PE20081194A1 - Produccion de glicoproteinas - Google Patents
Produccion de glicoproteinasInfo
- Publication number
- PE20081194A1 PE20081194A1 PE2007000892A PE2007000892A PE20081194A1 PE 20081194 A1 PE20081194 A1 PE 20081194A1 PE 2007000892 A PE2007000892 A PE 2007000892A PE 2007000892 A PE2007000892 A PE 2007000892A PE 20081194 A1 PE20081194 A1 PE 20081194A1
- Authority
- PE
- Peru
- Prior art keywords
- glycoprotein
- crop
- concentration
- temperature range
- allow
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN METODO PARA PRODUCIR UNA GLICOPROTEINA TAL COMO EL FACTOR DE COAGULACION HUMANO RECOMBINANTE IX O UN ANTICUERPO MONOCLONAL IgG1 PEPTIDICO ANTI-ABETA HUMANIZADO EN UN CULTIVO CELULAR QUE COMPRENDE: A) CULTIVAR CELULAS DE MAMIFEROS QUE CONTIENEN UN GEN QUE CODIFICA UNA GLICOPROTEINA DE INTERES EN UN MEDIO DE CULTIVO CELULAR QUE COMPRENDE MANGANESO EN UNA CONCENTRACION DE 10nM A 600nM; B) MANTENER EL CULTIVO EN UN PRIMER RANGO DE TEMPERATURA DE 37 ºC DURANTE UN TIEMPO SUFICIENTE PARA PERMITIR A LAS CELULAS REPRODUCIRCE HASTA UNA DENSIDAD CELULAR VIABLE DE 20% A 80%; C) CAMBIAR EL CULTIVO A UN SEGUNDO RANGO DE TEMPERATURA DE 31 ºC DURANTE UN TIEMPO SUFICIENTE PARA PERMITIR LA EXPRESION DE LA GLICOPROTEINA, EN DONDE EL PATRON DE GLICOSILACION DE LA GLICOPROTEINA EXPRESADA ES MAS EXTENSO QUE EL PATRON DE GLICOSILACION OBSERVADO EN CARENCIA DE MANGANESO. DICHO MEDIO DE CULTIVO COMPRENDE ADEMAS GLUTAMINA EN UNA CONCENTRACION DE 8mM Y COMPONENTES SUPLEMENTARIOS TAL COMO HORMONAS, IONES INORGANICOS, VITAMINAS, GLUCOSA, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83065806P | 2006-07-13 | 2006-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081194A1 true PE20081194A1 (es) | 2008-09-22 |
Family
ID=38645762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000892A PE20081194A1 (es) | 2006-07-13 | 2007-07-11 | Produccion de glicoproteinas |
Country Status (23)
Country | Link |
---|---|
US (1) | US8129145B2 (es) |
EP (3) | EP3255141B1 (es) |
JP (1) | JP5401310B2 (es) |
KR (1) | KR101495549B1 (es) |
CN (2) | CN104878064A (es) |
AR (1) | AR061976A1 (es) |
AU (1) | AU2007272957B2 (es) |
BR (1) | BRPI0714212B8 (es) |
CA (1) | CA2657248C (es) |
DK (3) | DK3255141T3 (es) |
ES (2) | ES2440487T3 (es) |
HK (1) | HK1214307A1 (es) |
HU (1) | HUE039128T2 (es) |
IL (1) | IL196252A (es) |
MX (1) | MX2009000349A (es) |
PE (1) | PE20081194A1 (es) |
PL (2) | PL2495307T3 (es) |
PT (2) | PT2041270E (es) |
RU (1) | RU2463345C2 (es) |
SI (1) | SI2495307T1 (es) |
TR (1) | TR201807021T4 (es) |
TW (1) | TW200812577A (es) |
WO (1) | WO2008008360A1 (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
EP3255141B1 (en) | 2006-07-13 | 2021-12-01 | Wyeth LLC | Production of antibodies with improved glycosylation pattern |
MY161866A (en) | 2006-09-13 | 2017-05-15 | Abbvie Inc | Cell culture improvements |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
US8192951B2 (en) * | 2006-11-03 | 2012-06-05 | Wyeth Llc | Glycolysis-inhibiting substances in cell culture |
DK2115126T3 (en) * | 2007-03-02 | 2015-05-04 | Wyeth Llc | Use of copper and glutamate in cell culture for the preparation of polypeptides |
TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
US20090233334A1 (en) * | 2008-03-11 | 2009-09-17 | Excellgene Sa | Cell cultivation and production of recombinant proteins by means of an orbital shake bioreactor system with disposable bags at the 1,500 liter scale |
SG10201702922VA (en) | 2008-10-20 | 2017-06-29 | Abbvie Inc | Isolation and purification of antibodies using protein a affinity chromatography |
CN104974251A (zh) | 2008-10-20 | 2015-10-14 | Abbvie公司 | 在抗体纯化过程中的病毒灭活 |
WO2011011674A2 (en) * | 2009-07-24 | 2011-01-27 | Dr. Reddy's Laboratories Ltd. | Production of erythropoiesis stimulating protein using metal ions |
WO2011017177A1 (en) * | 2009-07-28 | 2011-02-10 | Shire Human Genetic Therapies | Compositions and methods for treating gaucher disease |
PT2563906T (pt) | 2010-04-26 | 2018-02-16 | Novartis Ag | Processo para cultivo de células cho |
MY163081A (en) * | 2010-12-28 | 2017-08-15 | Chugai Pharmaceutical Co Ltd | Animal cell culturing method |
WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
ES2560470T3 (es) | 2011-04-29 | 2016-02-19 | Biocon Research Limited | Un método para reducir la heterogeneidad de anticuerpos y un proceso de producción de dichos anticuerpos |
BR112014001120A2 (pt) | 2011-07-20 | 2017-02-21 | Zepteon Incorporated | métodos de separação de polipeptídeos |
WO2013114245A1 (en) | 2012-01-30 | 2013-08-08 | Dr. Reddy's Laboratories Limited | Process of modulating man5 and/or afucosylation content of glycoprotein composition |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
US9206390B2 (en) | 2012-09-02 | 2015-12-08 | Abbvie, Inc. | Methods to control protein heterogeneity |
WO2014143205A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
WO2014170866A2 (en) * | 2013-04-18 | 2014-10-23 | Dr. Reddy's Laboratories Limited | Process of obtaining glycoprotein composition with increased galactosylation content |
JP2016527911A (ja) * | 2013-08-20 | 2016-09-15 | レック・ファーマシューティカルズ・ディー・ディーLek Pharmaceuticals D.D. | ポリペプチドのα−アミド化および/またはC末端アミノ酸開裂を制御するための細胞培養用培地およびプロセス |
EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
EP3110941A4 (en) * | 2014-02-25 | 2017-10-18 | Dr. Reddy's Laboratories Ltd. | Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation |
WO2015128314A1 (en) | 2014-02-27 | 2015-09-03 | F. Hoffmann-La Roche Ag | Modulation of cell growth and glycosylation in recombinant glycoprotein production |
WO2016089919A1 (en) | 2014-12-01 | 2016-06-09 | Amgen Inc. | Process for manipulating the level of glycan content of a glycoprotein |
KR102007930B1 (ko) * | 2014-12-31 | 2019-08-06 | 주식회사 엘지화학 | 재조합 당단백질의 글리코실화 조절 방법 |
EP3042952A1 (en) * | 2015-01-07 | 2016-07-13 | CEVEC Pharmaceuticals GmbH | O-glycan sialylated recombinant glycoproteins and cell lines for producing the same |
EP3298036B1 (en) | 2015-05-22 | 2022-04-06 | CSL Behring Lengnau AG | Methods for preparing modified von willebrand factor |
WO2016196621A1 (en) | 2015-06-01 | 2016-12-08 | Biogen Ma Inc. | Manganese supplementation for control of glycosylation in mammalian cell culture process |
CN104894055B (zh) * | 2015-06-15 | 2018-07-17 | 成都金凯生物技术有限公司 | 一种优化的细胞培养基、细胞培养方法及其在制备蛋白和抗体中的应用 |
KR101932137B1 (ko) * | 2017-01-02 | 2018-12-24 | 연세대학교 산학협력단 | 당화 증강용 조성물 및 당화 증강된 단백질의 제조방법 |
WO2018210771A1 (en) | 2017-05-17 | 2018-11-22 | Octapharma Ag | Method for the production of a recombinant target protein |
HUP1800376A2 (hu) * | 2018-11-07 | 2020-05-28 | Richter Gedeon Nyrt | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
JP2020188737A (ja) * | 2019-05-23 | 2020-11-26 | 東ソー株式会社 | 抗体依存性細胞傷害活性が向上した抗体の製造方法 |
SG11202110968VA (en) | 2019-12-06 | 2021-10-28 | Regeneron Pharma | Anti-vegf protein compositions and methods for producing the same |
WO2022204120A1 (en) * | 2021-03-23 | 2022-09-29 | Biogen Ma Inc. | Reducing host cell impurities during recombinant protein production |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US5078996A (en) | 1985-08-16 | 1992-01-07 | Immunex Corporation | Activation of macrophage tumoricidal activity by granulocyte-macrophage colony stimulating factor |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
NO162160C (no) | 1987-01-09 | 1989-11-15 | Medi Cult As | Serumfritt vekstmedium, samt anvendelse derav. |
US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
SU1587450A1 (ru) * | 1988-05-04 | 1990-08-23 | Институт биоорганической химии АН БССР | Способ разделени гликозилированной и негликозилированной форм пролактина биологического материала |
US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
US5549892A (en) | 1988-12-23 | 1996-08-27 | Genzyme Corporation | Enhanced in vivo uptake of glucocerebrosidase |
JPH0396383A (ja) | 1989-09-08 | 1991-04-22 | Riso Kagaku Corp | 画像形成装置 |
EP1132471A3 (de) | 1989-09-12 | 2001-11-28 | F. Hoffmann-La Roche Ag | TNF-bindende Proteine |
US5156964A (en) | 1990-08-16 | 1992-10-20 | Cetus Corporation | Methods for adapting cells for increased product production through exposure to ammonia |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
GB9021679D0 (en) | 1990-10-05 | 1990-11-21 | Gorman Scott David | Antibody preparation |
GB9022545D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
US5118816A (en) | 1990-12-26 | 1992-06-02 | American Cyanamid Company | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles |
CA2372251A1 (en) | 1991-01-21 | 1992-08-06 | Michael John Mullan | Test and model for alzheimer's disease |
DK1589107T3 (da) | 1992-08-21 | 2010-04-26 | Univ Bruxelles | Immonuglobuliner uden lette kæder |
US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
US5571515A (en) | 1994-04-18 | 1996-11-05 | The Wistar Institute Of Anatomy & Biology | Compositions and methods for use of IL-12 as an adjuvant |
US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
AU729579B2 (en) | 1996-10-23 | 2001-02-01 | Trustees Of The University Of Pennsylvania, The | Immunotherapy and improved vaccines |
US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
EP1047938A2 (en) | 1998-01-12 | 2000-11-02 | Betagene, Inc. | Identification of substances that modify cellular secretory function |
EP1078093B1 (en) | 1998-02-27 | 2011-06-08 | The Trustees of The University of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
ATE378066T1 (de) | 1998-09-30 | 2007-11-15 | Wyeth Corp | Mutiertes cholera holotoxin als hilfsmittel |
WO2000065070A2 (en) * | 1999-04-26 | 2000-11-02 | Genentech, Inc. | Cell culture process for glycoproteins |
JP2001120262A (ja) * | 1999-10-26 | 2001-05-08 | Welfide Corp | 生理活性物質の産生増強方法 |
IL151857A0 (en) | 2000-03-22 | 2003-04-10 | Octagene Gmbh | Production of recombinant blood clotting factors in human cell lines |
US20040001822A1 (en) * | 2000-12-29 | 2004-01-01 | Avigdor Levanon | Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
AU2002322380B2 (en) | 2001-06-07 | 2006-11-02 | Government Of The United States Of America As Represented By The Uniformed Services University Of The Health Sciences | Mutant forms of cholera holotoxin as an adjuvant |
DE60234695D1 (de) | 2001-06-07 | 2010-01-21 | Univ Colorado | Mutantenformen von cholera holotoxin als adjuvans |
PL224150B1 (pl) | 2002-05-02 | 2016-11-30 | Wyeth Corp | Kompozycja zawierająca koniugat leku obejmujący pochodne kalicheamycyny i przeciwciało, oraz kompozycja farmaceutyczna ją zawierająca |
CA2492267C (en) | 2002-07-15 | 2013-09-10 | Immunex Corporation | Methods and media for controlling sialylation of proteins produced by mammalian cells |
TWI374935B (en) * | 2004-08-27 | 2012-10-21 | Pfizer Ireland Pharmaceuticals | Production of α-abeta |
US7300773B2 (en) * | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
TWI384069B (zh) * | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
AR058140A1 (es) | 2005-10-24 | 2008-01-23 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
EP1943333A2 (en) * | 2005-11-02 | 2008-07-16 | Wyeth a Corporation of the State of Delaware | Methods for adapting mammalian cells |
EP3026109B1 (en) * | 2005-12-08 | 2022-03-09 | Amgen Inc. | Improved production of glycoproteins using manganese |
EP3255141B1 (en) | 2006-07-13 | 2021-12-01 | Wyeth LLC | Production of antibodies with improved glycosylation pattern |
-
2007
- 2007-07-11 EP EP17179340.9A patent/EP3255141B1/en not_active Revoked
- 2007-07-11 CN CN201510345792.0A patent/CN104878064A/zh active Pending
- 2007-07-11 US US11/827,301 patent/US8129145B2/en active Active
- 2007-07-11 ES ES07796784T patent/ES2440487T3/es active Active
- 2007-07-11 CN CNA2007800331125A patent/CN101541950A/zh active Pending
- 2007-07-11 DK DK17179340.9T patent/DK3255141T3/da active
- 2007-07-11 PL PL12164058T patent/PL2495307T3/pl unknown
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