PL3129378T3 - Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworu - Google Patents

Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworu

Info

Publication number
PL3129378T3
PL3129378T3 PL15776821T PL15776821T PL3129378T3 PL 3129378 T3 PL3129378 T3 PL 3129378T3 PL 15776821 T PL15776821 T PL 15776821T PL 15776821 T PL15776821 T PL 15776821T PL 3129378 T3 PL3129378 T3 PL 3129378T3
Authority
PL
Poland
Prior art keywords
bromodomain
cancer
treating
preventing
pharmaceutical composition
Prior art date
Application number
PL15776821T
Other languages
English (en)
Inventor
Su-Sung OH
MinJeong CHOI
Original Assignee
Kainos Medicine, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kainos Medicine, Inc. filed Critical Kainos Medicine, Inc.
Publication of PL3129378T3 publication Critical patent/PL3129378T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL15776821T 2014-04-09 2015-04-08 Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworu PL3129378T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461977370P 2014-04-09 2014-04-09
EP15776821.9A EP3129378B1 (en) 2014-04-09 2015-04-08 Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer
PCT/KR2015/003530 WO2015156601A1 (en) 2014-04-09 2015-04-08 Bromodomain-inhibiting compounds and pharmaceutical composition comprising same for preventing or treating a cancer

Publications (1)

Publication Number Publication Date
PL3129378T3 true PL3129378T3 (pl) 2020-03-31

Family

ID=54288110

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15776821T PL3129378T3 (pl) 2014-04-09 2015-04-08 Związki hamujące bromodomenę i zawierająca je kompozycja farmaceutyczna do zapobiegania lub leczenia nowotworu

Country Status (9)

Country Link
US (1) US9884874B2 (pl)
EP (1) EP3129378B1 (pl)
JP (1) JP6333996B2 (pl)
KR (1) KR101928521B1 (pl)
CN (1) CN106132968B (pl)
DK (1) DK3129378T3 (pl)
ES (1) ES2751642T3 (pl)
PL (1) PL3129378T3 (pl)
WO (1) WO2015156601A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3454862A4 (en) 2016-05-10 2020-02-12 C4 Therapeutics, Inc. SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
CN107629057B (zh) * 2016-07-19 2020-03-27 上海勋和医药科技有限公司 Bet蛋白抑制剂及其应用
BR112019008435A2 (pt) 2016-12-16 2019-07-09 Hoffmann La Roche processos para a preparação de um composto de fórmula, processo para a fabricação de um composto de fórmula, processos para a purificação de um composto de fórmula, composto e presente invenção
BR112020025003A2 (pt) 2018-06-13 2021-03-23 Dybly Ag preparação de derivados de triazepina condensados e uso dos mesmos como inibidores de bet
CN114702451B (zh) * 2022-03-29 2024-05-14 国药集团国瑞药业有限公司 一种氯硝西泮及其中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3239364B2 (ja) * 1991-10-11 2001-12-17 ウェルファイド株式会社 骨粗鬆症治療薬およびジアゼピン化合物
EP0661284A1 (en) * 1992-09-18 1995-07-05 Yoshitomi Pharmaceutical Industries, Ltd. Thienodiazepine compound and medicinal use thereof
BRPI0817537B1 (pt) 2007-10-17 2022-04-05 Kudos Pharmaceuticals Limited 4-[3-(4-ciclopropanocarbonil-piperazina-1-carbonil)-4-fluoro-benzil]-2h-ftalazin-1-ona, método para obtê-lo, composição farmacêutica compreendendo o mesmo, bem como usos terapêuticos do dito composto
US8476260B2 (en) * 2007-12-28 2013-07-02 Mitsubishi Tanabe Pharma Corporation Antitumor agent
PT2722334E (pt) 2009-11-05 2016-03-11 Glaxosmithkline Llc Inibidor do bromodomínio da benzodiazepina
DK2496582T3 (en) * 2009-11-05 2016-03-21 Glaxosmithkline Llc Benzodiazepine-BROMDOMAeNEINHIBITOR.
GB0919426D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN103119160B (zh) 2010-05-14 2016-06-01 达那-法伯癌症研究所 用于调节代谢的组合物和方法
EP2571503B1 (en) 2010-05-14 2015-01-07 Dana-Farber Cancer Institute, Inc. Compositions and their use in treating neoplasia, inflammatory disease and other disorders
AR084070A1 (es) * 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc Inhibidores del bromodominio y usos de los mismos
WO2013033268A2 (en) * 2011-08-29 2013-03-07 Coferon, Inc. Bivalent bromodomain ligands, and methods of using same

Also Published As

Publication number Publication date
JP2017510605A (ja) 2017-04-13
KR20160133006A (ko) 2016-11-21
EP3129378A1 (en) 2017-02-15
CN106132968B (zh) 2019-04-05
DK3129378T3 (da) 2019-10-07
US9884874B2 (en) 2018-02-06
JP6333996B2 (ja) 2018-05-30
ES2751642T3 (es) 2020-04-01
CN106132968A (zh) 2016-11-16
WO2015156601A1 (en) 2015-10-15
KR101928521B1 (ko) 2018-12-13
US20170174702A1 (en) 2017-06-22
EP3129378B1 (en) 2019-06-26
EP3129378A4 (en) 2017-08-23

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