PE20160030A1 - COMPOSICIONES DE ARNi DE SERPINA 1 Y SUS METODOS DE USO - Google Patents

COMPOSICIONES DE ARNi DE SERPINA 1 Y SUS METODOS DE USO

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Publication number
PE20160030A1
PE20160030A1 PE2015002439A PE2015002439A PE20160030A1 PE 20160030 A1 PE20160030 A1 PE 20160030A1 PE 2015002439 A PE2015002439 A PE 2015002439A PE 2015002439 A PE2015002439 A PE 2015002439A PE 20160030 A1 PE20160030 A1 PE 20160030A1
Authority
PE
Peru
Prior art keywords
methods
rnai
serpine
compositions
rnai agents
Prior art date
Application number
PE2015002439A
Other languages
English (en)
Inventor
Brian Bettencourt
Klaus Charisse
Gregory Hinkle
Alfica Sehgal
Muthiah Manoharan
Kallanthottathil G Rajeev
Martin Maier
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of PE20160030A1 publication Critical patent/PE20160030A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

La invencion se refiere a los agentes de ARNi, por ejemplo, agentes de ARNi bicatenario, dirigidos al gen de Serpina1, y metodos de uso de tales agentes de ARNi para inhibir la expresion de Serpina1 y metodos de tratamiento de los sujetos que tienen una enfermedad asociada con Serpina1, tal como un trastorno hepatico
PE2015002439A 2013-05-22 2014-05-22 COMPOSICIONES DE ARNi DE SERPINA 1 Y SUS METODOS DE USO PE20160030A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361826125P 2013-05-22 2013-05-22
US201361898695P 2013-11-01 2013-11-01
US201461979727P 2014-04-15 2014-04-15
US201461989028P 2014-05-06 2014-05-06

Publications (1)

Publication Number Publication Date
PE20160030A1 true PE20160030A1 (es) 2016-02-14

Family

ID=51934144

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2015002439A PE20160030A1 (es) 2013-05-22 2014-05-22 COMPOSICIONES DE ARNi DE SERPINA 1 Y SUS METODOS DE USO
PE2020001926A PE20210921A1 (es) 2013-05-22 2014-05-22 Agentes arni como inhibidores de la transcripcion de la serpina 1 y composiciones que los comprenden

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2020001926A PE20210921A1 (es) 2013-05-22 2014-05-22 Agentes arni como inhibidores de la transcripcion de la serpina 1 y composiciones que los comprenden

Country Status (33)

Country Link
US (5) US9574192B2 (es)
EP (2) EP2999785B1 (es)
JP (3) JP6495250B2 (es)
KR (3) KR20220154244A (es)
CN (2) CN105408481B (es)
AU (2) AU2014268509B2 (es)
BR (1) BR112015029139B1 (es)
CA (1) CA2912826A1 (es)
CL (1) CL2015003441A1 (es)
CY (1) CY1122159T1 (es)
DK (1) DK2999785T3 (es)
DO (1) DOP2015000288A (es)
EA (1) EA038792B1 (es)
ES (1) ES2676146T3 (es)
GT (1) GT201500330A (es)
HK (1) HK1221979A1 (es)
HR (1) HRP20181030T1 (es)
HU (1) HUE038146T2 (es)
IL (3) IL242637B (es)
LT (1) LT2999785T (es)
MX (1) MX2021000656A (es)
MY (1) MY176712A (es)
PE (2) PE20160030A1 (es)
PL (1) PL2999785T3 (es)
PT (1) PT2999785T (es)
RS (1) RS57418B1 (es)
RU (1) RU2015154721A (es)
SG (3) SG10201804472YA (es)
SI (1) SI2999785T1 (es)
TW (2) TW201936624A (es)
UY (1) UY35582A (es)
WO (1) WO2014190137A1 (es)
ZA (1) ZA201509252B (es)

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WO2018013912A1 (en) * 2016-07-15 2018-01-18 The Board Of Regents Of The University Of Oklahoma Anti-arid3a treatments for inflammatory disorders
TWI788312B (zh) * 2016-11-23 2023-01-01 美商阿尼拉製藥公司 絲胺酸蛋白酶抑制因子Ａ１ ｉＲＮＡ組成物及其使用方法
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EP3600345A4 (en) * 2017-03-29 2021-01-06 Cornell University OXIDATION-RESISTANT AAT GENE THERAPY
KR20200086670A (ko) 2017-10-13 2020-07-17 셀렉타 바이오사이언시즈, 인크. 항바이러스 전달 벡터 IgM 반응을 약화시키기 위한 방법 및 조성물
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TW202016304A (zh) 2018-05-14 2020-05-01 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
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