PL2953944T3 - Pochodne pirydazynonowe-amidowe - Google Patents

Pochodne pirydazynonowe-amidowe

Info

Publication number
PL2953944T3
PL2953944T3 PL14703537T PL14703537T PL2953944T3 PL 2953944 T3 PL2953944 T3 PL 2953944T3 PL 14703537 T PL14703537 T PL 14703537T PL 14703537 T PL14703537 T PL 14703537T PL 2953944 T3 PL2953944 T3 PL 2953944T3
Authority
PL
Poland
Prior art keywords
pyridazinone
amides derivatives
amides
derivatives
Prior art date
Application number
PL14703537T
Other languages
English (en)
Inventor
Catherine Jorand-Lebrun
Santosh Kulkarni
Stefano Crosignani
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL2953944T3 publication Critical patent/PL2953944T3/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
PL14703537T 2013-02-07 2014-02-06 Pochodne pirydazynonowe-amidowe PL2953944T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13154390 2013-02-07

Publications (1)

Publication Number Publication Date
PL2953944T3 true PL2953944T3 (pl) 2017-09-29

Family

ID=47681772

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14703537T PL2953944T3 (pl) 2013-02-07 2014-02-06 Pochodne pirydazynonowe-amidowe

Country Status (23)

Country Link
US (2) US9567320B2 (pl)
EP (1) EP2953944B1 (pl)
JP (1) JP6483624B2 (pl)
KR (1) KR102293952B1 (pl)
CN (1) CN104968658B (pl)
AU (1) AU2014214321B2 (pl)
BR (1) BR112015018663A2 (pl)
CA (1) CA2900431C (pl)
DK (1) DK2953944T3 (pl)
ES (1) ES2634627T3 (pl)
HK (1) HK1215708A1 (pl)
HR (1) HRP20171076T1 (pl)
HU (1) HUE032863T2 (pl)
IL (1) IL240290B (pl)
LT (1) LT2953944T (pl)
MX (1) MX364486B (pl)
PL (1) PL2953944T3 (pl)
PT (1) PT2953944T (pl)
RS (1) RS56331B1 (pl)
RU (1) RU2666899C2 (pl)
SG (1) SG11201506100XA (pl)
SI (1) SI2953944T1 (pl)
WO (1) WO2014121931A1 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6920202B2 (ja) * 2015-02-06 2021-08-18 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｉｒａｋ阻害剤としてのピリダジノン大環状化合物及びその使用
BR112017022349B1 (pt) 2015-04-22 2023-11-07 Rigel Pharmaceuticals, Inc Composto, composição o compreendendo, seus usos, e, método
AU2016323612B2 (en) * 2015-09-18 2021-04-08 Merck Patent Gmbh Heteroaryl compounds as IRAK inhibitors and uses thereof
US10208024B2 (en) 2015-10-23 2019-02-19 Array Biopharma Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
AU2018338314A1 (en) 2017-09-22 2020-04-09 Kymera Therapeutics, Inc Protein degraders and uses thereof
EP3684366A4 (en) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES OF THE LATEST
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
US10874743B2 (en) 2017-12-26 2020-12-29 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
EP3737675A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. CRBN LIGANDS AND THEIR USES
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. PROTEIN DEGRADANTS AND USES THEREOF
US11292792B2 (en) 2018-07-06 2022-04-05 Kymera Therapeutics, Inc. Tricyclic CRBN ligands and uses thereof
TW202136268A (zh) 2018-07-13 2021-10-01 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
MX2021005350A (es) 2018-11-06 2021-08-11 Edgewise Therapeutics Inc Compuestos de piridazinona y usos de los mismos.
AU2019374812A1 (en) * 2018-11-06 2021-06-10 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
ES2957383T3 (es) 2018-11-06 2024-01-18 Edgewise Therapeutics Inc Compuestos de piridazinona y usos de estos
BR112021010484A2 (pt) 2018-11-30 2021-08-24 Kymera Therapeutics, Inc. Degradadores de irak e usos dos mesmos
JOP20220050A1 (ar) 2019-08-30 2023-01-30 Rigel Pharmaceuticals Inc مركبات بيرازول، صياغات منها وطريقة لاستخدام المركبات و/ أو صياغات
BR112022011651A2 (pt) 2019-12-17 2022-08-23 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
EP4076524A4 (en) 2019-12-17 2023-11-29 Kymera Therapeutics, Inc. IRAQ DEGRADERS AND USES THEREOF
EP4149466A1 (en) * 2020-05-13 2023-03-22 Edgewise Therapeutics, Inc. Substituted pyridazinone for use in the treatment of neuromuscular diseases
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
CN114957132A (zh) * 2021-02-20 2022-08-30 中国科学院上海药物研究所 含s构型的氨基苯甲酰胺基哒嗪酮类化合物、其制备方法、药物组合物及应用
WO2022222890A1 (en) * 2021-04-19 2022-10-27 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734083A1 (de) * 1987-10-08 1989-04-20 Heumann Pharma Gmbh & Co Benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
AU5310096A (en) * 1995-03-17 1996-10-08 Du Pont Merck Pharmaceutical Company, The Cyclic urea hiv protease inhibitors
JP2000247959A (ja) * 1999-02-26 2000-09-12 Kowa Co ピリダジン−３−オン誘導体及びこれを含有する医薬
WO2003030902A1 (en) * 2001-10-09 2003-04-17 Tularik Inc. Imidazole derivates as anti-inflammatory agents
KR20050113627A (ko) 2003-03-18 2005-12-02 코와 가부시키가이샤 수용성 페닐피리다진 유도체 및 이를 함유하는 의약
DE102006037478A1 (de) * 2006-08-10 2008-02-14 Merck Patent Gmbh 2-(Heterocyclylbenzyl)-pyridazinonderivate
JP2008063265A (ja) * 2006-09-06 2008-03-21 Kyorin Pharmaceut Co Ltd ピリダジノン誘導体及びそれらを有効成分とするｐｄｅ阻害剤
CA2663100A1 (en) * 2006-09-07 2008-03-13 Biogen Idec Ma Inc. Indazole derivatives as modulators of interleukin-1 receptor-associated kinase
DE102007025717A1 (de) * 2007-06-01 2008-12-11 Merck Patent Gmbh Arylether-pyridazinonderivate
DE102007032507A1 (de) * 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102008062826A1 (de) * 2008-12-23 2010-07-01 Merck Patent Gmbh Pyridazinonderivate
RS55165B1 (sr) * 2010-12-20 2017-01-31 Merck Serono Sa Indazolil triazol derivati kao irak inhibitori
US9169260B2 (en) 2011-03-22 2015-10-27 Merck Sharp & Dohme Corp. Amidopyrazole inhibitors of interleukin receptor-associated kinases
CA2900442C (en) * 2013-02-07 2021-09-21 Merck Patent Gmbh Macrocyclic pyridazinone derivatives

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US9567320B2 (en) 2017-02-14
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ES2634627T3 (es) 2017-09-28
WO2014121931A1 (en) 2014-08-14
CA2900431A1 (en) 2014-08-14
PT2953944T (pt) 2017-08-01
IL240290B (en) 2019-06-30
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HRP20171076T1 (hr) 2017-10-06
AU2014214321A1 (en) 2015-09-17
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JP6483624B2 (ja) 2019-03-13
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SG11201506100XA (en) 2015-09-29
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RS56331B1 (sr) 2017-12-29
US20170071936A1 (en) 2017-03-16
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