60204229T2 (de) * | 2002-12-02 | 2006-02-02 | Schwarz Pharma Ag | Verabreichung von Rotigotine zur Behandlung der Parkinson'schen Krankheit durch Iontophorese |
DE10261696A1 (de) * | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
NZ541576A (en) * | 2003-02-07 | 2008-03-28 | Lohmann Therapie Syst Lts | Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof |
DE10334188B4 (de) | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
DE10334187A1 (de) * | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
DE10359528A1 (de) | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
EP1547592A1 (en) | 2003-12-23 | 2005-06-29 | Schwarz Pharma Ag | Intranasal formulation of rotigotine |
DE10361258A1 (de) | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
DE102004014841B4 (de) | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
WO2006039532A2 (en) * | 2004-09-29 | 2006-04-13 | Schwarz Pharma, Inc. | Transdermal therapeutic system for parkinson’s disease |
CA2548864C (en) | 2005-06-06 | 2012-12-11 | Nitto Denko Corporation | Percutaneous absorption-type pharmaceutical preparation |
JP5025998B2 (ja) * | 2005-06-06 | 2012-09-12 | 日東電工株式会社 | 経皮吸収製剤 |
TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的2-胺基萘滿之於製造用於預防、減緩及/或治療各種類型疼痛之藥物上的用途 |
DE102006028987A1 (de) | 2006-06-24 | 2007-12-27 | Lts Lohmann Therapie-Systeme Ag | Ultraschallverstärktes transdermales therapeutisches System |
DE102006054732B4 (de) * | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
EP1987815A1 (en) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders |
CN101147739B (zh) | 2007-07-06 | 2010-12-08 | 北京康倍得医药技术开发有限公司 | 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂 |
WO2009063171A1 (en) * | 2007-11-16 | 2009-05-22 | Pliva Hrvatska D.O.O. | Novel rotigotine salts |
CN101970422B (zh) * | 2007-11-28 | 2014-10-22 | Ucb制药有限公司 | 罗替高汀的多晶型物 |
JP6054013B2 (ja) * | 2008-02-27 | 2016-12-27 | 久光製薬株式会社 | 貼付製剤 |
US9155725B2 (en) | 2008-02-27 | 2015-10-13 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive skin patch and packaged product |
DE102008013701A1 (de) * | 2008-03-11 | 2009-09-17 | Lts Lohmann Therapie-Systeme Ag | Transdermales Therapeutisches System mit stabilisierter Membran |
US20090247537A1 (en) * | 2008-03-25 | 2009-10-01 | William Dale Overfield | Methods for preventing or treating bruxism using dopaminergic agents |
JPWO2009139213A1 (ja) * | 2008-05-15 | 2011-09-15 | 日本臓器製薬株式会社 | プロクロルペラジン含有外用医薬組成物 |
DE102008060203A1 (de) | 2008-12-07 | 2010-06-10 | Dietrich Wilhelm Schacht | Wirkstoffstabilisierende flächenförmige Vorrichtung |
EP2201941A1 (de) * | 2008-12-29 | 2010-06-30 | UCB Pharma GmbH | Pflaster-Herstellungstechnologie |
DE102009022915A1 (de) * | 2009-05-27 | 2010-12-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit gesteuertem Wirkstofffluss |
EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
EP2490673A2 (en) * | 2009-10-19 | 2012-08-29 | Actavis Group Ptc Ehf | Amorphous rotigotine co-precipitates |
EP2338873A1 (en) | 2009-12-22 | 2011-06-29 | Gmeiner, Peter | New aminotetraline derivatives |
ME03053B (me) | 2009-12-22 | 2018-10-20 | Ucb Biopharma Sprl | Polivinilpirolidon za stabilizaciju čvrste disperzije nekristalnog oblika rotigotina |
EP2457565A1 (de) | 2010-11-29 | 2012-05-30 | Ratiopharm GmbH | Transdermales therapeutisches System enthaltend Rotigotin |
EA201300607A8 (ru) | 2010-12-02 | 2014-02-28 | Ратиофарм Гмбх | Ионная жидкость ротиготина |
WO2012084969A1 (en) | 2010-12-22 | 2012-06-28 | Hexal Ag | Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition |
WO2013020527A1 (en) | 2011-08-11 | 2013-02-14 | University Of Veterinary And Pharmaceutical Sciences Brno Faculty Of Pharmacy | Utilization of alaptide as transdermal penetration modifier in pharmaceutical compositions for human and veterinary applications containing anti-inflammatory drugs and/or antimicrobial chemotherapeutics |
EP2559435A1 (en) | 2011-08-19 | 2013-02-20 | UCB Pharma GmbH | Rotigotine in the treatment of hemispatial neglect, stroke and deficits following stroke |
CN102499906B (zh) * | 2011-10-12 | 2013-04-17 | 长春健欣生物医药科技开发有限公司 | 一种罗替戈汀盐酸盐或自由碱成膜凝胶制剂及其制备方法 |
WO2013075823A1 (en) | 2011-11-22 | 2013-05-30 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermal therapeutic system comprising rotigotine and crystallization inhibitor |
DE102011119043A1 (de) | 2011-11-22 | 2013-05-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TDS) mit Rotigotin |
DE102012013439A1 (de) | 2012-07-03 | 2014-01-23 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System umfassend Rotigotin und Kristallisationsinhibitor |
DE102012013421A1 (de) | 2012-07-03 | 2014-01-09 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Transdermales therapeutisches System (TTS) mit Rotigotin |
DE102011090178A1 (de) * | 2011-12-30 | 2013-07-04 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation |
DE102012205493A1 (de) * | 2012-04-03 | 2013-10-10 | Acino Ag | Einen Dopamin-Agonisten enthaltendes transdermales Applikationssystem |
EP2870962B1 (en) | 2012-07-05 | 2018-09-12 | SK Chemicals Co., Ltd. | Transdermally absorbable preparation containing rotigotine |
WO2014007597A1 (ko) | 2012-07-06 | 2014-01-09 | 에스케이케미칼(주) | 로티고틴 함유 경피흡수제제 |
TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀(Rotigotine)之多天式貼片 |
WO2014198422A1 (de) | 2013-06-14 | 2014-12-18 | Tesa Labtec Gmbh | Transdermales therapiesystem (tts) mit rotigotin |
BR112015032929B1 (pt) | 2013-07-03 | 2022-08-23 | Lts Lohmann Therapie-Systeme Ag | Sistema terapêutico transdérmico com componente eletrônico e métodos de produção de um sistema terapêutico transdérmico |
CN106456566B (zh) | 2014-05-20 | 2020-06-16 | Lts勒曼治疗***股份公司 | 含罗替戈汀的经皮递送*** |
US11752110B2 (en) | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
CN106456567A (zh) | 2014-05-20 | 2017-02-22 | Lts勒曼治疗***股份公司 | 在经皮递送***中调节活性剂释放的方法 |
KR102364378B1 (ko) | 2014-05-21 | 2022-02-16 | 에스케이케미칼 주식회사 | 안정성을 향상시킨 로티고틴 함유 경피흡수제제 |
MX2017013956A (es) | 2015-05-01 | 2018-09-05 | Cocrystal Pharma Inc | Analogos de nucleosidos para el tratamiento de la familia de virus flaviviridae y cancer. |
TWI754702B (zh) | 2016-12-28 | 2022-02-11 | 德商Ucb製藥有限公司 | (氮雜)吲哚-和苯並呋喃-3-磺醯胺類 |
CN109806243B (zh) * | 2017-11-20 | 2022-07-15 | 北京泰德制药股份有限公司 | 一种含有氟吡汀或其药用盐的皮肤外用贴剂 |
WO2019124261A1 (ja) | 2017-12-19 | 2019-06-27 | 久光製薬株式会社 | ロチゴチン含有貼付剤 |
TW202016088A (zh) | 2018-06-19 | 2020-05-01 | 德商Ucb製藥有限公司 | 吡啶基及吡基-(氮)吲哚磺醯胺 |
EP3584244A1 (en) | 2018-06-20 | 2019-12-25 | UCB Pharma GmbH | Substituted alkoxypyridinyl indolsulfonamides |
KR20200046461A (ko) | 2018-10-24 | 2020-05-07 | 에스케이케미칼 주식회사 | 비결정 로티고틴 함유 조성물 및 이의 제조 방법 |
KR20210104101A (ko) | 2019-02-15 | 2021-08-24 | 히사미쓰 세이야꾸 가부시키가이샤 | 로티고틴 안정화 방법 |
CN113950356A (zh) | 2019-06-14 | 2022-01-18 | 久光制药株式会社 | 含罗替戈汀的贴附剂 |
WO2020254289A1 (en) | 2019-06-17 | 2020-12-24 | Ucb Pharma Gmbh | N-(phenyl)-indole-3-sulfonamide derivatives and related compounds as gpr17 modulators for treating cns disorders such as multiple sclerosis |
ES2966170T3 (es) | 2020-01-24 | 2024-04-18 | Luye Pharma Switzerland Ag | Sistema terapéutico transdérmico que comprende rotigotina y al menos un adhesivo de silicona no resistente a las aminas |
CN113368083A (zh) * | 2021-06-16 | 2021-09-10 | 华健医疗(深圳)有限公司 | 一种***二酚cbd透皮给药*** |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5268385A (en) | 1983-01-03 | 1993-12-07 | Whitby Research, Inc. | Method for treating schizophrenia |
US5177112A (en) * | 1983-01-03 | 1993-01-05 | Whitby Research, Inc. | Substituted 2-aminotetralins |
US4655767A (en) | 1984-10-29 | 1987-04-07 | Dow Corning Corporation | Transdermal drug delivery devices with amine-resistant silicone adhesives |
US4863970A (en) * | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
US5273757A (en) * | 1987-09-01 | 1993-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Apparatus for the delivery of substances, processes for the production thereof and use thereof |
US4915950A (en) * | 1988-02-12 | 1990-04-10 | Cygnus Research Corporation | Printed transdermal drug delivery device |
US5656286A (en) * | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
US4942037A (en) * | 1988-06-02 | 1990-07-17 | Merck & Co., Inc. | Transdermal delivery systems |
DE3827561C1 (pt) * | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
EP0387751B1 (en) * | 1989-03-15 | 1994-06-08 | Nitto Denko Corporation | Medicated plasters |
US4973468A (en) * | 1989-03-22 | 1990-11-27 | Cygnus Research Corporation | Skin permeation enhancer compositions |
FR2648131B1 (fr) * | 1989-06-13 | 1991-10-18 | Oreal | Nouveaux derives de tetrahydro -5,6,7,8 naphtalenol-1, leur procede de preparation et leur utilisation en tant qu'agents antioxydants dans des compositions cosmetiques et pharmaceutiques les contenant |
US5252335A (en) * | 1989-07-12 | 1993-10-12 | Cygnus Therapeutic Systems | Transdermal administration of lisuride |
US5091186A (en) * | 1989-08-15 | 1992-02-25 | Cygnus Therapeutic Systems | Biphasic transdermal drug delivery device |
US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
US5252334A (en) * | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
US5271940A (en) * | 1989-09-14 | 1993-12-21 | Cygnus Therapeutic Systems | Transdermal delivery device having delayed onset |
DE3933460A1 (de) * | 1989-10-06 | 1991-04-18 | Lohmann Therapie Syst Lts | Oestrogenhaltiges wirkstoffpflaster |
US5246997A (en) * | 1990-02-21 | 1993-09-21 | Dow Corning Corporation | Method of making a hot-melt silicone pressure sensitive adhesive-coated substrate |
US5147916A (en) * | 1990-02-21 | 1992-09-15 | Dow Corning Corporation | Hot-melt silicone pressure sensitive adhesive composition and related methods and articles |
US5069909A (en) * | 1990-06-20 | 1991-12-03 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine |
US5382569A (en) * | 1991-05-16 | 1995-01-17 | Warner-Lambert Company | Endotherlin antagonists |
US5232702A (en) * | 1991-07-22 | 1993-08-03 | Dow Corning Corporation | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices |
US5273756A (en) * | 1991-08-23 | 1993-12-28 | Cygnus Therapeutic Systems | Transdermal drug delivery device using a membrane-protected microporous membrane to achieve delayed onset |
US5234690A (en) * | 1991-08-23 | 1993-08-10 | Cygnus Therapeutic Systems | Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset |
US5273755A (en) * | 1991-08-23 | 1993-12-28 | Cygnus Therapeutic Systems | Transdermal drug delivery device using a polymer-filled microporous membrane to achieve delayed onset |
US5225198A (en) * | 1991-08-27 | 1993-07-06 | Cygnus Therapeutic Systems | Transdermal administration of short or intermediate half-life benzodiazepines |
WO1993003697A1 (en) * | 1991-08-27 | 1993-03-04 | Cygnus Therapeutic Systems | Transdermal formulations for administering prazosin |
WO1993007842A1 (en) | 1991-10-15 | 1993-04-29 | Cygnus Therapeutic Systems | Thermal enhancement of transdermal drug administration |
WO1993014727A1 (en) | 1992-01-31 | 1993-08-05 | Cygnus Therapeutic Systems | Transdermal administration of buprenorphine in the form of ion pair complexes |
GB9202915D0 (en) | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
AU3247193A (en) | 1992-08-25 | 1994-03-15 | Cygnus Therapeutic Systems | Printed transdermal drug delivery device |
US5308625A (en) * | 1992-09-02 | 1994-05-03 | Cygnus Therapeutic Systems | Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters |
US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
US5462746A (en) * | 1992-11-02 | 1995-10-31 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
DE4301781C2 (de) * | 1993-01-23 | 1995-07-20 | Lohmann Therapie Syst Lts | Nitroglycerinhaltiges Pflaster, Verfahren zu seiner Herstellung und Verwendung |
WO1995000122A1 (en) | 1993-06-24 | 1995-01-05 | Cygnus Therapeutic Systems | Transdermal delivery system package |
WO1995001767A1 (en) | 1993-07-08 | 1995-01-19 | Cygnus Therapeutic Systems | Monolithic matrix transdermal delivery system |
US5382596A (en) * | 1993-08-05 | 1995-01-17 | Whitby Research, Inc. | Substituted 2-aminotetralins |
US5554381A (en) * | 1993-08-09 | 1996-09-10 | Cygnus, Inc. | Low flux matrix system for delivering potent drugs transdermally |
AU7566994A (en) | 1993-08-16 | 1995-03-14 | Cygnus Therapeutic Systems | Contact adhesive extends wear time on skin |
WO1995005137A1 (en) | 1993-08-16 | 1995-02-23 | Cygnus Therapeutic Systems | Transdermal delivery system using a combination of permeation enhancers |
WO1995024776A2 (en) | 1994-03-11 | 1995-09-14 | Philips Electronics N.V. | Transmission system for quasi-periodic signals |
US5771890A (en) * | 1994-06-24 | 1998-06-30 | Cygnus, Inc. | Device and method for sampling of substances using alternating polarity |
ATE196741T1 (de) | 1994-06-24 | 2000-10-15 | Cygnus Therapeutic Systems | Einrichtung zur iontophoretischen probennahme |
GB2290964A (en) * | 1994-07-08 | 1996-01-17 | Arto Olavi Urtti | Transdermal drug delivery system |
US6024974A (en) * | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
AU4761196A (en) | 1995-01-19 | 1996-08-07 | Cygnus, Inc. | Polymer adhesive formulation containing sorbent particles |
WO1996022083A1 (en) | 1995-01-19 | 1996-07-25 | Cygnus, Inc. | POLYISOBUTYLENE ADHESIVES CONTAINING HIGH Tg TACKIFIER FOR TRANSDERMAL DEVICES |
US5601839A (en) * | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
GB9511366D0 (en) * | 1995-06-06 | 1995-08-02 | Smithkline Beecham Plc | Novel formulations |
US6316022B1 (en) * | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
AU6032696A (en) | 1995-06-07 | 1996-12-30 | Cygnus Therapeutic Systems | Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group |
PL181582B1 (pl) * | 1995-06-07 | 2001-08-31 | Ortho Mcneil Pharm Inc | Plaster na skóre do zapobiegania owulacji u kobiety oraz plaster na skóre do przeprowadzania hormonalnej terapii substytucyjnej PL PL PL PL PL PL PL PL |
US5906830A (en) * | 1995-09-08 | 1999-05-25 | Cygnus, Inc. | Supersaturated transdermal drug delivery systems, and methods for manufacturing the same |
WO1997009971A2 (en) | 1995-09-14 | 1997-03-20 | Cygnus, Inc. | High capacity, superabsorbent drug reservoirs for use in transdermal drug delivery systems |
US5902603A (en) * | 1995-09-14 | 1999-05-11 | Cygnus, Inc. | Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use |
US5891461A (en) * | 1995-09-14 | 1999-04-06 | Cygnus, Inc. | Transdermal administration of olanzapine |
US6063398A (en) * | 1995-09-20 | 2000-05-16 | L'oreal | Cosmetic or dermopharmaceutical patch containing, in an anhydrous polymeric matrix, at least one active compound which is, in particular, unstable in oxidizing mediums, and at least one water-absorbing agent |
US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
US5733571A (en) * | 1995-12-08 | 1998-03-31 | Euro-Celtique, S.A. | Transdermal patch for comparative evaluations |
AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
US5879701A (en) * | 1997-02-28 | 1999-03-09 | Cygnus, Inc. | Transdermal delivery of basic drugs using nonpolar adhesive systems and acidic solubilizing agents |
US5843472A (en) * | 1997-02-28 | 1998-12-01 | Cygnus, Inc. | Transdermal drug delivery sytem for the administration of tamsulosin, and related compositions and methods of use |
DE19814084B4 (de) * | 1998-03-30 | 2005-12-22 | Lts Lohmann Therapie-Systeme Ag | D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung |
DE19814083C2 (de) * | 1998-03-30 | 2002-02-07 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung von transdermalen therapeutischen Systemen unter Verwendung von basischen Alkalimetallsalzen zur Umwandlung von Wirkstoffsalzen in die freien Basen |
JP3507437B2 (ja) * | 1998-05-13 | 2004-03-15 | シグナス, インコーポレイテッド | 経皮サンプリング系のための収集アセンブリ |
DE19828273B4 (de) * | 1998-06-25 | 2005-02-24 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System, enthaltend Hormone und Kristallisationsinhibitoren |
JP2002524178A (ja) * | 1998-09-17 | 2002-08-06 | シグナス, インコーポレイテッド | ゲル/センサアセンブリ用のプレス装置 |
FR2792529B1 (fr) | 1999-04-26 | 2001-09-28 | Sod Conseils Rech Applic | Nouvelles compositions pharmaceutiques comprenant des derives de 2-isoxazole-8-aminotetralines |
AU5325000A (en) * | 1999-06-05 | 2000-12-28 | David Houze | Solubility enhancement of drugs in transdermal drug delivery systems and methodsof use |
US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
DE19940238A1 (de) * | 1999-08-25 | 2001-03-01 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges therapeutisches System zur Applikation auf der Haut mit mindestens zwei polymerhaltigen Schichten |
KR100317533B1 (ko) * | 1999-11-10 | 2001-12-24 | 윤종용 | 반도체 집적회로 장치에서의 레이저 퓨즈박스의 구조 및그에 따른 제조 방법 |
AR026505A1 (es) * | 1999-11-23 | 2003-02-12 | Aderis Pharmaceuticals Inc | Proceso mejorado para la preparacion de aminotetralinas sustituidas con nitrogeno |
CZ295031B6 (cs) * | 1999-11-29 | 2005-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermální terapeutické systémy se zlepšenou stabilitou a způsob jejich výroby |
US20020110585A1 (en) * | 1999-11-30 | 2002-08-15 | Godbey Kristin J. | Patch therapeutic agent delivery device having texturized backing |
DE10018467A1 (de) | 2000-04-14 | 2001-10-25 | Bosch Gmbh Robert | Elektrische Maschine |
DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
DE10060550C1 (de) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Oxybutynin und Verfahren zur Herstellung Oxybutynin enthaltender Wirkstoffschichten |
US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
FR2829028B1 (fr) * | 2001-08-29 | 2004-12-17 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et d'un produit qui active la neurotransmission dopaminergique dans le cerveau, les compositions pharmaceutiques les contenant et leur utilisation pour le traitement de la maladie de |
US20060263419A1 (en) * | 2002-03-12 | 2006-11-23 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
EP1494664A2 (en) * | 2002-04-18 | 2005-01-12 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease |
US20040048779A1 (en) * | 2002-05-06 | 2004-03-11 | Erwin Schollmayer | Use of rotigotine for treating the restless leg syndrome |
US20060216336A1 (en) | 2002-05-07 | 2006-09-28 | Hans-Michael Wolff | Transdermal therapeutic system for Parkinson's Disease |
KR20050045946A (ko) * | 2002-06-25 | 2005-05-17 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
DE10234673B4 (de) * | 2002-07-30 | 2007-08-16 | Schwarz Pharma Ag | Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
US8211462B2 (en) * | 2002-07-30 | 2012-07-03 | Ucb Pharma Gmbh | Hot-melt TTS for administering rotigotine |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
DE60204229T2 (de) * | 2002-12-02 | 2006-02-02 | Schwarz Pharma Ag | Verabreichung von Rotigotine zur Behandlung der Parkinson'schen Krankheit durch Iontophorese |
US9102726B2 (en) * | 2002-12-04 | 2015-08-11 | Argos Therapeutics, Inc. | Nucleic acid of recombination expression vector encoding soluble forms of CD83, host cells transformed/transfected therewith and pharmaceutical compositions containing same |
DE10261696A1 (de) | 2002-12-30 | 2004-07-15 | Schwarz Pharma Ag | Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base |
DE10334187A1 (de) | 2003-07-26 | 2005-03-03 | Schwarz Pharma Ag | Substituierte 2-Aminotetraline zur Behandlung von Depressionen |
DE10334188B4 (de) | 2003-07-26 | 2007-07-05 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung von Depressionen |
US7379762B2 (en) | 2003-09-04 | 2008-05-27 | Creative Technology Ltd. | Portable digital device orientation |
DE10359528A1 (de) * | 2003-12-18 | 2005-07-28 | Schwarz Pharma Ag | (S)-2-N-Propylamino-5-hydroxytetralin als D3-agonistisches Therapeutikum |
EP1547592A1 (en) * | 2003-12-23 | 2005-06-29 | Schwarz Pharma Ag | Intranasal formulation of rotigotine |
DE10361258A1 (de) | 2003-12-24 | 2005-07-28 | Schwarz Pharma Ag | Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson |
US20050197385A1 (en) * | 2004-02-20 | 2005-09-08 | Schwarz Pharma Ag | Use of rotigotine for treatment or prevention of dopaminergic neuron loss |
DE102004014841B4 (de) * | 2004-03-24 | 2006-07-06 | Schwarz Pharma Ag | Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的2-胺基萘滿之於製造用於預防、減緩及/或治療各種類型疼痛之藥物上的用途 |
EP1987815A1 (en) * | 2007-05-04 | 2008-11-05 | Schwarz Pharma Ag | Oronasopharyngeally deliverable pharmaceutical compositions of dopamine agonists for the prevention and/or treatment of restless limb disorders |
CN101970422B (zh) * | 2007-11-28 | 2014-10-22 | Ucb制药有限公司 | 罗替高汀的多晶型物 |
EP2281559A1 (en) | 2009-06-26 | 2011-02-09 | UCB Pharma GmbH | Pharmaceutical composition comprising rotigotine salts (acid or Na), especially for iontophoresis |
ME03053B (me) | 2009-12-22 | 2018-10-20 | Ucb Biopharma Sprl | Polivinilpirolidon za stabilizaciju čvrste disperzije nekristalnog oblika rotigotina |
-
1998
- 1998-03-30 DE DE19814084A patent/DE19814084B4/de not_active Expired - Lifetime
-
1999
- 1999-03-18 PL PL343255A patent/PL193074B1/pl unknown
- 1999-03-18 DE DE59900581T patent/DE59900581D1/de not_active Expired - Lifetime
- 1999-03-18 AT AT99910359T patent/ATE210973T1/de active
- 1999-03-18 DK DK99910359T patent/DK1033978T3/da active
- 1999-03-18 HU HU0101519A patent/HU226733B1/hu active Protection Beyond IP Right Term
- 1999-03-18 TR TR2000/02829T patent/TR200002829T2/xx unknown
- 1999-03-18 IL IL13872299A patent/IL138722A/xx not_active IP Right Cessation
- 1999-03-18 AU AU29341/99A patent/AU746856B2/en not_active Expired
- 1999-03-18 NZ NZ507066A patent/NZ507066A/xx not_active IP Right Cessation
- 1999-03-18 CA CA002326630A patent/CA2326630C/en not_active Expired - Lifetime
- 1999-03-18 EP EP99910359A patent/EP1033978B1/de not_active Expired - Lifetime
- 1999-03-18 WO PCT/EP1999/001795 patent/WO1999049852A1/de active IP Right Grant
- 1999-03-18 JP JP2000540818A patent/JP3984785B2/ja not_active Expired - Lifetime
- 1999-03-18 CN CNB998047511A patent/CN1142773C/zh not_active Expired - Lifetime
- 1999-03-18 US US09/647,290 patent/US6884434B1/en not_active Expired - Lifetime
- 1999-03-18 DE DE122006000035C patent/DE122006000035I2/de active Active
- 1999-03-18 ES ES99910359T patent/ES2170573T3/es not_active Expired - Lifetime
- 1999-03-18 ID IDW20001959A patent/ID26646A/id unknown
- 1999-03-18 KR KR10-2000-7010896A patent/KR100432276B1/ko active Protection Beyond IP Right Term
- 1999-03-18 BR BRPI9909313A patent/BRPI9909313B8/pt not_active IP Right Cessation
- 1999-03-18 CZ CZ20003581A patent/CZ297889B6/cs not_active IP Right Cessation
- 1999-03-18 DE DE1999500581 patent/DE122006000035I1/de active Pending
- 1999-03-18 PT PT99910359T patent/PT1033978E/pt unknown
- 1999-03-18 SK SK1446-2000A patent/SK284618B6/sk not_active IP Right Cessation
- 1999-03-26 AR ARP990101336A patent/AR014778A1/es active IP Right Grant
- 1999-03-26 MY MYPI99001191A patent/MY119660A/en unknown
- 1999-07-17 TW TW088104112A patent/TW579299B/zh active
-
2000
- 2000-09-29 NO NO20004915A patent/NO325766B1/no not_active IP Right Cessation
- 2000-09-29 ZA ZA200005261A patent/ZA200005261B/xx unknown
-
2001
- 2001-02-07 HK HK01100865A patent/HK1031196A1/xx unknown
-
2004
- 2004-09-07 US US10/936,620 patent/US10322093B2/en not_active Expired - Fee Related
-
2006
- 2006-07-26 LU LU91269C patent/LU91269I2/fr unknown
- 2006-07-28 FR FR06C0025C patent/FR06C0025I2/fr active Active
- 2006-08-01 NL NL300236C patent/NL300236I2/nl unknown
-
2007
- 2007-10-31 US US11/931,666 patent/US7413747B2/en not_active Expired - Fee Related
- 2007-10-31 US US11/931,762 patent/US10251844B2/en not_active Expired - Lifetime
-
2008
- 2008-01-25 NO NO20080489A patent/NO20080489L/no unknown
- 2008-10-14 NO NO2008014C patent/NO2008014I2/no unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT1033978E (pt) | Sistema terapeutico transdermico compreendendo um agonista d2 para o tratamento do sindroma de parkinson e processo para a sua producao | |
BR9503638A (pt) | Composto processo para sua produção e formulação farmacêutica | |
BR9403442A (pt) | Silanos, processo para sua produção e aplicação dos ditos silanos | |
BR9704007A (pt) | Sistema catalisador e processo para a produção de um polímero | |
ITMI940241A0 (it) | Sistema catalitico e processo per la produzione di polidiolefine | |
BR9505940A (pt) | Comprimido mastigável e processo para sua preparação | |
BR9407869A (pt) | Combinaçao composiçao farmacêutica e processo para o tratamento de osteoporose | |
BR9504509A (pt) | Composto processo para sua preparaçao e formulaçao farmaceûtica | |
BR9609780A (pt) | Composto uso de um composto processo para o tratamento de condições composição farmacêutica processos para preparar uma composição farmacêutica e para preparar um composto | |
BR9609834A (pt) | Inalador descartável processo para sua fabricação e utilização do mesmo | |
BR9305606A (pt) | Novo dispositivo de fixação para produtos sanitários e processo para sua produção | |
BR9609262A (pt) | Agente antiespumante para fermentação e processo para produção de fermentação utilizando o mesmo | |
PT1233763E (pt) | Sistemas terapeuticos transdermicos com estabilidade melhorada e um processo para a sua producao | |
BR9601275A (pt) | Compostos processo para sua preparação medicamentos preparação farmacêutica processo para sua produção e uso | |
BR9708336A (pt) | Diidrato de eprosartan e processo para sua produção e formulação | |
BR9601308A (pt) | Rolamento de agulhas e processo para sua fabricação | |
BR9506106A (pt) | Composto processo para sua preparação medicamento e composição farmacêutica | |
BR9602789A (pt) | Processo para a produção de aminas aromáticas e catalisador | |
BR9303370A (pt) | Processo para tratamento termico de um produto alimentar,aplicacao do referido processo e instalacao para sua realizacao | |
BR9602337A (pt) | Composto processo para sua preparação usos do mesmo processo para tratamento de arritmias e medicamento | |
BR9407090A (pt) | Processo para a preparação de N-(4-hidroxifenil)-retinamida | |
BR9704691A (pt) | Processo para a preparação de uma solução de um complexo de ródio e processo para a produção de um aldeído | |
BR9505962A (pt) | Suspensão farmacêutica aquosa e processo para sua preparação | |
BR9400338A (pt) | Processo para preparação de 1,1,1,2-tetrafluoro-2-cloroetano e de pentafluoretano | |
BR9806081A (pt) | Processo aperfei-oado de sintese de ur-ia e aparelho para o mesmo |