PL2396325T3 - Pochodne azaindoli jako inhibitory kinaz białkowych abl i src - Google Patents

Pochodne azaindoli jako inhibitory kinaz białkowych abl i src

Info

Publication number
PL2396325T3
PL2396325T3 PL10710439T PL10710439T PL2396325T3 PL 2396325 T3 PL2396325 T3 PL 2396325T3 PL 10710439 T PL10710439 T PL 10710439T PL 10710439 T PL10710439 T PL 10710439T PL 2396325 T3 PL2396325 T3 PL 2396325T3
Authority
PL
Poland
Prior art keywords
azaindoles
src
inhibitors
derivatives
protein kinases
Prior art date
Application number
PL10710439T
Other languages
English (en)
Inventor
Abdelaziz Yasri
Gwénaël Cheve
Cédric Bories
Louis Delon
Original Assignee
Oribase Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oribase Pharma filed Critical Oribase Pharma
Publication of PL2396325T3 publication Critical patent/PL2396325T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PL10710439T 2009-02-12 2010-02-12 Pochodne azaindoli jako inhibitory kinaz białkowych abl i src PL2396325T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20227909P 2009-02-12 2009-02-12
FR0900631A FR2941948B1 (fr) 2009-02-12 2009-02-12 Derives d'azaindoles en tant qu'inhibiteur des proteines kinases abl et src
EP10710439.0A EP2396325B1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src
PCT/IB2010/000593 WO2010092489A1 (en) 2009-02-12 2010-02-12 Derivatives of azaindoles as inhibitors of protein kinases abl and src

Publications (1)

Publication Number Publication Date
PL2396325T3 true PL2396325T3 (pl) 2015-10-30

Family

ID=40886859

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10710439T PL2396325T3 (pl) 2009-02-12 2010-02-12 Pochodne azaindoli jako inhibitory kinaz białkowych abl i src

Country Status (15)

Country Link
US (1) US8580815B2 (pl)
EP (1) EP2396325B1 (pl)
JP (1) JP5583698B2 (pl)
AU (1) AU2010212560B2 (pl)
CA (1) CA2751478A1 (pl)
DK (1) DK2396325T3 (pl)
ES (1) ES2540962T3 (pl)
FR (1) FR2941948B1 (pl)
HR (1) HRP20150697T8 (pl)
HU (1) HUE024989T2 (pl)
PL (1) PL2396325T3 (pl)
PT (1) PT2396325E (pl)
SI (1) SI2396325T1 (pl)
SM (1) SMT201500175B (pl)
WO (1) WO2010092489A1 (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102212923B1 (ko) 2012-12-21 2021-02-04 플렉시콘 인코퍼레이티드 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
FR3000494B1 (fr) * 2012-12-28 2015-08-21 Oribase Pharma Nouveaux derives d'azaindoles en tant qu'inhibiteurs de proteines kinases
FR3000493A1 (fr) * 2012-12-28 2014-07-04 Oribase Pharma Nouveaux inhibiteurs de proteines kinases
FR3000492B1 (fr) * 2012-12-28 2015-09-11 Oribase Pharma Nouveaux derives azaindole en tant qu'inhibiteurs multikinases
WO2017156350A1 (en) 2016-03-09 2017-09-14 K-Gen, Inc. Methods of cancer treatment
US11098010B2 (en) 2017-03-21 2021-08-24 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
CN111943947B (zh) * 2020-07-24 2021-04-30 重庆文理学院 1H-吡咯[2,3-b]吡啶衍生物及其合成方法与应用
IL301740A (en) * 2020-10-05 2023-05-01 Enliven Therapeutics Inc 7-Azaindole compounds for inhibition of BCR-ABL tyrosine kinases
EP4225742A1 (en) * 2020-10-05 2023-08-16 Enliven Therapeutics, Inc. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0330042D0 (en) 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them
GB0330043D0 (en) * 2003-12-24 2004-01-28 Pharmacia Italia Spa Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them
AU2005265017A1 (en) * 2004-06-17 2006-01-26 Plexxikon, Inc. Azaindoles modulating c-kit activity and uses therefor
BRPI0513916A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de pirrol-piridina cinase
US7709645B2 (en) 2004-07-27 2010-05-04 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
ES2319462T3 (es) * 2005-03-28 2009-05-07 Bristol-Myers Squibb Company Inhibidores competitivos de atp cinasas.
CA2662031A1 (en) 2006-09-06 2008-03-13 F. Hoffmann-La Roche Ag Heteroaryl derivatives as protein kinase inhibitors
US8148361B2 (en) * 2006-11-10 2012-04-03 Bristol-Myers Squibb Company Kinase inhibitors
WO2008144253A1 (en) * 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
EP2265608A2 (en) * 2008-02-29 2010-12-29 Array Biopharma, Inc. Raf inhibitor compounds and methods of use thereof
MX2011004625A (es) * 2008-11-03 2011-07-20 Syntarga Bv Analogos cc-1065 novedosos y sus conjugados.

Also Published As

Publication number Publication date
ES2540962T3 (es) 2015-07-15
HRP20150697T1 (hr) 2015-08-14
WO2010092489A1 (en) 2010-08-19
JP2012517465A (ja) 2012-08-02
EP2396325B1 (en) 2015-04-01
FR2941948B1 (fr) 2013-04-05
AU2010212560A1 (en) 2011-08-11
US8580815B2 (en) 2013-11-12
HUE024989T2 (en) 2016-01-28
SMT201500175B (it) 2015-09-07
FR2941948A1 (fr) 2010-08-13
CA2751478A1 (en) 2010-08-19
HRP20150697T8 (en) 2015-11-06
EP2396325A1 (en) 2011-12-21
AU2010212560B2 (en) 2016-01-21
SI2396325T1 (sl) 2015-08-31
US20110312959A1 (en) 2011-12-22
JP5583698B2 (ja) 2014-09-03
PT2396325E (pt) 2015-08-21
DK2396325T3 (en) 2015-06-29

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