MX2022006633A - Metodos de tratamiento del aumento de peso inducido por antipsicoticos con miricorilant. - Google Patents
Metodos de tratamiento del aumento de peso inducido por antipsicoticos con miricorilant.Info
- Publication number
- MX2022006633A MX2022006633A MX2022006633A MX2022006633A MX2022006633A MX 2022006633 A MX2022006633 A MX 2022006633A MX 2022006633 A MX2022006633 A MX 2022006633A MX 2022006633 A MX2022006633 A MX 2022006633A MX 2022006633 A MX2022006633 A MX 2022006633A
- Authority
- MX
- Mexico
- Prior art keywords
- antipsychotic
- gain
- weight gain
- grm
- methods
- Prior art date
Links
- 230000004584 weight gain Effects 0.000 title abstract 5
- 235000019786 weight gain Nutrition 0.000 title abstract 5
- 230000000561 anti-psychotic effect Effects 0.000 title abstract 3
- GVVUZBSCYAVFTI-IYARVYRRSA-N miricorilant Chemical compound FC(F)(F)C1=CC=CC(CC2=C(NC(=O)NC2=O)[C@H]2CC[C@@H](CC2)C2=CC=CC=C2)=C1 GVVUZBSCYAVFTI-IYARVYRRSA-N 0.000 title abstract 3
- 229940121462 miricorilant Drugs 0.000 title abstract 3
- 229940117965 Glucocorticoid receptor modulator Drugs 0.000 abstract 5
- 229940124604 anti-psychotic medication Drugs 0.000 abstract 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- YJDDXMSIMBMMGY-UHFFFAOYSA-N 2-cyclohexylpyrimidine Chemical compound C1CCCCC1C1=NC=CC=N1 YJDDXMSIMBMMGY-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 229960004170 clozapine Drugs 0.000 abstract 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960005017 olanzapine Drugs 0.000 abstract 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 abstract 1
- 229960001534 risperidone Drugs 0.000 abstract 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 abstract 1
- 150000003626 triacylglycerols Chemical class 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Child & Adolescent Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describen métodos y composiciones para tratar a un sujeto en riesgo de, o que sufre de aumento de peso inducido por antipsicóticos. Los métodos incluyen la administración de un modulador del receptor de glucocorticoides (GRM) de ciclohexil pirimidina tal como miricorilant (CORT118335) a un paciente que recibe, ha recibido o se espera que reciba un fármaco antipsicótico como olanzapina, risperidona, clozapina u otro medicamento antipsicótico inductor de peso. El GRM (por ejemplo, miricorilant) puede administrarse por vía oral. La administración de tal GRM junto con la medicación antipsicótica puede reducir la cantidad de peso, o reducir la tasa de aumento de peso, o prevenir el aumento de peso, que de otro modo se debería a la medicación antipsicótica sola. Los métodos pueden revertir el aumento de peso en un paciente al que se le administró previamente medicación antipsicótica. La administración de tal GRM con medicación antipsicótica puede reducir, o evitar el aumento, o prevenir el aumento, o revertir el aumento de la resistencia a la insulina o de los niveles sanguíneos de las enzimas hepáticas (AST, ALT), los triglicéridos o la insulina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962946957P | 2019-12-11 | 2019-12-11 | |
| PCT/US2020/064520 WO2021119432A1 (en) | 2019-12-11 | 2020-12-11 | Methods of treating antipsychotic-induced weight gain with miricorilant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022006633A true MX2022006633A (es) | 2022-06-24 |
Family
ID=76316599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022006633A MX2022006633A (es) | 2019-12-11 | 2020-12-11 | Metodos de tratamiento del aumento de peso inducido por antipsicoticos con miricorilant. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11903945B2 (es) |
| EP (1) | EP4072556A4 (es) |
| JP (1) | JP2023505948A (es) |
| KR (1) | KR20220113767A (es) |
| CN (1) | CN114929229A (es) |
| AU (1) | AU2020400061A1 (es) |
| CA (1) | CA3158745A1 (es) |
| CL (1) | CL2022001250A1 (es) |
| IL (1) | IL291775A (es) |
| MX (1) | MX2022006633A (es) |
| WO (1) | WO2021119432A1 (es) |
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| IL72729A (en) | 1983-09-26 | 1988-02-29 | Lilly Co Eli | Trans(+_)octahydropyrazole-ring alkylated pyrazoloquinolines,their preparation and pharmaceutical compositions containing them |
| JPS6417555A (en) | 1987-07-13 | 1989-01-20 | Tokyo Electric Co Ltd | Facsimile |
| US5008267A (en) | 1988-10-29 | 1991-04-16 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione compounds, method of producing the same and antiarrythmic agents containing the same |
| GB8828669D0 (en) | 1988-12-08 | 1989-01-11 | Lilly Industries Ltd | Organic compounds |
| JP3160941B2 (ja) | 1991-06-17 | 2001-04-25 | 東レ株式会社 | カルバゾール誘導体および免疫抑制剤 |
| JPH06128238A (ja) | 1992-10-20 | 1994-05-10 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体 |
| FR2697252B1 (fr) | 1992-10-28 | 1994-12-09 | Fournier Ind & Sante | Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| CA2168853A1 (en) | 1993-08-06 | 1995-02-16 | Giulio Dondio | Hydroisoquinoline derivatives |
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| GB0029100D0 (en) | 2000-11-29 | 2001-01-10 | Karobio Ab | Compounds active at the glucocorticoid receptor |
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| JP2004537563A (ja) * | 2001-07-23 | 2004-12-16 | コーセプト セラピューティクス， インコーポレイテッド | 抗神経病薬誘導性体重増加を予防するための方法 |
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-
2020
- 2020-12-11 US US17/119,582 patent/US11903945B2/en active Active
- 2020-12-11 IL IL291775A patent/IL291775A/en unknown
- 2020-12-11 CA CA3158745A patent/CA3158745A1/en active Pending
- 2020-12-11 JP JP2022528536A patent/JP2023505948A/ja active Pending
- 2020-12-11 MX MX2022006633A patent/MX2022006633A/es unknown
- 2020-12-11 CN CN202080086165.9A patent/CN114929229A/zh active Pending
- 2020-12-11 WO PCT/US2020/064520 patent/WO2021119432A1/en unknown
- 2020-12-11 EP EP20900160.1A patent/EP4072556A4/en active Pending
- 2020-12-11 AU AU2020400061A patent/AU2020400061A1/en active Pending
- 2020-12-11 KR KR1020227023596A patent/KR20220113767A/ko unknown
-
2022
- 2022-05-12 CL CL2022001250A patent/CL2022001250A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021119432A1 (en) | 2021-06-17 |
| EP4072556A4 (en) | 2024-01-03 |
| CA3158745A1 (en) | 2021-06-17 |
| JP2023505948A (ja) | 2023-02-14 |
| KR20220113767A (ko) | 2022-08-16 |
| US11903945B2 (en) | 2024-02-20 |
| EP4072556A1 (en) | 2022-10-19 |
| US20210177848A1 (en) | 2021-06-17 |
| IL291775A (en) | 2022-06-01 |
| AU2020400061A1 (en) | 2022-04-14 |
| CN114929229A (zh) | 2022-08-19 |
| CL2022001250A1 (es) | 2023-02-10 |
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