PL3277683T3 - Trójpierścieniowe pochodne 1-(cyklo)alkilopirydyn-2-onu użyteczne w leczeniu raka - Google Patents
Trójpierścieniowe pochodne 1-(cyklo)alkilopirydyn-2-onu użyteczne w leczeniu rakaInfo
- Publication number
- PL3277683T3 PL3277683T3 PL16723536T PL16723536T PL3277683T3 PL 3277683 T3 PL3277683 T3 PL 3277683T3 PL 16723536 T PL16723536 T PL 16723536T PL 16723536 T PL16723536 T PL 16723536T PL 3277683 T3 PL3277683 T3 PL 3277683T3
- Authority
- PL
- Poland
- Prior art keywords
- cyclo
- cancer
- useful
- treatment
- tricyclic fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1636CH2015 | 2015-03-30 | ||
| PCT/IN2016/050098 WO2016157221A1 (en) | 2015-03-30 | 2016-03-30 | Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer |
| EP16723536.5A EP3277683B1 (en) | 2015-03-30 | 2016-03-30 | Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3277683T3 true PL3277683T3 (pl) | 2022-05-23 |
Family
ID=56015058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16723536T PL3277683T3 (pl) | 2015-03-30 | 2016-03-30 | Trójpierścieniowe pochodne 1-(cyklo)alkilopirydyn-2-onu użyteczne w leczeniu raka |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10689390B2 (pl) |
| EP (1) | EP3277683B1 (pl) |
| JP (1) | JP6764877B2 (pl) |
| KR (1) | KR102588109B1 (pl) |
| CN (1) | CN107548393B (pl) |
| AU (1) | AU2016242473B2 (pl) |
| BR (1) | BR112017020739B1 (pl) |
| CA (1) | CA2980266A1 (pl) |
| DK (1) | DK3277683T3 (pl) |
| ES (1) | ES2911886T3 (pl) |
| HK (1) | HK1248686A1 (pl) |
| IL (1) | IL254528B (pl) |
| MX (1) | MX2017012387A (pl) |
| PL (1) | PL3277683T3 (pl) |
| PT (1) | PT3277683T (pl) |
| RU (1) | RU2721120C2 (pl) |
| WO (1) | WO2016157221A1 (pl) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2866073T3 (es) * | 2015-09-09 | 2021-10-19 | Jubilant Biosys Ltd | Derivados tricíclicos fusionados de piridin-2-ona y su uso como inhibidores de BRD4 |
| KR20190075131A (ko) * | 2016-11-10 | 2019-06-28 | 뤄신 파마슈티컬 (상하이) 컴퍼니 리미티드 | 질소 함유 거대 고리계 화합물, 이의 제조 방법, 약물 조성물 및 용도 |
| WO2019214399A1 (zh) * | 2018-05-10 | 2019-11-14 | 罗欣药业(上海)有限公司 | 苯并七元杂环类化合物、其制备方法、药物组合物及应用 |
| CN110172068A (zh) * | 2019-06-05 | 2019-08-27 | 河南龙湖生物技术有限公司 | 具有抗肿瘤活性的苯并噻唑类化合物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1545767A (en) * | 1976-06-30 | 1979-05-16 | Aspro Nicholas Ltd | Isoquinoline derivatives |
| TW200904403A (en) | 2007-04-25 | 2009-02-01 | Daiichi Sankyo Co Ltd | Tricyclic aryl compounds |
| CL2009000780A1 (es) | 2008-03-31 | 2010-01-15 | Genentech Inc | Compuestos derivados de heterociclil-pirano-heterociclilo, heterociclil-oxepina-heterociclilo, benzopirano-heterociclilo y benzoxepina-heterociclilo sustituidos; composicion farmaceutica; procedimiento de preparacion de la composicion; kit farmaceutico; y su uso en el tratamiento del cancer, mediado por la inhibicion de pi3k. |
| ES2526671T3 (es) | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| AU2014220838A1 (en) * | 2013-02-19 | 2015-09-10 | Bayer Pharma Aktiengesellschaft | Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines |
| KR102224992B1 (ko) | 2013-03-12 | 2021-03-10 | 애브비 인코포레이티드 | 테트라사이클릭 브로모도메인 억제제 |
| WO2015018520A1 (en) | 2013-08-06 | 2015-02-12 | Oncoethix Sa | A bet-brd inhibitor represents a novel agent for alk positive anaplastic large cell lymphoma |
| US9814728B2 (en) | 2013-09-20 | 2017-11-14 | Saint Louis University | Inhibition of DUX4 expression using bromodomain and extra-terminal domain protein inhibitors (BETi) |
-
2016
- 2016-03-30 PL PL16723536T patent/PL3277683T3/pl unknown
- 2016-03-30 PT PT167235365T patent/PT3277683T/pt unknown
- 2016-03-30 DK DK16723536.5T patent/DK3277683T3/da active
- 2016-03-30 WO PCT/IN2016/050098 patent/WO2016157221A1/en active Application Filing
- 2016-03-30 KR KR1020177031273A patent/KR102588109B1/ko active IP Right Grant
- 2016-03-30 US US15/562,381 patent/US10689390B2/en active Active
- 2016-03-30 MX MX2017012387A patent/MX2017012387A/es active IP Right Grant
- 2016-03-30 BR BR112017020739-7A patent/BR112017020739B1/pt active IP Right Grant
- 2016-03-30 EP EP16723536.5A patent/EP3277683B1/en active Active
- 2016-03-30 CN CN201680020269.3A patent/CN107548393B/zh active Active
- 2016-03-30 ES ES16723536T patent/ES2911886T3/es active Active
- 2016-03-30 RU RU2017135205A patent/RU2721120C2/ru active
- 2016-03-30 CA CA2980266A patent/CA2980266A1/en active Pending
- 2016-03-30 AU AU2016242473A patent/AU2016242473B2/en active Active
- 2016-03-30 JP JP2017551712A patent/JP6764877B2/ja active Active
-
2017
- 2017-09-17 IL IL254528A patent/IL254528B/en active IP Right Grant
-
2018
- 2018-06-26 HK HK18108222.3A patent/HK1248686A1/zh unknown
-
2020
- 2020-05-07 US US16/869,517 patent/US11319326B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2911886T3 (es) | 2022-05-23 |
| BR112017020739B1 (pt) | 2023-03-14 |
| US10689390B2 (en) | 2020-06-23 |
| CN107548393A (zh) | 2018-01-05 |
| AU2016242473A1 (en) | 2017-10-26 |
| EP3277683B1 (en) | 2022-03-09 |
| KR102588109B1 (ko) | 2023-10-12 |
| JP6764877B2 (ja) | 2020-10-07 |
| US20180282345A1 (en) | 2018-10-04 |
| RU2017135205A3 (pl) | 2019-07-17 |
| US20200331926A1 (en) | 2020-10-22 |
| HK1248686A1 (zh) | 2018-10-19 |
| KR20170132278A (ko) | 2017-12-01 |
| JP2018510203A (ja) | 2018-04-12 |
| WO2016157221A1 (en) | 2016-10-06 |
| US11319326B2 (en) | 2022-05-03 |
| EP3277683A1 (en) | 2018-02-07 |
| RU2721120C2 (ru) | 2020-05-15 |
| IL254528A0 (en) | 2017-11-30 |
| RU2017135205A (ru) | 2019-04-10 |
| MX2017012387A (es) | 2018-06-11 |
| DK3277683T3 (en) | 2022-05-02 |
| BR112017020739A2 (pt) | 2018-07-17 |
| AU2016242473B2 (en) | 2020-06-25 |
| CN107548393B (zh) | 2021-03-02 |
| IL254528B (en) | 2020-11-30 |
| CA2980266A1 (en) | 2016-10-06 |
| PT3277683T (pt) | 2022-06-28 |
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