DE602007005167D1 - 4-benzyl-1(2h)-phthalazinone als h1-rezeptor-antagonisten - Google Patents
4-benzyl-1(2h)-phthalazinone als h1-rezeptor-antagonistenInfo
- Publication number
- DE602007005167D1 DE602007005167D1 DE602007005167T DE602007005167T DE602007005167D1 DE 602007005167 D1 DE602007005167 D1 DE 602007005167D1 DE 602007005167 T DE602007005167 T DE 602007005167T DE 602007005167 T DE602007005167 T DE 602007005167T DE 602007005167 D1 DE602007005167 D1 DE 602007005167D1
- Authority
- DE
- Germany
- Prior art keywords
- phthalazinone
- benzyl
- receptor antagonists
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87087506P | 2006-12-20 | 2006-12-20 | |
US97844707P | 2007-10-09 | 2007-10-09 | |
US99122707P | 2007-11-30 | 2007-11-30 | |
PCT/EP2007/064140 WO2008074803A2 (en) | 2006-12-20 | 2007-12-18 | 4-benzyl-l ( 2h) -phthalazinones as h1 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602007005167D1 true DE602007005167D1 (de) | 2010-04-15 |
Family
ID=39536783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602007005167T Active DE602007005167D1 (de) | 2006-12-20 | 2007-12-18 | 4-benzyl-1(2h)-phthalazinone als h1-rezeptor-antagonisten |
Country Status (10)
Country | Link |
---|---|
US (1) | US20100184770A1 (de) |
EP (1) | EP2091538B1 (de) |
JP (1) | JP2010513393A (de) |
AR (1) | AR064424A1 (de) |
AT (1) | ATE459358T1 (de) |
DE (1) | DE602007005167D1 (de) |
ES (1) | ES2341813T3 (de) |
PE (1) | PE20081657A1 (de) |
TW (1) | TW200831493A (de) |
WO (1) | WO2008074803A2 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101163681A (zh) * | 2005-04-21 | 2008-04-16 | 日本新药株式会社 | 2,3-二氮杂萘酮衍生物及其医药品 |
US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
RS53196B (en) * | 2006-12-28 | 2014-06-30 | Abbvie Inc. | INHIBITORI POLI (ADP-RIBOZA) POLIMERAZE |
ES2369320T3 (es) * | 2007-10-11 | 2011-11-29 | Glaxo Group Limited | Compuestos de ftalazina y pirido(3,4-d)piridazina como antagonistas del receptor h1. |
WO2009150101A1 (en) * | 2008-06-09 | 2009-12-17 | Glaxo Group Limited | Pharmaceutical compositions comprising n-[2-((2r)-2-{[4-[(4-chlorophenyl)methyl]-l-oxo-2(ih)-phthalaz inyl]methyl}-l- pyrrolidinyl)ethyl]-4-(methyloxy)butanamide |
WO2010019417A2 (en) * | 2008-08-13 | 2010-02-18 | Boehringer Ingelheim International Gmbh | Chymase inhibitors |
WO2012045729A1 (en) | 2010-10-05 | 2012-04-12 | Glaxo Group Limited | Imidazo [1, 2 -a] pyridine and pyrazolo [1, 5 -a] pyridine derivatives as trpv1 antagonists |
WO2012072512A1 (en) | 2010-11-29 | 2012-06-07 | Glaxo Group Limited | N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists |
EP2697221A1 (de) | 2011-04-11 | 2014-02-19 | Glaxo Group Limited | Cyclobutyl n- imidazopyridin-methylamin als trpv1-antagonisten |
KR20240013792A (ko) * | 2021-05-27 | 2024-01-30 | 슈뢰딩거, 인크. | 헤테로시클릭 화합물 및 사용 방법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE60598T1 (de) * | 1985-11-11 | 1991-02-15 | Asta Pharma Ag | 4-benzyl-1-(2h)-phthalazinon-derivate. |
DE3634942A1 (de) * | 1985-11-11 | 1987-05-14 | Asta Werke Ag Chem Fab | Neue 4-benzyl-1-(2h)-phthalazinon-derivate |
CZ199593A3 (en) * | 1992-10-02 | 1994-04-13 | Asta Medica Ag | Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr) |
DE69912379T2 (de) * | 1998-08-14 | 2004-05-06 | Pfizer Inc. | Antithrombosemittel |
AU2002234634B2 (en) * | 2001-02-15 | 2007-07-26 | Takeda Gmbh | Phthalayinone-piperidino-derivatives as PDE4 inhibitors |
TWI347845B (en) * | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
US7553841B2 (en) * | 2003-03-18 | 2009-06-30 | Merck & Co., Inc. | Amino cyclobutylamide modulators of chemokine receptor activity |
WO2005007644A1 (ja) * | 2003-06-27 | 2005-01-27 | Banyu Pharmaceutical Co., Ltd | ヘテロアリールオキシ含窒素飽和へテロ環誘導体 |
CN101163681A (zh) * | 2005-04-21 | 2008-04-16 | 日本新药株式会社 | 2,3-二氮杂萘酮衍生物及其医药品 |
DE602007010118D1 (de) * | 2006-04-20 | 2010-12-09 | Glaxo Group Ltd | 2-substituierte 4-benzylphthalazinonderivate als histamin-h1- und h3-antagonisten |
-
2007
- 2007-12-18 JP JP2009542033A patent/JP2010513393A/ja active Pending
- 2007-12-18 US US12/065,775 patent/US20100184770A1/en not_active Abandoned
- 2007-12-18 ES ES07857765T patent/ES2341813T3/es active Active
- 2007-12-18 AT AT07857765T patent/ATE459358T1/de not_active IP Right Cessation
- 2007-12-18 EP EP07857765A patent/EP2091538B1/de active Active
- 2007-12-18 DE DE602007005167T patent/DE602007005167D1/de active Active
- 2007-12-18 WO PCT/EP2007/064140 patent/WO2008074803A2/en active Application Filing
- 2007-12-18 TW TW096148520A patent/TW200831493A/zh unknown
- 2007-12-18 AR ARP070105701A patent/AR064424A1/es unknown
-
2008
- 2008-01-02 PE PE2008000040A patent/PE20081657A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2341813T3 (es) | 2010-06-28 |
ATE459358T1 (de) | 2010-03-15 |
WO2008074803A3 (en) | 2008-09-18 |
WO2008074803A2 (en) | 2008-06-26 |
US20100184770A1 (en) | 2010-07-22 |
TW200831493A (en) | 2008-08-01 |
EP2091538B1 (de) | 2010-03-03 |
EP2091538A2 (de) | 2009-08-26 |
PE20081657A1 (es) | 2008-12-23 |
AR064424A1 (es) | 2009-04-01 |
JP2010513393A (ja) | 2010-04-30 |
WO2008074803A8 (en) | 2009-05-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |