PE20150754A1 - Derivados de azaindol que actuan como inhibidores de pi 3k - Google Patents
Derivados de azaindol que actuan como inhibidores de pi 3kInfo
- Publication number
- PE20150754A1 PE20150754A1 PE2015000013A PE2015000013A PE20150754A1 PE 20150754 A1 PE20150754 A1 PE 20150754A1 PE 2015000013 A PE2015000013 A PE 2015000013A PE 2015000013 A PE2015000013 A PE 2015000013A PE 20150754 A1 PE20150754 A1 PE 20150754A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pyrrolo
- pyrazol
- pyrimidine
- ethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invencion se refiere a los compuestos de la Formula 1, y una de sus sales farmaceuticamente aceptables, donde R1, R2, R3, R4, R5, R6, R7, R8, R9 y R10 se definen en la memoria. La presente revelacion tambien se refiere a los materiales y metodos para preparar compuestos de la Formula 1, a composiciones farmaceuticas que los contienen y a su empleo para tratar trastornos inmunologicos, enfermedades cardiovasculares, cancer y otros trastornos, enfermedades y afecciones que se asocian con la P13Kdelta. Son compuestos preferidos: (S)5-Cloro-N4-(1-(1-metil-6-(1-metil-1H-pirazol-5-il) -1H-pirrolo[3,2-b]piridin-5-il)etil)pirimidina-2 ,4-diamina; (S)-2 ,4-Diamino-6-((1-(1-metil-6-(1-metil-1H-pirazol-5-il)-1H-pirrolo[3,2-b]piridin-5-il)etil)amino)pirimidina-5-carbonitrilo ; (S)-2-Amino-4-metil-6-((1-(1-metil-6-(1-metil-1H-pirazol-5-il)-1H-pirrolo[3 ,2-b]piridin-5-il)etil)amino)pirimidina-5-carbonitrilo ; entre otros
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261670116P | 2012-07-10 | 2012-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20150754A1 true PE20150754A1 (es) | 2015-05-15 |
Family
ID=48795966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2015000013A PE20150754A1 (es) | 2012-07-10 | 2013-07-08 | Derivados de azaindol que actuan como inhibidores de pi 3k |
Country Status (26)
Country | Link |
---|---|
US (2) | US8835420B2 (es) |
EP (1) | EP2872507A1 (es) |
JP (1) | JP2015522074A (es) |
KR (1) | KR20150031334A (es) |
CN (1) | CN104619708A (es) |
AP (1) | AP2015008236A0 (es) |
AR (1) | AR092347A1 (es) |
AU (1) | AU2013288895A1 (es) |
BR (1) | BR112015000386A2 (es) |
CA (1) | CA2878502A1 (es) |
CO (1) | CO7280475A2 (es) |
CR (1) | CR20150056A (es) |
DO (1) | DOP2015000002A (es) |
EA (1) | EA201590183A1 (es) |
HK (1) | HK1210771A1 (es) |
IL (1) | IL236535A0 (es) |
MA (1) | MA37831B1 (es) |
MX (1) | MX2015000107A (es) |
NZ (1) | NZ704160A (es) |
PE (1) | PE20150754A1 (es) |
PH (1) | PH12015500063B1 (es) |
SG (1) | SG11201500063UA (es) |
TN (1) | TN2015000005A1 (es) |
TW (1) | TW201414734A (es) |
UY (1) | UY34893A (es) |
WO (1) | WO2014011568A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX354412B (es) | 2011-06-10 | 2018-03-05 | Merck Patent Gmbh | Composiciones y metodos para la produccion de compuestos de pirimidina con actividad inhibidora de tirosina cinasa de bruton. |
UY35945A (es) * | 2014-01-09 | 2015-08-31 | Takeda Pharmaceutical | Derivados de azaindol |
WO2015106014A1 (en) * | 2014-01-09 | 2015-07-16 | Takeda Pharmaceutical Company Limited | Azaindole derivatives |
EP3209665B1 (en) | 2014-10-22 | 2019-08-14 | Bristol-Myers Squibb Company | Substituted pyrrolotriazine amine compounds as pi3k inhibitors |
US10214537B2 (en) | 2014-10-22 | 2019-02-26 | Bristol-Myers Squibb Company | Bicyclic heteroaryl amine compounds |
US9997391B2 (en) * | 2015-10-19 | 2018-06-12 | QROMIS, Inc. | Lift off process for chip scale package solid state devices on engineered substrate |
JP6913100B2 (ja) * | 2015-11-04 | 2021-08-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Btk阻害活性を有するピリミジン及びピリジン化合物を用いた癌の治療方法 |
LT3377484T (lt) | 2015-11-17 | 2023-12-27 | Merck Patent Gmbh | Dauginės sklerozės gydymo būdai, panaudojant pirimidino ir piridino junginius su btk inhibitoriniu aktyvumu |
CN112250665A (zh) * | 2016-03-05 | 2021-01-22 | 杭州征祥医药有限公司 | 作为磷脂酰肌醇3-激酶抑制剂的喹啉类似物 |
US10755986B2 (en) * | 2016-03-29 | 2020-08-25 | QROMIS, Inc. | Aluminum nitride based Silicon-on-Insulator substrate structure |
CN107964018A (zh) * | 2016-10-19 | 2018-04-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 取代嘌呤酮类衍生物及其医药用途 |
KR20220007111A (ko) * | 2019-05-08 | 2022-01-18 | 티와이케이 메디슨즈, 인코포레이티드 | 키나아제 억제제로 사용되는 화합물 및 이의 응용 |
CN112794851B (zh) * | 2021-01-26 | 2022-08-23 | 复旦大学 | 3-(吡啶-3基)-7-氮杂吲哚衍生物PI3Kδ抑制剂及其制备方法与应用 |
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JP2008510771A (ja) | 2004-08-27 | 2008-04-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法および医薬薬剤としてのその使用 |
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-
2013
- 2013-07-05 UY UY0001034893A patent/UY34893A/es not_active Application Discontinuation
- 2013-07-05 TW TW102124297A patent/TW201414734A/zh unknown
- 2013-07-08 KR KR20157003555A patent/KR20150031334A/ko not_active Application Discontinuation
- 2013-07-08 MA MA37831A patent/MA37831B1/fr unknown
- 2013-07-08 CA CA2878502A patent/CA2878502A1/en not_active Abandoned
- 2013-07-08 US US13/937,081 patent/US8835420B2/en not_active Expired - Fee Related
- 2013-07-08 NZ NZ704160A patent/NZ704160A/en not_active IP Right Cessation
- 2013-07-08 EA EA201590183A patent/EA201590183A1/ru unknown
- 2013-07-08 MX MX2015000107A patent/MX2015000107A/es unknown
- 2013-07-08 EP EP13737976.4A patent/EP2872507A1/en not_active Withdrawn
- 2013-07-08 CN CN201380043657.XA patent/CN104619708A/zh active Pending
- 2013-07-08 SG SG11201500063UA patent/SG11201500063UA/en unknown
- 2013-07-08 WO PCT/US2013/049612 patent/WO2014011568A1/en active Application Filing
- 2013-07-08 BR BR112015000386A patent/BR112015000386A2/pt not_active Application Discontinuation
- 2013-07-08 AR ARP130102427A patent/AR092347A1/es unknown
- 2013-07-08 AP AP2015008236A patent/AP2015008236A0/xx unknown
- 2013-07-08 AU AU2013288895A patent/AU2013288895A1/en not_active Abandoned
- 2013-07-08 PE PE2015000013A patent/PE20150754A1/es not_active Application Discontinuation
- 2013-07-08 JP JP2015521701A patent/JP2015522074A/ja active Pending
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2014
- 2014-08-04 US US14/451,254 patent/US20140343033A1/en not_active Abandoned
- 2014-12-31 IL IL236535A patent/IL236535A0/en unknown
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2015
- 2015-01-07 DO DO2015000002A patent/DOP2015000002A/es unknown
- 2015-01-07 TN TNP2015000005A patent/TN2015000005A1/fr unknown
- 2015-01-09 PH PH12015500063A patent/PH12015500063B1/en unknown
- 2015-02-04 CO CO15021949A patent/CO7280475A2/es unknown
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- 2015-11-19 HK HK15111423.7A patent/HK1210771A1/xx unknown
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AP2015008236A0 (en) | 2015-01-31 |
BR112015000386A2 (pt) | 2017-06-27 |
WO2014011568A1 (en) | 2014-01-16 |
AU2013288895A1 (en) | 2015-02-12 |
CA2878502A1 (en) | 2014-01-16 |
US8835420B2 (en) | 2014-09-16 |
MA37831A1 (fr) | 2018-02-28 |
CR20150056A (es) | 2015-05-25 |
CO7280475A2 (es) | 2015-05-29 |
US20140018344A1 (en) | 2014-01-16 |
US20140343033A1 (en) | 2014-11-20 |
EA201590183A1 (ru) | 2015-06-30 |
PH12015500063A1 (en) | 2015-03-02 |
SG11201500063UA (en) | 2015-03-30 |
JP2015522074A (ja) | 2015-08-03 |
TW201414734A (zh) | 2014-04-16 |
AR092347A1 (es) | 2015-04-15 |
HK1210771A1 (en) | 2016-05-06 |
KR20150031334A (ko) | 2015-03-23 |
UY34893A (es) | 2014-02-28 |
EP2872507A1 (en) | 2015-05-20 |
DOP2015000002A (es) | 2015-04-15 |
MA37831B1 (fr) | 2018-09-28 |
NZ704160A (en) | 2017-01-27 |
TN2015000005A1 (en) | 2016-06-29 |
PH12015500063B1 (en) | 2015-03-02 |
MX2015000107A (es) | 2015-04-14 |
IL236535A0 (en) | 2015-02-26 |
CN104619708A (zh) | 2015-05-13 |
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