PE20081657A1 - Derivados de ftalazina como antagonistas de los receptores de histamina h1 - Google Patents

Derivados de ftalazina como antagonistas de los receptores de histamina h1

Info

Publication number
PE20081657A1
PE20081657A1 PE2008000040A PE2008000040A PE20081657A1 PE 20081657 A1 PE20081657 A1 PE 20081657A1 PE 2008000040 A PE2008000040 A PE 2008000040A PE 2008000040 A PE2008000040 A PE 2008000040A PE 20081657 A1 PE20081657 A1 PE 20081657A1
Authority
PE
Peru
Prior art keywords
alkyl
methyl
phthalazine
histamine
antagonists
Prior art date
Application number
PE2008000040A
Other languages
English (en)
Inventor
Paul Martin Gore
Michael Joachim Kranz
Brian Edgar Looker
Sadie Vile
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20081657A1 publication Critical patent/PE20081657A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE FTALAZINA DE FORMULA (I) DONDE A ES N O CH; R1 Y R2 SON CADA UNO HALOGENO, ALQUILO(C1-C3), ALCOXI(C1-C3), OH O TRIFLUOROMETILO; x E y SON CADA UNO DE 0 A 2; m ES 0 O 1; n ES 2 O 0; p ES 1 O 2; R3 ES ALQUILENO(C1-C6) OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C3); R4 ES -C(O)N(R5)R6, -N(R7)C(O)R8, ENTRE OTROS, DONDE R5 ES H O ALQUILO(C1-C6); R6 ES H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HALOGENO E HIDROXI, CICLOALQUILO(C3-C7), ALQUIL(C1-C6)-O-ALQUILO(C1-C6), ENTRE OTROS; R7 ES H O ALQUILO(C1-C6); R8 ES ALQUILO(C1-C6), ALQUIL(C1-C6)-O-ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, HIDROXI, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: N-[2-((2R)-2-{[4-[(4-CLOROFENIL)METIL]-1-OXO-2(1H)-FTALAZINIL]METIL}-1-PIRROLIDINIL)ETIL]-4-(METILOXI)BUTANAMIDA, 3-((2R)-2-{[4-[(4-CLOROFENIL)METIL]-1-OXO-2(1H)-FTALAZINIL]METIL}-1-PIRROLIDINIL)-N-(2,2,2-TRIFLUOROETIL)PROPANAMIDA, TRIFLUOROACETATO DE 3-((2R)-2-{[4-[(4-CLOROFENIL)METIL]-1-OXO-2(1H)-FTALAZINIL]METIL}-1-PIRROLIDINIL)-N-ETILPROPANAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE HISTAMINA H1 SIENDO UTILES EN EL TRATAMIENTO DE RINITIS ALERGICA
PE2008000040A 2006-12-20 2008-01-02 Derivados de ftalazina como antagonistas de los receptores de histamina h1 PE20081657A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87087506P 2006-12-20 2006-12-20
US97844707P 2007-10-09 2007-10-09
US99122707P 2007-11-30 2007-11-30

Publications (1)

Publication Number Publication Date
PE20081657A1 true PE20081657A1 (es) 2008-12-23

Family

ID=39536783

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000040A PE20081657A1 (es) 2006-12-20 2008-01-02 Derivados de ftalazina como antagonistas de los receptores de histamina h1

Country Status (10)

Country Link
US (1) US20100184770A1 (es)
EP (1) EP2091538B1 (es)
JP (1) JP2010513393A (es)
AR (1) AR064424A1 (es)
AT (1) ATE459358T1 (es)
DE (1) DE602007005167D1 (es)
ES (1) ES2341813T3 (es)
PE (1) PE20081657A1 (es)
TW (1) TW200831493A (es)
WO (1) WO2008074803A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101163681A (zh) * 2005-04-21 2008-04-16 日本新药株式会社 2,3-二氮杂萘酮衍生物及其医药品
US8466150B2 (en) * 2006-12-28 2013-06-18 Abbott Laboratories Inhibitors of poly(ADP-ribose)polymerase
RS53196B (en) * 2006-12-28 2014-06-30 Abbvie Inc. INHIBITORI POLI (ADP-RIBOZA) POLIMERAZE
ES2369320T3 (es) * 2007-10-11 2011-11-29 Glaxo Group Limited Compuestos de ftalazina y pirido(3,4-d)piridazina como antagonistas del receptor h1.
WO2009150101A1 (en) * 2008-06-09 2009-12-17 Glaxo Group Limited Pharmaceutical compositions comprising n-[2-((2r)-2-{[4-[(4-chlorophenyl)methyl]-l-oxo-2(ih)-phthalaz inyl]methyl}-l- pyrrolidinyl)ethyl]-4-(methyloxy)butanamide
WO2010019417A2 (en) * 2008-08-13 2010-02-18 Boehringer Ingelheim International Gmbh Chymase inhibitors
WO2012045729A1 (en) 2010-10-05 2012-04-12 Glaxo Group Limited Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists
WO2012072512A1 (en) 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
EP2697221A1 (en) 2011-04-11 2014-02-19 Glaxo Group Limited N- cyclobutyl - imidazopyridine - methylamine as trpv1 antagonists
KR20240013792A (ko) * 2021-05-27 2024-01-30 슈뢰딩거, 인크. 헤테로시클릭 화합물 및 사용 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE60598T1 (de) * 1985-11-11 1991-02-15 Asta Pharma Ag 4-benzyl-1-(2h)-phthalazinon-derivate.
DE3634942A1 (de) * 1985-11-11 1987-05-14 Asta Werke Ag Chem Fab Neue 4-benzyl-1-(2h)-phthalazinon-derivate
CZ199593A3 (en) * 1992-10-02 1994-04-13 Asta Medica Ag Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
DE69912379T2 (de) * 1998-08-14 2004-05-06 Pfizer Inc. Antithrombosemittel
AU2002234634B2 (en) * 2001-02-15 2007-07-26 Takeda Gmbh Phthalayinone-piperidino-derivatives as PDE4 inhibitors
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
US7553841B2 (en) * 2003-03-18 2009-06-30 Merck & Co., Inc. Amino cyclobutylamide modulators of chemokine receptor activity
WO2005007644A1 (ja) * 2003-06-27 2005-01-27 Banyu Pharmaceutical Co., Ltd ヘテロアリールオキシ含窒素飽和へテロ環誘導体
CN101163681A (zh) * 2005-04-21 2008-04-16 日本新药株式会社 2,3-二氮杂萘酮衍生物及其医药品
DE602007010118D1 (de) * 2006-04-20 2010-12-09 Glaxo Group Ltd 2-substituierte 4-benzylphthalazinonderivate als histamin-h1- und h3-antagonisten

Also Published As

Publication number Publication date
ES2341813T3 (es) 2010-06-28
ATE459358T1 (de) 2010-03-15
WO2008074803A3 (en) 2008-09-18
WO2008074803A2 (en) 2008-06-26
US20100184770A1 (en) 2010-07-22
TW200831493A (en) 2008-08-01
EP2091538B1 (en) 2010-03-03
EP2091538A2 (en) 2009-08-26
AR064424A1 (es) 2009-04-01
JP2010513393A (ja) 2010-04-30
WO2008074803A8 (en) 2009-05-14
DE602007005167D1 (de) 2010-04-15

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