PL2439205T3 - Związki karboksamidowe i ich zastosowanie jako inhibitorów kalpainy - Google Patents

Związki karboksamidowe i ich zastosowanie jako inhibitorów kalpainy

Info

Publication number
PL2439205T3
PL2439205T3 PL11195099T PL11195099T PL2439205T3 PL 2439205 T3 PL2439205 T3 PL 2439205T3 PL 11195099 T PL11195099 T PL 11195099T PL 11195099 T PL11195099 T PL 11195099T PL 2439205 T3 PL2439205 T3 PL 2439205T3
Authority
PL
Poland
Prior art keywords
carboxamide compounds
calpain inhibitors
calpain
inhibitors
carboxamide
Prior art date
Application number
PL11195099T
Other languages
English (en)
Inventor
Andreas Kling
Wilfried Hornberger
Helmut Mack
Achim Moeller
Volker Nimmrich
Dietmar Seemann
Wilfried Lubisch
Original Assignee
Abbvie Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39226751&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2439205(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Deutschland filed Critical Abbvie Deutschland
Publication of PL2439205T3 publication Critical patent/PL2439205T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
PL11195099T 2006-12-29 2007-12-28 Związki karboksamidowe i ich zastosowanie jako inhibitorów kalpainy PL2439205T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06127369 2006-12-29
EP11195099.4A EP2439205B1 (en) 2006-12-29 2007-12-28 Carboxamide compounds and their use as calpain inhibitors
EP07866322A EP2121653B1 (en) 2006-12-29 2007-12-28 Carboxamide compounds and their use as calpain inhibitors

Publications (1)

Publication Number Publication Date
PL2439205T3 true PL2439205T3 (pl) 2015-08-31

Family

ID=39226751

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11195099T PL2439205T3 (pl) 2006-12-29 2007-12-28 Związki karboksamidowe i ich zastosowanie jako inhibitorów kalpainy

Country Status (29)

Country Link
US (4) US8436034B2 (pl)
EP (2) EP2121653B1 (pl)
JP (1) JP5295976B2 (pl)
KR (3) KR20150090282A (pl)
CN (1) CN101616908B (pl)
AR (2) AR064693A1 (pl)
AT (1) ATE544758T1 (pl)
AU (1) AU2007341232B2 (pl)
BR (1) BRPI0721298A2 (pl)
CA (1) CA2673580C (pl)
CL (1) CL2007003879A1 (pl)
CO (1) CO6190617A2 (pl)
DK (1) DK2439205T3 (pl)
EC (1) ECSP099476A (pl)
ES (2) ES2536626T3 (pl)
GT (1) GT200900186A (pl)
HK (1) HK1138833A1 (pl)
IL (2) IL199447A (pl)
MX (1) MX2009007050A (pl)
MY (1) MY147780A (pl)
NZ (2) NZ599860A (pl)
PE (1) PE20081609A1 (pl)
PL (1) PL2439205T3 (pl)
PT (1) PT2439205E (pl)
RU (2) RU2485114C2 (pl)
TW (1) TWI405571B (pl)
UA (1) UA100501C2 (pl)
UY (1) UY30850A1 (pl)
WO (1) WO2008080969A1 (pl)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY147780A (en) 2006-12-29 2013-01-31 Abbvie Deutschland Carboxamide compounds and their use as calpain inhibitors
TWI453019B (zh) 2007-12-28 2014-09-21 Abbvie Deutschland 甲醯胺化合物
BRPI0918430A2 (pt) * 2008-08-14 2015-11-24 Bayer Cropscience Ag 4-fenil-1h-pirazóis inseticidas.
TWI519530B (zh) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
US8236798B2 (en) * 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
EP2845592A1 (en) * 2009-09-28 2015-03-11 F. Hoffmann-La Roche AG Benzoxazepin PI3K inhibitor compounds and methods of use
US8598211B2 (en) * 2009-12-22 2013-12-03 Abbvie Inc. Carboxamide compounds and their use as calpain inhibitors IV
US9051304B2 (en) 2009-12-22 2015-06-09 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
GB2505572B (en) 2010-04-30 2014-08-06 Abbott Cardiovascular Systems Catheter system providing step reduction for postconditioning
CN103501784A (zh) * 2010-12-09 2014-01-08 Abbvie德国有限责任两合公司 甲酰胺化合物及它们作为钙蛋白酶抑制剂v的用途
US8669370B2 (en) 2011-01-26 2014-03-11 Sanofi Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals
WO2013126283A1 (en) 2012-02-20 2013-08-29 E. I. Du Pont De Nemours And Company Fungicidal pyrazoles
US9150545B2 (en) 2012-04-03 2015-10-06 AbbVie Deutschland GmbH & Co. KG Carboxamide compounds and their use as calpain inhibitors V
AP2015008783A0 (en) 2013-03-29 2015-10-31 Takeda Pharmaceutical 6-(5-hydroxy-1h-pyrazol-1-yl) nicotinamida derivatives and their use as phd inhibitors
CA2920815C (en) 2013-08-14 2021-09-21 Kalvista Pharmaceuticals Limited Inhibitors of plasma kallikrein
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
EP3393245A1 (en) 2015-12-22 2018-10-31 Syngenta Participations AG Pesticidally active pyrazole derivatives
CN107827833A (zh) * 2016-01-26 2018-03-23 绍兴瑞康生物科技有限公司 三嗪类多功能光吸收抗氧剂类化合物及其制备方法和应用
EP3426674A4 (en) 2016-03-09 2019-08-14 Blade Therapeutics, Inc. CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF
PL3464271T3 (pl) 2016-05-31 2021-01-25 Kalvista Pharmaceuticals Limited Pochodne pirazolowe jako inhibitory kalikreiny osoczowej
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
WO2018009417A1 (en) 2016-07-05 2018-01-11 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
WO2018064119A1 (en) * 2016-09-28 2018-04-05 Blade Therapeutics, Inc. Calpain modulators and therapeutic uses thereof
HUE057050T2 (hu) * 2017-08-16 2022-04-28 Glaxosmithkline Intellectual Property Dev Új vegyületek
HRP20220367T1 (hr) 2017-11-29 2022-05-27 Kalvista Pharmaceuticals Limited Oblici za doziranje koji sadrže plazmatski kalikrein inhibitor
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
RU2020130022A (ru) * 2018-03-28 2022-05-04 Блэйд Терапьютикс, Инк. Модуляторы кальпаина и их терапевтическое применение
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH21213A (en) 1984-10-26 1987-08-21 Fujisawa Pharmaceutical Co Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same
US4826835A (en) 1985-10-23 1989-05-02 Rorer Pharmaceutical Corporation Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure
US4743608A (en) 1986-07-15 1988-05-10 Rorer Pharmaceutical Corporation Pyridone-pyridyl-imidazolyl and triazolyl compounds and their use as cardiotonic agents
US4888352A (en) 1989-03-22 1989-12-19 Sterling Drug Inc. 3,4, or 5-aryl-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use
GB9412603D0 (en) * 1994-06-23 1994-08-10 Sandoz Ltd Organic compounds
DE19642591A1 (de) 1996-10-15 1998-04-16 Basf Ag Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung
DE19650975A1 (de) 1996-12-09 1998-06-10 Basf Ag Neue heterocyclisch substituierte Benzamide und deren Anwendung
ATE244216T1 (de) 1996-12-11 2003-07-15 Abbott Gmbh & Co Kg Ketobenzamide als calpain-inhibitoren
US6127556A (en) 1996-12-31 2000-10-03 G. D. Searle & Co. Epoxide formation by continuous in-situ synthesis process
US6083944A (en) * 1997-10-07 2000-07-04 Cephalon, Inc. Quinoline-containing α-ketoamide cysteine and serine protease inhibitors
DE19817459A1 (de) * 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung
HUP0101599A3 (en) * 1998-04-20 2002-12-28 Basf Ag Heterocyclically substituted amides, process for producing them, use of them and pharmaceutical compositions containing them
EP1080083A1 (de) 1998-04-20 2001-03-07 Basf Aktiengesellschaft Neue heterocyclisch substituierte amide mit cystein-protease hemmender wirkung
SK14512000A3 (sk) 1998-04-20 2001-04-09 Basf Aktiengesellschaft Substituované amidy, ich príprava a použitie
DE19817461A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Benzamide, deren Herstellung und Anwendung
DE19818614A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Amide, deren Herstellung und Anwendung
WO1999061423A1 (de) * 1998-05-25 1999-12-02 Basf Aktiengesellschaft Neue heterocyclische substituierte amide, deren herstellung und anwendung
AR018915A1 (es) * 1998-06-24 2001-12-12 Smithkline Beecham Corp Inhibidores de proteasas diacilhidrazinicos, composicion farmaceutica que la comprenden, usos de los mismos para la manufactura de un medicamento, unprocedimiento de fabricacion de dichos compuestos
AU2001245764A1 (en) * 2000-03-15 2001-09-24 Axys Pharmaceuticals, Inc. Novel compounds and compositions as protease inhibitors
JP2001261675A (ja) 2000-03-21 2001-09-26 Mitsui Chemicals Inc ピラゾリン誘導体またはテトラヒドロピリダジン誘導体を含有する医薬
US6995162B2 (en) * 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
DE10114762A1 (de) 2001-03-26 2002-10-02 Knoll Gmbh Verwendung von Cysteinprotease-Inhibitoren
NZ534583A (en) * 2002-03-05 2006-11-30 Axys Pharm Inc Leucinamide derivatives suitable as cathepsin cysteine protease inhibitors
EP1610263A1 (en) 2004-06-18 2005-12-28 Sicpa Holding S.A. Item carrying at least two data storage elements
WO2006080439A1 (ja) 2005-01-28 2006-08-03 Taisho Pharmaceutical Co., Ltd. 三環性化合物
MY147780A (en) * 2006-12-29 2013-01-31 Abbvie Deutschland Carboxamide compounds and their use as calpain inhibitors
TWI453019B (zh) * 2007-12-28 2014-09-21 Abbvie Deutschland 甲醯胺化合物

Also Published As

Publication number Publication date
EP2439205B1 (en) 2015-03-11
EP2121653B1 (en) 2012-02-08
CO6190617A2 (es) 2010-08-19
TWI405571B (zh) 2013-08-21
US7799809B2 (en) 2010-09-21
ES2381879T3 (es) 2012-06-01
IL231463A0 (en) 2014-04-30
PT2439205E (pt) 2015-07-16
EP2439205A1 (en) 2012-04-11
UY30850A1 (es) 2008-07-31
AU2007341232B2 (en) 2013-01-31
KR20150090281A (ko) 2015-08-05
US8436034B2 (en) 2013-05-07
RU2485114C2 (ru) 2013-06-20
IL231463A (en) 2016-02-29
KR20150090282A (ko) 2015-08-05
MY147780A (en) 2013-01-31
ATE544758T1 (de) 2012-02-15
MX2009007050A (es) 2009-09-23
WO2008080969A1 (en) 2008-07-10
GT200900186A (es) 2012-03-16
JP5295976B2 (ja) 2013-09-18
NZ599860A (en) 2013-09-27
US20100298326A1 (en) 2010-11-25
CN101616908B (zh) 2014-09-10
AR077477A2 (es) 2011-08-31
ES2536626T3 (es) 2015-05-27
JP2010514738A (ja) 2010-05-06
EP2121653A1 (en) 2009-11-25
KR20090097205A (ko) 2009-09-15
CA2673580C (en) 2015-11-24
HK1138833A1 (en) 2010-09-03
TW200845979A (en) 2008-12-01
DK2439205T3 (da) 2015-06-22
BRPI0721298A2 (pt) 2014-03-25
US20130245003A1 (en) 2013-09-19
AU2007341232A1 (en) 2008-07-10
CL2007003879A1 (es) 2008-07-04
US7728012B2 (en) 2010-06-01
CA2673580A1 (en) 2008-07-10
KR101578674B1 (ko) 2015-12-18
US20080234330A1 (en) 2008-09-25
UA100501C2 (uk) 2013-01-10
RU2013104459A (ru) 2014-08-10
NZ577719A (en) 2012-06-29
RU2009129119A (ru) 2011-02-10
US20080234329A1 (en) 2008-09-25
AR064693A1 (es) 2009-04-22
PE20081609A1 (es) 2008-11-12
IL199447A (en) 2014-04-30
ECSP099476A (es) 2009-07-31
CN101616908A (zh) 2009-12-30
US9139557B2 (en) 2015-09-22

Similar Documents

Publication Publication Date Title
HK1138833A1 (en) Carboxamide compounds and their use as calpain inhibitors
HUS2200052I1 (hu) Imidazotriazinok és imidazopirimidinek mint kinázgátlók
ZA200802585B (en) Pyridopyrimidinone inhibitors of Pl3Kα
IL190292A0 (en) PYRIDOPYRIMIDINONE INHIBITORS OF P13Ka
ZA200706345B (en) Amino-pyridines as inhibitors of ß-secretase
IL196956A0 (en) Aza-benzofuranyl compounds and methods of use
EP2057171A4 (en) GLYCOSIDASE SELECTIVE INHIBITORS AND USES THEREOF
ZA200903554B (en) Substituted isoquinolines and their use as rho-kinase inhibitors
IL198231A0 (en) Pyridine carboxamides as 11??hsd1 inhibitors
PL2040728T3 (pl) FKBP-L i jego zastosowanie jako inhibitora angiogenezy
ZA200707650B (en) Azolylacylguanidines as ß-secretase inhibitors
EP2023718A4 (en) CREATINLIGATE COMPOUNDS AND APPLICATION METHOD THEREFOR
EP2049505A4 (en) ISOFORM SELECTIVE HDAC HEMMER
HK1122034A1 (en) Azolopyrimidines as inhibitors of cannabinoid 1 activity
HK1137756A1 (en) Substituted dihydropyrazolones and use thereof as hif-prolyl-4 -hydroxylase inhibitors hif--4-
EP2084139A4 (en) OXAZOLIDINIUM COMPOUNDS AND USE AS HYDRATINE HIBITORS
IL197060A0 (en) Aza-benzothiophenyl compounds and methods of use
IL194028A0 (en) Tetrahydropyridothienopyrimidine compounds and methods of use thereof
GB0622084D0 (en) Inhibitors of HSP90
EP2036552A4 (en) SENESCENCE INHIBITOR
IL215835A0 (en) Carboxamide compounds and their use as calpain inhibitors
HK1176066A1 (en) Carboxamide compounds and their use as calpain inhibitors
ZA200804681B (en) Inhibitors of C-Met and uses thereof
EP1887002A4 (en) CARBOXYLIC AMIDE COMPOUND AND USE THEREOF
EP2036894A4 (en) AURORA INHIBITOR