PE20120105A1 - Combinaciones farmaceuticas que comprenden refametinib - Google Patents
Combinaciones farmaceuticas que comprenden refametinibInfo
- Publication number
- PE20120105A1 PE20120105A1 PE2011001622A PE2011001622A PE20120105A1 PE 20120105 A1 PE20120105 A1 PE 20120105A1 PE 2011001622 A PE2011001622 A PE 2011001622A PE 2011001622 A PE2011001622 A PE 2011001622A PE 20120105 A1 PE20120105 A1 PE 20120105A1
- Authority
- PE
- Peru
- Prior art keywords
- cancer
- quinazolin
- difluoro
- hydroxy
- refametinib
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) EL COMPUESTO (S)-N-(3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)-6-METOXIFENIL)-1-(2,3-DIHIDROXIPROPIL)CICLOPROPAN-1-SULFONAMIDA; Y B) UNO DE LOS COMPUESTOS i) 3-(6,7-BIS(2-METOXIETOXI)QUINAZOLIN-4-ILAMINO)BENZONITRILO, ii) N-(3-CLORO-4-FLUOROFENIL)-7-METOXI-6-(3-MORFOLINOPROPOXI)QUINAZOLIN-4-AMINA, iii) 4-AMINO-1-[3,3-DIFLUORO-4-HIDROXI-5-(HIDROXIMETIL)TETRAHIDROFURAN-2-IL]-1H-PIRIMIDIN-2-ONA, iv) N-HIDROXI-N'-FENIL-OCTANDIAMIDA, v) 4-METIL-5-OXO-2,3,4,6,8-PENTAZABICICLO[4.3.0]NONA-2,7,9-TRIEN-9-CARBOXAMIDA, ENTRE OTROS. DICHA COMPOSICION ES UNA COMBINACION SINERGICA SIENDO UTIL EN EL TRATAMIENTO DE CANCER DE PULMON DE CELULA NO PEQUENA, CANCER DE MAMA, CANCER DE TIROIDES, MELANOMA, CANCER DE PANCREAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15940309P | 2009-03-11 | 2009-03-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20120105A1 true PE20120105A1 (es) | 2012-02-22 |
Family
ID=42135921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2011001622A PE20120105A1 (es) | 2009-03-11 | 2010-03-11 | Combinaciones farmaceuticas que comprenden refametinib |
Country Status (23)
Country | Link |
---|---|
US (2) | US8673876B2 (es) |
EP (1) | EP2405908B1 (es) |
JP (2) | JP5767122B2 (es) |
KR (1) | KR20110132371A (es) |
CN (2) | CN103948600A (es) |
AU (1) | AU2010224044A1 (es) |
BR (1) | BRPI1009448A2 (es) |
CA (2) | CA2972379A1 (es) |
CL (1) | CL2011002233A1 (es) |
CO (1) | CO6430423A2 (es) |
CR (1) | CR20110479A (es) |
CU (1) | CU20110170A7 (es) |
DO (1) | DOP2011000282A (es) |
EA (1) | EA201101302A1 (es) |
EC (1) | ECSP11011314A (es) |
HK (2) | HK1169603A1 (es) |
IL (1) | IL214749A0 (es) |
MA (1) | MA33091B1 (es) |
MX (1) | MX2011009498A (es) |
PE (1) | PE20120105A1 (es) |
SG (1) | SG174272A1 (es) |
TN (1) | TN2011000455A1 (es) |
WO (1) | WO2010105110A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
JP5792621B2 (ja) | 2008-09-26 | 2015-10-14 | オンコメッド ファーマシューティカルズ インコーポレイテッド | frizzled結合剤およびその使用 |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
WO2013001372A2 (en) * | 2011-06-30 | 2013-01-03 | University Of Oslo | Methods and compositions for inhibition of activation of regulatory t cells |
US20150132301A1 (en) * | 2011-12-09 | 2015-05-14 | Oncomed Pharmaceuticals, Inc. | Combination Therapy for Treatment of Cancer |
AU2013337702A1 (en) | 2012-11-02 | 2015-05-21 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a MEK inhibitor |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
DK3043778T3 (da) * | 2013-09-13 | 2017-11-27 | Bayer Pharma AG | Farmaceutiske sammensætninger, der indeholder refametinib |
EP2848246A1 (en) * | 2013-09-13 | 2015-03-18 | Bayer Pharma Aktiengesellschaft | Pharmaceutical compositions containing refametinib |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9925958D0 (en) | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
WO2002039958A2 (en) * | 2000-11-03 | 2002-05-23 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
US20040191254A1 (en) * | 2001-10-09 | 2004-09-30 | Fagin James Alexander | Method of treatment of thyroid cancer |
AU2004233897A1 (en) * | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
JP5291345B2 (ja) * | 2004-12-17 | 2013-09-18 | スミスクライン ビーチャム (コーク) リミテッド | 癌治療法 |
WO2006076463A2 (en) * | 2005-01-12 | 2006-07-20 | Amgen Inc. | Kinase-directed, activity-based probes |
WO2006090931A1 (ja) * | 2005-02-28 | 2006-08-31 | Eisai R & D Management Co., Ltd. | スルホンアミド化合物の抗癌剤との新規併用 |
PL1912636T3 (pl) | 2005-07-21 | 2015-02-27 | Ardea Biosciences Inc | N-(aryloamino)sulfonamidowe inhibitory mek |
US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
WO2009012181A2 (en) * | 2007-07-13 | 2009-01-22 | Ventana Medical Systems, Inc. | Method of identifying diagnostic reagents |
UA99731C2 (ru) * | 2007-07-30 | 2012-09-25 | Ардеа Биосайенсис, Инк | Кристаллические полиморфные формы n-(ариламино)сульфонамидов как ингибиторы мэк, композиция (варианты) и применение |
CN101808516B (zh) * | 2007-07-30 | 2013-08-28 | 阿迪生物科学公司 | 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 |
US8044240B2 (en) * | 2008-03-06 | 2011-10-25 | Ardea Biosciences Inc. | Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof |
DE102008031039A1 (de) * | 2008-06-30 | 2009-12-31 | Dömling, Alexander, Priv.-Doz. Dr. | Tarceva zur Anwendung in der Organtransplantation. |
-
2010
- 2010-03-11 EA EA201101302A patent/EA201101302A1/ru unknown
- 2010-03-11 BR BRPI1009448A patent/BRPI1009448A2/pt not_active IP Right Cessation
- 2010-03-11 MX MX2011009498A patent/MX2011009498A/es not_active Application Discontinuation
- 2010-03-11 KR KR1020117021234A patent/KR20110132371A/ko not_active Application Discontinuation
- 2010-03-11 CA CA2972379A patent/CA2972379A1/en not_active Abandoned
- 2010-03-11 WO PCT/US2010/027060 patent/WO2010105110A1/en active Application Filing
- 2010-03-11 MA MA34134A patent/MA33091B1/fr unknown
- 2010-03-11 JP JP2011554220A patent/JP5767122B2/ja not_active Expired - Fee Related
- 2010-03-11 PE PE2011001622A patent/PE20120105A1/es not_active Application Discontinuation
- 2010-03-11 AU AU2010224044A patent/AU2010224044A1/en not_active Abandoned
- 2010-03-11 CA CA2754913A patent/CA2754913C/en not_active Expired - Fee Related
- 2010-03-11 CN CN201310462579.9A patent/CN103948600A/zh active Pending
- 2010-03-11 SG SG2011064300A patent/SG174272A1/en unknown
- 2010-03-11 CN CN2010800209977A patent/CN102421427B/zh not_active Expired - Fee Related
- 2010-03-11 EP EP10709139.9A patent/EP2405908B1/en active Active
- 2010-03-11 US US13/255,278 patent/US8673876B2/en not_active Expired - Fee Related
-
2011
- 2011-08-18 IL IL214749A patent/IL214749A0/en unknown
- 2011-09-09 CO CO11116967A patent/CO6430423A2/es not_active Application Discontinuation
- 2011-09-09 CU CU20110170A patent/CU20110170A7/es unknown
- 2011-09-09 CL CL2011002233A patent/CL2011002233A1/es unknown
- 2011-09-09 CR CR20110479A patent/CR20110479A/es unknown
- 2011-09-09 TN TN2011000455A patent/TN2011000455A1/fr unknown
- 2011-09-09 DO DO2011000282A patent/DOP2011000282A/es unknown
- 2011-09-09 EC EC2011011314A patent/ECSP11011314A/es unknown
-
2012
- 2012-10-18 HK HK12110337.7A patent/HK1169603A1/xx not_active IP Right Cessation
-
2013
- 2013-11-18 US US14/082,681 patent/US9220696B2/en not_active Expired - Fee Related
-
2014
- 2014-09-04 JP JP2014180216A patent/JP5911929B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-08 HK HK15100195.6A patent/HK1199710A1/xx unknown
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