PE20141378A1 - Moduladores de receptores de glucocorticoides de pirimidina ciclohexilo - Google Patents
Moduladores de receptores de glucocorticoides de pirimidina ciclohexiloInfo
- Publication number
- PE20141378A1 PE20141378A1 PE2013002053A PE2013002053A PE20141378A1 PE 20141378 A1 PE20141378 A1 PE 20141378A1 PE 2013002053 A PE2013002053 A PE 2013002053A PE 2013002053 A PE2013002053 A PE 2013002053A PE 20141378 A1 PE20141378 A1 PE 20141378A1
- Authority
- PE
- Peru
- Prior art keywords
- glucocorticoid receptors
- alkyl
- receptors modulators
- modulators
- pyrimidine
- Prior art date
Links
- 102000003676 Glucocorticoid Receptors Human genes 0.000 title abstract 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract 2
- -1 PYRIMIDINE CYCLOHEXYL Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
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- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE: LA LINEA DE GUIONES ESTA AUSENTE O ES UN ENLACE; X ES O Y S; R1 SE SELECCIONA DE CICLOALQUILO, HETEROCICLOALQUILO, ARILO Y HETEROARILO, OPCIONALMENTE SUSTITUIDO; R2 ES H, ALQUILO C1-6, ALQUILO C1-6-OR1b, ENTRE OTROS, R1b ES H Y ALQUILO C1-6; R3 SE SELECCIONA DE H Y ALQUILO C1-6; Ar ES ARILO OPCIONALMENTE SUSTITUIDO; L1 ES UN ENLACE O ALQUILENO C1-6; n ES UN NUMERO ENTERO DE 0 A 3. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE RECEPTORES DE GLUCOCORTICOIDES
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WO (1) | WO2012129074A1 (es) |
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CN103596431B (zh) * | 2011-03-18 | 2016-06-22 | 科赛普特治疗公司 | 嘧啶环己基糖皮质激素受体调节剂 |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
US10183949B2 (en) | 2014-08-29 | 2019-01-22 | The University Of Tokyo | Pyrimidinone derivative having autotaxin-inhibitory activity |
US10238659B2 (en) * | 2014-10-15 | 2019-03-26 | Corcept Therapeutics, Inc. | Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists |
CN107530435A (zh) * | 2015-03-02 | 2018-01-02 | 科赛普特治疗学股份有限公司 | 使用糖皮质激素受体拮抗剂和生长抑素治疗acth分泌型肿瘤 |
CA2978960C (en) | 2015-03-30 | 2023-05-02 | Corcept Therapeutics, Inc. | Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency |
WO2017027851A1 (en) | 2015-08-13 | 2017-02-16 | Corcept Therapeutics, Inc. | Method for differentially diagnosing acth-dependent cushing's syndrome |
DK3350175T3 (da) * | 2015-09-15 | 2020-02-03 | Leo Pharma As | Ikke-steroidale glucocorticoidreceptormodulatorer til lokal lægemiddelafgivelse |
JP6765443B2 (ja) | 2016-01-19 | 2020-10-07 | コーセプト セラピューティクス, インコーポレイテッド | 異所性クッシング症候群の鑑別診断 |
EP3592358A4 (en) | 2017-03-09 | 2020-12-16 | Corcept Therapeutics, Inc. | USE OF GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF CATECHOLAMIN SECRETING TUMORS |
KR102342620B1 (ko) | 2017-03-31 | 2021-12-22 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 자궁경부암을 치료하기 위한 글루코코르티코이드 수용체 조정제 |
KR102589213B1 (ko) * | 2018-06-04 | 2023-10-12 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 피리미딘 사이클로헥세닐 글루코코르티코이드 수용체 조절제 |
IL263184A (en) | 2018-11-21 | 2020-05-31 | Yarden Yosef | Method of treating cancer and compositions for same |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
CA3121193C (en) | 2018-12-19 | 2024-03-12 | Corcept Therapeutics Incorporated | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
MX2022006633A (es) | 2019-12-11 | 2022-06-24 | Corcept Therapeutics Inc | Metodos de tratamiento del aumento de peso inducido por antipsicoticos con miricorilant. |
US20230358768A1 (en) | 2019-12-21 | 2023-11-09 | Corcept Therapeutics Incorporated | Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome |
CA3182272A1 (en) * | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators |
US20210361651A1 (en) * | 2020-05-06 | 2021-11-25 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
MX2023007403A (es) * | 2020-12-21 | 2023-08-16 | Corcept Therapeutics Inc | Método de preparación de los moduladores del receptor de ciclohexilo de pirimidina glucocorticoides. |
CA3217413A1 (en) * | 2021-05-05 | 2022-11-10 | Ada Lee | Methods for reducing liver fat and for treating fatty liver disorders |
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DE3011809A1 (de) | 1980-03-27 | 1981-10-01 | Cassella Ag, 6000 Frankfurt | Pyrimidyl-chinazoline, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische praeparate und ihre verwendung |
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JPH1017555A (ja) | 1996-07-02 | 1998-01-20 | Mitsui Petrochem Ind Ltd | 6−アミノ−5−メチルウラシル誘導体 |
ATE303369T1 (de) | 2000-10-30 | 2005-09-15 | Pfizer Prod Inc | Glucocorticoid rezeptor modulatoren |
GB0029100D0 (en) | 2000-11-29 | 2001-01-10 | Karobio Ab | Compounds active at the glucocorticoid receptor |
AU2003216591A1 (en) | 2002-04-10 | 2003-10-20 | Orichid Chemicals And Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
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NZ548374A (en) * | 2004-01-09 | 2010-05-28 | Corcept Therapeutics Inc | Azadecalin glucocorticoid receptor modulators |
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KR101237312B1 (ko) * | 2006-02-10 | 2013-03-04 | 삼진제약주식회사 | 피리미딘다이온 유도체를 포함하는 c형 간염의 예방 및치료용 약학 조성물 |
DE102006033109A1 (de) * | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
CN103596431B (zh) | 2011-03-18 | 2016-06-22 | 科赛普特治疗公司 | 嘧啶环己基糖皮质激素受体调节剂 |
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- 2012-03-16 KR KR1020137027459A patent/KR101889742B1/ko active IP Right Grant
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- 2012-03-16 PE PE2013002053A patent/PE20141378A1/es active IP Right Grant
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