PE20120655A1 - Derivados de triazolopiridina como inhibidores de proteinas cinasas activadas por mitogeno p38 (map) - Google Patents

Derivados de triazolopiridina como inhibidores de proteinas cinasas activadas por mitogeno p38 (map)

Info

Publication number
PE20120655A1
PE20120655A1 PE2011001509A PE2011001509A PE20120655A1 PE 20120655 A1 PE20120655 A1 PE 20120655A1 PE 2011001509 A PE2011001509 A PE 2011001509A PE 2011001509 A PE2011001509 A PE 2011001509A PE 20120655 A1 PE20120655 A1 PE 20120655A1
Authority
PE
Peru
Prior art keywords
phenyl
map
pyridin
inhibitors
kines
Prior art date
Application number
PE2011001509A
Other languages
English (en)
Inventor
Harry Finch
John Montana
Niel Monique Bodil Van
Chi-Kit Woo
Jamie Knight
Bohdan Waszkowycz
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42232647&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120655(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0902651A external-priority patent/GB0902651D0/en
Priority claimed from GB0908069A external-priority patent/GB0908069D0/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20120655A1 publication Critical patent/PE20120655A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO C1-C6, CICLOALQUILO C3-C6, FENILO, ENTRE OTROS; Y ES O, S(O)p; p ES 0-2; A ES ARILENO DIVALENT OPCIONALMENTE SUSTITUIDO, RADICAL CICLOALQUILENO DIVALENTE C3-C6 QUE TIENE 5-6 ATOMOS EN EL ANILLO, ENTRE OTROS; W ES UN ENLACE, NH-, CRARB; RA Y RB SON CADA UNO H, METILO, ETILO, AMINO, ENTRE OTROS; R2 ES CICLOPROPILMETIL, 2-(4-MORFOLIN)-PIRIDIN, N-(4-METILFENIL)-5-TERCBUTIL-PIRAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-CICLOPROPILMETIL-3-{3-[3-(2-MORFOLIN4-IL-ETOXI)-FENIL]-[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-6-ILSULFANIL}-BENZAMIDA; N-{5-TERC-BUTIL-2-[4-(2-MORFOLIN-4-ILETOXI)-FENIL]-2H-PIRAZOL-3-IL}-2-[4-(3-ISOPROPIL-[1,2,4]TRIAZOLO[4,3-a]PIRIDIN-6-ILSULFANIL)-FENIL]-ACETAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE CINASA p38 MAP, UTILES COMO AGENTES ANTIINFLAMATORIOS
PE2011001509A 2009-02-17 2010-02-16 Derivados de triazolopiridina como inhibidores de proteinas cinasas activadas por mitogeno p38 (map) PE20120655A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0902651A GB0902651D0 (en) 2009-02-17 2009-02-17 Pharmaceutical compounds and compositions
GB0908069A GB0908069D0 (en) 2009-05-11 2009-05-11 Pharmaceutical compounds and compositions

Publications (1)

Publication Number Publication Date
PE20120655A1 true PE20120655A1 (es) 2012-06-07

Family

ID=42232647

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001509A PE20120655A1 (es) 2009-02-17 2010-02-16 Derivados de triazolopiridina como inhibidores de proteinas cinasas activadas por mitogeno p38 (map)

Country Status (19)

Country Link
US (1) US8557797B2 (es)
EP (1) EP2398798A1 (es)
JP (1) JP2012517992A (es)
KR (1) KR20110116030A (es)
CN (2) CN102395586A (es)
AU (1) AU2010215261A1 (es)
BR (1) BRPI1005327A2 (es)
CA (1) CA2752693A1 (es)
CL (1) CL2011001977A1 (es)
CO (1) CO6420344A2 (es)
EA (1) EA201190119A1 (es)
IL (1) IL214658A0 (es)
MA (1) MA33128B1 (es)
MX (1) MX2011008496A (es)
PE (1) PE20120655A1 (es)
SG (1) SG174134A1 (es)
TN (1) TN2011000380A1 (es)
WO (1) WO2010094956A1 (es)
ZA (1) ZA201105993B (es)

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US8637513B2 (en) * 2007-10-24 2014-01-28 Merck Sharp & Dohme Corp. Heterocycle phenyl amide T-type calcium channel antagonists
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
BR112014001714A2 (pt) 2011-07-26 2017-02-14 Gruenenthal Gmbh derivados de carboxamida e ureia aromáticos bicíclicos substituídos como ligantes de receptor vaniloide
BR112014013178A2 (pt) 2011-12-09 2017-06-13 Chiesi Farm Spa composto, composição farmacêutica e uso de um composto
CN105968110B (zh) * 2011-12-09 2018-04-27 奇斯药制品公司 激酶抑制剂
CA2860479A1 (en) 2011-12-09 2013-06-13 Chiesi Farmaceutici S.P.A. Kinase inhibitors
WO2014015056A2 (en) * 2012-07-17 2014-01-23 Washington University Anti-mucus drugs and uses therefor
US9573949B2 (en) * 2013-06-06 2017-02-21 Chiesi Farmaceutici S.P.A. Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38—MAP kinase inhibitors
BR112015029970A2 (pt) 2013-06-06 2017-07-25 Chiesi Farm Spa inibidores de cinase
CN105308046A (zh) * 2013-06-06 2016-02-03 奇斯药制品公司 激酶抑制剂
GB201321742D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
MX2017005462A (es) 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
CA3128468A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

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US6034057A (en) 1995-07-06 2000-03-07 Zeneca Limited Peptide inhibitors of fibronectine
US6248713B1 (en) 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
GB0028383D0 (en) 2000-11-21 2001-01-03 Novartis Ag Organic compounds
EP1241176A1 (en) 2001-03-16 2002-09-18 Pfizer Products Inc. Purine derivatives for the treatment of ischemia
WO2003053930A1 (en) 2001-12-20 2003-07-03 Bayer Healthcare Ag 1,4-dihydro-1,4-diphenylpyridine derivatives
ES2264795T3 (es) 2003-02-14 2007-01-16 Pfizer Products Inc. Triazolo-piridinas como compuestos antiinflamatorios.
SE0302487D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
JP2007535565A (ja) 2004-04-30 2007-12-06 バイエル ファーマシューティカルス コーポレーション 癌の治療に有用な置換ピラゾリル尿素誘導体
DK1761520T3 (da) 2004-06-23 2008-10-27 Lilly Co Eli Kinaseinhibitorer
EP1609789A1 (en) 2004-06-23 2005-12-28 Eli Lilly And Company Ureido-pyrazole derivatives and their use as kinase inhibitors
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AP2326A (en) 2004-08-12 2011-11-24 Pfizer Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors.
WO2006018727A2 (en) 2004-08-18 2006-02-23 Pharmacia & Upjohn Company Llc Triazolopyridine compounds useful for the treatment of inflammation
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GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions

Also Published As

Publication number Publication date
AU2010215261A1 (en) 2011-09-08
WO2010094956A1 (en) 2010-08-26
TN2011000380A1 (en) 2013-03-27
KR20110116030A (ko) 2011-10-24
MX2011008496A (es) 2011-11-18
SG174134A1 (en) 2011-10-28
JP2012517992A (ja) 2012-08-09
EP2398798A1 (en) 2011-12-28
CN103483338A (zh) 2014-01-01
EA201190119A1 (ru) 2012-05-30
US8557797B2 (en) 2013-10-15
BRPI1005327A2 (pt) 2019-09-24
CN102395586A (zh) 2012-03-28
CO6420344A2 (es) 2012-04-16
CL2011001977A1 (es) 2011-11-18
CA2752693A1 (en) 2010-08-26
US20120088763A1 (en) 2012-04-12
MA33128B1 (fr) 2012-03-01
IL214658A0 (en) 2011-09-27
ZA201105993B (en) 2012-10-31

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