PH25036A - Process for the manufacture of isoquinolines - Google Patents

Process for the manufacture of isoquinolines

Info

Publication number
PH25036A
PH25036A PH36664A PH36664A PH25036A PH 25036 A PH25036 A PH 25036A PH 36664 A PH36664 A PH 36664A PH 36664 A PH36664 A PH 36664A PH 25036 A PH25036 A PH 25036A
Authority
PH
Philippines
Prior art keywords
isoquinolines
manufacture
formula
image
solution
Prior art date
Application number
PH36664A
Inventor
Philippe Dr Peter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PH25036A publication Critical patent/PH25036A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

Abstract

Process for the preparation of isoquinolines of the formula <IMAGE> in which R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, characterised in that a solution of an enamine of the formula <IMAGE> in which R and R' have the above meaning, is reacted in a hydrocarbon with an anhydrous solution of p-toluenesulphonic acid in toluene or xylene at elevated temperature.
PH36664A 1987-03-20 1988-03-18 Process for the manufacture of isoquinolines PH25036A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH106487 1987-03-20

Publications (1)

Publication Number Publication Date
PH25036A true PH25036A (en) 1991-01-28

Family

ID=4201606

Family Applications (1)

Application Number Title Priority Date Filing Date
PH36664A PH25036A (en) 1987-03-20 1988-03-18 Process for the manufacture of isoquinolines

Country Status (12)

Country Link
EP (1) EP0283848B1 (en)
JP (1) JP2507523B2 (en)
AT (1) ATE63545T1 (en)
AU (1) AU613605B2 (en)
CA (1) CA1310012C (en)
DE (1) DE3862787D1 (en)
DK (1) DK168625B1 (en)
HU (1) HU203876B (en)
IE (1) IE61069B1 (en)
NZ (1) NZ223879A (en)
PH (1) PH25036A (en)
ZA (1) ZA881811B (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE834103C (en) * 1950-01-03 1952-03-17 Bayer Ag Process for the preparation of 1-benzyl-1, 2, 3, 4, 5, 6, 7, 8, -octahydroisoquinoline
DE908138C (en) * 1951-01-16 1954-04-01 Hoffmann La Roche Process for the preparation of 1-benzyl-2-alkyl-1,2,3,4,5,6,7,8, -octa-hydroisoquinolines and their salts
DE1003211B (en) * 1952-06-16 1957-02-28 Hoffmann La Roche Process for the preparation of 1-benzyl-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinolines optionally substituted in the benzyl radical and their salts
DE955769C (en) * 1953-08-13 1957-01-10 Hoffmann La Roche Process for the racemization of optically active 1- (p-methoxybenzyl) -2-methyl-octahydroisoquinolines

Also Published As

Publication number Publication date
EP0283848B1 (en) 1991-05-15
NZ223879A (en) 1991-01-29
IE61069B1 (en) 1994-09-21
ATE63545T1 (en) 1991-06-15
DE3862787D1 (en) 1991-06-20
HUT49123A (en) 1989-08-28
HU203876B (en) 1991-10-28
ZA881811B (en) 1988-09-20
EP0283848A1 (en) 1988-09-28
AU613605B2 (en) 1991-08-08
DK102388D0 (en) 1988-02-26
IE880805L (en) 1988-09-20
DK168625B1 (en) 1994-05-09
AU1307488A (en) 1988-09-22
JPS63238062A (en) 1988-10-04
JP2507523B2 (en) 1996-06-12
DK102388A (en) 1988-09-21
CA1310012C (en) 1992-11-10

Similar Documents

Publication Publication Date Title
LU90159I2 (en) Difloxacin optionally in the form of a pharmaceutical salt or ester
GR76342B (en)
PT82931A (en) Process for the preparation of 1-substituted oxindole-3-carboxamides useful as antiinflammatory and analgesic agents
NZ222554A (en) Thienopyridones and pharmaceutical compositions
GB8630702D0 (en) Quinoline compound
IL103374A0 (en) Process for the preparation of substituted n-(aryl)-1,2,4-triazolopyrimidine-2-sulfonamides
PH18860A (en) Pesticidally acitve novel substituted hydroxymalonic acid diamides
OA07984A (en) Stereocontrolled process for the preparation of acetoxyazetidione.
PH25036A (en) Process for the manufacture of isoquinolines
CY1839A (en) Process for converting the lower melting polymorphic crystalline form of buspirone hydrochloride into the higher melting form thereof
GR3002486T3 (en) Substituted 5-amino-pyrazoles and fungicides containing them
DE3660762D1 (en) Process for the preparation of 2-(n-formylamino)-propionitrile
FR2567121B1 (en) IGNITION MIXTURE FOR CHEMICAL OXYGEN GENERATORS
YU94984A (en) Process for making 2-bromo-4-methyl-imidazole-5-carbonic acid
GR3001784T3 (en) Amino compounds and fungicides containing them
GB8719695D0 (en) Chemical process
GR3003715T3 (en)
EP0214566A3 (en) 3-propenyl pyridines and their use as fungicides
IN170286B (en)
FR2624951B1 (en) DEVICE FOR COOLING A BURNER
ZA882101B (en) Chemical process
YU249080A (en) Process for obtaining 6-beta-(2-(2&#39;-methylphenoxy-carbonyl)-2-thiene-3&#39;-ylacetamido)penicillanic acid
PT83526B (en) PROCESS FOR THE PREPARATION OF FUNGICIDE COMPOSITIONS BASED ON DICHLORO-3,5-PHENYL 1,2-DICARBOXIMIDE
DE3662195D1 (en) Thiophenone derivatives and process for their preparation
ES2055155T3 (en) PROCEDURE FOR OBTAINING OPTICALLY ACTIVE ACILOXIACETIDINONES.