PL342995A1 - Inhibitors of phospholipase enzymes - Google Patents
Inhibitors of phospholipase enzymesInfo
- Publication number
- PL342995A1 PL342995A1 PL99342995A PL34299599A PL342995A1 PL 342995 A1 PL342995 A1 PL 342995A1 PL 99342995 A PL99342995 A PL 99342995A PL 34299599 A PL34299599 A PL 34299599A PL 342995 A1 PL342995 A1 PL 342995A1
- Authority
- PL
- Poland
- Prior art keywords
- inhibitors
- phospholipase enzymes
- phospholipase
- enzymes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3006298A | 1998-02-25 | 1998-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL342995A1 true PL342995A1 (en) | 2001-07-16 |
Family
ID=21852314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL99342995A PL342995A1 (en) | 1998-02-25 | 1999-02-24 | Inhibitors of phospholipase enzymes |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1056719A2 (en) |
| JP (1) | JP2002504539A (en) |
| KR (1) | KR20010041343A (en) |
| CN (1) | CN1299347A (en) |
| AU (1) | AU2782699A (en) |
| BG (1) | BG104780A (en) |
| BR (1) | BR9908280A (en) |
| CA (1) | CA2322161A1 (en) |
| EA (1) | EA200000868A1 (en) |
| EE (1) | EE200000486A (en) |
| HR (1) | HRP20000552A2 (en) |
| HU (1) | HUP0100757A3 (en) |
| ID (1) | ID27280A (en) |
| IL (1) | IL137718A0 (en) |
| NO (1) | NO20004220L (en) |
| PL (1) | PL342995A1 (en) |
| SK (1) | SK12742000A3 (en) |
| TR (1) | TR200002446T2 (en) |
| WO (1) | WO1999043651A2 (en) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4591800A (en) * | 1999-05-05 | 2000-11-21 | Aventis Pharma Limited | Ureas as cell adhesion modulators |
| ATE362468T1 (en) | 2000-07-25 | 2007-06-15 | Merck & Co Inc | N-SUBSTITUTED INDOLES WITH APPLICATION IN THE TREATMENT OF DIABETES |
| KR100854424B1 (en) | 2001-01-29 | 2008-08-27 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | Substituted indoles and their use as integrin antagonists |
| DE60228954D1 (en) | 2001-05-03 | 2008-10-30 | Galileo Lab Inc | Pyruvatderivate |
| US6608196B2 (en) | 2001-05-03 | 2003-08-19 | Galileo Pharmaceuticals, Inc. | Process for solid supported synthesis of pyruvate-derived compounds |
| JP4399253B2 (en) | 2001-06-20 | 2010-01-13 | ワイス | Substituted indoleic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| WO2003000668A1 (en) * | 2001-06-25 | 2003-01-03 | Nippon Soda Co., Ltd. | Oxa(thia)zolidine compounds, process for preparation thereof and anti-inflammatory agents |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| EP1892239B1 (en) * | 2001-12-03 | 2013-02-20 | Wyeth LLC | Inhibitors of cytosolic phospholipase A2 |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US6797708B2 (en) * | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| ES2300490T3 (en) * | 2001-12-03 | 2008-06-16 | Wyeth | CITOSOLICA A2 PHOSPHOLIPASE INHIBITORS. |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| US7393960B2 (en) | 2002-08-29 | 2008-07-01 | Merck & Co., Inc. | Indoles having anti-diabetic activity |
| ES2342596T3 (en) | 2002-08-29 | 2010-07-09 | MERCK SHARP & DOHME CORP. | INDOLES WITH ANTI-DIABETIC ACTIVITY. |
| US7795280B2 (en) | 2002-11-07 | 2010-09-14 | N.V. Organon | Indoles useful in the treatment of androgen-receptor related diseases |
| DE60306547T2 (en) | 2002-12-10 | 2007-06-28 | Wyeth | SUBSTITUTED 3-ALKYL AND 3-ARYL ALKYL-1H-INDOL-1-YL-ACETIC ACID DERIVATIVES AS PLASMINOGEN ACTIVATOR |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| EP1569901B1 (en) | 2002-12-10 | 2008-10-15 | Wyeth | ARYL, ARYLOXY, AND ALKYLOXY SUBSTITUTED i 1H /i -INDOL-3-YL GLYOXYLIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) |
| US7056943B2 (en) | 2002-12-10 | 2006-06-06 | Wyeth | Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| ATE331709T1 (en) | 2002-12-10 | 2006-07-15 | Wyeth Corp | SUBSTITUTED 3-CARBONYL-1-YL ACETIC ACID DERIVATIVES AS PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) INHIBITORS |
| TW200510305A (en) * | 2003-07-25 | 2005-03-16 | Wyeth Corp | Process for the preparation of CPLA2 inhibitors |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7420083B2 (en) | 2003-09-25 | 2008-09-02 | Wyeth | Substituted aryloximes |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7342039B2 (en) | 2003-09-25 | 2008-03-11 | Wyeth | Substituted indole oximes |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| CA2570363A1 (en) | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7754747B2 (en) | 2004-08-23 | 2010-07-13 | Wyeth Llc | Oxazolo-naphthyl acids |
| WO2006045478A1 (en) * | 2004-10-27 | 2006-05-04 | F. Hoffmann-La Roche Ag | New indole or benzimidazole derivatives |
| US8097623B2 (en) | 2005-01-19 | 2012-01-17 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| AU2006279496A1 (en) | 2005-08-17 | 2007-02-22 | Wyeth | Substituted indoles and use thereof |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
| AR072297A1 (en) | 2008-06-27 | 2010-08-18 | Novartis Ag | DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE. |
| JP5677425B2 (en) | 2009-06-29 | 2015-02-25 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Pyrimidinone as a PI3K inhibitor |
| WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| CA2796311A1 (en) | 2010-04-14 | 2011-10-20 | Incyte Corporation | Fused derivatives as pi3k.delta. inhibitors |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| EP2655374B1 (en) | 2010-12-20 | 2019-10-23 | Incyte Holdings Corporation | N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| KR102507287B1 (en) | 2011-09-02 | 2023-03-07 | 인사이트 홀딩스 코포레이션 | Heterocyclylamines as pi3k inhibitors |
| AR090548A1 (en) | 2012-04-02 | 2014-11-19 | Incyte Corp | BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS |
| MY173845A (en) | 2012-07-17 | 2020-02-24 | Glaxosmithkline Ip No 2 Ltd | Indolecarbonitriles as selective androgen receptor modulators |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| US10077277B2 (en) | 2014-06-11 | 2018-09-18 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors |
| PE20180129A1 (en) | 2015-02-27 | 2018-01-18 | Incyte Corp | PI3K INHIBITOR SALTS AND PREPARATION PROCESSES |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| DK3860998T3 (en) | 2018-10-05 | 2024-03-25 | Annapurna Bio Inc | Compounds and compositions for treating conditions associated with APJ receptor activity |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE314373B (en) * | 1966-04-12 | 1969-09-08 | Sumitomo Chemical Co | |
| FR1492929A (en) * | 1966-05-11 | 1967-08-25 | Roussel Uclaf | Novel substituted 1- (omega-carboxyalkyl) indoles and method of preparation |
| US3505354A (en) * | 1967-05-18 | 1970-04-07 | Geigy Chem Corp | 2-methyl-3-p-halobenzoylindole-n-aliphatic acids |
| DE1816335A1 (en) * | 1968-12-21 | 1970-07-09 | Thiemann Gmbh Chem Pharm Fabri | 2-methyl-5-alkoxy-3-acyl-indole-1-acetic - acid and esters thereof |
| US4894386A (en) * | 1987-04-15 | 1990-01-16 | Ici Americas Inc. | Aliphatic carboxamides |
| DE68904342T2 (en) * | 1988-04-13 | 1993-05-06 | Ici America Inc | CYCLIC AMIDES. |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| NZ249729A (en) * | 1992-05-13 | 1996-12-20 | Syntex Inc | Substituted indoles and azaindoles, preparation and pharmaceutical compositions thereof |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
| DE4338770A1 (en) * | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indole-2-alkanoic acids and their derivatives as inhibitors of phospholipase A¶2¶ |
| JP2000515529A (en) * | 1996-08-01 | 2000-11-21 | メルクル・ゲーエムベーハー | Acylpyrrolidone dicarboxylic acid, acyl indole dicarboxylic acid and derivatives thereof as inhibitors of cytoplasmic phospholipase A |
| JP2000516958A (en) * | 1996-08-26 | 2000-12-19 | ジェネティックス・インスチチュート・インコーポレーテッド | Phospholipase enzyme inhibitors |
-
1999
- 1999-02-24 SK SK1274-2000A patent/SK12742000A3/en unknown
- 1999-02-24 CN CN99805385A patent/CN1299347A/en active Pending
- 1999-02-24 KR KR1020007009456A patent/KR20010041343A/en not_active Application Discontinuation
- 1999-02-24 EE EEP200000486A patent/EE200000486A/en unknown
- 1999-02-24 TR TR2000/02446T patent/TR200002446T2/en unknown
- 1999-02-24 IL IL13771899A patent/IL137718A0/en unknown
- 1999-02-24 AU AU27826/99A patent/AU2782699A/en not_active Abandoned
- 1999-02-24 PL PL99342995A patent/PL342995A1/en unknown
- 1999-02-24 BR BR9908280-2A patent/BR9908280A/en not_active IP Right Cessation
- 1999-02-24 EP EP99908379A patent/EP1056719A2/en not_active Withdrawn
- 1999-02-24 WO PCT/US1999/003899 patent/WO1999043651A2/en not_active Application Discontinuation
- 1999-02-24 HU HU0100757A patent/HUP0100757A3/en unknown
- 1999-02-24 JP JP2000533409A patent/JP2002504539A/en not_active Withdrawn
- 1999-02-24 EA EA200000868A patent/EA200000868A1/en unknown
- 1999-02-24 CA CA002322161A patent/CA2322161A1/en not_active Abandoned
- 1999-02-24 ID IDW20001594A patent/ID27280A/en unknown
-
2000
- 2000-08-23 NO NO20004220A patent/NO20004220L/en unknown
- 2000-08-24 HR HR20000552A patent/HRP20000552A2/en not_active Application Discontinuation
- 2000-09-19 BG BG104780A patent/BG104780A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID27280A (en) | 2001-03-22 |
| NO20004220D0 (en) | 2000-08-23 |
| SK12742000A3 (en) | 2001-05-10 |
| WO1999043651A3 (en) | 1999-12-16 |
| HUP0100757A3 (en) | 2001-11-28 |
| WO1999043651A2 (en) | 1999-09-02 |
| EE200000486A (en) | 2002-02-15 |
| JP2002504539A (en) | 2002-02-12 |
| CN1299347A (en) | 2001-06-13 |
| KR20010041343A (en) | 2001-05-15 |
| BR9908280A (en) | 2000-10-31 |
| EA200000868A1 (en) | 2001-04-23 |
| HUP0100757A1 (en) | 2001-08-28 |
| TR200002446T2 (en) | 2000-12-21 |
| CA2322161A1 (en) | 1999-09-02 |
| BG104780A (en) | 2001-10-31 |
| EP1056719A2 (en) | 2000-12-06 |
| NO20004220L (en) | 2000-10-05 |
| AU2782699A (en) | 1999-09-15 |
| HRP20000552A2 (en) | 2001-04-30 |
| IL137718A0 (en) | 2001-10-31 |
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