PL2301908T3 - (-)-stereoizomer 2,6-di-sec-butylofenolu i jego analogi do propagowania działania przeciwwymiotnego, leczenia nudności i wymiotów oraz do leczenia migreny - Google Patents

(-)-stereoizomer 2,6-di-sec-butylofenolu i jego analogi do propagowania działania przeciwwymiotnego, leczenia nudności i wymiotów oraz do leczenia migreny

Info

Publication number
PL2301908T3
PL2301908T3 PL10014318T PL10014318T PL2301908T3 PL 2301908 T3 PL2301908 T3 PL 2301908T3 PL 10014318 T PL10014318 T PL 10014318T PL 10014318 T PL10014318 T PL 10014318T PL 2301908 T3 PL2301908 T3 PL 2301908T3
Authority
PL
Poland
Prior art keywords
treatment
stereoisomer
butylphenol
migraine
nausea
Prior art date
Application number
PL10014318T
Other languages
English (en)
Inventor
Thomas E Jenkins
Original Assignee
Sowood Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sowood Healthcare Llc filed Critical Sowood Healthcare Llc
Publication of PL2301908T3 publication Critical patent/PL2301908T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/06—Alkylated phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/44—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
    • C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
    • C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
    • C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL10014318T 2007-05-09 2008-05-08 (-)-stereoizomer 2,6-di-sec-butylofenolu i jego analogi do propagowania działania przeciwwymiotnego, leczenia nudności i wymiotów oraz do leczenia migreny PL2301908T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US92842907P 2007-05-09 2007-05-09
US92832707P 2007-05-09 2007-05-09
US92829607P 2007-05-09 2007-05-09
EP08769338A EP2146946B1 (en) 2007-05-09 2008-05-08 (-)- stereoisomer of 2,6-di-sec-butylphenol and analogs thereof
EP10014318.9A EP2301908B8 (en) 2007-05-09 2008-05-08 (-)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof for promoting antiemetic effect, treatment of nausea and vomiting and treatment of migraine

Publications (1)

Publication Number Publication Date
PL2301908T3 true PL2301908T3 (pl) 2015-02-27

Family

ID=39798084

Family Applications (2)

Application Number Title Priority Date Filing Date
PL10014318T PL2301908T3 (pl) 2007-05-09 2008-05-08 (-)-stereoizomer 2,6-di-sec-butylofenolu i jego analogi do propagowania działania przeciwwymiotnego, leczenia nudności i wymiotów oraz do leczenia migreny
PL08769338T PL2146946T3 (pl) 2007-05-09 2008-05-08 (-)-Stereoizomer 2,6-di-sec-butylofenolu i jego analogi

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL08769338T PL2146946T3 (pl) 2007-05-09 2008-05-08 (-)-Stereoizomer 2,6-di-sec-butylofenolu i jego analogi

Country Status (23)

Country Link
US (4) US8071818B2 (pl)
EP (4) EP2810927A1 (pl)
JP (1) JP5651009B2 (pl)
KR (1) KR20100017436A (pl)
CN (1) CN101715437B (pl)
AT (1) ATE487685T1 (pl)
AU (1) AU2008251482C1 (pl)
BR (1) BRPI0811220A2 (pl)
CA (1) CA2685570A1 (pl)
DE (1) DE602008003431D1 (pl)
DK (2) DK2301908T3 (pl)
ES (1) ES2501592T3 (pl)
HK (2) HK1138829A1 (pl)
HR (1) HRP20140896T1 (pl)
IL (1) IL201795A0 (pl)
MX (1) MX2009012124A (pl)
NZ (1) NZ580752A (pl)
PL (2) PL2301908T3 (pl)
PT (1) PT2146946E (pl)
RU (1) RU2470908C2 (pl)
SI (1) SI2301908T1 (pl)
WO (1) WO2008141097A2 (pl)
ZA (1) ZA201007603B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2301908T1 (sl) 2007-05-09 2014-10-30 Sowood Healthcare Llc (-)-stereoizomer 2,6-di-sek.-butilfenola in njegovi analogi za pospeševanje antiemetičnega učinka, zdravljenje slabosti in bruhanja in zdravljenje migrene
JP5924539B2 (ja) * 2010-08-03 2016-05-25 学校法人 久留米大学 実験用小動物の脳波測定用装置及び脳波測定方法
CN102731265B (zh) * 2012-06-12 2014-12-10 四川百利药业有限责任公司 一种高纯度丙泊酚的制备方法
WO2017205632A1 (en) * 2016-05-27 2017-11-30 The Johns Hopkins University Buccal, sublingual and intranasal delivery of fospropofol
RU2635532C1 (ru) * 2016-09-06 2017-11-13 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Способ профилактики ажитационного синдрома у детей с онкологической патологией
CN115708819A (zh) * 2022-11-24 2023-02-24 中国科学院深圳先进技术研究院 丙泊酚的抗焦虑制药用途及抗焦虑药物制剂

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US237213A (en) 1881-02-01 William j
US2747982A (en) * 1955-05-11 1956-05-29 Dow Chemical Co Method and composition for the control of the growth of vegetation
GB1472793A (en) 1974-03-28 1977-05-04 Ici Ltd Pharmaceutical compositions
US4798846A (en) 1974-03-28 1989-01-17 Imperial Chemical Industries Plc Pharmaceutical compositions
SU1525139A1 (ru) * 1987-11-10 1989-11-30 Куйбышевский политехнический институт им.В.В.Куйбышева Способ получени о-втор-бутилфенола
ES2087019B1 (es) * 1994-02-08 1997-03-16 Bobel246 S L Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa.
US5731355A (en) 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
GB9405593D0 (en) 1994-03-22 1994-05-11 Zeneca Ltd Pharmaceutical compositions
US6254853B1 (en) 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6140374A (en) 1998-10-23 2000-10-31 Abbott Laboratories Propofol composition
US7060290B1 (en) 1999-02-18 2006-06-13 Supergen, Inc. Phosphocholine linked prodrug derivatives
US6716452B1 (en) 2000-08-22 2004-04-06 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6362234B1 (en) 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
US20020099013A1 (en) 2000-11-14 2002-07-25 Thomas Piccariello Active agent delivery systems and methods for protecting and administering active agents
WO2002028411A1 (en) 2000-10-06 2002-04-11 Xenoport, Inc. Compounds for sustained release of orally delivered drugs
CA2441744C (en) * 2001-03-20 2011-07-12 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin
CA2470500C (en) 2001-12-28 2012-05-15 Guilford Pharmaceuticals, Inc. Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
AU2002316231A1 (en) 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
RU2297216C2 (ru) 2002-04-08 2007-04-20 Эм-Джи-Ай Джи-Пи,Инк. Фармацевтические композиции, содержащие растворимые в воде пролекарства пропофола, и способы их применения
DE20215415U1 (de) 2002-10-08 2004-02-26 Biotechnologie Gesellschaft Mittelhessen Mbh Wasserlösliche Medikamentenvorstufen von Propofol
AU2003273413A1 (en) 2002-10-08 2004-05-04 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
ZA200504940B (en) 2003-01-28 2006-09-27 Xenoport Inc Amino acid derived prodrugs of propofol, compositions and uses thereof
AU2003901815A0 (en) 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Phosphate derivatives
WO2005023204A2 (en) 2003-09-09 2005-03-17 Xenoport, Inc. Aromatic prodrugs of propofol, compositions and uses thereof
WO2005033279A2 (en) * 2003-09-29 2005-04-14 University Of Virginia Patent Foundation Discovery of novel soluble crystalline anesthetics
US7241807B2 (en) 2004-07-12 2007-07-10 Xenoport, Inc. Prodrugs of propofol, compositions and uses thereof
WO2006033911A2 (en) 2004-09-17 2006-03-30 Mgi Gp, Inc. Methods of administering water-soluble prodrugs of propofol
WO2006071995A1 (en) 2004-12-23 2006-07-06 Xenoport, Inc. Serine amino acid derived prodrugs of propofol, compositions, uses and crystalline forms thereof
DE102005033496A1 (de) * 2005-07-19 2007-01-25 Bayer Healthcare Ag Desinfektionsmittel
CA2632561C (en) 2005-12-19 2015-01-27 The University Of Liverpool Substituted propofol derivatives as analgesics
US7535698B2 (en) 2006-03-07 2009-05-19 Panasonic Corporation Case, portable information equipment using the same and manufacturing method of the case
US7731356B1 (en) 2006-07-24 2010-06-08 Daniel Ayers Gilbert Hanging eyeglasses
CA2685813A1 (en) 2007-05-09 2008-11-20 Pharmacofore, Inc. Therapeutic compounds
SI2301908T1 (sl) 2007-05-09 2014-10-30 Sowood Healthcare Llc (-)-stereoizomer 2,6-di-sek.-butilfenola in njegovi analogi za pospeševanje antiemetičnega učinka, zdravljenje slabosti in bruhanja in zdravljenje migrene

Also Published As

Publication number Publication date
ATE487685T1 (de) 2010-11-15
EP2301908B1 (en) 2014-06-25
US20130059919A1 (en) 2013-03-07
JP5651009B2 (ja) 2015-01-07
ZA201007603B (en) 2012-08-29
AU2008251482A1 (en) 2008-11-20
WO2008141097A9 (en) 2009-04-02
WO2008141097A2 (en) 2008-11-20
CA2685570A1 (en) 2008-11-20
US8575400B2 (en) 2013-11-05
CN101715437B (zh) 2013-06-12
AU2008251482B2 (en) 2013-09-26
US8071818B2 (en) 2011-12-06
US20120035271A1 (en) 2012-02-09
DE602008003431D1 (de) 2010-12-23
MX2009012124A (es) 2010-02-18
RU2470908C2 (ru) 2012-12-27
AU2008251482C1 (en) 2014-04-03
HK1138829A1 (en) 2010-09-03
JP2010526826A (ja) 2010-08-05
EP2146946B1 (en) 2010-11-10
US8871815B2 (en) 2014-10-28
PT2146946E (pt) 2011-02-14
HRP20140896T1 (hr) 2015-01-02
NZ580752A (en) 2012-03-30
ES2501592T3 (es) 2014-10-02
EP2301908A1 (en) 2011-03-30
EP2292577A1 (en) 2011-03-09
RU2009145537A (ru) 2011-06-20
EP2146946A2 (en) 2010-01-27
KR20100017436A (ko) 2010-02-16
BRPI0811220A2 (pt) 2014-10-29
EP2301908B8 (en) 2014-09-03
IL201795A0 (en) 2010-06-16
WO2008141097A3 (en) 2008-12-31
DK2301908T3 (da) 2014-09-15
PL2146946T3 (pl) 2011-04-29
CN101715437A (zh) 2010-05-26
US20140206773A1 (en) 2014-07-24
US20100292346A1 (en) 2010-11-18
HK1156019A1 (en) 2012-06-01
SI2301908T1 (sl) 2014-10-30
EP2810927A1 (en) 2014-12-10
DK2146946T3 (da) 2011-02-14
US8242315B2 (en) 2012-08-14

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