PL163432B1 - Sposób wytwarzania nowych pochodnych peptydu somatostatyny PL PL PL PL - Google Patents

Sposób wytwarzania nowych pochodnych peptydu somatostatyny PL PL PL PL

Info

Publication number: PL163432B1
Authority: PL; Poland
Prior art keywords: group; peptide; acid; chelating; formula
Prior art date: 1988-12-05

Application number

PL89296879A

Other languages

English (en)

Polish (pl)

Inventor

Rainer Albert

Eric P Krenning

Steven W J Lamberts

Janos Pless

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-05

Filing date

1989-12-04

Publication date

1994-03-31

1989-12-04 Application filed by Sandoz Ag filed Critical Sandoz Ag

1994-03-31 Publication of PL163432B1 publication Critical patent/PL163432B1/pl

Links

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210000003169 central nervous system Anatomy 0.000 description 1
201000007455 central nervous system cancer Diseases 0.000 description 1
208000025997 central nervous system neoplasm Diseases 0.000 description 1
150000004697 chelate complex Chemical class 0.000 description 1
230000009920 chelation Effects 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
210000001072 colon Anatomy 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
238000002591 computed tomography Methods 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000011109 contamination Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
239000000539 dimer Substances 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
239000012458 free base Substances 0.000 description 1
229910052733 gallium Inorganic materials 0.000 description 1
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
238000000097 high energy electron diffraction Methods 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
238000007654 immersion Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
229910052738 indium Inorganic materials 0.000 description 1
APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
201000009019 intestinal benign neoplasm Diseases 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
201000005202 lung cancer Diseases 0.000 description 1
208000020816 lung neoplasm Diseases 0.000 description 1
239000000463 material Substances 0.000 description 1
125000002950 monocyclic group Chemical group 0.000 description 1
201000000050 myeloid neoplasm Diseases 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
238000009206 nuclear medicine Methods 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000013110 organic ligand Substances 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
125000004430 oxygen atom Chemical group O* 0.000 description 1
125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
210000003899 penis Anatomy 0.000 description 1
125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
238000000163 radioactive labelling Methods 0.000 description 1
239000012217 radiopharmaceutical Substances 0.000 description 1
229940121896 radiopharmaceutical Drugs 0.000 description 1
230000002799 radiopharmaceutical effect Effects 0.000 description 1
229910052761 rare earth metal Inorganic materials 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229940075620 somatostatin analogue Drugs 0.000 description 1
238000003756 stirring Methods 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000000542 sulfonic acid group Chemical group 0.000 description 1
GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
238000012360 testing method Methods 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
229910052716 thallium Inorganic materials 0.000 description 1
BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
210000003708 urethra Anatomy 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000012800 visualization Methods 0.000 description 1
VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Veterinary Medicine (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

PL89296879A 1988-12-05 1989-12-04 Sposób wytwarzania nowych pochodnych peptydu somatostatyny PL PL PL PL PL163432B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888828364A GB8828364D0 (en)	1988-12-05	1988-12-05	Improvements in/relating to organic compounds

Publications (1)

Publication Number	Publication Date
PL163432B1 true PL163432B1 (pl)	1994-03-31

Family

ID=10647978

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL89296879A PL163432B1 (pl)	1988-12-05	1989-12-04	Sposób wytwarzania nowych pochodnych peptydu somatostatyny PL PL PL PL

Country Status (5)

Country	Link
CY (1)	CY1893A (it)
GB (1)	GB8828364D0 (it)
IT (1)	IT1239285B (it)
PL (1)	PL163432B1 (it)
ZA (1)	ZA899285B (it)

1988
- 1988-12-05 GB GB888828364A patent/GB8828364D0/en active Pending
1989
- 1989-12-04 PL PL89296879A patent/PL163432B1/pl unknown
- 1989-12-05 ZA ZA899285A patent/ZA899285B/xx unknown
- 1989-12-06 IT IT22642A patent/IT1239285B/it active IP Right Grant
1996
- 1996-08-30 CY CY189396A patent/CY1893A/xx unknown

Also Published As

Publication number	Publication date
CY1893A (en)	1996-08-30
IT8922642A0 (it)	1989-12-06
IT1239285B (it)	1993-10-19
IT8922642A1 (it)	1991-06-06
GB8828364D0 (en)	1989-01-05
ZA899285B (en)	1991-08-28

Publication	Publication Date	Title
CA2004532C (en)	2000-02-22	Peptide derivatives
EP0436005B1 (en)	1995-03-29	Labeled polypeptide derivatives
US5650134A (en)	1997-07-22	Peptides
EP0831938B1 (en)	2008-05-21	Radiolabeled peptide compositions for site-specific targeting
CA2069154C (en)	2003-01-07	Polypeptides
US5776894A (en)	1998-07-07	Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5686410A (en)	1997-11-11	Polypeptide derivatives
US5753627A (en)	1998-05-19	Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
CZ5594A3 (en)	1994-07-13	Somatostatin polypeptides, process of their preparation and their utilization as medicaments
EP0741747A1 (en)	1996-11-13	Inhibitors of serine proteases, bearing a chelating group
PL163432B1 (pl)	1994-03-31	Sposób wytwarzania nowych pochodnych peptydu somatostatyny PL PL PL PL
CA2060537A1 (en)	1993-12-15	Msh peptide derivatives
FI101967B (fi)	1998-09-30	Menetelmä farmaseuttisesti käyttökelpoisen radionuklidin kanssa komple ksoidun ligandin valmistamiseksi