PL2326651T3 - Analogi buprenorfiny - Google Patents

Analogi buprenorfiny

Info

Publication number
PL2326651T3
PL2326651T3 PL09789036T PL09789036T PL2326651T3 PL 2326651 T3 PL2326651 T3 PL 2326651T3 PL 09789036 T PL09789036 T PL 09789036T PL 09789036 T PL09789036 T PL 09789036T PL 2326651 T3 PL2326651 T3 PL 2326651T3
Authority
PL
Poland
Prior art keywords
buprenorphine analogs
buprenorphine
analogs
Prior art date
Application number
PL09789036T
Other languages
English (en)
Inventor
Donald J Kyle
R Richard Goehring
Marian E Fundytus
Original Assignee
Purdue Pharma Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Pharma Lp filed Critical Purdue Pharma Lp
Publication of PL2326651T3 publication Critical patent/PL2326651T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PL09789036T 2008-07-30 2009-07-30 Analogi buprenorfiny PL2326651T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8476408P 2008-07-30 2008-07-30
US22611909P 2009-07-16 2009-07-16
EP09789036.2A EP2326651B1 (en) 2008-07-30 2009-07-30 Buprenorphine analogs
PCT/US2009/004391 WO2010014229A1 (en) 2008-07-30 2009-07-30 Buprenorphine analogs

Publications (1)

Publication Number Publication Date
PL2326651T3 true PL2326651T3 (pl) 2014-05-30

Family

ID=41119539

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09789036T PL2326651T3 (pl) 2008-07-30 2009-07-30 Analogi buprenorfiny

Country Status (25)

Country Link
US (1) US8530494B2 (pl)
EP (2) EP2703404A1 (pl)
JP (2) JP5525524B2 (pl)
KR (1) KR101343395B1 (pl)
CN (2) CN103450206A (pl)
AU (1) AU2009277095B2 (pl)
CA (1) CA2731939C (pl)
CO (1) CO6341635A2 (pl)
DK (1) DK2326651T3 (pl)
ES (1) ES2449222T3 (pl)
HK (1) HK1158622A1 (pl)
HR (1) HRP20140182T1 (pl)
IL (1) IL210391A0 (pl)
ME (1) ME01665B (pl)
MX (1) MX2011001268A (pl)
NZ (1) NZ590650A (pl)
PL (1) PL2326651T3 (pl)
PT (1) PT2326651E (pl)
RS (1) RS53154B (pl)
RU (2) RU2520222C2 (pl)
SI (1) SI2326651T1 (pl)
SM (1) SMT201400023B (pl)
UA (1) UA104004C2 (pl)
WO (1) WO2010014229A1 (pl)
ZA (1) ZA201100188B (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012038813A1 (en) * 2010-09-21 2012-03-29 Purdue Pharma L.P. Buprenorphine analogs
FR2975912B1 (fr) 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
US9096606B2 (en) 2011-12-08 2015-08-04 Purdue Pharma, L.P. Quarternized buprenorphine analogs
US10138207B2 (en) 2012-11-09 2018-11-27 Purdue Pharma, L.P. Benzomorphan analogs and the use thereof
JP6317755B2 (ja) * 2012-12-07 2018-04-25 パーデュー、ファーマ、リミテッド、パートナーシップ オピオイド受容体モジュレーターとしてのブプレノルフィン類似体
US8987287B2 (en) 2012-12-14 2015-03-24 Purdue Pharma L.P. Spirocyclic morphinans and their use
ES2631197T3 (es) 2012-12-14 2017-08-29 Purdue Pharma Lp Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
CA2896202A1 (en) * 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
US9056836B2 (en) 2013-01-31 2015-06-16 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
US8969358B2 (en) 2013-03-15 2015-03-03 Purdue Pharma L.P. Buprenorphine analogs
WO2015097545A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
CA2934913A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Ring-contracted morphinans and the use thereof
US9988392B2 (en) 2013-12-26 2018-06-05 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
EP3087073B1 (en) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituted morphinan hydantoins
EP3089982A4 (en) * 2013-12-26 2017-09-27 Purdue Pharma L.P. 7-beta analogs of orvinols
EP3086790A4 (en) 2013-12-27 2017-07-19 Purdue Pharma LP 6-substituted and 7-substituted morphinan analogs and the use thereof
JP2017521373A (ja) * 2014-05-27 2017-08-03 パーデュー、ファーマ、リミテッド、パートナーシップ スピロ環モルフィナン及びその使用
MA40171A (fr) 2014-06-13 2017-04-19 Purdue Pharma Lp Dérivés d'azamophinan et leur utilisation
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
MA41125A (fr) 2014-12-05 2017-10-10 Purdue Pharma Lp Dérivés de 6.7-cyclomorphinane et leur utilisation
WO2018125716A1 (en) 2017-01-02 2018-07-05 Purdue Pharma L.P. Morphinan derivatives and use thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1136214A (en) * 1965-06-15 1968-12-11 Reckitt & Sons Ltd Thebaine and oripavine derivatives
US3474101A (en) * 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
NL289751A (pl) 1962-03-02
GB1136764A (en) * 1965-08-13 1968-12-18 Reckitt & Sons Ltd Derivatives of thebaine and oripavine
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
DE2230154A1 (de) 1972-06-21 1974-01-17 Boehringer Sohn Ingelheim N-(heteroaryl-methyl)-6,14-endoaetheno7alpha-hydroxyalkyl-tetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
PT95069B (pt) 1989-08-24 1997-10-31 Searle & Co Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5552406A (en) 1994-06-17 1996-09-03 The Mclean Hospital Corporation Method for treating pain and brain perfusion abnormalities using mixed opioid agonist-antagonists
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6136839A (en) 1995-06-12 2000-10-24 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor
ATE276242T1 (de) 1997-05-30 2004-10-15 Banyu Pharma Co Ltd 2-oxoimidazol-derivate
WO1999048492A1 (fr) 1998-03-26 1999-09-30 Japan Tobacco Inc. Derives d'amide et antagonistes de nociceptine
JP2004538256A (ja) * 2001-03-02 2004-12-24 ユーロ−セルティーク，エス．エイ． Ｎ−ブト−３−エチル＝ノルブプレノルフィン及び使用方法
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
CN1939920B (zh) * 2005-09-29 2011-08-31 中国人民解放军军事医学科学院毒物药物研究所 东罂粟碱类化合物及其医药用途

Also Published As

Publication number Publication date
NZ590650A (en) 2013-01-25
RU2011107440A (ru) 2012-09-10
EP2326651A1 (en) 2011-06-01
WO2010014229A1 (en) 2010-02-04
SMT201400023B (it) 2014-05-07
CO6341635A2 (es) 2011-11-21
JP5525524B2 (ja) 2014-06-18
JP2014208640A (ja) 2014-11-06
HRP20140182T1 (hr) 2014-04-11
PT2326651E (pt) 2014-02-12
AU2009277095B2 (en) 2012-09-06
SI2326651T1 (sl) 2014-03-31
DK2326651T3 (da) 2014-01-20
KR101343395B1 (ko) 2013-12-19
IL210391A0 (en) 2011-03-31
RU2013106944A (ru) 2014-08-27
UA104004C2 (uk) 2013-12-25
ES2449222T3 (es) 2014-03-18
AU2009277095A1 (en) 2010-02-04
ZA201100188B (en) 2011-09-28
ME01665B (me) 2014-09-20
US20110136846A1 (en) 2011-06-09
HK1158622A1 (en) 2012-07-20
US8530494B2 (en) 2013-09-10
RS53154B (en) 2014-06-30
CN102112479B (zh) 2014-10-29
CA2731939C (en) 2017-05-23
CN102112479A (zh) 2011-06-29
EP2326651B1 (en) 2013-11-27
KR20110036859A (ko) 2011-04-11
RU2520222C2 (ru) 2014-06-20
JP2012506839A (ja) 2012-03-22
CN103450206A (zh) 2013-12-18
CA2731939A1 (en) 2010-02-04
EP2703404A1 (en) 2014-03-05
MX2011001268A (es) 2011-07-29

Similar Documents

Publication Publication Date Title
HK1158622A1 (en) Buprenorphine analogs
ZA201301217B (en) Buprenorphine analogs
GB0807862D0 (en) Compounds
GB0800035D0 (en) Compounds
GB0804702D0 (en) Compounds
GB0818072D0 (en) Compounds
GB0807103D0 (en) Compounds
GB0800367D0 (en) Compounds
EP2285379A4 (en) ANALOGUES OF 1-METHYLNICOTINAMIDE
HK1156630A1 (en) Schweinfurthin analogues schweinfurthin
GB0807910D0 (en) Compounds
GB0801220D0 (en) Compounds
GB0801265D0 (en) Compounds
GB0802191D0 (en) Compounds
GB0805048D0 (en) Niovel compounds
GB0801219D0 (en) Compounds
GB0800841D0 (en) Compounds
GB0800455D0 (en) Compounds
GB0801596D0 (en) Compounds
GB0800338D0 (en) Compounds
GB0802192D0 (en) Compounds
GB0802586D0 (en) Compounds
GB0802587D0 (en) Compounds
GB0803493D0 (en) Compounds
GB0803495D0 (en) Compounds