PE20130062A1 - Compuestos de sililo triciclicos fusionados para el tratamiento de enfermedades virales - Google Patents
Compuestos de sililo triciclicos fusionados para el tratamiento de enfermedades viralesInfo
- Publication number
- PE20130062A1 PE20130062A1 PE2012001466A PE2012001466A PE20130062A1 PE 20130062 A1 PE20130062 A1 PE 20130062A1 PE 2012001466 A PE2012001466 A PE 2012001466A PE 2012001466 A PE2012001466 A PE 2012001466A PE 20130062 A1 PE20130062 A1 PE 20130062A1
- Authority
- PE
- Peru
- Prior art keywords
- members
- compounds
- heteroarylene
- ring
- heterocycloalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000003612 virological effect Effects 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical class CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
- C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Abstract
SE REFIERE A COMPUESTOS DE SILILO TRICICLICOS FUSIONADOS DE FORMULA (I), DONDE: A Y D SON CADA UNO, HETEROCICLOALQUILO MONOCICLICO DE 4 A 7 MIEMBROS, HETEROCICLOALQUILO BICICLO DE 7 A 11 MIEMBROS O R15, QUE PUEDEN ESTAR OPCIONALMENTE FUSIONADOS A CICLOALQUILO C3-C7, ENTRE OTROS O PUEDEN ESTAR OPCIONALMENTE SUSTITUIDOS SOBRE UNO O MAS NITROGENOS ANULARES CON R4 Y CARBONOS ANULARES CON R12, DE TAL MANERA QUE DOS GRUPOS R12 SOBRE EL MISMO CARBONO ANULAR JUNTO CON EL CARBONO AL CUAL ESTAN UNIDOS PUEDAN UNIRSE PARA FORMAR CICLOALQUILO ESPIROCICLICO DE 3 A 7 MIEMBROS O HETEROCICLOALQUILO ESPIROCICLICO DE 4 A 7 MIEMBROS; B ES HETEROARILENO MONOCICLICO DE 5 MIEMBROS O HETEROARILENO BICICLICO DE 9 MIEMBROS CON AL MENOS UN ATOMO DE N, PUEDEN OPCIONALMENTE FUSIONARSE CON UN ANILLO DE BENCENO, PIRIDINA O PIRIMIDINA; C ES UN ENLACE, FENILENO, HETEROARILENO MONOCICLICO O HETEROARILENO BICICLICO QUE PUEDE OPCIONALMENTE SUSTITUIRSE SOBRE UNO O MAS NITROGENOS ANULARES CON R6 Y SOBRE UNO O MAS CARBONOS CON R12; R15 ES INDEPENDIENTEMENTE UN ANILLO SILILHETEROCICLOALQUILO MONOCICLICO DE 5 A 7 MIEMBROS O SILILHETEROCICLOALQUILO BICICLICO DE 7 A 11 MIEMBROS; R4 Y R12 SON CADA UNO H, ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; M1 ES UN ENLACE, -C(R7)2-, -O-, -S(O)2-, ENTRE OTROS; X1 Y X2 SON INDEPENDIENTEMENTE -C(R5)- O -N-. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE LA INFECCION POR EL VIRUS DE LA HEPATITIS C (VHC)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31201610P | 2010-03-09 | 2010-03-09 | |
US37193510P | 2010-08-09 | 2010-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130062A1 true PE20130062A1 (es) | 2013-02-28 |
Family
ID=43939669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2012001466A PE20130062A1 (es) | 2010-03-09 | 2011-03-04 | Compuestos de sililo triciclicos fusionados para el tratamiento de enfermedades virales |
Country Status (25)
Country | Link |
---|---|
US (1) | US8609635B2 (es) |
EP (1) | EP2545060B1 (es) |
JP (1) | JP2013522202A (es) |
KR (1) | KR20130008040A (es) |
CN (1) | CN102918049A (es) |
AR (1) | AR080676A1 (es) |
AU (1) | AU2011224698A1 (es) |
BR (1) | BR112012022125A2 (es) |
CA (1) | CA2792121A1 (es) |
CL (1) | CL2012002489A1 (es) |
CO (1) | CO6592102A2 (es) |
CR (1) | CR20120460A (es) |
DO (1) | DOP2012000243A (es) |
EA (1) | EA201290882A1 (es) |
EC (1) | ECSP12012147A (es) |
ES (1) | ES2558554T3 (es) |
MA (1) | MA34147B1 (es) |
MX (1) | MX2012010392A (es) |
NI (1) | NI201200139A (es) |
PE (1) | PE20130062A1 (es) |
SG (1) | SG183526A1 (es) |
TN (1) | TN2012000416A1 (es) |
TW (1) | TW201136943A (es) |
WO (1) | WO2011112429A1 (es) |
ZA (1) | ZA201206716B (es) |
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-
2011
- 2011-03-04 MA MA35291A patent/MA34147B1/fr unknown
- 2011-03-04 SG SG2012063780A patent/SG183526A1/en unknown
- 2011-03-04 JP JP2012557114A patent/JP2013522202A/ja not_active Withdrawn
- 2011-03-04 CN CN2011800233538A patent/CN102918049A/zh active Pending
- 2011-03-04 US US13/041,082 patent/US8609635B2/en active Active
- 2011-03-04 EP EP11707763.6A patent/EP2545060B1/en active Active
- 2011-03-04 WO PCT/US2011/027117 patent/WO2011112429A1/en active Application Filing
- 2011-03-04 AU AU2011224698A patent/AU2011224698A1/en not_active Abandoned
- 2011-03-04 AR ARP110100696A patent/AR080676A1/es unknown
- 2011-03-04 BR BR112012022125A patent/BR112012022125A2/pt not_active IP Right Cessation
- 2011-03-04 CA CA2792121A patent/CA2792121A1/en not_active Abandoned
- 2011-03-04 EA EA201290882A patent/EA201290882A1/ru unknown
- 2011-03-04 MX MX2012010392A patent/MX2012010392A/es active IP Right Grant
- 2011-03-04 PE PE2012001466A patent/PE20130062A1/es not_active Application Discontinuation
- 2011-03-04 KR KR1020127026331A patent/KR20130008040A/ko not_active Application Discontinuation
- 2011-03-04 ES ES11707763.6T patent/ES2558554T3/es active Active
- 2011-03-08 TW TW100107798A patent/TW201136943A/zh unknown
-
2012
- 2012-08-15 TN TNP2012000416A patent/TN2012000416A1/en unknown
- 2012-09-07 DO DO2012000243A patent/DOP2012000243A/es unknown
- 2012-09-07 NI NI201200139A patent/NI201200139A/es unknown
- 2012-09-07 CL CL2012002489A patent/CL2012002489A1/es unknown
- 2012-09-07 ZA ZA2012/06716A patent/ZA201206716B/en unknown
- 2012-09-10 EC ECSP12012147 patent/ECSP12012147A/es unknown
- 2012-09-10 CR CR20120460A patent/CR20120460A/es unknown
- 2012-09-10 CO CO12155041A patent/CO6592102A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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AR080676A1 (es) | 2012-05-02 |
EP2545060B1 (en) | 2015-11-25 |
EP2545060A1 (en) | 2013-01-16 |
SG183526A1 (en) | 2012-09-27 |
CN102918049A (zh) | 2013-02-06 |
CL2012002489A1 (es) | 2012-11-30 |
ZA201206716B (en) | 2013-05-29 |
CR20120460A (es) | 2012-11-01 |
ECSP12012147A (es) | 2012-10-30 |
ES2558554T3 (es) | 2016-02-05 |
US8609635B2 (en) | 2013-12-17 |
DOP2012000243A (es) | 2012-12-31 |
MA34147B1 (fr) | 2013-04-03 |
MX2012010392A (es) | 2012-10-03 |
US20110223134A1 (en) | 2011-09-15 |
BR112012022125A2 (pt) | 2016-11-01 |
AU2011224698A1 (en) | 2012-11-01 |
NI201200139A (es) | 2013-01-24 |
WO2011112429A1 (en) | 2011-09-15 |
JP2013522202A (ja) | 2013-06-13 |
CO6592102A2 (es) | 2013-01-02 |
EA201290882A1 (ru) | 2013-04-30 |
TN2012000416A1 (en) | 2014-01-30 |
KR20130008040A (ko) | 2013-01-21 |
CA2792121A1 (en) | 2011-09-15 |
TW201136943A (en) | 2011-11-01 |
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