PL3958969T3 - Estrowe i węglanowe związki pirymidynowe jako inhibitory kinaz - Google Patents
Estrowe i węglanowe związki pirymidynowe jako inhibitory kinazInfo
- Publication number
- PL3958969T3 PL3958969T3 PL20726591.9T PL20726591T PL3958969T3 PL 3958969 T3 PL3958969 T3 PL 3958969T3 PL 20726591 T PL20726591 T PL 20726591T PL 3958969 T3 PL3958969 T3 PL 3958969T3
- Authority
- PL
- Poland
- Prior art keywords
- carbonate
- ester
- kinase inhibitors
- pyrimidine compounds
- jak kinase
- Prior art date
Links
- FNKLZPHAAKLNBX-UHFFFAOYSA-N carbonic acid;pyrimidine Chemical class OC(O)=O.C1=CN=CN=C1 FNKLZPHAAKLNBX-UHFFFAOYSA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962837829P | 2019-04-24 | 2019-04-24 | |
| PCT/US2020/029465 WO2020219639A1 (en) | 2019-04-24 | 2020-04-23 | Ester and carbonate pyrimidine compounds as jak kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3958969T3 true PL3958969T3 (pl) | 2024-05-20 |
Family
ID=70740750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20726591.9T PL3958969T3 (pl) | 2019-04-24 | 2020-04-23 | Estrowe i węglanowe związki pirymidynowe jako inhibitory kinaz |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11155549B2 (pl) |
| EP (1) | EP3958969B1 (pl) |
| JP (1) | JP7470713B2 (pl) |
| AR (1) | AR118768A1 (pl) |
| CA (1) | CA3135383A1 (pl) |
| HR (1) | HRP20240346T1 (pl) |
| PL (1) | PL3958969T3 (pl) |
| TW (1) | TW202106682A (pl) |
| WO (1) | WO2020219639A1 (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3672965T (pt) | 2017-10-27 | 2022-09-29 | Theravance Biopharma R&D Ip Llc | Composto de pirimidina como inibidor de jak cinase |
| CA3135388A1 (en) * | 2019-04-24 | 2020-10-29 | Theravance Biopharma R&D Ip, Llc | Pyrimidine jak inhibitors for the treatment of skin diseases |
| PL3958969T3 (pl) | 2019-04-24 | 2024-05-20 | Theravance Biopharma R&D Ip, Llc | Estrowe i węglanowe związki pirymidynowe jako inhibitory kinaz |
| US20210212962A1 (en) * | 2020-01-13 | 2021-07-15 | Sol-Gel Technologies Ltd. | Methods and compositions for the treatment of granuloma annulare or subcutaneous inflammation and non-infection granulomatous diseases |
| BR112023021870A2 (pt) * | 2021-04-22 | 2023-12-19 | Shenzhen Chipscreen Biosciences Co Ltd | Composição farmacêutica que contém inibidor seletivo de jak3/jak1/tbk1 e uso médico da mesma |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4919934A (en) | 1989-03-02 | 1990-04-24 | Richardson-Vicks Inc. | Cosmetic sticks |
| WO2002022605A1 (en) | 2000-09-15 | 2002-03-21 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6989385B2 (en) | 2000-12-21 | 2006-01-24 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2006315334B2 (en) | 2005-11-16 | 2011-05-19 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| AU2007263655A1 (en) | 2006-06-30 | 2008-01-03 | Astrazeneca Ab | Pyrimidine derivatives useful in the treatment of cancer |
| CA2656290A1 (en) | 2006-07-05 | 2008-01-10 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
| RU2014129740A (ru) | 2011-12-22 | 2016-02-10 | Ф.Хоффманн-Ля Рош Аг | Производные 2,4-диаминопиримидина в качестве ингибиторов серин/треонин киназы |
| WO2015094803A1 (en) | 2013-12-16 | 2015-06-25 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| NO2721710T3 (pl) * | 2014-08-21 | 2018-03-31 | ||
| EA032953B1 (ru) | 2015-05-28 | 2019-08-30 | ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи | Нафтиридиновые соединения в качестве ингибиторов jak киназы |
| KR102244257B1 (ko) * | 2016-04-28 | 2021-04-26 | 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 | Jak 키나제 저해제로서 피리미딘 화합물 |
| PT3672965T (pt) | 2017-10-27 | 2022-09-29 | Theravance Biopharma R&D Ip Llc | Composto de pirimidina como inibidor de jak cinase |
| TWI740288B (zh) | 2018-11-27 | 2021-09-21 | 大陸商江蘇豪森藥業集團有限公司 | 含氮雜芳類衍生物調節劑、其製備方法和應用 |
| EP3889152A4 (en) | 2018-11-30 | 2022-09-07 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | HETEROAROMATIC DERIVATIVES FOR USE AS REGULATORS, PROCESS FOR THEIR PREPARATION AND THEIR USE |
| PL3958969T3 (pl) * | 2019-04-24 | 2024-05-20 | Theravance Biopharma R&D Ip, Llc | Estrowe i węglanowe związki pirymidynowe jako inhibitory kinaz |
| CA3135388A1 (en) | 2019-04-24 | 2020-10-29 | Theravance Biopharma R&D Ip, Llc | Pyrimidine jak inhibitors for the treatment of skin diseases |
| CN113372351A (zh) | 2020-03-10 | 2021-09-10 | 明慧医药（杭州）有限公司 | 一类jak激酶抑制剂及其制备和应用 |
| CN113372364B (zh) | 2020-03-10 | 2024-05-31 | 明慧医药（上海）有限公司 | 一类jak激酶抑制剂及其制备和应用 |
-
2020
- 2020-04-23 PL PL20726591.9T patent/PL3958969T3/pl unknown
- 2020-04-23 JP JP2021562810A patent/JP7470713B2/ja active Active
- 2020-04-23 EP EP20726591.9A patent/EP3958969B1/en active Active
- 2020-04-23 US US16/856,280 patent/US11155549B2/en active Active
- 2020-04-23 TW TW109113575A patent/TW202106682A/zh unknown
- 2020-04-23 AR ARP200101152A patent/AR118768A1/es unknown
- 2020-04-23 CA CA3135383A patent/CA3135383A1/en active Pending
- 2020-04-23 WO PCT/US2020/029465 patent/WO2020219639A1/en unknown
- 2020-04-23 HR HRP20240346TT patent/HRP20240346T1/hr unknown
-
2021
- 2021-09-27 US US17/448,922 patent/US11845747B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200339580A1 (en) | 2020-10-29 |
| US20220009926A1 (en) | 2022-01-13 |
| CA3135383A1 (en) | 2020-10-29 |
| EP3958969C0 (en) | 2024-01-10 |
| US11155549B2 (en) | 2021-10-26 |
| EP3958969B1 (en) | 2024-01-10 |
| EP3958969A1 (en) | 2022-03-02 |
| JP2022529370A (ja) | 2022-06-21 |
| AR118768A1 (es) | 2021-10-27 |
| HRP20240346T1 (hr) | 2024-05-24 |
| TW202106682A (zh) | 2021-02-16 |
| WO2020219639A1 (en) | 2020-10-29 |
| US11845747B2 (en) | 2023-12-19 |
| JP7470713B2 (ja) | 2024-04-18 |
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