DK2439205T3 - Carboxamidforbindelser og deres anvendelse som calpaininhibitorer - Google Patents
Carboxamidforbindelser og deres anvendelse som calpaininhibitorerInfo
- Publication number
- DK2439205T3 DK2439205T3 DK11195099.4T DK11195099T DK2439205T3 DK 2439205 T3 DK2439205 T3 DK 2439205T3 DK 11195099 T DK11195099 T DK 11195099T DK 2439205 T3 DK2439205 T3 DK 2439205T3
- Authority
- DK
- Denmark
- Prior art keywords
- carboxamide compounds
- calpain inhibitors
- calpain
- inhibitors
- carboxamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06127369 | 2006-12-29 | ||
EP07866322A EP2121653B1 (en) | 2006-12-29 | 2007-12-28 | Carboxamide compounds and their use as calpain inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2439205T3 true DK2439205T3 (da) | 2015-06-22 |
Family
ID=39226751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11195099.4T DK2439205T3 (da) | 2006-12-29 | 2007-12-28 | Carboxamidforbindelser og deres anvendelse som calpaininhibitorer |
Country Status (29)
Country | Link |
---|---|
US (4) | US8436034B2 (da) |
EP (2) | EP2121653B1 (da) |
JP (1) | JP5295976B2 (da) |
KR (3) | KR20150090282A (da) |
CN (1) | CN101616908B (da) |
AR (2) | AR064693A1 (da) |
AT (1) | ATE544758T1 (da) |
AU (1) | AU2007341232B2 (da) |
BR (1) | BRPI0721298A2 (da) |
CA (1) | CA2673580C (da) |
CL (1) | CL2007003879A1 (da) |
CO (1) | CO6190617A2 (da) |
DK (1) | DK2439205T3 (da) |
EC (1) | ECSP099476A (da) |
ES (2) | ES2381879T3 (da) |
GT (1) | GT200900186A (da) |
HK (1) | HK1138833A1 (da) |
IL (2) | IL199447A (da) |
MX (1) | MX2009007050A (da) |
MY (1) | MY147780A (da) |
NZ (2) | NZ599860A (da) |
PE (1) | PE20081609A1 (da) |
PL (1) | PL2439205T3 (da) |
PT (1) | PT2439205E (da) |
RU (2) | RU2485114C2 (da) |
TW (1) | TWI405571B (da) |
UA (1) | UA100501C2 (da) |
UY (1) | UY30850A1 (da) |
WO (1) | WO2008080969A1 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY147780A (en) * | 2006-12-29 | 2013-01-31 | Abbvie Deutschland | Carboxamide compounds and their use as calpain inhibitors |
TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
PE20110672A1 (es) * | 2008-08-14 | 2011-09-25 | Bayer Cropscience Ag | 4-fenil-1-h-pirazoles insecticidas |
TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶(calpain)抑制劑之用途 |
US8236798B2 (en) | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
SG10201405049RA (en) * | 2009-09-28 | 2014-10-30 | Hoffmann La Roche | Benzoxazepin pi3k inhibitor compounds and methods of use |
US8598211B2 (en) * | 2009-12-22 | 2013-12-03 | Abbvie Inc. | Carboxamide compounds and their use as calpain inhibitors IV |
US9051304B2 (en) * | 2009-12-22 | 2015-06-09 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
CN103599588B (zh) | 2010-04-30 | 2017-04-26 | 雅培心脏血管***股份有限公司 | 呈现迅速膨胀和收缩的改进型球囊导管 |
CA2819087A1 (en) | 2010-12-09 | 2012-06-14 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors v |
UY33874A (es) * | 2011-01-26 | 2012-08-31 | Sanofi Aventis | Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas |
WO2013126283A1 (en) | 2012-02-20 | 2013-08-29 | E. I. Du Pont De Nemours And Company | Fungicidal pyrazoles |
US9150545B2 (en) | 2012-04-03 | 2015-10-06 | AbbVie Deutschland GmbH & Co. KG | Carboxamide compounds and their use as calpain inhibitors V |
EA031647B1 (ru) | 2013-03-29 | 2019-02-28 | Такеда Фармасьютикал Компани Лимитед | 6-(5-гидрокси-1h-пиразол-1-ил)никотинамидные ингибиторы phd |
ES2674088T3 (es) * | 2013-08-14 | 2018-06-27 | Kalvista Pharmaceuticals Limited | Inhibidores de la calicreína plasmática |
TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
WO2017108569A1 (en) | 2015-12-22 | 2017-06-29 | Syngenta Participations Ag | Pesticidally active pyrazole derivatives |
CN105693545B (zh) * | 2016-01-26 | 2018-05-18 | 绍兴瑞康生物科技有限公司 | 一种羧酰胺类化合物及其制备方法和应用 |
US10590084B2 (en) | 2016-03-09 | 2020-03-17 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
AU2017275820B2 (en) | 2016-05-31 | 2020-10-22 | Kalvista Pharmaceuticals Limited | Pyrazole derivatives as plasma kallikrein inhibitors |
GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
AU2017292646A1 (en) | 2016-07-05 | 2019-02-07 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
SG10201912574WA (en) * | 2016-09-28 | 2020-02-27 | Blade Therapeutics Inc | Calpain modulators and therapeutic uses thereof |
HRP20211894T1 (hr) * | 2017-08-16 | 2022-08-19 | Glaxosmithkline Intellectual Property Development Limited | Novi spojevi |
PT3716952T (pt) | 2017-11-29 | 2022-04-14 | Kalvista Pharmaceuticals Ltd | Formas de administração que incluem um inibidor de calicreína plasmática |
GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
BR112020019560A2 (pt) * | 2018-03-28 | 2021-01-05 | Blade Therapeutics, Inc. | Moduladores de calpaína e usos terapêuticos dos mesmos |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
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PH21213A (en) | 1984-10-26 | 1987-08-21 | Fujisawa Pharmaceutical Co | Benzene- and pyrazole- fused heterocyclic compound and pharmaceutical composition comprising the same |
US4826835A (en) | 1985-10-23 | 1989-05-02 | Rorer Pharmaceutical Corporation | Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in the treatment of congestive heart failure |
US4743608A (en) | 1986-07-15 | 1988-05-10 | Rorer Pharmaceutical Corporation | Pyridone-pyridyl-imidazolyl and triazolyl compounds and their use as cardiotonic agents |
US4888352A (en) | 1989-03-22 | 1989-12-19 | Sterling Drug Inc. | 3,4, or 5-aryl-1H-pyrazole-1-alkanamides as antiarrhythmic agents, compositions and use |
GB9412603D0 (en) * | 1994-06-23 | 1994-08-10 | Sandoz Ltd | Organic compounds |
DE19642591A1 (de) | 1996-10-15 | 1998-04-16 | Basf Ag | Neue Piperidin-Ketocarbonsäure-Derivate, deren Herstellung und Anwendung |
DE19650975A1 (de) | 1996-12-09 | 1998-06-10 | Basf Ag | Neue heterocyclisch substituierte Benzamide und deren Anwendung |
IL130124A0 (en) | 1996-12-11 | 2000-06-01 | Basf Ag | Ketobenzamides as calpain inhibitors |
US6127556A (en) | 1996-12-31 | 2000-10-03 | G. D. Searle & Co. | Epoxide formation by continuous in-situ synthesis process |
US6083944A (en) * | 1997-10-07 | 2000-07-04 | Cephalon, Inc. | Quinoline-containing α-ketoamide cysteine and serine protease inhibitors |
DE19817459A1 (de) * | 1998-04-20 | 1999-10-21 | Basf Ag | Neue heterozyklische substituierte Amide, Herstellung und Anwendung |
CN1306526A (zh) | 1998-04-20 | 2001-08-01 | Basf公司 | 具有半胱氨酸蛋白酶抑制作用的新的杂环取代酰胺 |
HUP0101599A3 (en) * | 1998-04-20 | 2002-12-28 | Basf Ag | Heterocyclically substituted amides, process for producing them, use of them and pharmaceutical compositions containing them |
TR200003068T2 (tr) | 1998-04-20 | 2001-03-21 | Basf Aktiengesellschaft | Yeni amidler, üretimi ve kullanımı |
DE19818614A1 (de) | 1998-04-20 | 1999-10-21 | Basf Ag | Neue substituierte Amide, deren Herstellung und Anwendung |
DE19817461A1 (de) | 1998-04-20 | 1999-10-21 | Basf Ag | Neue substituierte Benzamide, deren Herstellung und Anwendung |
BR9910701A (pt) * | 1998-05-25 | 2001-01-30 | Basf Ag | Amida, uso de amidas, e, preparação farmacêutica |
AR018915A1 (es) * | 1998-06-24 | 2001-12-12 | Smithkline Beecham Corp | Inhibidores de proteasas diacilhidrazinicos, composicion farmaceutica que la comprenden, usos de los mismos para la manufactura de un medicamento, unprocedimiento de fabricacion de dichos compuestos |
WO2001068645A2 (en) * | 2000-03-15 | 2001-09-20 | Axys Pharmaceuticals, Inc. | N-cyanomethylcarboxamides and their use as protease inhibitors |
JP2001261675A (ja) | 2000-03-21 | 2001-09-26 | Mitsui Chemicals Inc | ピラゾリン誘導体またはテトラヒドロピリダジン誘導体を含有する医薬 |
US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
DE10114762A1 (de) | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
PT1482924E (pt) * | 2002-03-05 | 2008-08-27 | Axys Pharm Inc | Inibidores de proteases da cisteína catepsina |
EP1610263A1 (en) | 2004-06-18 | 2005-12-28 | Sicpa Holding S.A. | Item carrying at least two data storage elements |
WO2006080439A1 (ja) | 2005-01-28 | 2006-08-03 | Taisho Pharmaceutical Co., Ltd. | 三環性化合物 |
MY147780A (en) * | 2006-12-29 | 2013-01-31 | Abbvie Deutschland | Carboxamide compounds and their use as calpain inhibitors |
TWI453019B (zh) * | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
-
2007
- 2007-12-28 MY MYPI20092635A patent/MY147780A/en unknown
- 2007-12-28 AU AU2007341232A patent/AU2007341232B2/en not_active Ceased
- 2007-12-28 NZ NZ599860A patent/NZ599860A/xx not_active IP Right Cessation
- 2007-12-28 PT PT111950994T patent/PT2439205E/pt unknown
- 2007-12-28 PL PL11195099T patent/PL2439205T3/pl unknown
- 2007-12-28 US US11/990,652 patent/US8436034B2/en active Active
- 2007-12-28 CA CA2673580A patent/CA2673580C/en not_active Expired - Fee Related
- 2007-12-28 ES ES07866322T patent/ES2381879T3/es active Active
- 2007-12-28 ES ES11195099.4T patent/ES2536626T3/es active Active
- 2007-12-28 KR KR1020157020182A patent/KR20150090282A/ko not_active Application Discontinuation
- 2007-12-28 KR KR1020097016007A patent/KR101578674B1/ko not_active IP Right Cessation
- 2007-12-28 CN CN200780051850.2A patent/CN101616908B/zh not_active Expired - Fee Related
- 2007-12-28 KR KR1020157020180A patent/KR20150090281A/ko not_active Application Discontinuation
- 2007-12-28 NZ NZ577719A patent/NZ577719A/en not_active IP Right Cessation
- 2007-12-28 TW TW096150930A patent/TWI405571B/zh not_active IP Right Cessation
- 2007-12-28 BR BRPI0721298-4A patent/BRPI0721298A2/pt not_active IP Right Cessation
- 2007-12-28 UA UAA200907938A patent/UA100501C2/uk unknown
- 2007-12-28 RU RU2009129119/04A patent/RU2485114C2/ru not_active IP Right Cessation
- 2007-12-28 AT AT07866322T patent/ATE544758T1/de active
- 2007-12-28 WO PCT/EP2007/064617 patent/WO2008080969A1/en active Application Filing
- 2007-12-28 MX MX2009007050A patent/MX2009007050A/es active IP Right Grant
- 2007-12-28 EP EP07866322A patent/EP2121653B1/en active Active
- 2007-12-28 UY UY30850A patent/UY30850A1/es not_active Application Discontinuation
- 2007-12-28 DK DK11195099.4T patent/DK2439205T3/da active
- 2007-12-28 EP EP11195099.4A patent/EP2439205B1/en not_active Not-in-force
- 2007-12-28 CL CL200703879A patent/CL2007003879A1/es unknown
- 2007-12-28 JP JP2009543479A patent/JP5295976B2/ja not_active Expired - Fee Related
- 2007-12-28 AR ARP070105965A patent/AR064693A1/es unknown
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2008
- 2008-01-02 PE PE2008000057A patent/PE20081609A1/es not_active Application Discontinuation
- 2008-02-22 US US12/072,065 patent/US7799809B2/en not_active Expired - Fee Related
- 2008-02-22 US US12/070,941 patent/US7728012B2/en not_active Expired - Fee Related
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2009
- 2009-06-18 IL IL199447A patent/IL199447A/en not_active IP Right Cessation
- 2009-06-26 CO CO09066778A patent/CO6190617A2/es active IP Right Grant
- 2009-06-29 EC EC2009009476A patent/ECSP099476A/es unknown
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2010
- 2010-05-14 HK HK10104679.8A patent/HK1138833A1/xx not_active IP Right Cessation
- 2010-07-15 AR ARP100102569A patent/AR077477A2/es unknown
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2013
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- 2013-03-25 US US13/849,826 patent/US9139557B2/en not_active Expired - Fee Related
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2014
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