PE31095A1 - Derivados cristalinos del acido n-acetil neuraminico y procesos para su preparacion - Google Patents
Derivados cristalinos del acido n-acetil neuraminico y procesos para su preparacionInfo
- Publication number
- PE31095A1 PE31095A1 PE1994257245A PE25724594A PE31095A1 PE 31095 A1 PE31095 A1 PE 31095A1 PE 1994257245 A PE1994257245 A PE 1994257245A PE 25724594 A PE25724594 A PE 25724594A PE 31095 A1 PE31095 A1 PE 31095A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- processes
- guanidino
- neuraminic acid
- acetyl neuraminic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A FORMAS CRISTALINAS DEL ACIDO 5-ACETAMIDO-2,3,4,5-TETRADESOXI-4-GUANIDINO-D-GLICERO-D-GALACTO-NON-2-ENOPIRANOSONICO (ANALOGO 4-GUANIDINO DE DANA), UTIL COMO FARMACO ANTIVIRAL, DE FORMULA GENERAL I, TALES COMO: 1) UN MONOHIDRATO TABULAR QUE PUEDE CAPTAR AGUA DEPENDIENDO DE LA HUMEDAD RELATIVA DEL MEDIO AMBIENTE, AL PERDER ENTRE 80ºC A 90ºC SU AGUA DE CRISTALIZACION, ES ADECUADO PARA LA MICRONIZACION Y SE OBTIENE A PARTIR DE UNA SOLUCION ACUOSA RELATIVAMENTE CONCENTRADA A UNA TEMPERATURA ENTRE 50º A 55ºC QUE ES SEMBRADA CON CRISTALES; 2) UN DIHIDRATO EN AGUJAS, ESTABLE A LA HUMEDAD, QUE PIERDE SU AGUA DE CRISTALIZACION ENTRE 84º A 90ºC Y 135ºC A 143ºC, ES ADECUADO PARA LA PREPARACION DE SOLUCIONES Y SUSPENSIONES ACUOSAS Y SE OBTIENE A PARTIR DE UNA SOLUCION ACUOSA RELATIVAMENTE DILUIDA A UNA TEMPERATURA ENTRE 20ºC A 30ºC A LA QUE SE ADICIONA UN CONTRASOLVENTE COMO ACETONA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939325841A GB9325841D0 (en) | 1993-12-17 | 1993-12-17 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE31095A1 true PE31095A1 (es) | 1995-10-18 |
Family
ID=10746778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1994257245A PE31095A1 (es) | 1993-12-17 | 1994-12-15 | Derivados cristalinos del acido n-acetil neuraminico y procesos para su preparacion |
Country Status (44)
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9325841D0 (en) * | 1993-12-17 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
| US5866601A (en) * | 1995-02-27 | 1999-02-02 | Gilead Sciences, Inc. | Carbocyclic compounds |
| WO1996026933A1 (en) | 1995-02-27 | 1996-09-06 | Gilead Sciences, Inc. | Novel selective inhibitors of viral or bacterial neuraminidases |
| US5763483A (en) * | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
| US6451766B1 (en) | 1996-07-22 | 2002-09-17 | Sankyo Company, Limited | Neuraminic acid derivatives, their preparation and their medical use |
| US6340702B1 (en) | 1996-07-22 | 2002-01-22 | Sankyo Company, Limited | Neuraminic acid derivatives, their preparation and their medical use |
| ES2167682T3 (es) * | 1996-07-22 | 2002-05-16 | Sankyo Co | Derivados del acido neuraminico, su preparacion y su uso medico. |
| US5859284A (en) * | 1996-08-23 | 1999-01-12 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
| US6518438B2 (en) | 1996-08-23 | 2003-02-11 | Gilead Sciences, Inc. | Preparation of cyclohexene carboxylate derivatives |
| US5994377A (en) * | 1996-10-21 | 1999-11-30 | Gilead Sciences, Inc. | Piperidine compounds |
| US5886213A (en) * | 1997-08-22 | 1999-03-23 | Gilead Sciences, Inc. | Preparation of carbocyclic compounds |
| TW480247B (en) * | 1997-12-12 | 2002-03-21 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
| TWI291462B (en) | 2000-04-25 | 2007-12-21 | Daiichi Sankyo Co Ltd | Hydrate crystal of neuraminic acid compound |
| US20080063722A1 (en) * | 2006-09-08 | 2008-03-13 | Advanced Inhalation Research, Inc. | Composition of a Spray-Dried Powder for Pulmonary Delivery of a Long Acting Neuraminidase Inhibitor (LANI) |
| BR112014014635A2 (pt) * | 2011-12-16 | 2017-06-13 | Daiichi Sankyo Co Ltd | método para fabricar um composto, e, composto |
| CN109232677B (zh) * | 2018-10-18 | 2021-12-28 | 中国科学院合肥物质科学研究院 | 一种使n-乙酰神经氨酸水合物转化为n-乙酰神经氨酸的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ288492B6 (en) * | 1990-04-24 | 2001-06-13 | Biota Scient Management | Derivatives of alpha-D-neuraminic acid, process of their preparation, their use and pharmaceutical preparations based thereon |
| CA2081068C (en) * | 1991-10-23 | 2005-11-29 | Laurence Mark Von Itzstein | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of .alpha.-d-neuraminic acid |
| US5639786A (en) | 1992-12-04 | 1997-06-17 | Biota Scientific Management, Pty., Ltd. | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of α-D-neuraninic acid |
| GB9325841D0 (en) * | 1993-12-17 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
-
1993
- 1993-12-17 GB GB939325841A patent/GB9325841D0/en active Pending
-
1994
- 1994-12-02 TW TW083111229A patent/TW452577B/zh not_active IP Right Cessation
- 1994-12-13 IS IS4240A patent/IS4240A/is unknown
- 1994-12-15 EG EG79094A patent/EG20597A/xx active
- 1994-12-15 SK SK785-96A patent/SK282972B6/sk not_active IP Right Cessation
- 1994-12-15 RU RU96115122A patent/RU2134690C1/ru active Protection Beyond IP Right Term
- 1994-12-15 ZA ZA9410003A patent/ZA9410003B/xx unknown
- 1994-12-15 CN CNA2003101199989A patent/CN1502621A/zh active Pending
- 1994-12-15 NZ NZ277789A patent/NZ277789A/en not_active IP Right Cessation
- 1994-12-15 PL PL94315055A patent/PL186384B1/pl unknown
- 1994-12-15 CA CA002177990A patent/CA2177990C/en not_active Expired - Lifetime
- 1994-12-15 AP APAP/P/1996/000810A patent/AP9600810A0/en unknown
- 1994-12-15 EE EE9600135A patent/EE03353B1/xx unknown
- 1994-12-15 CO CO94056728A patent/CO4340619A1/es unknown
- 1994-12-15 HR HR941001A patent/HRP941001B1/xx not_active IP Right Cessation
- 1994-12-15 CN CN94194973A patent/CN1132829C/zh not_active Expired - Lifetime
- 1994-12-15 SI SI9430333T patent/SI0734382T1/xx unknown
- 1994-12-15 PT PT95904472T patent/PT734382E/pt unknown
- 1994-12-15 UA UA96062328A patent/UA46723C2/uk unknown
- 1994-12-15 KR KR1019960703180A patent/KR100403256B1/ko not_active IP Right Cessation
- 1994-12-15 SG SG1996007725A patent/SG46669A1/en unknown
- 1994-12-15 JP JP51653195A patent/JP3317972B2/ja not_active Expired - Lifetime
- 1994-12-15 MA MA23724A patent/MA23396A1/fr unknown
- 1994-12-15 EP EP95904472A patent/EP0734382B1/en not_active Expired - Lifetime
- 1994-12-15 ES ES95904472T patent/ES2155517T3/es not_active Expired - Lifetime
- 1994-12-15 PE PE1994257245A patent/PE31095A1/es not_active Application Discontinuation
- 1994-12-15 MY MYPI94003357A patent/MY116221A/en unknown
- 1994-12-15 CZ CZ19961693A patent/CZ289234B6/cs not_active IP Right Cessation
- 1994-12-15 SV SV1994000076A patent/SV1994000076A/es active IP Right Grant
- 1994-12-15 HU HU9601642A patent/HU221971B1/hu active IP Right Grant
- 1994-12-15 AP APAP/P/1994/000705A patent/AP541A/en active
- 1994-12-15 DK DK95904472T patent/DK0734382T3/da active
- 1994-12-15 RO RO96-01195A patent/RO114792B1/ro unknown
- 1994-12-15 AT AT95904472T patent/ATE199255T1/de active
- 1994-12-15 DE DE69426726T patent/DE69426726T2/de not_active Expired - Lifetime
- 1994-12-15 BR BR9408340A patent/BR9408340A/pt not_active Application Discontinuation
- 1994-12-15 WO PCT/EP1994/004154 patent/WO1995016680A1/en active IP Right Grant
- 1994-12-16 IL IL11201194A patent/IL112011A/en not_active IP Right Cessation
- 1994-12-28 SA SA94150417A patent/SA94150417B1/ar unknown
-
1996
- 1996-06-13 FI FI962464A patent/FI120453B/fi not_active IP Right Cessation
- 1996-06-14 OA OA60842A patent/OA10325A/fr unknown
- 1996-06-14 NO NO19962545A patent/NO314759B1/no not_active IP Right Cessation
- 1996-07-08 BG BG100709A patent/BG63338B1/bg unknown
-
1997
- 1997-05-13 BR BRPP1100548-KB1A patent/BR1100548KB1/pt unknown
-
1998
- 1998-12-24 HK HK98115499A patent/HK1014187A1/xx not_active IP Right Cessation
-
1999
- 1999-07-02 US US09/346,583 patent/US6294572B1/en not_active Expired - Lifetime
-
2000
- 2000-01-06 OA OA1200000004A patent/OA11275A/fr unknown
-
2001
- 2001-03-30 GR GR20010400531T patent/GR3035681T3/el unknown
- 2001-09-24 US US09/961,074 patent/US20020037865A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |