PH23197A - Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents - Google Patents

Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents

Info

Publication number: PH23197A
Authority: PH; Philippines
Prior art keywords: phenoxyalkyl; isoxazoles; furans; antiviral agents; heterocyclic substituted
Prior art date: 1985-07-02

Application number

PH33947A

Other languages

English (en)

Inventor

Guy Dominic Diana

Philip Michael Carabateas

Original Assignee

Sterling Drug Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-02

Filing date

1986-06-25

Publication date

1989-05-29

1986-06-25 Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc

1989-05-29 Publication of PH23197A publication Critical patent/PH23197A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Furan Compounds (AREA)

PH33947A 1985-07-02 1986-06-25 Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents PH23197A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US75134885A	1985-07-02	1985-07-02

Publications (1)

Publication Number	Publication Date
PH23197A true PH23197A (en)	1989-05-29

Family

ID=25021592

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PH33948A PH22321A (en)	1985-07-02	1986-06-25	Isoxazoles and furan derivatives, their preparation and use as antiviral agents
PH33947A PH23197A (en)	1985-07-02	1986-06-25	Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PH33948A PH22321A (en)	1985-07-02	1986-06-25	Isoxazoles and furan derivatives, their preparation and use as antiviral agents

Country Status (21)

Country	Link
EP (2)	EP0207453B1 (es)
JP (2)	JPH0819128B2 (es)
KR (2)	KR900001315B1 (es)
AR (4)	AR241705A1 (es)
AT (2)	ATE80397T1 (es)
AU (2)	AU587622B2 (es)
CA (2)	CA1280753C (es)
DE (3)	DE3689924T4 (es)
DK (2)	DK171275B1 (es)
ES (5)	ES8802518A1 (es)
FI (2)	FI862795A (es)
GR (2)	GR861695B (es)
IE (2)	IE66234B1 (es)
IL (2)	IL79308A (es)
MX (4)	MX2954A (es)
MY (1)	MY102908A (es)
NO (2)	NO164977C (es)
NZ (1)	NZ216678A (es)
PH (2)	PH22321A (es)
PT (2)	PT82892B (es)
ZA (2)	ZA864872B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1280753C (en) *	1985-07-02	1991-02-26	Philip Michael Carabateas	Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
IE59813B1 (en) *	1986-05-09	1994-04-06	Warner Lambert Co	Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
US5051437A (en) *	1986-06-24	1991-09-24	Sterling Drug Inc.	Thiazolylphenoxyalkylisoxazoles, related compounds, and their use as antiviral agents
GB8807275D0 (en) *	1988-03-26	1988-04-27	Synphar Lab Inc	Chemical compounds
ES2141076T3 (es)	1988-09-01	2000-03-16	Bayer Ag	Proteina del receptor de rinovirus humano que inhibe la infectividad del virus.
US6051231A (en) *	1988-09-01	2000-04-18	Bayer Corporation	Antiviral methods and prepations
US6143298A (en) *	1988-09-01	2000-11-07	Bayer Corporation	Soluble truncated forms of ICAM-1
ZA896668B (en) *	1988-09-01	1990-06-27	Molecular Therapeutics Inc	A human rhinovirus receptor protein that inhibits virus infectivity
US6514936B1 (en)	1988-09-01	2003-02-04	Bayer Corporation	Antiviral methods using human rhinovirus receptor (ICAM-1)
US5070090A (en) *	1989-05-15	1991-12-03	Janssen Pharmaceutica N.V.	Antipicorpaviral herterocyclic-substituted morpholinyl alkylphenol ethers
GB8911158D0 (en) *	1989-05-16	1989-07-05	Janssen Pharmaceutica Nv	Antiviral pyridazinamines
US5110821A (en) *	1989-08-18	1992-05-05	Sterling Drug Inc.	1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4945164A (en) *	1989-08-18	1990-07-31	Sterling Drug Inc.	1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US4942241A (en) *	1989-08-21	1990-07-17	Sterling Drug Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
NZ234760A (en) *	1989-08-18	1991-09-25	Sterling Drug Inc	Antiviral oxazole compounds and compositions
US5175178A (en) *	1989-08-21	1992-12-29	Sterling Drug Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US6107461A (en) *	1990-07-20	2000-08-22	Bayer Corporation	Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
ES2134762T3 (es) *	1990-07-20	1999-10-16	Bayer Ag	Formas multimericas de proteinas receptoras de rinovirus humanos.
US5686581A (en) *	1990-07-20	1997-11-11	Bayer Corporation	Multimeric form of human rhinovirus receptor protein
US5686582A (en) *	1990-07-20	1997-11-11	Bayer Corporation	Multimeric forms of human rhinovirus receptor protein
IT1247509B (it) *	1991-04-19	1994-12-17	Univ Cagliari	Composti di sintesi atti all'impiego nella terapia delle infezioni da rhinovirus
US5175177A (en) *	1991-07-17	1992-12-29	Sterling Drug Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) *	1992-04-15	1994-09-20	Sterling Winthrop Inc.	1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5514781A (en) *	1994-04-11	1996-05-07	Bayer Corporation	Use of azoles as virucidal agents in solutions of biologically active proteins
US5453433A (en) *	1994-05-13	1995-09-26	Sterling Winthrop Inc.	Thiadiazoles and antipicornaviral compositions
US5514679A (en) *	1994-05-13	1996-05-07	Sterling Winthrop Inc.	Therapeutic phenoxyalklpyridazines and intermediates therefor
KR100796093B1 (ko)	2003-07-02	2008-01-21	에프. 호프만-라 로슈 아게	티아졸 고리로 치환된 인돌릴 유도체 및 ｐｐａｒ조절제로서 그의 용도
US7790720B2 (en)	2005-03-31	2010-09-07	Ucb Pharma, S.A.	Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
US8993604B2 (en)	2009-06-30	2015-03-31	Siga Technologies, Inc.	Treatment and prevention of dengue virus infections
BRPI1009034A2 (pt) *	2009-06-30	2019-09-24	Siga Tech Inc	composição farmacêutica e método para o tratamento ou profilaxia de uma infecção viral ou doença associada a mesma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4451476A (en) *	1982-12-13	1984-05-29	Sterling Drug Inc.	Isoxazoles as antiviral agents
NZ209209A (en) *	1983-08-29	1988-02-12	Sterling Drug Inc	Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions
CA1280753C (en) *	1985-07-02	1991-02-26	Philip Michael Carabateas	Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans

1986
- 1986-06-24 CA CA000512258A patent/CA1280753C/en not_active Expired - Lifetime
- 1986-06-24 CA CA000512264A patent/CA1299176C/en not_active Expired - Lifetime
- 1986-06-25 ES ES556812A patent/ES8802518A1/es not_active Expired
- 1986-06-25 PH PH33948A patent/PH22321A/en unknown
- 1986-06-25 ES ES556811A patent/ES8802517A1/es not_active Expired
- 1986-06-25 PH PH33947A patent/PH23197A/en unknown
- 1986-06-26 DE DE3689924T patent/DE3689924T4/de not_active Expired - Lifetime
- 1986-06-26 DE DE8686108745T patent/DE3686677T2/de not_active Expired - Fee Related
- 1986-06-26 AT AT86108745T patent/ATE80397T1/de not_active IP Right Cessation
- 1986-06-26 IE IE172386A patent/IE66234B1/en not_active IP Right Cessation
- 1986-06-26 DE DE3689924A patent/DE3689924D1/de not_active Expired - Fee Related
- 1986-06-26 EP EP86108744A patent/EP0207453B1/en not_active Expired - Lifetime
- 1986-06-26 IE IE172486A patent/IE59755B1/en not_active IP Right Cessation
- 1986-06-26 EP EP86108745A patent/EP0207454B1/en not_active Expired - Lifetime
- 1986-06-26 NZ NZ216678A patent/NZ216678A/xx unknown
- 1986-06-26 AT AT86108744T patent/ATE107645T1/de not_active IP Right Cessation
- 1986-06-27 MX MX295486A patent/MX2954A/es unknown
- 1986-06-30 GR GR861695A patent/GR861695B/el unknown
- 1986-06-30 GR GR861697A patent/GR861697B/el unknown
- 1986-07-01 KR KR1019860005308A patent/KR900001315B1/ko not_active IP Right Cessation
- 1986-07-01 AU AU59456/86A patent/AU587622B2/en not_active Ceased
- 1986-07-01 IL IL79308A patent/IL79308A/xx not_active IP Right Cessation
- 1986-07-01 FI FI862795A patent/FI862795A/fi not_active Application Discontinuation
- 1986-07-01 PT PT82892A patent/PT82892B/pt active IP Right Grant
- 1986-07-01 NO NO862651A patent/NO164977C/no not_active IP Right Cessation
- 1986-07-01 ZA ZA864872A patent/ZA864872B/xx unknown
- 1986-07-01 ZA ZA864873A patent/ZA864873B/xx unknown
- 1986-07-01 NO NO862650A patent/NO165023C/no not_active IP Right Cessation
- 1986-07-01 PT PT82891A patent/PT82891B/pt not_active IP Right Cessation
- 1986-07-01 DK DK312986A patent/DK171275B1/da not_active IP Right Cessation
- 1986-07-01 FI FI862794A patent/FI85021C/fi not_active IP Right Cessation
- 1986-07-01 AU AU59457/86A patent/AU589190B2/en not_active Ceased
- 1986-07-01 DK DK198603130A patent/DK173467B1/da not_active IP Right Cessation
- 1986-07-01 IL IL79309A patent/IL79309A/xx not_active IP Right Cessation
- 1986-07-01 KR KR1019860005307A patent/KR900001314B1/ko not_active IP Right Cessation
- 1986-07-02 JP JP61155927A patent/JPH0819128B2/ja not_active Expired - Fee Related
- 1986-07-02 AR AR86304418A patent/AR241705A1/es active
- 1986-07-02 JP JP61155928A patent/JPH0768242B2/ja not_active Expired - Fee Related
1987
- 1987-09-28 MY MYPI87002033A patent/MY102908A/en unknown
- 1987-12-04 ES ES557778A patent/ES8802153A1/es not_active Expired
- 1987-12-07 ES ES557780A patent/ES8801651A1/es not_active Expired
- 1987-12-07 ES ES557779A patent/ES8801649A1/es not_active Expired
1990
- 1990-03-07 AR AR90316339A patent/AR242572A1/es active
- 1990-03-28 AR AR90316484A patent/AR242573A1/es active
- 1990-03-28 AR AR90316483A patent/AR244686A1/es active
1991
- 1991-06-28 MX MX9100032A patent/MX9100032A/es unknown
- 1991-06-28 MX MX9100033A patent/MX9100033A/es unknown
- 1991-06-28 MX MX9100029A patent/MX9100029A/es unknown

Also Published As

Publication number	Publication date
DE3689924T2 (de)	1995-01-19
NO862651L (no)	1987-01-05
AU5945786A (en)	1987-01-08
ZA864872B (en)	1987-02-25
ZA864873B (en)	1987-02-25
IL79309A (en)	1990-11-29
DK312986D0 (da)	1986-07-01
AU5945686A (en)	1987-01-08
AR242573A1 (es)	1993-04-30
FI862794A0 (fi)	1986-07-01
EP0207453A3 (en)	1988-11-23
NO862650D0 (no)	1986-07-01
KR900001315B1 (ko)	1990-03-08
ES8802517A1 (es)	1988-07-01
ES8802153A1 (es)	1988-04-01
NO165023B (no)	1990-09-03
GR861695B (en)	1986-11-04
KR870001202A (ko)	1987-03-12
NO165023C (no)	1990-12-12
EP0207454A3 (en)	1988-08-10
FI862795A (fi)	1987-01-03
IL79308A0 (en)	1986-10-31
EP0207453B1 (en)	1994-06-22
ES557779A0 (es)	1988-02-16
ATE107645T1 (de)	1994-07-15
JPH0768242B2 (ja)	1995-07-26
ATE80397T1 (de)	1992-09-15
MY102908A (en)	1993-03-31
DK173467B1 (da)	2000-12-04
FI862795A0 (fi)	1986-07-01
DK312986A (da)	1987-01-03
FI862794A (fi)	1987-01-03
ES8801649A1 (es)	1988-02-16
NO862651D0 (no)	1986-07-01
IE59755B1 (en)	1994-03-23
EP0207454B1 (en)	1992-09-09
EP0207453A2 (en)	1987-01-07
IL79309A0 (en)	1986-10-31
ES557778A0 (es)	1988-04-01
JPS6216480A (ja)	1987-01-24
FI85021B (fi)	1991-11-15
CA1280753C (en)	1991-02-26
AU587622B2 (en)	1989-08-24
KR870001205A (ko)	1987-03-12
NO164977C (no)	1990-12-05
ES8802518A1 (es)	1988-07-01
KR900001314B1 (ko)	1990-03-08
GR861697B (en)	1986-11-04
DE3686677T2 (de)	1993-03-11
NZ216678A (en)	1989-10-27
DE3689924D1 (de)	1994-07-28
DK171275B1 (da)	1996-08-19
PT82891A (en)	1986-08-01
PH22321A (en)	1988-07-29
IE66234B1 (en)	1995-12-13
NO862650L (no)	1987-01-05
NO164977B (no)	1990-08-27
PT82892B (pt)	1994-09-30
CA1299176C (en)	1992-04-21
AU589190B2 (en)	1989-10-05
IE861724L (en)	1987-01-02
DE3686677D1 (de)	1992-10-15
AR242572A1 (es)	1993-04-30
MX2954A (es)	1993-11-01
FI85021C (fi)	1992-02-25
MX9100032A (es)	1993-01-01
DK313086A (da)	1987-01-03
PT82892A (pt)	1987-01-26
ES557780A0 (es)	1988-02-16
ES556811A0 (es)	1988-07-01
PT82891B (pt)	1988-05-27
EP0207454A2 (en)	1987-01-07
ES556812A0 (es)	1988-07-01
DK313086D0 (da)	1986-07-01
MX9100029A (es)	1993-01-01
AR244686A1 (es)	1993-11-30
JPS6216479A (ja)	1987-01-24
ES8801651A1 (es)	1988-02-16
IE861723L (en)	1987-01-02
AR241705A1 (es)	1992-11-30
MX9100033A (es)	1993-01-01
DE3689924T4 (de)	1995-05-11
JPH0819128B2 (ja)	1996-02-28
IL79308A (en)	1991-01-31

Publication	Publication Date	Title
PH23197A (en)	1989-05-29	Heterocyclic substituted-phenoxyalkyl-isoxazoles and furans and use as antiviral agents
PH23081A (en)	1989-04-10	Avermectin derivatives and the use thereof as antiparasitic agents
PH23785A (en)	1989-11-03	Nucleosides and their use as anti-neoplastic agents
EP0204659A3 (en)	1988-06-08	Polyepoxydes and their use
PH24714A (en)	1990-10-01	Poly-4-aminopyrrole-2-carbosamido derivatives and their use as antiviral or antitumos agents
GB8504481D0 (en)	1985-03-27	Circuitry
GB8531549D0 (en)	1986-02-05	Undercarriage arrangement
PH21817A (en)	1988-03-04	Nitrogen containing heterocyclic compounds and their use
IL71679A0 (en)	1984-07-31	Hydroxyethyl-azolyl derivatives and antiviral agents containing them
DE3660256D1 (en)	1988-07-07	Camphor-di-thiolene-complexes and their use
GB8503424D0 (en)	1985-03-13	Heterocyclic derivatives
GR860648B (en)	1986-07-11	Heterocyclic sulfides and their use as immunmodulators
GR861727B (en)	1986-10-30	5-substituted-6-aminopyridine derivatives composition and uses
IL78446A0 (en)	1986-08-31	Orthopedic waistcoat
GB2183235B (en)	1989-10-25	Substituted benzylhydroxylamines and their use as stabilizers
GB8601760D0 (en)	1986-02-26	Protective circuitry
EP0189300A3 (en)	1987-05-20	Dihydrotriazole derivatives and their use as herbicides
GB8628049D0 (en)	1986-12-31	Use of tetrahydrobenzothienylurea derivatives
GB2211185B (en)	1991-07-10	Uridine derivatives and antiviral agents containing them
GR860649B (en)	1986-07-11	Heterocyclic disulfides and their use as immunmodulators
CY1620A (en)	1992-07-10	Thiadiazole antiviral agents
EP0440710A4 (en)	1992-03-18	New antiviral agents
GR861370B (en)	1986-09-17	N-phenyl-4-phenyl-1-piperazine carboxamidines and related compounds as antiarrythmic agents
GB8507808D0 (en)	1985-05-01	Heterocyclic herbicides
GB8518213D0 (en)	1985-08-29	Heterocyclic pentalenes