PL2663402T3 - Urządzenie przepływowe i sposób pozycjonowania urządzenia przepływowego - Google Patents

Urządzenie przepływowe i sposób pozycjonowania urządzenia przepływowego

Info

Publication number
PL2663402T3
PL2663402T3 PL11791076T PL11791076T PL2663402T3 PL 2663402 T3 PL2663402 T3 PL 2663402T3 PL 11791076 T PL11791076 T PL 11791076T PL 11791076 T PL11791076 T PL 11791076T PL 2663402 T3 PL2663402 T3 PL 2663402T3
Authority
PL
Poland
Prior art keywords
fluidic device
positioning
fluidic
Prior art date
Application number
PL11791076T
Other languages
English (en)
Inventor
Mark T. Reed
Erik Williamson
Bryan Crane
Patrick Leung
Dale Buermann
Alexander P. KINDWALL
Frederick ERIE
Mark Pratt
Jason Harris
Andrew James Carson
Stanley S. Hong
Jason Bryant
Mark Wang
Drew Verkade
Original Assignee
Illumina, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094202&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2663402(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina, Inc. filed Critical Illumina, Inc.
Publication of PL2663402T3 publication Critical patent/PL2663402T3/pl

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002Reagent dispensers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1011Control of the position or alignment of the transfer device
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065Multiple transfer devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/025Align devices or objects to ensure defined positions relative to each other
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02Adapting objects or devices to another
    • B01L2200/026Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04Exchange or ejection of cartridges, containers or reservoirs
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0689Sealing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/02Identification, exchange or storage of information
    • B01L2300/021Identification, e.g. bar codes
    • B01L2300/022Transponder chips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/043Hinged closures
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0816Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877Flow chambers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes
    • G01N2021/058Flat flow cell
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements
    • G01N2035/00435Refrigerated reagent storage
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
PL11791076T 2011-01-10 2011-10-21 Urządzenie przepływowe i sposób pozycjonowania urządzenia przepływowego PL2663402T3 (pl)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201161431429P 2011-01-10 2011-01-10
US201161431425P 2011-01-10 2011-01-10
US201161431440P 2011-01-11 2011-01-11
US201161431439P 2011-01-11 2011-01-11
US201161438530P 2011-02-01 2011-02-01
US201161438486P 2011-02-01 2011-02-01
US201161438567P 2011-02-01 2011-02-01
US13/273,666 US8951781B2 (en) 2011-01-10 2011-10-14 Systems, methods, and apparatuses to image a sample for biological or chemical analysis
EP11791076.0A EP2663402B1 (en) 2011-01-10 2011-10-21 Fluidic device and method of positioning a fluidic device
PCT/US2011/057221 WO2012096703A1 (en) 2011-01-10 2011-10-21 Systems, methods, and apparatuses to image a sample for biological or chemical analysis

Publications (1)

Publication Number Publication Date
PL2663402T3 true PL2663402T3 (pl) 2021-09-27

Family

ID=45094202

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11791076T PL2663402T3 (pl) 2011-01-10 2011-10-21 Urządzenie przepływowe i sposób pozycjonowania urządzenia przepływowego

Country Status (11)

Country Link
US (7) US8951781B2 (pl)
EP (3) EP2663402B1 (pl)
JP (4) JP3192220U (pl)
CN (1) CN103501907B (pl)
AU (1) AU2011354719B2 (pl)
CA (4) CA3035218C (pl)
DK (1) DK2663402T3 (pl)
ES (2) ES2864585T3 (pl)
PL (1) PL2663402T3 (pl)
PT (1) PT2663402T (pl)
WO (1) WO2012096703A1 (pl)

Families Citing this family (347)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US9102979B2 (en) * 2010-02-23 2015-08-11 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
EP2539719B1 (en) * 2010-02-23 2019-12-25 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US9371598B2 (en) 2010-04-05 2016-06-21 Prognosys Biosciences, Inc. Spatially encoded biological assays
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
CN102590087B (zh) * 2011-01-10 2015-11-25 伊鲁米那股份有限公司 用于生物或化学分析的样品的成像方法
AU2012212148B8 (en) 2011-02-02 2017-07-06 University Of Washington Through Its Center For Commercialization Massively parallel contiguity mapping
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CA3003082C (en) 2011-10-28 2020-12-15 Illumina, Inc. Microarray fabrication system and method
WO2013096692A1 (en) 2011-12-21 2013-06-27 Illumina, Inc. Apparatus and methods for kinetic analysis and determination of nucleic acid sequences
EP2834622B1 (en) 2012-04-03 2023-04-12 Illumina, Inc. Integrated optoelectronic read head and fluidic cartridge useful for nucleic acid sequencing
US9444880B2 (en) 2012-04-11 2016-09-13 Illumina, Inc. Cloud computing environment for biological data
US20130274148A1 (en) 2012-04-11 2013-10-17 Illumina, Inc. Portable genetic detection and analysis system and method
CN103424304B (zh) 2012-05-18 2015-08-26 光宝科技股份有限公司 分析卡匣
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
US8895249B2 (en) 2012-06-15 2014-11-25 Illumina, Inc. Kinetic exclusion amplification of nucleic acid libraries
DK3511423T4 (da) 2012-10-17 2024-07-29 Spatial Transcriptomics Ab Fremgangsmåder og produkt til optimering af lokaliseret eller rumlig detektion af genekspression i en vævsprøve
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
WO2014066704A1 (en) 2012-10-24 2014-05-01 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
US9512422B2 (en) 2013-02-26 2016-12-06 Illumina, Inc. Gel patterned surfaces
WO2014142850A1 (en) 2013-03-13 2014-09-18 Illumina, Inc. Methods and compositions for nucleic acid sequencing
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
CN107866286A (zh) 2013-03-15 2018-04-03 金马克诊断股份有限公司 用于操纵可变形流体容器的***、方法和设备
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US9193998B2 (en) 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
US20140274747A1 (en) 2013-03-15 2014-09-18 Illumina, Inc. Super resolution imaging
KR20140141879A (ko) * 2013-05-31 2014-12-11 삼성전자주식회사 자동화된 핵산 분석 시스템
US9868979B2 (en) 2013-06-25 2018-01-16 Prognosys Biosciences, Inc. Spatially encoded biological assays using a microfluidic device
US9994687B2 (en) 2013-07-01 2018-06-12 Illumina, Inc. Catalyst-free surface functionalization and polymer grafting
CN105358715B (zh) 2013-07-03 2018-09-18 伊鲁米那股份有限公司 正交合成测序
SI3030645T1 (sl) 2013-08-08 2023-03-31 Illumina, Inc. Fluidni sistem za dovajanje reagenta v pretočno celico
US9540690B2 (en) 2013-08-28 2017-01-10 Illumina, Inc. Optical alignment tool
JP2016539343A (ja) 2013-08-30 2016-12-15 イルミナ インコーポレイテッド 親水性または斑状親水性表面上の液滴の操作
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US10540783B2 (en) * 2013-11-01 2020-01-21 Illumina, Inc. Image analysis useful for patterned objects
CA3181696A1 (en) 2013-12-03 2015-06-11 Paul BELITZ Methods and systems for analyzing image data
CN114089597A (zh) 2013-12-19 2022-02-25 Illumina公司 包括纳米图案化表面的基底及其制备方法
EP3957750A1 (en) 2013-12-20 2022-02-23 Illumina, Inc. Preserving genomic connectivity information in fragmented genomic dna samples
US20180073065A1 (en) 2013-12-23 2018-03-15 Illumina, Inc. Structured substrates for improving detection of light emissions and methods relating to the same
JP7011392B2 (ja) 2014-02-18 2022-01-26 イラミーナ インコーポレーテッド Dnaプロファイリングのための方法および組成物
CN106459869B (zh) 2014-03-11 2020-01-21 伊鲁米那股份有限公司 一次性的集成微流体盒及其制备和使用的方法
GB2539580B (en) * 2014-04-03 2021-02-24 Hitachi High Tech Corp Analysis device
WO2015161219A1 (en) * 2014-04-17 2015-10-22 SFC Fluidics, Inc. Microdialysis platform
CA2951118C (en) 2014-05-16 2024-01-09 Illumina, Inc. Nucleic acid synthesis techniques
BR112016027815B1 (pt) 2014-05-27 2022-07-12 Illumina, Inc. Sistemas e métodos para análise bioquímica incluindo um instrumento de base e cartucho removível
JP6687544B2 (ja) 2014-05-28 2020-04-22 チルドレンズ ホスピタル メディカル センター 前駆細胞を指向性分化によって胃組織に変換するための方法及びシステム
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
EP3715468A1 (en) 2014-06-13 2020-09-30 Illumina Cambridge Limited Methods and compositions for preparing sequencing libraries
US10577603B2 (en) 2014-06-30 2020-03-03 Illumina, Inc. Methods and compositions using one-sided transposition
WO2016026924A1 (en) 2014-08-21 2016-02-25 Illumina Cambridge Limited Reversible surface functionalization
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
CN106999850B (zh) 2014-10-09 2020-04-07 亿明达股份有限公司 用于分离不混溶的液体以有效地隔离至少一种液体的方法和装置
US9897791B2 (en) 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
US11873480B2 (en) 2014-10-17 2024-01-16 Illumina Cambridge Limited Contiguity preserving transposition
WO2016061464A1 (en) 2014-10-17 2016-04-21 Children's Hospital Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intetine using pluripotent stem cells and methods of making and using same
EP3632944B1 (en) 2014-10-31 2021-12-01 Illumina Cambridge Limited Polymers and dna copolymer coatings
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
ES2768762T3 (es) 2014-11-05 2020-06-23 Illumina Cambridge Ltd Reducción del daño al ADN durante la preparación de muestras y secuenciación usando agentes quelantes sideróforos
DK3218511T3 (da) 2014-11-11 2020-07-20 Illumina Cambridge Ltd Fremgangsmåder og arrays til frembringelse og sekventering af monoklonale klynger af nukleinsyre
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
EP3882356A1 (en) 2014-12-15 2021-09-22 Illumina, Inc. Compositions and methods for single molecular placement on a substrate
WO2016149122A2 (en) * 2015-03-13 2016-09-22 Illumina, Inc. Reading and writing codes using optical devices
EP3271073B1 (en) 2015-03-20 2019-06-12 Illumina, Inc. Fluidics cartridge for use in the vertical or substantially vertical position
US9976174B2 (en) 2015-03-24 2018-05-22 Illumina Cambridge Limited Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis
EP3783109B1 (en) 2015-03-31 2024-05-29 Illumina Cambridge Limited Surface concatamerization of templates
FI3901281T3 (fi) 2015-04-10 2023-01-31 Biologisten näytteiden spatiaalisesti eroteltu moninkertainen nukleiinihappoanalyysi
EP3696536A1 (en) 2015-04-14 2020-08-19 Illumina, Inc. A method of manufacturing a substrate and a method of analyzing biomolecules capable of generating light emissions
KR102175826B1 (ko) 2015-05-11 2020-11-06 일루미나, 인코포레이티드 치료제의 발견 및 분석을 위한 플랫폼
WO2016193695A1 (en) 2015-05-29 2016-12-08 Illumina Cambridge Limited Enhanced utilization of surface primers in clusters
US10640809B2 (en) 2015-05-29 2020-05-05 Epicentre Technologies Corporation Methods of analyzing nucleic acids
CA3158992C (en) * 2015-06-09 2022-10-25 Gen-Probe Incorporated Methods and devices for calibrating and/or monitoring optical measurement devices
US20180201974A1 (en) 2015-07-06 2018-07-19 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
US10857537B2 (en) 2015-07-06 2020-12-08 Illumina, Inc. Balanced AC modulation for driving droplet operations electrodes
EP3320399A1 (en) 2015-07-07 2018-05-16 Illumina, Inc. Selective surface patterning via nanoimprinting
WO2017015018A1 (en) 2015-07-17 2017-01-26 Illumina, Inc. Polymer sheets for sequencing applications
WO2017019456A2 (en) 2015-07-27 2017-02-02 Illumina, Inc. Spatial mapping of nucleic acid sequence information
CA2984702A1 (en) 2015-07-30 2017-02-02 Illumina, Inc. Orthogonal deblocking of nucleotides
DK3334839T3 (da) 2015-08-14 2021-04-26 Illumina Inc Systemer og fremgangsmåder under anvendelse af magnetisk reagerende sensorer til bestemmelse af en genetisk egenskab
CN108474805A (zh) 2015-08-24 2018-08-31 亿明达股份有限公司 用于生物和化学测定的线路内蓄压器和流量控制***
EP3907295A1 (en) 2015-12-01 2021-11-10 Illumina, Inc. Method for compartmentalizing individual reactions in a line or an array of microwells
CN108602066B (zh) 2015-12-01 2021-08-17 亿明达股份有限公司 液体存储输送机构以及方法
KR20180108578A (ko) * 2016-01-11 2018-10-04 일루미나, 인코포레이티드 마이크로 형광 측정기, 유체 시스템, 및 플로우 셀 래치 클램프 모듈을 구비하는 검출 장치
DK3377226T3 (da) 2016-03-28 2021-04-26 Illumina Inc Mikrorækker i flere niveauer
US11326206B2 (en) 2016-04-07 2022-05-10 Pacific Biosciences Of California, Inc. Methods of quantifying target nucleic acids and identifying sequence variants
WO2017176896A1 (en) 2016-04-07 2017-10-12 Illumina, Inc. Methods and systems for construction of normalized nucleic acid libraries
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
SG11201809376WA (en) 2016-05-18 2018-12-28 Illumina Inc Self assembled patterning using patterned hydrophobic surfaces
WO2018017771A1 (en) 2016-07-21 2018-01-25 Siemens Healthcare Diagnostics Inc. Automated clinical analyzer system and method
EP3488002B1 (en) 2016-07-22 2021-03-31 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
JP6828140B2 (ja) 2016-08-15 2021-02-10 オムニオム インコーポレイテッドOmniome, Inc. 核酸をシーケンシングするための方法及びシステム
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
US11530352B2 (en) 2016-10-03 2022-12-20 Illumina, Inc. Fluorescent detection of amines and hydrazines and assaying methods thereof
EP3523046B1 (en) 2016-10-07 2022-02-16 Boehringer Ingelheim Vetmedica GmbH Method and analysis system for testing a sample
ES2882331T3 (es) * 2016-10-07 2021-12-01 Boehringer Ingelheim Vetmedica Gmbh Método para analizar una muestra
MY194951A (en) * 2016-10-14 2022-12-28 Illumina Inc Cartridge assembly
GB201619458D0 (en) 2016-11-17 2017-01-04 Spatial Transcriptomics Ab Method for spatial tagging and analysing nucleic acids in a biological specimen
US10718786B2 (en) 2016-11-23 2020-07-21 Illumina, Inc. Flow cell assembly securement system and method
NL2017853B1 (en) * 2016-11-23 2018-05-28 Illumina Inc Flow cell assembly securement system and method
BR112018075854B1 (pt) * 2016-11-23 2023-05-02 Illumina, Inc Sistema e método de fixação de conjunto de células de fluxo
CN110062764B (zh) 2016-12-05 2024-07-02 儿童医院医学中心 结肠类器官及其制备和使用方法
CN108265112B (zh) 2016-12-30 2023-04-25 深圳市真迈生物科技有限公司 对序列测定反应进行控制的方法、序列测定***和控制装置
AU2017386515B2 (en) 2016-12-30 2021-08-19 Pacific Biosciences Of California, Inc. Method and system employing distinguishable polymerases for detecting ternary complexes and identifying cognate nucleotides
GB201704769D0 (en) 2017-01-03 2017-05-10 Illumina Inc Flowcell cartridge with floating seal bracket
GB201704758D0 (en) 2017-01-05 2017-05-10 Illumina Inc Reagent channel mixing systema and method
GB201704771D0 (en) 2017-01-05 2017-05-10 Illumina Inc Modular optical analytic systems and methods
GB201704772D0 (en) 2017-01-05 2017-05-10 Illumina Inc Automated volumetric reagent delivery testing
GB201704754D0 (en) 2017-01-05 2017-05-10 Illumina Inc Kinetic exclusion amplification of nucleic acid libraries
CN116612818A (zh) 2017-01-06 2023-08-18 伊鲁米那股份有限公司 移相校正
CA3049722C (en) 2017-01-10 2023-01-24 Omniome, Inc. Polymerases engineered to reduce nucleotide-independent dna binding
SG11201905640XA (en) 2017-01-17 2019-08-27 Illumina Inc Oncogenic splice variant determination
US10415029B2 (en) 2017-01-20 2019-09-17 Omniome, Inc. Allele-specific capture of nucleic acids
AU2017394645B2 (en) 2017-01-20 2020-01-23 Pacific Biosciences Of California, Inc. Genotyping by polymerase binding
CA3050695C (en) 2017-01-20 2024-02-20 Omniome, Inc. Process for cognate nucleotide detection in a nucleic acid sequencing workflow
GB201701691D0 (en) 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
CN109414673B (zh) 2017-02-01 2021-09-07 伊鲁米那股份有限公司 具有响应于多个激发频率的基准的***和方法
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
US11492666B2 (en) 2017-02-15 2022-11-08 Pacific Biosciences Of California, Inc. Distinguishing sequences by detecting polymerase dissociation
CN110603596B (zh) 2017-03-30 2023-09-29 Illumina公司 基因组数据分析***和方法
WO2018187013A1 (en) 2017-04-04 2018-10-11 Omniome, Inc. Fluidic apparatus and methods useful for chemical and biological reactions
CA3059839C (en) 2017-04-23 2023-01-03 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
US10161003B2 (en) 2017-04-25 2018-12-25 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
US9951385B1 (en) 2017-04-25 2018-04-24 Omniome, Inc. Methods and apparatus that increase sequencing-by-binding efficiency
SG10202108175RA (en) 2017-06-07 2021-09-29 Univ Oregon Health & Science Single cell whole genome libraries for methylation sequencing
WO2018236631A1 (en) 2017-06-20 2018-12-27 Illumina, Inc. METHODS AND COMPOSITIONS FOR RESOLVING INEFFICIENCY IN AMPLIFICATION REACTIONS
CA3070407C (en) 2017-07-18 2022-08-09 Omniome, Inc. Method of chemically modifying plastic surfaces
US20200202977A1 (en) 2017-07-31 2020-06-25 Illumina, Inc. Sequencing system with multiplexed biological sample aggregation
EP4289967A3 (en) 2017-08-01 2024-03-20 Illumina, Inc. Spatial indexing of genetic material and library preparation using hydrogel beads and flow cells
CN107369485B (zh) * 2017-08-04 2023-07-04 成都天翔环境股份有限公司 废树脂转运槽车卸料***、废料输送***以及转运槽车
CN107287106A (zh) * 2017-08-10 2017-10-24 卡尤迪生物科技宜兴有限公司 使用定量pcr和数字pcr进行核酸检测的新颖方法和***
KR20200075814A (ko) * 2017-08-15 2020-06-26 옴니옴 인코포레이티드 화학적 및 생물학적 분석물의 검출에 유용한 스캐닝 장치 및 방법
GB2565564B (en) * 2017-08-16 2020-04-08 Peratech Holdco Ltd Detecting force
WO2019036055A2 (en) 2017-08-18 2019-02-21 Ignite Biosciences, Inc. METHODS OF SELECTING BINDING REAGENTS
TWI695162B (zh) * 2017-09-28 2020-06-01 美商伊路米納有限公司 流體施配器總成與用於將流體施配至流體匣中的方法
AU2018353136B2 (en) 2017-10-19 2022-05-19 Pacific Biosciences Of California, Inc. Simultaneous background reduction and complex stabilization in binding assay workflows
US11740255B2 (en) 2017-11-14 2023-08-29 Illumina, Inc. Droplet dispensing
WO2019126626A1 (en) * 2017-12-21 2019-06-27 Children's Hospital Medical Center Digitalized human organoids and methods of using same
CN113789249B (zh) * 2018-01-23 2024-07-23 深圳市真迈生物科技有限公司 承载模块、核酸加载装置及用途
TWI699494B (zh) * 2018-01-24 2020-07-21 美商伊路米納有限公司 流體緩衝
EP3775278A1 (en) 2018-04-02 2021-02-17 Illumina Inc. Compositions and methods for making controls for sequence-based genetic testing
CN110343612B (zh) * 2018-04-08 2021-07-13 上海交通大学 基于多色荧光可逆终止核苷酸的dna单分子测序***与装置
AU2019255987A1 (en) 2018-04-19 2020-12-10 Pacific Biosciences Of California, Inc. Improving accuracy of base calls in nucleic acid sequencing methods
CN112567047A (zh) 2018-04-26 2021-03-26 欧姆尼欧美公司 用于稳定核酸-核苷酸-聚合酶复合物的方法和组合物
WO2019221913A1 (en) * 2018-05-15 2019-11-21 Illumina, Inc. Flow cell with flexible connection
NL2021147B1 (en) * 2018-05-15 2019-11-21 Illumina Inc Flow cell with flexible connection
ES2968459T3 (es) 2018-05-15 2024-05-09 Illumina Inc Composiciones y métodos para escisión química y desprotección de oligonucleótidos unidos a superficie
SG11202001827UA (en) 2018-05-17 2020-03-30 Illumina Inc High-throughput single-cell sequencing with reduced amplification bias
US11180794B2 (en) 2018-05-31 2021-11-23 Omniome, Inc. Methods and compositions for capping nucleic acids
WO2019231568A1 (en) 2018-05-31 2019-12-05 Omniome, Inc. Increased signal to noise in nucleic acid sequencing
DK3810774T3 (da) 2018-06-04 2023-12-11 Illumina Inc Enkeltcelletransskriptom-biblioteker med højt throughput og fremgangsmåder til fremstilling og anvendelse
EP3827097A1 (en) 2018-07-24 2021-06-02 Omniome, Inc. Serial formation of ternary complex species
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020047010A2 (en) 2018-08-28 2020-03-05 10X Genomics, Inc. Increasing spatial array resolution
US20210317524A1 (en) 2018-08-28 2021-10-14 10X Genomics, Inc. Resolving spatial arrays
US10731141B2 (en) 2018-09-17 2020-08-04 Omniome, Inc. Engineered polymerases for improved sequencing
WO2020072641A1 (en) * 2018-10-02 2020-04-09 Instrumentation Laboratory Company Disposable hemolysis sensor
CN109465047B (zh) * 2018-11-06 2019-07-30 东南大学 纳米孔检测芯片的便携式装夹装置
EP3884048A4 (en) 2018-11-20 2022-08-17 Nautilus Biotechnology, Inc. DESIGN AND SELECTION OF AFFINITY REAGENTS
WO2020112327A1 (en) * 2018-11-26 2020-06-04 Illumina, Inc. Flow cell systems and methods related to same
GB2578528B (en) 2018-12-04 2021-02-24 Omniome Inc Mixed-phase fluids for nucleic acid sequencing and other analytical assays
KR20210098842A (ko) 2018-12-05 2021-08-11 일루미나 케임브리지 리미티드 브릿지 증폭에 의한 클러스터 생성을 위한 방법 및 조성물
EP3894587A1 (en) 2018-12-10 2021-10-20 10X Genomics, Inc. Resolving spatial arrays by proximity-based deconvolution
GB201820300D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for spatial tagging and analysing genomic DNA in a biological specimen
GB201820341D0 (en) 2018-12-13 2019-01-30 10X Genomics Inc Method for transposase-mediated spatial tagging and analysing genomic DNA in a biological specimen
WO2020118610A1 (zh) * 2018-12-13 2020-06-18 深圳华大智造科技有限公司 便携式加样装置
KR20210104554A (ko) 2018-12-18 2021-08-25 일루미나 케임브리지 리미티드 단일 표면 프라이머를 사용하는 페어드 엔드 서열분석을 위한 방법 및 조성물
CN112654715A (zh) 2018-12-19 2021-04-13 亿明达股份有限公司 改进多核苷酸簇克隆性优先性的方法
WO2020132350A2 (en) 2018-12-20 2020-06-25 Omniome, Inc. Temperature control for analysis of nucleic acids and other analytes
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11493441B2 (en) * 2019-01-15 2022-11-08 Wyatt Technology Corporation Flow cell, read head, and skid attachment
WO2020167574A1 (en) 2019-02-14 2020-08-20 Omniome, Inc. Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes
US11680950B2 (en) 2019-02-20 2023-06-20 Pacific Biosciences Of California, Inc. Scanning apparatus and methods for detecting chemical and biological analytes
WO2020176788A1 (en) 2019-02-28 2020-09-03 10X Genomics, Inc. Profiling of biological analytes with spatially barcoded oligonucleotide arrays
JP2022522917A (ja) 2019-03-01 2022-04-21 イルミナ インコーポレイテッド ハイスループット単一核及び単一細胞ライブラリー、並びに製造及び使用方法
CN114127309A (zh) 2019-03-15 2022-03-01 10X基因组学有限公司 使用空间阵列进行单细胞测序的方法
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
NL2023310B1 (en) 2019-03-21 2020-09-28 Illumina Inc Training data generation for artificial intelligence-based sequencing
NL2023314B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based quality scoring
WO2020191390A2 (en) 2019-03-21 2020-09-24 Illumina, Inc. Artificial intelligence-based quality scoring
NL2023311B9 (en) 2019-03-21 2021-03-12 Illumina Inc Artificial intelligence-based generation of sequencing metadata
NL2023312B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based base calling
NL2023316B1 (en) 2019-03-21 2020-09-28 Illumina Inc Artificial intelligence-based sequencing
EP3887542A1 (en) 2019-03-22 2021-10-06 10X Genomics, Inc. Three-dimensional spatial analysis
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
US11644406B2 (en) 2019-06-11 2023-05-09 Pacific Biosciences Of California, Inc. Calibrated focus sensing
US11377655B2 (en) 2019-07-16 2022-07-05 Pacific Biosciences Of California, Inc. Synthetic nucleic acids having non-natural structures
US10656368B1 (en) 2019-07-24 2020-05-19 Omniome, Inc. Method and system for biological imaging using a wide field objective lens
WO2021050681A1 (en) 2019-09-10 2021-03-18 Omniome, Inc. Reversible modification of nucleotides
EP4038546B1 (en) 2019-10-01 2024-08-21 10X Genomics, Inc. Systems and methods for identifying morphological patterns in tissue samples
WO2021076152A1 (en) 2019-10-18 2021-04-22 Omniome, Inc. Methods and compositions for capping nucleic acids
EP4055185A1 (en) 2019-11-08 2022-09-14 10X Genomics, Inc. Spatially-tagged analyte capture agents for analyte multiplexing
WO2021092431A1 (en) 2019-11-08 2021-05-14 Omniome, Inc. Engineered polymerases for improved sequencing by binding
CA3158888A1 (en) 2019-11-21 2021-05-27 Yifeng YIN Spatial analysis of analytes
DE202019106694U1 (de) 2019-12-02 2020-03-19 Omniome, Inc. System zur Sequenzierung von Nukleinsäuren in Fluidschaum
CA3134746A1 (en) 2019-12-19 2021-06-24 Illumina, Inc. High-throughput single-cell libraries and methods of making and of using
US11498078B2 (en) 2019-12-23 2022-11-15 Singular Genomics Systems, Inc. Flow cell receiver and methods of use
US11747262B2 (en) 2019-12-23 2023-09-05 Singular Genomics Systems, Inc. Flow cell carrier and methods of use
WO2021158511A1 (en) 2020-02-04 2021-08-12 Omniome, Inc. Flow cells and methods for their manufacture and use
WO2021167986A1 (en) 2020-02-17 2021-08-26 10X Genomics, Inc. In situ analysis of chromatin interaction
US20210265018A1 (en) 2020-02-20 2021-08-26 Illumina, Inc. Knowledge Distillation and Gradient Pruning-Based Compression of Artificial Intelligence-Based Base Caller
CA3168202A1 (en) 2020-02-21 2021-08-26 Felice Alessio BAVA Methods and compositions for integrated in situ spatial assay
EP4114966A1 (en) 2020-03-03 2023-01-11 Pacific Biosciences Of California, Inc. Methods and compositions for sequencing double stranded nucleic acids
US11768175B1 (en) 2020-03-04 2023-09-26 10X Genomics, Inc. Electrophoretic methods for spatial analysis
WO2021189064A1 (en) * 2020-03-16 2021-09-23 Siemens Healthcare Diagnostics Inc. Sample holders, pcr station assemblies, and methods of operating pcr testing systems
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US20230183798A1 (en) 2020-05-05 2023-06-15 Pacific Biosciences Of California, Inc. Compositions and methods for modifying polymerase-nucleic acid complexes
US20230203592A1 (en) 2020-05-05 2023-06-29 Akershus Universitetssykehus Hf Compositions and methods for characterizing bowel cancer
WO2021231477A2 (en) 2020-05-12 2021-11-18 Illumina, Inc. Generating nucleic acids with modified bases using recombinant terminal deoxynucleotidyl transferase
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
EP3916394A1 (en) * 2020-05-29 2021-12-01 Roche Diagnostics GmbH Module for an automated laboratory system
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
WO2021252499A1 (en) 2020-06-08 2021-12-16 10X Genomics, Inc. Methods of determining a surgical margin and methods of use thereof
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
AU2021288692A1 (en) 2020-06-11 2023-02-02 Nautilus Subsidiary, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
CA3177293A1 (en) 2020-06-22 2021-12-30 Illumina Cambridge Limited Nucleosides and nucleotides with 3' acetal blocking group
US20210403993A1 (en) 2020-06-30 2021-12-30 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
CA3186976A1 (en) 2020-07-08 2022-01-13 Illumina, Inc. Beads as transposome carriers
KR20230051508A (ko) 2020-08-18 2023-04-18 일루미나, 인코포레이티드 핵산의 서열-특이적 표적화된 전위 및 선택과 분류
GB202013141D0 (en) 2020-08-21 2020-10-07 Univ College Cardiff Consultants Ltd A screening method for the detection of DNA damage
WO2022053610A1 (en) 2020-09-11 2022-03-17 Illumina Cambridge Limited Methods of enriching a target sequence from a sequencing library using hairpin adaptors
WO2022094415A1 (en) 2020-10-30 2022-05-05 Singular Genomics Systems, Inc. Methods and compositions for reducing nucleotide impurities
CA3196729A1 (en) 2020-11-11 2022-05-19 Tural AKSEL Affinity reagents having enhanced binding and detection characteristics
WO2022108790A1 (en) 2020-11-17 2022-05-27 Singular Genomics Systems, Inc. Multiport disconnect couplings
US20220186300A1 (en) 2020-12-11 2022-06-16 10X Genomics, Inc. Methods and compositions for multimodal in situ analysis
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
WO2022140291A1 (en) 2020-12-21 2022-06-30 Singular Genomics Systems, Inc. Systems and methods for multicolor imaging
WO2022140028A1 (en) 2020-12-21 2022-06-30 10X Genomics, Inc. Methods, compositions, and systems for capturing probes and/or barcodes
US12060603B2 (en) 2021-01-19 2024-08-13 10X Genomics, Inc. Methods for internally controlled in situ assays using padlock probes
AU2022209365A1 (en) 2021-01-21 2023-07-20 Nautilus Subsidiary, Inc. Systems and methods for biomolecule preparation
US20220235403A1 (en) 2021-01-26 2022-07-28 10X Genomics, Inc. Nucleic acid analog probes for in situ analysis
US20220282319A1 (en) 2021-03-03 2022-09-08 10X Genomics, Inc. Analyte detection in situ using nucleic acid origami
CA3209038A1 (en) 2021-03-11 2022-09-15 Tural AKSEL Systems and methods for biomolecule retention
EP4263868A1 (en) 2021-03-12 2023-10-25 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
US11884977B2 (en) 2021-03-12 2024-01-30 Singular Genomics Systems, Inc. Nanoarrays and methods of use thereof
US20220333178A1 (en) 2021-03-22 2022-10-20 Illumina Cambridge Limited Methods for improving nucleic acid cluster clonality
EP4314279A1 (en) 2021-03-29 2024-02-07 Illumina, Inc. Improved methods of library preparation
JP2024513187A (ja) 2021-03-29 2024-03-22 イルミナ インコーポレイテッド ライブラリー中のdna損傷を評価し、アンプリコンサイズバイアスを正規化するための組成物及び方法
IL307378A (en) 2021-04-02 2023-11-01 Illumina Inc A machine learning model for bubble detection within a nucleotide sample slide for sequencing
FR3121936A1 (fr) 2021-04-20 2022-10-21 Naos Institute Of Life Science Methode de criblage d’ingredients et de compositions topiques ecobiologiques, et son utilisation pour realiser un soin cosmetique de restauration du microbiote cutane
WO2022235764A1 (en) * 2021-05-05 2022-11-10 Singular Genomics Systems, Inc. Multiomic analysis device and methods of use thereof
WO2022240766A1 (en) 2021-05-10 2022-11-17 Pacific Biosciences Of California, Inc. Dna amplification buffer replenishment during rolling circle amplification
US20220356519A1 (en) 2021-05-10 2022-11-10 Pacific Biosciences Of California, Inc. Single-molecule seeding and amplification on a surface
EP4347877A1 (en) 2021-06-01 2024-04-10 10X Genomics, Inc. Methods and compositions for analyte detection and probe resolution
US20230084407A1 (en) 2021-06-02 2023-03-16 10X Genomics, Inc. Sample analysis using asymmetric circularizable probes
US20220403450A1 (en) 2021-06-03 2022-12-22 Illumina Software, Inc. Systems and methods for sequencing nucleotides using two optical channels
CN117677435A (zh) 2021-06-15 2024-03-08 伊鲁米纳公司 用于测序的不含水凝胶的表面官能化
EP4359555A1 (en) 2021-06-23 2024-05-01 Illumina, Inc. Compositions, methods, kits, cartridges, and systems for sequencing reagents
EP4360097A1 (en) 2021-06-24 2024-05-01 Nautilus Subsidiary, Inc. Methods and systems for assay refinement
WO2022271689A1 (en) 2021-06-25 2022-12-29 Illumina, Inc. Fiducials for use in registration of a patterned surface
AU2022296802A1 (en) 2021-06-25 2024-01-04 Illumina, Inc. Linear fourier fiducial
EP4364154A1 (en) 2021-06-29 2024-05-08 Illumina, Inc. Signal-to-noise-ratio metric for determining nucleotide-base calls and base-call quality
CN117546245A (zh) 2021-06-29 2024-02-09 因美纳有限公司 用于生成基因组坐标的置信度分类的机器学习模型
US20230026886A1 (en) 2021-07-13 2023-01-26 10X Genomics, Inc. Methods for preparing polymerized matrix with controllable thickness
WO2023003757A1 (en) 2021-07-19 2023-01-26 Illumina Software, Inc. Intensity extraction with interpolation and adaptation for base calling
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
CN117813391A (zh) 2021-07-23 2024-04-02 因美纳有限公司 制备用于dna测序的基底表面的方法
US20230021577A1 (en) 2021-07-23 2023-01-26 Illumina Software, Inc. Machine-learning model for recalibrating nucleotide-base calls
US20230057571A1 (en) 2021-08-03 2023-02-23 10X Genomics, Inc. Nucleic acid concatemers and methods for stabilizing and/or compacting the same
WO2023023484A1 (en) 2021-08-16 2023-02-23 10X Genomics, Inc. Probes comprising a split barcode region and methods of use
KR20240049214A (ko) 2021-09-01 2024-04-16 일루미나, 인코포레이티드 가속 염기 호출을 위한 진폭 변조
AU2022341171A1 (en) 2021-09-09 2024-02-22 Nautilus Subsidiary, Inc. Characterization and localization of protein modifications
GB202112907D0 (en) 2021-09-10 2021-10-27 Res & Innovation Uk Methods of biomolecule display
US20230088338A1 (en) 2021-09-10 2023-03-23 Illumina, Inc. Sequencer focus quality metrics and focus tracking for periodically patterned surfaces
US20230080069A1 (en) * 2021-09-13 2023-03-16 Applied Materials, Inc. Flow-cell designs for biological imaging
WO2023044229A1 (en) 2021-09-17 2023-03-23 Illumina, Inc. Automatically identifying failure sources in nucleotide sequencing from base-call-error patterns
CN117546243A (zh) 2021-09-21 2024-02-09 因美纳有限公司 使用推算的单倍型的图参考基因组和碱基检出方法
WO2023049073A1 (en) 2021-09-22 2023-03-30 Nautilus Biotechnology, Inc. Methods and systems for determining polypeptide interactions
WO2023049215A1 (en) 2021-09-22 2023-03-30 Illumina, Inc. Compressed state-based base calling
KR20240074839A (ko) 2021-10-11 2024-05-28 노틸러스 서브시디어리, 인크. 단백질 및 프로테옴의 고도로 다중화 가능한 분석
AU2022371198A1 (en) 2021-10-20 2024-05-02 Illumina, Inc. Methods for capturing library dna for sequencing
US20230149883A1 (en) 2021-11-03 2023-05-18 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
WO2023081485A1 (en) 2021-11-08 2023-05-11 Pacific Biosciences Of California, Inc. Stepwise sequencing of a polynucleotide with a homogenous reaction mixture
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
US20230343415A1 (en) 2021-12-02 2023-10-26 Illumina Software, Inc. Generating cluster-specific-signal corrections for determining nucleotide-base calls
CN117813397A (zh) 2021-12-21 2024-04-02 因美纳有限公司 蜡-微球基质组合物及其制备和使用方法
WO2023122589A2 (en) * 2021-12-22 2023-06-29 Nautilus Subsidiary, Inc. Systems and methods for carrying out highly multiplexed bioanalyses
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129898A2 (en) 2021-12-27 2023-07-06 10X Genomics, Inc. Methods and compositions for rolling circle amplification
US20230207050A1 (en) 2021-12-28 2023-06-29 Illumina Software, Inc. Machine learning model for recalibrating nucleotide base calls corresponding to target variants
AU2022425440A1 (en) 2021-12-29 2024-07-11 Illumina, Inc. Automatically switching variant analysis model versions for genomic analysis applications
US20230279475A1 (en) 2022-01-21 2023-09-07 10X Genomics, Inc. Multiple readout signals for analyzing a sample
WO2023164570A1 (en) 2022-02-23 2023-08-31 Insitro, Inc. Pooled optical screening and transcriptional measurements of cells comprising barcoded genetic perturbations
WO2023164492A1 (en) 2022-02-25 2023-08-31 Illumina, Inc. Machine-learning models for detecting and adjusting values for nucleotide methylation levels
WO2023164660A1 (en) 2022-02-25 2023-08-31 Illumina, Inc. Calibration sequences for nucelotide sequencing
US11795505B2 (en) 2022-03-10 2023-10-24 Singular Genomics Systems, Inc. Nucleic acid delivery scaffolds
US20230330659A1 (en) 2022-03-22 2023-10-19 Illumina Cambridge Limited Substrate with orthogonally functional nanodomains
WO2023183937A1 (en) 2022-03-25 2023-09-28 Illumina, Inc. Sequence-to-sequence base calling
US20230314324A1 (en) 2022-03-29 2023-10-05 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
WO2023192616A1 (en) 2022-04-01 2023-10-05 10X Genomics, Inc. Compositions and methods for targeted masking of autofluorescence
WO2023196526A1 (en) 2022-04-06 2023-10-12 10X Genomics, Inc. Methods for multiplex cell analysis
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
US20230340571A1 (en) 2022-04-26 2023-10-26 Illumina, Inc. Machine-learning models for selecting oligonucleotide probes for array technologies
WO2023209606A1 (en) 2022-04-29 2023-11-02 Illumina Cambridge Limited Methods and systems for encapsulating lyophilised microspheres
WO2023215612A1 (en) 2022-05-06 2023-11-09 10X Genomics, Inc. Analysis of antigen and antigen receptor interactions
US20230368866A1 (en) 2022-05-10 2023-11-16 Illumina Software, Inc. Adaptive neural network for nucelotide sequencing
US20230407386A1 (en) 2022-06-09 2023-12-21 Illumina, Inc. Dependence of base calling on flow cell tilt
WO2023245190A1 (en) 2022-06-17 2023-12-21 10X Genomics, Inc. Catalytic de-crosslinking of samples for in situ analysis
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
GB202209189D0 (en) 2022-06-22 2022-08-10 Broken String Biosciences Ltd Methods and compositions for nucleic acid sequencing
WO2023250504A1 (en) 2022-06-24 2023-12-28 Illumina Software, Inc. Improving split-read alignment by intelligently identifying and scoring candidate split groups
US20230420075A1 (en) 2022-06-27 2023-12-28 Illumina Software, Inc. Accelerators for a genotype imputation model
WO2024006769A1 (en) 2022-06-27 2024-01-04 Illumina Software, Inc. Generating and implementing a structural variation graph genome
WO2024006705A1 (en) 2022-06-27 2024-01-04 Illumina Software, Inc. Improved human leukocyte antigen (hla) genotyping
WO2024026356A1 (en) 2022-07-26 2024-02-01 Illumina, Inc. Rapid single-cell multiomics processing using an executable file
WO2024025806A1 (en) 2022-07-27 2024-02-01 Illumina, Inc. Motion feedback using patterned flowcells
US20240101978A1 (en) 2022-08-12 2024-03-28 10X Genomics, Inc. Puma1 polymerases and uses thereof
US20240084373A1 (en) 2022-08-16 2024-03-14 10X Genomics, Inc. Ap50 polymerases and uses thereof
DE102022209394A1 (de) * 2022-09-09 2024-03-14 Robert Bosch Gesellschaft mit beschränkter Haftung Aufnahmevorrichtung, Analysegerät und Verfahren zum Herstellen einer Aufnahmevorrichtung
WO2024059655A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024072799A1 (en) 2022-09-26 2024-04-04 Illumina, Inc. Flow cell based motion system calibration and control methods
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024073516A1 (en) 2022-09-29 2024-04-04 Illumina, Inc. A target-variant-reference panel for imputing target variants
WO2024073519A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Machine-learning model for refining structural variant calls
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides
US20240127905A1 (en) 2022-10-05 2024-04-18 Illumina, Inc. Integrating variant calls from multiple sequencing pipelines utilizing a machine learning architecture
WO2024081649A1 (en) 2022-10-11 2024-04-18 Illumina, Inc. Detecting and correcting methylation values from methylation sequencing assays
WO2024081869A1 (en) 2022-10-14 2024-04-18 10X Genomics, Inc. Methods for analysis of biological samples
WO2024102736A1 (en) 2022-11-08 2024-05-16 10X Genomics, Inc. Immobilization methods and compositions for in situ detection
WO2024107887A1 (en) 2022-11-16 2024-05-23 10X Genomics, Inc. Methods and compositions for assessing performance of in situ assays
WO2024118791A1 (en) 2022-11-30 2024-06-06 Illumina, Inc. Accurately predicting variants from methylation sequencing data
WO2024123748A1 (en) 2022-12-07 2024-06-13 Illumina, Inc. Etch-free photoresist patterning in multi-depth nanowells
WO2024124073A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. A method comprising performing on a single-analyte array at least 50 cycles of a process
WO2024129969A1 (en) 2022-12-14 2024-06-20 Illumina, Inc. Systems and methods for capture and enrichment of clustered beads on flow cell substrates
US20240201182A1 (en) 2022-12-15 2024-06-20 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
WO2024130203A1 (en) 2022-12-16 2024-06-20 10X Genomics, Inc. Methods and compositions for assessing performance
US20240218424A1 (en) 2022-12-21 2024-07-04 10X Genomics, Inc. Methods for tethering ribonucleic acids in biological samples
US20240263219A1 (en) 2023-01-06 2024-08-08 10X Genomics, Inc. Methods and compositions for in situ analysis of variant sequences
WO2024151373A1 (en) 2023-01-12 2024-07-18 Nautilus Subsidiary, Inc. Characterization of glycans and glycoconjugates
WO2024158538A1 (en) 2023-01-27 2024-08-02 Illumina, Inc. Jitter correction image analysis
US20240266003A1 (en) 2023-02-06 2024-08-08 Illumina, Inc. Determining and removing inter-cluster light interference

Family Cites Families (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099921A (en) 1977-03-28 1978-07-11 Instrumentation Specialties Company Chemical analyzer
US4264810A (en) * 1977-12-24 1981-04-28 Nippon Kogaku K. K. Focus detecting apparatus
JPS5841358A (ja) 1981-09-04 1983-03-10 Hitachi Ltd 自動分析装置
US4478094A (en) 1983-01-21 1984-10-23 Cetus Corporation Liquid sample handling system
US4681742A (en) 1984-10-01 1987-07-21 Cetus Corporation Assay tray
EP0311440B1 (en) 1987-10-09 1992-06-24 Seiko Instruments Inc. Apparatus for carrying out a liquid reaction
US5306510A (en) 1988-01-14 1994-04-26 Cyberlab, Inc. Automated pipetting system
US4863243A (en) 1988-05-09 1989-09-05 Eastman Kodak Company Mount for an optical element including a holder with a generally semicylindrical surface
JPH02309929A (ja) * 1989-05-24 1990-12-25 Sumitomo Electric Ind Ltd 肝機能検査装置
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
CA2044616A1 (en) 1989-10-26 1991-04-27 Roger Y. Tsien Dna sequencing
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
DE4041905A1 (de) * 1990-12-27 1992-07-02 Boehringer Mannheim Gmbh Testtraeger-analysesystem
EP0773227A1 (en) 1991-09-18 1997-05-14 Affymax Technologies N.V. Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides
US5324633A (en) 1991-11-22 1994-06-28 Affymax Technologies N.V. Method and apparatus for measuring binding affinity
EP0972564B1 (en) 1991-11-22 2003-05-28 Affymetrix, Inc. (a Delaware Corporation) Method of forming arrays of polymers
US5491074A (en) 1993-04-01 1996-02-13 Affymax Technologies Nv Association peptides
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US6090555A (en) 1997-12-11 2000-07-18 Affymetrix, Inc. Scanned image alignment systems and methods
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
WO1995030774A1 (en) 1994-05-05 1995-11-16 Beckman Instruments, Inc. Oligonucleotide repeat arrays
US5571639A (en) 1994-05-24 1996-11-05 Affymax Technologies N.V. Computer-aided engineering system for design of sequence arrays and lithographic masks
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US5599695A (en) 1995-02-27 1997-02-04 Affymetrix, Inc. Printing molecular library arrays using deprotection agents solely in the vapor phase
US5578270A (en) 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5968740A (en) 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
WO1997043611A1 (en) 1996-05-16 1997-11-20 Affymetrix, Inc. Systems and methods for detection of labeled materials
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US6083697A (en) 1996-11-14 2000-07-04 Affymetrix, Inc. Chemical amplification for the synthesis of patterned arrays
GB9626815D0 (en) 1996-12-23 1997-02-12 Cemu Bioteknik Ab Method of sequencing DNA
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
ATE545710T1 (de) 1997-04-01 2012-03-15 Illumina Cambridge Ltd Verfahren zur vervielfältigung von nukleinsäuren
WO1998044152A1 (en) 1997-04-01 1998-10-08 Glaxo Group Limited Method of nucleic acid sequencing
EP0994960A1 (en) 1997-06-25 2000-04-26 Orchid Biocomputer, Inc. Methods for the detection of multiple single nucleotide polymorphisms in a single reaction
CA2792122C (en) 1997-07-07 2015-09-08 Medical Research Council In vitro sorting method
CN1224600A (zh) * 1997-08-06 1999-08-04 仓敷纺织株式会社 调节作用于生物体上的压力的压力调节装置和方法
US6838051B2 (en) 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
AU1287799A (en) 1997-10-31 1999-05-24 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6428752B1 (en) 1998-05-14 2002-08-06 Affymetrix, Inc. Cleaning deposit devices that form microarrays and the like
JP2002502588A (ja) 1998-02-06 2002-01-29 アフィメトリックス インコーポレイテッド 製造プロセスにおける品質管理の方法
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
JP2000121511A (ja) 1998-10-13 2000-04-28 Hitachi Koki Co Ltd 自動分離抽出装置及びその制御方法
US20020176801A1 (en) 1999-03-23 2002-11-28 Giebeler Robert H. Fluid delivery and analysis systems
US20030215821A1 (en) 1999-04-20 2003-11-20 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20030108867A1 (en) 1999-04-20 2003-06-12 Chee Mark S Nucleic acid sequencing using microsphere arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
DE60040741D1 (de) 1999-04-20 2008-12-18 Illumina Inc Detektion von nukleinsäurereaktionen auf kügelchen-arrays
US6225109B1 (en) 1999-05-27 2001-05-01 Orchid Biosciences, Inc. Genetic analysis device
JP3640840B2 (ja) 1999-07-16 2005-04-20 アロカ株式会社 核酸断片の分離方法及び核酸シークエンス前処理装置
US6274320B1 (en) 1999-09-16 2001-08-14 Curagen Corporation Method of sequencing a nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US7001792B2 (en) 2000-04-24 2006-02-21 Eagle Research & Development, Llc Ultra-fast nucleic acid sequencing device and a method for making and using the same
JP3638503B2 (ja) 2000-06-12 2005-04-13 アークレイ株式会社 カートリッジ式容器を用いる測定装置および測定方法並びに記録媒体
CN101525660A (zh) 2000-07-07 2009-09-09 维西根生物技术公司 实时序列测定
US20030160957A1 (en) * 2000-07-14 2003-08-28 Applera Corporation Scanning system and method for scanning a plurality of samples
US7000330B2 (en) 2002-08-21 2006-02-21 Honeywell International Inc. Method and apparatus for receiving a removable media member
US7277166B2 (en) * 2000-08-02 2007-10-02 Honeywell International Inc. Cytometer analysis cartridge optical configuration
US7211414B2 (en) 2000-12-01 2007-05-01 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
AR031640A1 (es) 2000-12-08 2003-09-24 Applied Research Systems Amplificacion isotermica de acidos nucleicos en un soporte solido
GB0117706D0 (en) 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Automated semi-solid matrix assay and liquid handler apparatus for the same
CA2450676C (en) 2001-03-09 2010-03-30 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US20030059823A1 (en) 2001-09-21 2003-03-27 Juki Corporation Hybridization apparatus and method for detecting nucleic acid in sample using the same
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
JP4080208B2 (ja) 2002-01-22 2008-04-23 フジノン株式会社 反射鏡の保持構造
CA2473860A1 (en) 2002-01-25 2003-08-07 Innovadyne Technologies, Inc. Low volume, non-contact liquid dispensing method
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
JP2005532043A (ja) 2002-04-11 2005-10-27 シークエノム, インコーポレイテッド 固相支持体上で化学反応を実行するための方法および装置
JP2004017212A (ja) 2002-06-17 2004-01-22 Sumitomo Heavy Ind Ltd ダイプレス抜機
JP2004028681A (ja) 2002-06-24 2004-01-29 Juki Corp 液体分注装置用ヘッド
US7125722B2 (en) 2002-07-03 2006-10-24 Abbott Laboratories Apparatus and method for handling fluids for analysis
US20050227252A1 (en) 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
US7399643B2 (en) 2002-09-12 2008-07-15 Cyvera Corporation Method and apparatus for aligning microbeads in order to interrogate the same
DK3363809T3 (da) 2002-08-23 2020-05-04 Illumina Cambridge Ltd Modificerede nukleotider til polynukleotidsekvensering
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
JP4016811B2 (ja) 2002-11-15 2007-12-05 日立工機株式会社 自動分注装置
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
CA2727850C (en) 2003-01-29 2013-04-30 454 Corporation Methods of amplifying and sequencing nucleic acids
US7025935B2 (en) 2003-04-11 2006-04-11 Illumina, Inc. Apparatus and methods for reformatting liquid samples
JP3733124B2 (ja) 2003-04-14 2006-01-11 アロカ株式会社 液体貯留部
WO2004092710A1 (ja) 2003-04-15 2004-10-28 Universal Bio Research Co., Ltd. 分注用シリンダ、大容量分注装置および大容量分注装置の使用方法
JP2004325329A (ja) 2003-04-25 2004-11-18 Hitachi High-Technologies Corp 分注方法及び分注装置
TW579430B (en) 2003-05-02 2004-03-11 Dr Chip Biotechnology Inc Automatic micro-fluid hybridization chip platform
US7055695B2 (en) * 2003-06-02 2006-06-06 Caliper Life Sciencee, Inc. Container providing a controlled hydrated environment
US20050181394A1 (en) 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
EP2918595B1 (en) 2003-07-05 2019-12-11 The Johns-Hopkins University Method and compositions for detection and enumeration of genetic variations
CN100365418C (zh) 2003-09-16 2008-01-30 山东省科学院生物研究所 用于固定化酶生物传感器分析仪的流动注射装置
US20050220675A1 (en) 2003-09-19 2005-10-06 Reed Mark T High density plate filler
CA2559801A1 (en) 2003-10-01 2005-04-14 Cyvera Corporation Optical reader for diffraction grating-based encoded optical identification elements
US7695952B2 (en) * 2003-11-07 2010-04-13 Nanosphere, Inc. Disposable sample processing module for detecting nucleic acids
CN101006344B (zh) 2004-05-21 2011-07-13 卡钳生命科学股份有限公司 用于输送微流体装置的自动化***
CA2579150C (en) 2004-09-17 2014-11-25 Pacific Biosciences Of California, Inc. Apparatus and method for analysis of molecules
KR100601966B1 (ko) 2004-10-07 2006-07-18 삼성전자주식회사 마이크로 칩 유니트 및 상기 마이크로 칩 유니트를이용하여 생화학 반응을 수행하는 방법
GB0427236D0 (en) 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
KR100657298B1 (ko) 2004-12-18 2006-12-14 삼성전자주식회사 미러 지지 장치, 이를 구비하는 광주사장치 및 전자사진방식 화상형성장치
JP2006194689A (ja) 2005-01-12 2006-07-27 Olympus Corp 分注装置、液面検出方法および培養処理装置
JP4633484B2 (ja) 2005-01-19 2011-02-16 オリンパス株式会社 光学素子の支持機構
US20060180489A1 (en) * 2005-02-02 2006-08-17 Cytyc Corporation Slide tray
AU2006223223B2 (en) 2005-03-10 2012-04-12 Gen-Probe Incorporated Systems and methods to perform assays for detecting or quantifying analytes within samples
WO2006132666A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
EP1907583B2 (en) 2005-06-15 2019-10-23 Complete Genomics Inc. Single molecule arrays for genetic and chemical analysis
CN1333231C (zh) 2005-07-01 2007-08-22 清华大学 一种用线阵ccd测量光束中心位置的方法
GB0514910D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Method for sequencing a polynucleotide template
JP2009503555A (ja) * 2005-08-04 2009-01-29 ヘリコス バイオサイエンシーズ コーポレイション マルチチャネルフローセル
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
JP4981295B2 (ja) 2005-10-04 2012-07-18 キヤノン株式会社 Dna処理方法およびdna処理装置
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US20070179436A1 (en) 2005-12-21 2007-08-02 Braig James R Analyte detection system with periodic sample draw and laboratory-grade analyzer
CN1794034A (zh) 2005-12-21 2006-06-28 天津理工大学 紧凑型光学扫描检测***
CN108931509B (zh) 2005-12-21 2022-04-15 梅索斯卡莱科技公司 分析装置、方法和试剂
EP3121601A1 (en) * 2005-12-22 2017-01-25 Honeywell International Inc. Portable sample analyzer system
US20070154895A1 (en) 2005-12-30 2007-07-05 Caliper Life Sciences, Inc. Multi-assay microfluidic chips
JP5009533B2 (ja) 2006-01-20 2012-08-22 凸版印刷株式会社 試薬用容器
US8192698B2 (en) 2006-01-27 2012-06-05 Parker-Hannifin Corporation Sampling probe, gripper and interface for laboratory sample management systems
BE1016981A3 (fr) 2006-02-08 2007-11-06 Fn Herstal Sa Viseur ameliore a pont rouge mobile.
WO2007107710A1 (en) 2006-03-17 2007-09-27 Solexa Limited Isothermal methods for creating clonal single molecule arrays
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP3373174A1 (en) 2006-03-31 2018-09-12 Illumina, Inc. Systems and devices for sequence by synthesis analysis
DE102006022511B3 (de) 2006-05-11 2007-08-16 Fachhochschule Jena Vorrichtung zur Fassung einer planaren ein- oder mehrteiligen Mikroreaktionskammer
JP4964518B2 (ja) 2006-06-30 2012-07-04 株式会社サカエ 自動分析装置
WO2008030433A2 (en) 2006-09-06 2008-03-13 Canon U.S. Life Sciences, Inc. Chip and cartridge design configuration for performing micro-fluidic assays
JP4912096B2 (ja) * 2006-09-07 2012-04-04 ローム株式会社 マイクロチップ検査装置
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
WO2008051530A2 (en) 2006-10-23 2008-05-02 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US7753095B2 (en) 2006-12-15 2010-07-13 Helicos Biosciences Corporation Storing and handling liquid reagents
CN101606053A (zh) 2007-02-08 2009-12-16 皇家飞利浦电子股份有限公司 具有渐逝波导和集成传感器的生物传感器
GB0704490D0 (en) * 2007-03-08 2007-04-18 Bg Res Ltd Improvements in thermal cyclers
US8105783B2 (en) * 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8133671B2 (en) * 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) * 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
EP2201352B2 (en) 2007-09-28 2018-08-29 Illumina, Inc. Fluorescence excitation and detection system and method
CN108333379B (zh) 2007-10-02 2021-09-07 拉布拉多诊断有限责任公司 模块化现场护理装置及其应用
CN101397863A (zh) 2007-12-01 2009-04-01 莫兵刚 全封闭离合式防盗锁
EP2254825A4 (en) * 2008-02-22 2016-03-02 Fluidigm Corp INTEGRATED CARRIER FOR MICROFLUIDIC DEVICE
JP2009229194A (ja) 2008-03-21 2009-10-08 Toshiba Corp 試薬容器及びこれを備える自動分析装置
CN201222492Y (zh) 2008-04-03 2009-04-15 东捷科技股份有限公司 固定装置及其***
US8961902B2 (en) 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
US7995208B2 (en) 2008-08-06 2011-08-09 Ftrx Llc Monolithic interferometer with optics of different material
CN102203605B (zh) 2008-08-27 2014-07-23 生命技术公司 处理生物样品的设备和方法
US9034257B2 (en) * 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
US8169006B2 (en) 2008-11-29 2012-05-01 Electronics And Telecommunications Research Institute Bio-sensor chip for detecting target material
US20100157086A1 (en) 2008-12-15 2010-06-24 Illumina, Inc Dynamic autofocus method and system for assay imager
US20110318728A1 (en) 2008-12-30 2011-12-29 Huan Lac Phan Systems, devices, methods and kits for fluid handling
WO2011026136A1 (en) 2009-08-31 2011-03-03 Life Technologies Corporation Low-volume sequencing system and method of use
CN201550179U (zh) 2009-10-12 2010-08-11 上海祥网瑞电子科技有限公司 带可旋转镜片平面图像采集器
EP4060325B1 (en) * 2009-12-07 2024-08-21 Meso Scale Technologies, LLC. Assay cartridge reader
US8574832B2 (en) 2010-02-03 2013-11-05 Massachusetts Institute Of Technology Methods for preparing sequencing libraries
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
US9115353B2 (en) 2011-01-31 2015-08-25 Illumina, Inc. Method for nucleotide detection
US8687180B2 (en) * 2012-06-07 2014-04-01 Molecular Devices, Llc System, method, and device for determining a focal position of an objective in a microscopy imaging system
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments

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