PE20151163A1 - Derivados de imidazopiridazina como moduladores del receptor gabaa - Google Patents
Derivados de imidazopiridazina como moduladores del receptor gabaaInfo
- Publication number
- PE20151163A1 PE20151163A1 PE2015000912A PE2015000912A PE20151163A1 PE 20151163 A1 PE20151163 A1 PE 20151163A1 PE 2015000912 A PE2015000912 A PE 2015000912A PE 2015000912 A PE2015000912 A PE 2015000912A PE 20151163 A1 PE20151163 A1 PE 20151163A1
- Authority
- PE
- Peru
- Prior art keywords
- gabaa receptor
- receptor modulators
- derivatives
- imidazopyridazine derivatives
- imidazopyridazine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invencion se refiere a derivados de imidazopiridazina. Particularmente, se refiere a derivados de 4-(bifenil-3-il)-7H-imidazo[4,5-c]piridazina de la Formula (I): donde R1 y R2 son -CH2-CH2-, -N(NH3)-CH2; R3 es H, F, CN, etc; R4 es H, F, Cl; R5 es (C2-C4)alquilo. Los derivados de imidazopiridazina de la presente invencion modulan la actividad del receptor GABAA. Son utiles para el tratamiento de diversas afecciones, por ejemplo, el dolor
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261737157P | 2012-12-14 | 2012-12-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20151163A1 true PE20151163A1 (es) | 2015-08-14 |
Family
ID=49880883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015000912A PE20151163A1 (es) | 2012-12-14 | 2013-12-04 | Derivados de imidazopiridazina como moduladores del receptor gabaa |
Country Status (44)
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015189744A1 (en) * | 2014-06-12 | 2015-12-17 | Pfizer Limited | Imidazopyridazine derivatives as modulators of the gabaa receptor activity. |
AU2015295287B2 (en) | 2014-07-31 | 2019-07-04 | Basf Se | Process for preparing pyrazoles |
MX2017014287A (es) | 2015-05-11 | 2018-03-07 | Basf Se | Proceso para preparar 4-amino-piridazinas. |
EP3386983A1 (en) | 2015-12-10 | 2018-10-17 | Pfizer Limited | 4-(biphen-3-yl)-1h-pyrazolo[3,4-c]pyridazine derivatives of formula (i) as gaba receptor modulators for use in the treatment of epilepsy and pain |
UY37412A (es) * | 2016-09-23 | 2018-04-30 | Novartis Ag | Compuestos de indazol para uso en lesiones de tendones y/o ligamentos |
JOP20190053A1 (ar) * | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
WO2018082964A1 (en) | 2016-11-04 | 2018-05-11 | Basf Se | Process for the production of pyridazinyl-amides in a one-pot synthesis |
JP7119003B2 (ja) | 2017-05-02 | 2022-08-16 | バイエル・アクチエンゲゼルシヤフト | 有害生物防除剤としての2-(ヘタ)アリール置換縮合二環式ヘテロ環式誘導体 |
CN117695286A (zh) * | 2017-06-06 | 2024-03-15 | 住友制药(苏州)有限公司 | 使用维贝隆以治疗膀胱过度活动症 |
EP3796907A4 (en) * | 2018-05-22 | 2021-11-03 | Neurocycle Therapeutics, Inc. | GABAA POSITIVE ALLOSTERIC MODULATING COMPOUNDS FOR THE TREATMENT OF PRURITUS AND / OR DERMATITIS |
TWI752400B (zh) * | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
CN116693555A (zh) * | 2022-02-25 | 2023-09-05 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
CN117069725A (zh) * | 2022-05-10 | 2023-11-17 | 上海赛默罗生物科技有限公司 | 咪唑并哒嗪取代苯环类衍生物、制备方法、药物组合物及用途 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
US6365589B1 (en) * | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
US6936608B2 (en) | 2000-11-10 | 2005-08-30 | Merck Sharp & Dohme Ltd. | Imidazo-triazine derivatives as ligands for GABA receptors |
GB0117277D0 (en) * | 2001-07-16 | 2001-09-05 | Merck Sharp & Dohme | Therapeutic agents |
US20090023737A1 (en) * | 2004-02-12 | 2009-01-22 | Neurogen Corporation | Imidazo-Pyridazines, Triazolo-Pyridazines and Related Benzodiazepine Receptor Ligands |
EP1838152A2 (en) | 2005-01-21 | 2007-10-03 | Neurogen Corporation | Imidazolylmethyl and pyrazolylmethyl heteroaryl derivatives |
EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
DE602008000809D1 (de) | 2007-03-23 | 2010-04-29 | Icagen Inc | Ionenkanal-Hemmer |
DK2385938T3 (en) | 2009-01-12 | 2015-04-27 | Pfizer Ltd | Sulfonamidderivater |
MX2012004990A (es) * | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
WO2012004714A2 (en) * | 2010-07-09 | 2012-01-12 | Pfizer Limited | Chemical compounds |
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2013
- 2013-04-12 UA UAA201504677A patent/UA112028C2/uk unknown
- 2013-12-04 BR BR112015014097-1A patent/BR112015014097B1/pt active IP Right Grant
- 2013-12-04 GE GEAP201313849A patent/GEP201706710B/en unknown
- 2013-12-04 MA MA38112A patent/MA38112B1/fr unknown
- 2013-12-04 LT LTEP13812165.2T patent/LT2938615T/lt unknown
- 2013-12-04 CU CUP2015000058A patent/CU24338B1/es unknown
- 2013-12-04 SI SI201330382T patent/SI2938615T1/sl unknown
- 2013-12-04 JP JP2015547219A patent/JP5869740B2/ja active Active
- 2013-12-04 DK DK13812165.2T patent/DK2938615T3/da active
- 2013-12-04 PL PL13812165T patent/PL2938615T3/pl unknown
- 2013-12-04 AU AU2013356894A patent/AU2013356894B2/en active Active
- 2013-12-04 RS RS20160986A patent/RS55307B1/sr unknown
- 2013-12-04 CA CA2892174A patent/CA2892174C/en active Active
- 2013-12-04 MD MDA20150051A patent/MD4651B1/ro not_active IP Right Cessation
- 2013-12-04 MX MX2015007598A patent/MX366023B/es active IP Right Grant
- 2013-12-04 AP AP2015008526A patent/AP2015008526A0/xx unknown
- 2013-12-04 CN CN201380065006.0A patent/CN104837843B/zh active Active
- 2013-12-04 EA EA201590761A patent/EA025635B1/ru not_active IP Right Cessation
- 2013-12-04 ES ES13812165.2T patent/ES2608640T3/es active Active
- 2013-12-04 PE PE2015000912A patent/PE20151163A1/es not_active Application Discontinuation
- 2013-12-04 KR KR1020157017073A patent/KR101746314B1/ko active IP Right Grant
- 2013-12-04 EP EP13812165.2A patent/EP2938615B1/en active Active
- 2013-12-04 WO PCT/IB2013/060631 patent/WO2014091368A1/en active Application Filing
- 2013-12-04 PT PT138121652T patent/PT2938615T/pt unknown
- 2013-12-04 SG SG11201503735YA patent/SG11201503735YA/en unknown
- 2013-12-04 HU HUE13812165A patent/HUE032400T2/hu unknown
- 2013-12-04 ME MEP-2016-258A patent/ME02566B/me unknown
- 2013-12-11 TW TW102145600A patent/TWI478926B/zh active
- 2013-12-12 UY UY35185A patent/UY35185A/es unknown
- 2013-12-12 AR ARP130104648A patent/AR093937A1/es unknown
- 2013-12-12 US US14/103,960 patent/US8952008B2/en active Active
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2014
- 2014-12-19 US US14/576,796 patent/US20150105396A1/en not_active Abandoned
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2015
- 2015-05-14 CR CR20150254A patent/CR20150254A/es unknown
- 2015-05-29 US US14/725,234 patent/US20150259352A1/en not_active Abandoned
- 2015-06-04 IL IL239243A patent/IL239243A0/en active IP Right Grant
- 2015-06-05 PH PH12015501293A patent/PH12015501293A1/en unknown
- 2015-06-09 TN TNP2015000261A patent/TN2015000261A1/fr unknown
- 2015-06-11 NI NI201500081A patent/NI201500081A/es unknown
- 2015-06-11 ZA ZA2015/04226A patent/ZA201504226B/en unknown
- 2015-06-12 CL CL2015001652A patent/CL2015001652A1/es unknown
- 2015-06-12 DO DO2015000147A patent/DOP2015000147A/es unknown
- 2015-07-11 EC ECIEPI201529822A patent/ECSP15029822A/es unknown
- 2015-08-04 GT GT201500159A patent/GT201500159A/es unknown
- 2015-10-28 HK HK15110627.3A patent/HK1209743A1/zh unknown
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2016
- 2016-11-22 HR HRP20161559TT patent/HRP20161559T1/hr unknown
- 2016-12-05 CY CY20161101251T patent/CY1118568T1/el unknown
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Legal Events
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FD | Application declared void or lapsed |