PE20081806A1 - Imidazo- y triazolopirimidinas sustituidas - Google Patents
Imidazo- y triazolopirimidinas sustituidasInfo
- Publication number
- PE20081806A1 PE20081806A1 PE2008000448A PE2008000448A PE20081806A1 PE 20081806 A1 PE20081806 A1 PE 20081806A1 PE 2008000448 A PE2008000448 A PE 2008000448A PE 2008000448 A PE2008000448 A PE 2008000448A PE 20081806 A1 PE20081806 A1 PE 20081806A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazo
- amino
- pyrimidin
- trifluoromethyl
- triazolopyrimidines
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZO Y TRIAZOLOPIRIMIDINAS SUSTITUIDAS DE FORMULA (I) DONDE A ES N O CR15, EN DONDE R15 ES H, Br O Cl; R1 ES H, HIDROXI, NH2, TRIFLUOROMETILO, CN, ALQUILO(C1-C4), ENTRE OTROS; R2 ES ARILO(C6-C10) O HETEROARILO DE 5 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON HIDROXI, NH2, HALOGENO, CN, ENTRE OTROS; R4 ES H, HALOGENO, CN, TRIFLUOROMETILO, ENTRE OTROS; R16 ES UN COMPUESTO DE FORMULA (i), (ii), ENTRE OTROS, DONDE R3 ES 2-PIRIDILO, PIRIMID-2-ILO, 2-CICLOPROPILAMINOPIRIMID-4-ILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[(2-{[7-(2,4-DICLOROFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]AMINO}ETIL)AMINO]-NICOTINONITRILO, N-[7-(2,4-DICLOROFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]-N'-[5-(TRIFLUOROMETIL)PIRIDIN-2-IL]ETANO-1,2-DIAMINA, 1-{6-[(2-{[7-(2,4-DICLOROFENIL)IMIDAZO[1,2-c]PIRIMIDIN-5-IL]AMINO}ETIL)AMINO]PIRIDIN-3-IL}ETANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA GLICOGENO SINTASA QUINASA 3B (GSK3B) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS HEMATOLOGICOS TALES COMO LEUCOPENIAS Y NEUTROPENIAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007012645A DE102007012645A1 (de) | 2007-03-16 | 2007-03-16 | Substituierte Imidazo- und Triazolopyrimidine |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081806A1 true PE20081806A1 (es) | 2009-02-07 |
Family
ID=39688187
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000448A PE20081806A1 (es) | 2007-03-16 | 2008-03-10 | Imidazo- y triazolopirimidinas sustituidas |
Country Status (13)
Country | Link |
---|---|
US (2) | US8273752B2 (es) |
EP (1) | EP2137188B1 (es) |
JP (1) | JP5400626B2 (es) |
AR (1) | AR065719A1 (es) |
CA (1) | CA2680697C (es) |
CL (1) | CL2008000703A1 (es) |
DE (1) | DE102007012645A1 (es) |
ES (1) | ES2387223T3 (es) |
PA (1) | PA8772101A1 (es) |
PE (1) | PE20081806A1 (es) |
TW (1) | TW200904819A (es) |
UY (1) | UY30956A1 (es) |
WO (1) | WO2008113469A2 (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007012645A1 (de) | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
DE102008023801A1 (de) * | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
DE102008035552A1 (de) * | 2008-07-30 | 2010-02-04 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Pyridine und ihre Verwendung |
CN102361872B (zh) * | 2009-02-13 | 2014-12-03 | 拜耳知识产权有限责任公司 | 作为akt抑制剂的稠合嘧啶 |
JP5503930B2 (ja) * | 2009-09-18 | 2014-05-28 | 住友化学株式会社 | 3−アミノ−1−tert−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩 |
SI2480546T1 (sl) * | 2009-09-24 | 2015-03-31 | F. Hoffmann-La Roche Ag | Derivati imidazopiridina ali imidazopirimidina kot inhibitorji fosfodiesteraze 10a |
AU2010306415A1 (en) | 2009-10-15 | 2012-05-03 | Monash University | Affinity ligands and methods for protein purification |
WO2011089400A1 (en) | 2010-01-22 | 2011-07-28 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Inhibitors of pi3 kinase |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2546235B1 (en) * | 2010-03-12 | 2019-05-22 | Nippon Soda Co., Ltd. | PROCESS FOR PREPARATION OF t-BUTOXYCARBONYLAMINE COMPOUNDS |
KR20130094710A (ko) * | 2010-04-14 | 2013-08-26 | 어레이 바이오파마 인크. | Jak 키나아제의 억제제로서 5,7-치환된-이미다조[1,2-c]피리미딘 |
US20130131057A1 (en) | 2010-05-13 | 2013-05-23 | Centro Nacional De Investigaciones Oncologicas (Cnio | New bicyclic compounds as pi3-k and mtor inhibitors |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
US8703946B2 (en) | 2010-12-08 | 2014-04-22 | Vanderbilt University | Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
KR20140076619A (ko) * | 2011-10-12 | 2014-06-20 | 어레이 바이오파마 인크. | 5,7-치환된-이미다조[1,2-c]피리미딘 |
HUE045725T2 (hu) | 2014-02-13 | 2020-01-28 | Incyte Corp | Ciklopropilaminok mint LSD1 inhibitorok |
US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
EP3392244A1 (en) | 2014-02-13 | 2018-10-24 | Incyte Corporation | Cyclopropylamines as lsd1 inhibitors |
AU2015217073B2 (en) | 2014-02-13 | 2019-08-22 | Incyte Holdings Corporation | Cyclopropylamines as LSD1 inhibitors |
LT3119772T (lt) | 2014-03-19 | 2019-08-26 | Boehringer Ingelheim International Gmbh | Heteroarilo sik inhibitoriai |
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UA123912C2 (uk) | 2016-04-01 | 2021-06-23 | Басф Се | Біциклічні сполуки |
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GEP20237560B (en) | 2018-07-05 | 2023-10-25 | Incyte Corp | Fused pyrazine derivatives as a2a / a2b inhibitors |
US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
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EP3873608A1 (en) | 2018-10-31 | 2021-09-08 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity |
US20220040184A1 (en) * | 2018-11-20 | 2022-02-10 | Merck Sharp Dohme Corp. | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶 |
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CA2136228A1 (en) | 1992-05-21 | 1993-11-25 | Masao Hisadome | Use for treating thrombocytopenia, use for treating erythropenia and optically active fused pyrazole compound |
JP2001302667A (ja) | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
US20030078232A1 (en) | 2001-08-08 | 2003-04-24 | Elfatih Elzein | Adenosine receptor A3 agonists |
AU2002364536B2 (en) * | 2001-12-07 | 2008-10-23 | Vertex Pharmaceuticals, Inc. | Pyrimidine-based compounds useful as GSK-3 inhibitors |
MXPA05002571A (es) * | 2002-09-04 | 2005-09-08 | Schering Corp | Pirazolopirimidinas como inhibidores de cinasa dependientes de ciclina. |
WO2005035532A1 (en) * | 2003-10-10 | 2005-04-21 | Pfizer Products Inc. | Substituted 2h-[1,2,4]triazolo[4,3-a]pyrazines as gsk-3 inhibitors |
US7713973B2 (en) | 2004-10-15 | 2010-05-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
DE102007012645A1 (de) | 2007-03-16 | 2008-09-18 | Bayer Healthcare Ag | Substituierte Imidazo- und Triazolopyrimidine |
DE102008023801A1 (de) * | 2008-05-15 | 2009-11-19 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Imidazo- und Triazolopyrimidine, Imidazo- und Pyrazolopyrazine und Imidazotriazine |
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2007
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2008
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- 2008-03-04 WO PCT/EP2008/001682 patent/WO2008113469A2/de active Application Filing
- 2008-03-04 EP EP08716201A patent/EP2137188B1/de not_active Not-in-force
- 2008-03-04 US US12/529,711 patent/US8273752B2/en not_active Expired - Fee Related
- 2008-03-04 ES ES08716201T patent/ES2387223T3/es active Active
- 2008-03-04 JP JP2009553944A patent/JP5400626B2/ja not_active Expired - Fee Related
- 2008-03-10 PE PE2008000448A patent/PE20081806A1/es not_active Application Discontinuation
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- 2008-03-14 TW TW097108955A patent/TW200904819A/zh unknown
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WO2008113469A3 (de) | 2008-11-13 |
US20100113441A1 (en) | 2010-05-06 |
EP2137188B1 (de) | 2012-06-06 |
CA2680697A1 (en) | 2008-09-25 |
WO2008113469A8 (de) | 2009-09-24 |
JP2010521506A (ja) | 2010-06-24 |
EP2137188A2 (de) | 2009-12-30 |
CA2680697C (en) | 2016-09-20 |
PA8772101A1 (es) | 2009-02-09 |
ES2387223T3 (es) | 2012-09-18 |
AR065719A1 (es) | 2009-06-24 |
CL2008000703A1 (es) | 2008-09-26 |
US9051323B2 (en) | 2015-06-09 |
TW200904819A (en) | 2009-02-01 |
UY30956A1 (es) | 2008-10-31 |
JP5400626B2 (ja) | 2014-01-29 |
DE102007012645A1 (de) | 2008-09-18 |
US8273752B2 (en) | 2012-09-25 |
US20130040946A1 (en) | 2013-02-14 |
WO2008113469A2 (de) | 2008-09-25 |
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