PE20230820A1 - Derivados de biarilo como inhibidores de la interaccion proteina-proteina de yap/taz-tead - Google Patents

Derivados de biarilo como inhibidores de la interaccion proteina-proteina de yap/taz-tead

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Publication number
PE20230820A1
PE20230820A1 PE2022001962A PE2022001962A PE20230820A1 PE 20230820 A1 PE20230820 A1 PE 20230820A1 PE 2022001962 A PE2022001962 A PE 2022001962A PE 2022001962 A PE2022001962 A PE 2022001962A PE 20230820 A1 PE20230820 A1 PE 20230820A1
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Peru
Prior art keywords
halo
heteroatom
protein
yap
taz
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PE2022001962A
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English (en)
Inventor
Vincent Bordas
Cara Brocklehurst
Patrick Chene
Zhongbo Fei
Pascal Furet
Vito Guagnano
Patricia Imbach-Weese
Joerg Kallen
Douget Mickael Le
Jialiang Li
Wei Li
Edwige Liliane Jeanne Lorthiois
Joseph Mckenna
Bahaa Salem
Tobias Schmelzle
Holger Sellner
Nicolas Soldermann
Markus Voegtle
Markus Wartmann
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Novartis Ag
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Publication of PE20230820A1 publication Critical patent/PE20230820A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

Referido a un compuesto derivado de biarilo de formula (I) o una sal farmaceuticamente aceptable del mismo, en donde W se selecciona entre O y CH-Rw; X se selecciona entre CH y N; Y se selecciona entre CH y N; Z se selecciona entre CH2, O y NH; en donde cuando Y es N, W es CH-Rw, y Z es O; A se selecciona entre: fenilo, opcionalmente sustituido con halo o haloalcoxi C1-C3; un anillo heterociclico aromatico de 5 o 6 miembros que comprende por lo menos un heteroatomo seleccionado entre N, O, y S; entre otros; Q se selecciona entre -C(R7)2-N(R8)-R1; heteroarilo parcialmente saturado de 9 o 10 miembros que comprende por lo menos un heteroatomo N; y un anillo heterociclico de 4, 5, o 6 miembros que comprende por lo menos un heteroatomo o grupo de heteroatomo seleccionado entre N, O, S, -S(=O) y -S(=O)2; R2 se selecciona entre hidrogeno y halo; R3 se selecciona entre halo, haloalquilo C1-C3 y ciano; R4 se selecciona entre H, halo; y alquilo C1-C3; R5 se selecciona entre H, alcoxi C1-C6 opcionalmente sustituido con cicloalquilo C3-C6, CO2H, SO2 alquilo C1-C3, entre otros; R6 se selecciona entre H, ciano, C(O)NHR6a, entre otros. Un compuesto seleccionado es 2-((2S,4S)-2-(aminometil)-5-cloro-2-fenil-2,3-dihidrobenzofuran-4-il)-3-fluorobenzamida. Dichos compuestos son inhibidores de la interaccion proteina-proteina de YAP/TAZ-TEAD. Tambien se refiere a una composicion farmaceutica que comprende dichos compuestos; un proceso para la preparacion de dicho compuesto y su uso en el tratamiento de cancer o tumor particularmente en el tratamiento del mesotelioma (incluido el mesotelioma pleural maligno), cancer de pancreas, sarcoma y cancer de pulmon de celulas no pequenas.
PE2022001962A 2020-03-16 2021-03-15 Derivados de biarilo como inhibidores de la interaccion proteina-proteina de yap/taz-tead PE20230820A1 (es)

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PCT/IB2021/052136 WO2021186324A1 (en) 2020-03-16 2021-03-15 Biaryl derivatives as yap/taz-tead protein-protein interaction inhibitors

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023031801A1 (en) 2021-09-01 2023-03-09 Novartis Ag Bifunctional degraders comprising a tead binder
CN117835977A (zh) 2021-09-01 2024-04-05 诺华股份有限公司 Tead抑制剂的给药方案
CA3224341A1 (en) 2021-09-01 2023-03-09 Novartis Ag Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
CA3230505A1 (en) 2021-09-01 2023-03-09 Novartis Ag Crystalline forms of biaryl yap/taz-tead protein-protein interaction inhibitors
WO2023099592A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099620A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes
WO2023099612A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023099608A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
TW202340208A (zh) 2021-12-01 2023-10-16 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
TW202337431A (zh) 2021-12-01 2023-10-01 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
CA3223728A1 (en) * 2021-12-02 2023-06-08 Jian Chen Aromatic compound, pharmaceutical composition, and application thereof
WO2023137634A1 (zh) * 2022-01-19 2023-07-27 上海奕拓医药科技有限责任公司 三并环化合物、其制备、药物组合物及应用
WO2023155927A1 (zh) * 2022-02-21 2023-08-24 上海奕拓医药科技有限责任公司 Yap/taz与tead相互作用的抑制剂、其制备、药物组合物及应用
KR20240014034A (ko) * 2022-07-21 2024-01-31 주식회사 바오밥에이바이오 헤테로비시클릭 화합물 및 그를 포함하는 약제학적조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005010000A1 (de) * 2005-03-04 2006-09-07 Merck Patent Gmbh Indane
TW201028414A (en) 2009-01-16 2010-08-01 Merck Sharp & Dohme Oxadiazole beta carboline derivatives as antidiabetic compounds
EP2406243B1 (en) * 2009-03-10 2014-05-07 Takeda Pharmaceutical Company Limited Benzofuran derivatives
EP3156404A1 (en) * 2015-10-15 2017-04-19 Inventiva New compounds inhibitors of the yap/taz-tead interaction and their use in the treatment of malignant mesothelioma
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
WO2019232216A1 (en) * 2018-05-31 2019-12-05 Genentech, Inc. Therapeutic compounds
US20210236476A1 (en) * 2018-08-29 2021-08-05 Chemocentryx, Inc. Methods of treating cancer with small molecule pd-l1 inhibitors
EP3847154A1 (en) * 2018-09-03 2021-07-14 F. Hoffmann-La Roche AG Carboxamide and sulfonamide derivatives useful as tead modulators

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