PL3774862T3 - Nowe analogi glp-1 - Google Patents

Nowe analogi glp-1

Info

Publication number
PL3774862T3
PL3774862T3 PL19724915.4T PL19724915T PL3774862T3 PL 3774862 T3 PL3774862 T3 PL 3774862T3 PL 19724915 T PL19724915 T PL 19724915T PL 3774862 T3 PL3774862 T3 PL 3774862T3
Authority
PL
Poland
Prior art keywords
analogues
novel glp
glp
novel
Prior art date
Application number
PL19724915.4T
Other languages
English (en)
Inventor
Rajamannar Thennati
Nishith Chaturvedi
Vinod Sampatrao BURADE
Pradeep Dinesh SHAHI
Muthukumaran Natarajan
Ravishankara Madavati NAGARAJA
Rishit Mansukhlal ZALAWADIA
Kunal PANDYA
Brijeshkumar PATEL
Dhiren Rameshchandra JOSHI
Krunal Harishbhai SONI
Abhishek Tiwari
Vipulkumar Shankarbhai PATEL
Original Assignee
Sun Pharmaceutical Industries Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Limited filed Critical Sun Pharmaceutical Industries Limited
Publication of PL3774862T3 publication Critical patent/PL3774862T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmission And Conversion Of Sensor Element Output (AREA)
PL19724915.4T 2018-04-05 2019-04-05 Nowe analogi glp-1 PL3774862T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201821013109 2018-04-05
IN201821040474 2018-10-26
IN201821040468 2018-10-26
PCT/IB2019/052835 WO2019193576A1 (en) 2018-04-05 2019-04-05 Novel glp-1 analogues

Publications (1)

Publication Number Publication Date
PL3774862T3 true PL3774862T3 (pl) 2022-10-03

Family

ID=66589592

Family Applications (1)

Application Number Title Priority Date Filing Date
PL19724915.4T PL3774862T3 (pl) 2018-04-05 2019-04-05 Nowe analogi glp-1

Country Status (28)

Country Link
US (5) US11447535B2 (pl)
EP (3) EP4364751A2 (pl)
JP (2) JP7250814B2 (pl)
KR (1) KR20200141469A (pl)
CN (2) CN112236444A (pl)
AU (2) AU2019247936C1 (pl)
BR (1) BR112020020419A2 (pl)
CA (1) CA3095988A1 (pl)
CL (1) CL2020002574A1 (pl)
CO (1) CO2020012425A2 (pl)
DK (1) DK3774862T3 (pl)
EC (1) ECSP20070185A (pl)
ES (1) ES2925678T3 (pl)
HR (1) HRP20221054T1 (pl)
HU (1) HUE060135T2 (pl)
IL (1) IL277483A (pl)
JO (1) JOP20200251A1 (pl)
LT (1) LT3774862T (pl)
MX (1) MX2020010505A (pl)
PE (1) PE20211417A1 (pl)
PH (1) PH12020551591A1 (pl)
PL (1) PL3774862T3 (pl)
PT (1) PT3774862T (pl)
RS (1) RS63523B1 (pl)
SG (1) SG11202009467YA (pl)
SI (1) SI3774862T1 (pl)
WO (1) WO2019193576A1 (pl)
ZA (1) ZA202306729B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4364751A2 (en) * 2018-04-05 2024-05-08 Sun Pharmaceutical Industries Limited Novel glp-1 analogues
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
TW202216746A (zh) * 2020-06-22 2022-05-01 印度商太陽製藥工業有限公司 長效型glp-1/gip雙重促效劑
PE20231309A1 (es) * 2020-10-17 2023-08-24 Sun Pharmaceutical Ind Ltd Agonistas duales glp-1/gip
CN114685646B (zh) * 2020-12-31 2023-04-07 厦门赛诺邦格生物科技股份有限公司 一种多肽侧链类似物的制备方法及其应用
WO2022159395A1 (en) 2021-01-20 2022-07-28 Viking Therapeutics, Inc. Compositions and methods for the treatment of metabolic and liver disorders
CN115785249B (zh) * 2022-10-13 2023-07-21 江苏师范大学 一类glp-1类似物及其应用

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6849708B1 (en) 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
HU227021B1 (en) 1996-08-30 2010-05-28 Novo Nordisk As Glp-1 derivatives
US6268343B1 (en) 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
ATE466028T1 (de) 1998-02-27 2010-05-15 Novo Nordisk As N-terminal veränderte glp-1 abkömmlinge
ATE466027T1 (de) 1998-02-27 2010-05-15 Novo Nordisk As Abkömmlinge von glp-1 analogen
JP2002508162A (ja) 1998-02-27 2002-03-19 ノボ ノルディスク アクティーゼルスカブ N末端を短縮したglp−1誘導体
AU3247799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2353574C (en) 1998-12-07 2012-05-08 Zheng Xin Dong Analogues of glp-1
DZ3388A1 (fr) 2000-06-16 2001-12-27 Lilly Co Eli Analogues de peptide 1 du type glucagon
BR0116024A (pt) 2000-12-07 2005-12-13 Lilly Co Eli Proteìna de fusão heteróloga e uso da mesma
AR038102A1 (es) 2002-01-08 2004-12-29 Lilly Co Eli Analogos extendidos de peptido 1 de tipo glucagon
CN100354306C (zh) 2002-10-11 2007-12-12 株式会社三和化学研究所 Glp-1衍生物及其经粘膜吸收的制剂
WO2004078777A2 (en) 2003-03-04 2004-09-16 Biorexis Pharmaceutical Corporation Dipeptidyl-peptidase protected proteins
ATE549028T1 (de) 2003-05-15 2012-03-15 Tufts College Stabile analoga von glp-1
BRPI0414539B8 (pt) 2003-09-19 2021-05-25 Novo Nordisk As composto, composição farmacêutica, e, uso de um composto
JP2007536214A (ja) 2003-12-16 2007-12-13 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス Glp−1類似体
JP2008515856A (ja) 2004-10-07 2008-05-15 ノボ ノルディスク アクティーゼルスカブ 遅延性glp−1化合物
TWI372629B (en) 2005-03-18 2012-09-21 Novo Nordisk As Acylated glp-1 compounds
KR20070120112A (ko) 2005-03-18 2007-12-21 노보 노르디스크 에이/에스 연장형 glp-1 화합물
CA2607566A1 (en) 2005-05-06 2006-11-16 Bayer Pharmaceuticals Corporation Glucagon-like peptide 1 (glp-1) receptor agonists and their pharmacological methods of use
CA2621699A1 (en) 2005-09-08 2007-03-15 Trustees Of Tufts College Stabilized glp-1 analogs
ES2397289T3 (es) 2005-09-22 2013-03-06 Biocompatibles Uk Ltd. Polipéptidos de fusión de GLP-1 (péptido 1 de tipo glucagón) con resistencia a peptidasa incrementada
EP2190460B1 (en) 2007-09-05 2014-12-17 Novo Nordisk A/S Peptides derivatized with a-b-c-d- and their therapeutical use
JP5771005B2 (ja) 2007-10-30 2015-08-26 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation グルカゴンアンタゴニスト及びglp−1アゴニスト活性を示す化合物
CN102791731B (zh) 2009-12-16 2016-04-20 诺沃—诺迪斯克有限公司 Glp-1类似物和衍生物
BR112012027545B1 (pt) 2010-04-27 2020-09-24 Betta Pharmaceuticals Co., Ltd. Composto, composição farmacêutica, uso da composição farmacêutica e uso de um composto
WO2012016419A1 (zh) 2010-08-06 2012-02-09 浙江贝达药业有限公司 Glp-1衍生物及其应用
EP2637698B1 (en) 2010-11-09 2022-04-20 Novo Nordisk A/S Double-acylated glp-1 derivatives
RU2602601C2 (ru) 2011-04-12 2016-11-20 Ново Нордиск А/С Дважды ацилированные производные glp-1
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
CN107266558A (zh) 2011-09-06 2017-10-20 诺沃—诺迪斯克有限公司 Glp‑1衍生物
EP2578599A1 (en) 2011-10-07 2013-04-10 LanthioPep B.V. Cyclic analogs of GLP-1 and GLP-1 related peptides
CN104519902B (zh) 2012-05-08 2017-10-27 诺和诺德股份有限公司 双酰化glp‑1衍生物
US11274135B2 (en) 2012-05-08 2022-03-15 Novo Nordisk A/S Double-acylated GLP-1 derivatives
WO2013186240A2 (en) 2012-06-14 2013-12-19 Sanofi Exendin-4 peptide analogues
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
TWI617574B (zh) 2012-12-11 2018-03-11 梅迪繆思有限公司 用於治療肥胖之升糖素與glp-1共促效劑
CN104902919B (zh) 2012-12-21 2018-11-20 赛诺菲 Glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂
US10195255B2 (en) 2013-06-20 2019-02-05 Novo Nordisk A/S GLP-1 derivatives and uses thereof
US9738697B2 (en) 2013-06-23 2017-08-22 Wisconsin Alumni Research Foundation Alpha/beta-polypeptide analogs of glucagon-like peptide-1
US9498534B2 (en) 2013-07-04 2016-11-22 Novo Nordisk A/S Derivatives of GLP-1 like peptides, and uses thereof
CN105451776B (zh) 2013-08-15 2020-04-17 诺和诺德股份有限公司 Glp-1衍生物及其用途
BR112016008115B1 (pt) * 2013-10-17 2024-03-12 Boehringer Ingelheim International Gmbh Análogos de glucagon acilados
TW201609797A (zh) 2013-12-13 2016-03-16 賽諾菲公司 雙重glp-1/升糖素受體促效劑
SG10201805039UA (en) 2013-12-13 2018-07-30 Medimmune Ltd Protease resistant peptides
EP3080155A1 (en) 2013-12-13 2016-10-19 Sanofi Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
CN106999602B (zh) 2014-11-27 2022-02-01 诺和诺德股份有限公司 Glp-1衍生物及其用途
CN107108714B (zh) 2014-12-17 2022-02-08 诺和诺德股份有限公司 Glp-1衍生物及其用途
TWI726889B (zh) 2015-06-10 2021-05-11 英商梅迪繆思有限公司 蛋白酶抗性之脂化肽
WO2017035432A1 (en) 2015-08-26 2017-03-02 Robert Doyle Coagonists of glucagon-like peptide 1 receptor and neuropeptide y2 receptor
WO2017149070A1 (en) 2016-03-03 2017-09-08 Novo Nordisk A/S Glp-1 derivatives and uses thereof
JP2019525732A (ja) 2016-06-09 2019-09-12 メドイミューン・リミテッドMedImmune Limited プロテアーゼ耐性一脂質付加ペプチド
WO2018083335A1 (en) 2016-11-07 2018-05-11 Novo Nordisk A/S Dchbs-active esters of peg compounds and their use
TW201833131A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 作為胜肽類glp1/升糖素/gip受體促效劑之新化合物
WO2018178796A1 (en) * 2017-03-27 2018-10-04 Sun Pharmaceutical Industries Limited Method for making kex1 protease sensitive polypeptides using yeast strain
WO2019170918A1 (en) 2018-03-09 2019-09-12 Enzypep B.V. Chemo-enzymatic synthesis of liraglutide, semaglutide and glp-1
EP4364751A2 (en) * 2018-04-05 2024-05-08 Sun Pharmaceutical Industries Limited Novel glp-1 analogues

Also Published As

Publication number Publication date
PE20211417A1 (es) 2021-08-02
SI3774862T1 (sl) 2022-10-28
AU2019247936B2 (en) 2023-03-02
ES2925678T3 (es) 2022-10-19
ECSP20070185A (es) 2021-01-29
JP2021520346A (ja) 2021-08-19
LT3774862T (lt) 2022-09-12
US20220402991A1 (en) 2022-12-22
CA3095988A1 (en) 2019-10-10
US11242373B2 (en) 2022-02-08
RS63523B1 (sr) 2022-09-30
CN117964735A (zh) 2024-05-03
EP4122954B1 (en) 2024-04-03
US20190309040A1 (en) 2019-10-10
DK3774862T3 (da) 2022-09-05
US20220402992A1 (en) 2022-12-22
AU2019247936C1 (en) 2023-06-15
US20200362007A1 (en) 2020-11-19
CO2020012425A2 (es) 2020-12-21
US11447535B2 (en) 2022-09-20
ZA202306729B (en) 2024-03-27
CL2020002574A1 (es) 2021-06-04
IL277483A (en) 2020-11-30
EP3774862A1 (en) 2021-02-17
CN112236444A (zh) 2021-01-15
SG11202009467YA (en) 2020-10-29
US11873328B2 (en) 2024-01-16
JP2023078367A (ja) 2023-06-06
HUE060135T2 (hu) 2023-02-28
EP4364751A2 (en) 2024-05-08
PH12020551591A1 (en) 2021-08-16
MX2020010505A (es) 2021-01-15
US11485766B2 (en) 2022-11-01
US20210206823A1 (en) 2021-07-08
JP7250814B2 (ja) 2023-04-03
EP3774862B1 (en) 2022-06-08
BR112020020419A2 (pt) 2021-01-19
JOP20200251A1 (ar) 2020-10-04
US11866477B2 (en) 2024-01-09
HRP20221054T1 (hr) 2022-11-11
AU2019247936A1 (en) 2020-10-15
PT3774862T (pt) 2022-09-05
KR20200141469A (ko) 2020-12-18
EP4122954A1 (en) 2023-01-25
WO2019193576A1 (en) 2019-10-10
AU2023203430A1 (en) 2023-06-29

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