PL2253330T3 - Skoniugowane cząsteczki biologiczne i ich otrzymywanie - Google Patents
Skoniugowane cząsteczki biologiczne i ich otrzymywanieInfo
- Publication number
- PL2253330T3 PL2253330T3 PL10175140T PL10175140T PL2253330T3 PL 2253330 T3 PL2253330 T3 PL 2253330T3 PL 10175140 T PL10175140 T PL 10175140T PL 10175140 T PL10175140 T PL 10175140T PL 2253330 T3 PL2253330 T3 PL 2253330T3
- Authority
- PL
- Poland
- Prior art keywords
- group
- general formula
- protein
- compound
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F10/00—Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0316294.8A GB0316294D0 (en) | 2003-07-11 | 2003-07-11 | Conjugated biological molecules and their preparation |
| EP10175140.2A EP2253330B1 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| EP09167191.7A EP2133099B1 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
| EP04743335A EP1648518B1 (en) | 2003-07-11 | 2004-07-12 | Conjugated biological molecules and their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2253330T3 true PL2253330T3 (pl) | 2016-01-29 |
Family
ID=27742023
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04743335T PL1648518T3 (pl) | 2003-07-11 | 2004-07-12 | Skoniugowane cząsteczki biologiczne i ich wytwarzanie |
| PL10175140T PL2253330T3 (pl) | 2003-07-11 | 2004-07-12 | Skoniugowane cząsteczki biologiczne i ich otrzymywanie |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04743335T PL1648518T3 (pl) | 2003-07-11 | 2004-07-12 | Skoniugowane cząsteczki biologiczne i ich wytwarzanie |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7595292B2 (pl) |
| EP (4) | EP2253330B1 (pl) |
| JP (2) | JP4958549B2 (pl) |
| KR (1) | KR101152500B1 (pl) |
| CN (2) | CN101792525B (pl) |
| AT (1) | ATE440620T1 (pl) |
| AU (2) | AU2004257448B2 (pl) |
| DE (1) | DE602004022824D1 (pl) |
| DK (4) | DK2277550T3 (pl) |
| ES (4) | ES2632515T3 (pl) |
| GB (1) | GB0316294D0 (pl) |
| PL (2) | PL1648518T3 (pl) |
| WO (1) | WO2005007197A2 (pl) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ541124A (en) | 2002-12-26 | 2008-08-29 | Mountain View Pharmaceuticals | Polymer conjugates of interferon-beta with enhanced biological potency |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| US7046714B2 (en) * | 2003-09-10 | 2006-05-16 | Intel Corporation | Method and apparatus for Raman ring resonator based laser/wavelength converter |
| ES2533695T3 (es) * | 2004-03-02 | 2015-04-14 | Seattle Genetics, Inc. | Anticuerpos cargados parcialmente y métodos para su conjugación |
| WO2007019620A1 (en) * | 2005-08-15 | 2007-02-22 | Arana Therapeutics Limited | Engineered antibodies with new world primate framework regions |
| CN101400703B (zh) * | 2006-02-01 | 2013-05-08 | 赛法隆澳大利亚控股有限公司 | 结构域抗体构建体 |
| US20080139790A1 (en) * | 2006-12-08 | 2008-06-12 | Jennings Philip A | Chimeric antibodies |
| US8575397B2 (en) | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
| GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| TWI360535B (en) | 2007-08-30 | 2012-03-21 | Univ Nat Sun Yat Sen | Sulfur-containing compound, method of preparation |
| KR20100090684A (ko) * | 2007-10-09 | 2010-08-16 | 폴리테릭스 리미티드 | 신규한 접합 단백질 및 펩티드 |
| NZ588854A (en) * | 2008-04-24 | 2011-12-22 | Celtic Pharma Peg Ltd | Factor ix-polyethylene conjugates with extended half-lives |
| BRPI0915343A2 (pt) | 2008-06-30 | 2015-10-27 | Esbatech Alcon Biomed Res Unit | polipeptídeos funcionalizados |
| EP2303230A2 (en) | 2008-07-10 | 2011-04-06 | ESBATech, an Alcon Biomedical Research Unit LLC | Methods and compositions for enhanced delivery of macromolecules |
| JP5622117B2 (ja) | 2008-07-21 | 2014-11-12 | ポリテリクスリミテッド | 生体分子を接合するための新規な試薬及び方法 |
| GB0817978D0 (en) * | 2008-10-01 | 2008-11-05 | Imp Innovations Ltd | Peptides |
| MX2011004718A (es) * | 2008-11-04 | 2011-07-28 | Janssen Pharmaceutica Nv | Péptidos agonistas de crhr2 y usos de éstos. |
| GB0912485D0 (en) * | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| GB0922354D0 (en) | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
| EP2403538B1 (en) | 2009-03-04 | 2017-10-04 | Polytherics Limited | Conjugated proteins and peptides |
| BRPI1015424B1 (pt) | 2009-06-22 | 2022-01-18 | Burnham Institute For Medical Research | Composição compreendendo um elemento cendr e uma co-composição e composição para uso no reforço da internalização, penetração, ou ambas, de uma co-composição |
| GB0916576D0 (en) | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| GB0916578D0 (en) | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| FI124016B (fi) * | 2009-10-26 | 2014-01-31 | Vapo Oy | Menetelmä biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi välipiirinesteen avulla sekä vesi-glykoliseoksen tai sitä vastaavan jäätymättömän välipiirinesteen käyttö biomassakuivattimessa käytetyn kuivatusilman lämmittämiseksi |
| BR112012010661A2 (pt) | 2009-11-04 | 2016-11-22 | Janssen Pharmaceutica Nv | método para tratar insuficiência cardíaca com peptídeos semelhantes à estressecopina |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
| GB2490655A (en) | 2011-04-28 | 2012-11-14 | Univ Aston | Modulators of tissue transglutaminase |
| EP2715291A4 (en) | 2011-05-31 | 2015-10-21 | Airware Inc | NON-DISPERSIVE GAS SENSORS WITH ABSORPTION INFRARED ABSORPTION (NDIR) |
| US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
| JP2015512927A (ja) | 2012-04-16 | 2015-04-30 | カンタブ バイオファーマシューティカルズ パテンツ リミテッド | 最適化された皮下治療薬 |
| WO2013177481A1 (en) | 2012-05-25 | 2013-11-28 | Immunogen, Inc. | Benzodiazepines and conjugates thereof |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| GB201210770D0 (en) | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| EP2861261A2 (en) * | 2012-06-19 | 2015-04-22 | Polytherics Limited | Process for preparation of antibody conjugates and antibody conjugates |
| NO2789793T3 (pl) | 2012-10-24 | 2018-01-27 | ||
| SG11201501618WA (en) | 2012-10-24 | 2015-04-29 | Polytherics Ltd | Drug-protein conjugates |
| KR20150090081A (ko) * | 2012-11-30 | 2015-08-05 | 노파르티스 아게 | 디술피드-함유 단백질로부터 접합체를 제조하는 방법 |
| WO2014093379A1 (en) | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| AU2013359506B2 (en) | 2012-12-10 | 2018-05-24 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| EP2931316B1 (en) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxyl-polymer-drug-protein conjugates |
| KR102306490B1 (ko) | 2013-03-15 | 2021-09-28 | 리제너론 파아마슈티컬스, 인크. | 생물학적 활성 분자, 그의 접합체 및 치료 용도 |
| GB201308738D0 (en) * | 2013-05-15 | 2013-06-26 | Polytherics Ltd | Novel polymer conjugates |
| BR112016004023A2 (pt) | 2013-08-26 | 2022-11-16 | Regeneron Pharma | Composição, métodos para preparar uma composição e para tratar uma doença, e, composto |
| BR112016005526A2 (pt) | 2013-09-12 | 2017-09-12 | Halozyme Inc | anticorpos receptores de fator de crescimento anti-epidérmido modificado e métodos de uso dos mesmos |
| WO2015159118A2 (en) | 2013-09-17 | 2015-10-22 | Obi Pharma, Inc. | Compositions of a carbohydrate vaccine for inducing immune responses and uses thereof in cancer treatment |
| RU2016117810A (ru) | 2013-10-11 | 2017-11-17 | Асана Биосайенсис, Ллк | Конъюгаты белок-полимер-лекарственное средство |
| AU2014331714B2 (en) | 2013-10-11 | 2019-05-02 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| KR20160088429A (ko) * | 2013-11-26 | 2016-07-25 | 노파르티스 아게 | 케톤-변형된 폴리펩티드에 대한 옥심 접합을 위한 방법 |
| GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
| ES2792598T3 (es) | 2014-05-23 | 2020-11-11 | Novartis Ag | Métodos para preparar conjugados a partir de proteínas que contienen disulfuro |
| WO2015187596A2 (en) | 2014-06-02 | 2015-12-10 | Regeneron Pharmaceuticals, Inc. | Biologically active molecule conjugates, reagents and methods of manufacture, and therapeutic uses |
| GB201413913D0 (en) | 2014-08-06 | 2014-09-17 | Cantargia Ab | Novel antibodies and uses thereof |
| KR20230158134A (ko) | 2014-10-14 | 2023-11-17 | 폴리테릭스 리미티드 | Peg의 일부를 포함하는 이탈기를 포함하는 시약을 사용한, 펩티드 또는 단백질의 접합방법 |
| EP3262068A1 (en) * | 2015-02-05 | 2018-01-03 | Ablynx N.V. | Nanobody dimers linked via c-terminally engineered cysteins |
| US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
| US10509035B2 (en) | 2015-08-07 | 2019-12-17 | Gamamabs Pharma Sa | Antibodies, antibody drug conjugates and methods of use |
| CN108350605A (zh) | 2015-09-04 | 2018-07-31 | 台湾浩鼎生技股份有限公司 | 聚糖阵列以及使用方法 |
| US10975161B2 (en) | 2016-01-12 | 2021-04-13 | Crescendo Biologics Limited | Molecules that bind prostate specific membrane antigen (PSMA) |
| GB201601136D0 (en) | 2016-01-21 | 2016-03-09 | Mörgelin Matthias And Abdillahi Suado M | Novel polypeptides and medical uses thereof |
| SG11201806322QA (en) | 2016-01-25 | 2018-08-30 | Regeneron Pharma | Maytansinoid derivatives, conjugates thereof, and methods of use |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| CA3019560A1 (en) | 2016-03-29 | 2017-10-05 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| EP3442595A1 (en) | 2016-04-14 | 2019-02-20 | Polytherics Limited | Conjugates and conjugating reagents comprising a linker that includes at least two (-ch2-ch2-0-) units in a ring |
| CN109379889A (zh) | 2016-04-22 | 2019-02-22 | 台湾浩鼎生技股份有限公司 | 通过经由globo系列抗原的免疫激活或免疫调节的癌症免疫疗法 |
| GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| EP4282434A3 (en) | 2016-06-06 | 2024-03-06 | Abzena (UK) Limited | Antibodies, uses thereof and conjugates thereof |
| BR112019001656A2 (pt) | 2016-07-27 | 2019-05-28 | Obi Pharma Inc | composição, composição farmacêutica, vacina, método para induzir anticorpos em um indivíduo, método para tratar câncer em um paciente necessitando do mesmo e método para induzir ou melhorar a reação imune em um indivíduo necessitando do mesmo |
| EP3491026A4 (en) | 2016-07-29 | 2020-07-29 | OBI Pharma, Inc. | HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS |
| GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| GB201615725D0 (en) | 2016-09-15 | 2016-11-02 | Polytherics Ltd | Novel cytotoxic agents and conjugates thereof |
| CN110290800A (zh) | 2016-11-21 | 2019-09-27 | 台湾浩鼎生技股份有限公司 | 缀合生物分子、医药组合物及方法 |
| US11135307B2 (en) | 2016-11-23 | 2021-10-05 | Mersana Therapeutics, Inc. | Peptide-containing linkers for antibody-drug conjugates |
| CN111315414A (zh) | 2017-06-22 | 2020-06-19 | 梅尔莎纳医疗公司 | 产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法 |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| WO2020006176A1 (en) | 2018-06-27 | 2020-01-02 | Obi Pharma, Inc. | Glycosynthase variants for glycoprotein engineering and methods of use |
| GB201814281D0 (en) | 2018-09-03 | 2018-10-17 | Femtogenix Ltd | Cytotoxic agents |
| GB201901197D0 (en) | 2019-01-29 | 2019-03-20 | Femtogenix Ltd | G-A Crosslinking cytotoxic agents |
| GB201909298D0 (en) | 2019-06-28 | 2019-08-14 | Colzyx Ab | Novel compositions and uses thereof |
| GB2597532A (en) | 2020-07-28 | 2022-02-02 | Femtogenix Ltd | Cytotoxic compounds |
| GB202016456D0 (en) | 2020-10-16 | 2020-12-02 | Colzyx Ab | Novel bioactive peptide combinations and uses thereof |
| WO2024013724A1 (en) | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Antibody-drug conjugates |
| CN115304524A (zh) * | 2022-07-21 | 2022-11-08 | 湖南大学 | 一种β-酰基烯丙基甲基砜类化合物及其高效合成方法 |
| WO2024127332A1 (en) | 2022-12-14 | 2024-06-20 | Pheon Therapeutics Ltd | Cytotoxic compounds |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US680343A (en) * | 1899-04-15 | 1901-08-13 | Johan Peter Moeller | Glove. |
| US3828412A (en) * | 1971-03-19 | 1974-08-13 | Dunham Bush Inc | Method of forming high integrity epoxy joint between aluminum tubes |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| EP0298101A1 (en) | 1987-01-15 | 1989-01-11 | Celltech Limited | Thiol-reactive cross-linking reagents |
| DE69033192T3 (de) | 1989-04-19 | 2004-05-19 | Enzon, Inc. | Aktive karbonate von polyalkylenoxyden zur modifizierung von polypeptiden |
| US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| WO1992016221A1 (en) | 1991-03-15 | 1992-10-01 | Synergen, Inc. | Pegylation of polypeptides |
| WO1994004193A1 (en) | 1992-08-21 | 1994-03-03 | Enzon, Inc. | Novel attachment of polyalkylene oxides to bio-effecting substances |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| JP3631755B2 (ja) * | 1994-03-23 | 2005-03-23 | 明治製菓株式会社 | ポリオキシエチレン含有脂質二本鎖誘導体 |
| US5877224A (en) | 1995-07-28 | 1999-03-02 | Rutgers, The State University Of New Jersey | Polymeric drug formulations |
| GB9713979D0 (en) | 1997-07-03 | 1997-09-10 | Univ Nottingham | Method for attaching peg to macromolecules |
| EP1411075B1 (en) * | 1998-03-12 | 2008-07-02 | Nektar Therapeutics Al, Corporation | Method for preparing polymer conjugates |
| US6153655A (en) | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| AU762621B2 (en) | 1998-04-28 | 2003-07-03 | Merck Serono Sa | Polyol-IFN-beta conjugates |
| AU4934299A (en) * | 1999-07-15 | 2001-02-05 | Kuhnil Pharm. Co., Ltd. | Novel water soluble-cyclosporine conjugated compounds |
| US6828412B1 (en) | 1999-09-03 | 2004-12-07 | School Of Pharmacy, University Of London | Degradable polymers |
| JP2003528939A (ja) | 1999-09-03 | 2003-09-30 | スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン | 分解性ポリマー |
| ATE297954T1 (de) | 1999-09-08 | 2005-07-15 | Polytherics Ltd | Polymere mit uniformem molekulargewicht |
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| GB0400264D0 (en) | 2004-01-07 | 2004-02-11 | Polytherics Ltd | Complexes |
| US8575397B2 (en) | 2007-02-14 | 2013-11-05 | Biocompatibles Uk Limited | Derivatisation of biological molecules |
| KR20100090684A (ko) | 2007-10-09 | 2010-08-16 | 폴리테릭스 리미티드 | 신규한 접합 단백질 및 펩티드 |
| JP5622117B2 (ja) | 2008-07-21 | 2014-11-12 | ポリテリクスリミテッド | 生体分子を接合するための新規な試薬及び方法 |
| GB0912485D0 (en) | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| EP2403538B1 (en) | 2009-03-04 | 2017-10-04 | Polytherics Limited | Conjugated proteins and peptides |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
-
2003
- 2003-07-11 GB GBGB0316294.8A patent/GB0316294D0/en not_active Ceased
-
2004
- 2004-07-12 DK DK10175143.6T patent/DK2277550T3/en active
- 2004-07-12 AT AT04743335T patent/ATE440620T1/de active
- 2004-07-12 CN CN2010101399434A patent/CN101792525B/zh not_active Expired - Lifetime
- 2004-07-12 ES ES09167191.7T patent/ES2632515T3/es not_active Expired - Lifetime
- 2004-07-12 EP EP10175140.2A patent/EP2253330B1/en not_active Expired - Lifetime
- 2004-07-12 EP EP20100175143 patent/EP2277550B1/en not_active Expired - Lifetime
- 2004-07-12 PL PL04743335T patent/PL1648518T3/pl unknown
- 2004-07-12 DK DK09167191.7T patent/DK2133099T3/en active
- 2004-07-12 DK DK10175140.2T patent/DK2253330T3/en active
- 2004-07-12 ES ES04743335T patent/ES2331004T3/es not_active Expired - Lifetime
- 2004-07-12 PL PL10175140T patent/PL2253330T3/pl unknown
- 2004-07-12 EP EP09167191.7A patent/EP2133099B1/en not_active Expired - Lifetime
- 2004-07-12 US US10/564,340 patent/US7595292B2/en active Active
- 2004-07-12 EP EP04743335A patent/EP1648518B1/en not_active Expired - Lifetime
- 2004-07-12 DE DE602004022824T patent/DE602004022824D1/de not_active Expired - Lifetime
- 2004-07-12 KR KR1020067000278A patent/KR101152500B1/ko active IP Right Grant
- 2004-07-12 WO PCT/GB2004/002994 patent/WO2005007197A2/en active Application Filing
- 2004-07-12 ES ES10175143.6T patent/ES2542531T3/es not_active Expired - Lifetime
- 2004-07-12 DK DK04743335T patent/DK1648518T3/da active
- 2004-07-12 CN CN2004800198144A patent/CN1822860B/zh not_active Expired - Lifetime
- 2004-07-12 ES ES10175140.2T patent/ES2549427T3/es not_active Expired - Lifetime
- 2004-07-12 AU AU2004257448A patent/AU2004257448B2/en not_active Expired
- 2004-07-12 JP JP2006518372A patent/JP4958549B2/ja not_active Expired - Lifetime
-
2009
- 2009-07-28 US US12/458,931 patent/US7939630B2/en active Active
-
2010
- 2010-12-20 AU AU2010257308A patent/AU2010257308B2/en not_active Expired
-
2011
- 2011-03-31 US US13/077,980 patent/US8816051B2/en active Active
- 2011-08-04 JP JP2011170597A patent/JP5349552B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-28 US US14/444,859 patent/US9439974B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB0316294D0 (en) | Conjugated biological molecules and their preparation | |
| CN101200504B (zh) | 高分子巯基化改性衍生物及其交联材料 | |
| CA2191971A1 (en) | Pegylation reagents and compounds formed therewith | |
| WO2005065239A3 (en) | Novel recombinant proteins with n-terminal free thiol | |
| EA200000607A1 (ru) | Конъюгаты эритропоэтина | |
| EP2374481A3 (en) | Novel reagents and method for conjugating biological molecules | |
| AU5346896A (en) | Heterotelechelic block copolymers and process for producing the same | |
| AU5289096A (en) | Polyethylene oxides having saccharide residue at one end and different functional group at another end, and process for producing the same | |
| BR0116381A (pt) | Conjugado, composição farmacêutica que compreende o mesmo e sua utilização, processo para o tratamento profilático e/ou terapêutico de distúrbios, processo para a preparação de um conjugado, compostos e glicoproteìnas de eritropoetina | |
| CA2326347A1 (en) | Composition and method for producing polythioethers having pendent methyl chains | |
| DE69915004D1 (de) | 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate | |
| DE50000205D1 (de) | Verfahren zur Herstellung eines Thixotropie-Mittels und dessen Verwendung | |
| AU3994295A (en) | Novel amidinonaphthyl derivative or salt thereof | |
| AU1313295A (en) | Aryl acetic acid derivatives | |
| ATE276358T1 (de) | Polypeptid-polymer konjugat | |
| EP1167418A4 (en) | POLYOXYETHYLENE DERIVATIVES HAVING AN OPTIONALLY PROTECTED AMINO GROUP AT AN END AND A PROCESS FOR PRODUCING THE SAME | |
| BR0210542A (pt) | Processo para preparação de derivados de cicloexanol | |
| ATE203029T1 (de) | Organische polymerverbindung und ihre herstellung | |
| ATE553141T1 (de) | Neues polymer und herstellungsverfahren dafür | |
| DE69607890D1 (de) | Aromatische Hydroxamsäure-Verbindungen, ihre Herstellung und Verwendung | |
| Chen et al. | Synthesis and characterization of novel kinds of polyethylene oxide drugs containing 5-fluorouracil and nitrogen mustard at one end and 4-amino-N-(2-pyrimidinyl) benzene sulfonamide at the other end | |
| ATE232240T1 (de) | Verfahren zur herstellung von l-allysin acetal | |
| ATE232222T1 (de) | Verträglich machendes agens und methode zur herstellung desselben | |
| WO2002092615A3 (en) | Compositions and methods for array-based genomic nucleic acid analysis of biological molecules | |
| ATE167869T1 (de) | Thiolderivate von gallensäure |