BRPI0714212B8 - método de produzir uma glicoproteína em uma cultura celular - Google Patents
método de produzir uma glicoproteína em uma cultura celularInfo
- Publication number
- BRPI0714212B8 BRPI0714212B8 BRPI0714212A BRPI0714212A BRPI0714212B8 BR PI0714212 B8 BRPI0714212 B8 BR PI0714212B8 BR PI0714212 A BRPI0714212 A BR PI0714212A BR PI0714212 A BRPI0714212 A BR PI0714212A BR PI0714212 B8 BRPI0714212 B8 BR PI0714212B8
- Authority
- BR
- Brazil
- Prior art keywords
- glycoprotein
- cell culture
- producing
- present
- glycosylation pattern
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 8
- 108090000288 Glycoproteins Proteins 0.000 title abstract 8
- 238000004113 cell culture Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000013595 glycosylation Effects 0.000 abstract 3
- 238000006206 glycosylation reaction Methods 0.000 abstract 3
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract 1
- 239000006143 cell culture medium Substances 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 229910052748 manganese Inorganic materials 0.000 abstract 1
- 239000011572 manganese Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83065806P | 2006-07-13 | 2006-07-13 | |
US60/830,658 | 2006-07-13 | ||
PCT/US2007/015767 WO2008008360A1 (en) | 2006-07-13 | 2007-07-11 | Production of glycoproteins |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0714212A2 BRPI0714212A2 (pt) | 2013-03-26 |
BRPI0714212B1 BRPI0714212B1 (pt) | 2021-01-19 |
BRPI0714212B8 true BRPI0714212B8 (pt) | 2021-05-25 |
Family
ID=38645762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0714212A BRPI0714212B8 (pt) | 2006-07-13 | 2007-07-11 | método de produzir uma glicoproteína em uma cultura celular |
Country Status (23)
Country | Link |
---|---|
US (1) | US8129145B2 (pt) |
EP (3) | EP3255141B1 (pt) |
JP (1) | JP5401310B2 (pt) |
KR (1) | KR101495549B1 (pt) |
CN (2) | CN101541950A (pt) |
AR (1) | AR061976A1 (pt) |
AU (1) | AU2007272957B2 (pt) |
BR (1) | BRPI0714212B8 (pt) |
CA (1) | CA2657248C (pt) |
DK (3) | DK3255141T3 (pt) |
ES (2) | ES2440487T3 (pt) |
HK (1) | HK1214307A1 (pt) |
HU (1) | HUE039128T2 (pt) |
IL (1) | IL196252A (pt) |
MX (1) | MX2009000349A (pt) |
PE (1) | PE20081194A1 (pt) |
PL (2) | PL2041270T3 (pt) |
PT (2) | PT2495307T (pt) |
RU (1) | RU2463345C2 (pt) |
SI (1) | SI2495307T1 (pt) |
TR (1) | TR201807021T4 (pt) |
TW (1) | TW200812577A (pt) |
WO (1) | WO2008008360A1 (pt) |
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US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
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WO2014170866A2 (en) * | 2013-04-18 | 2014-10-23 | Dr. Reddy's Laboratories Limited | Process of obtaining glycoprotein composition with increased galactosylation content |
BR112016002622B1 (pt) * | 2013-08-20 | 2023-04-11 | Lek Pharmaceuticals D.D | Meio de cultura celular e uso de selênio |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
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US10590455B2 (en) * | 2014-02-25 | 2020-03-17 | Dr. Reddy's Laboratories Limited | Process for modifying galactosylation and G0F content of a glycoprotein composition by glutamine supplementation |
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-
2007
- 2007-07-11 CN CNA2007800331125A patent/CN101541950A/zh active Pending
- 2007-07-11 SI SI200732024T patent/SI2495307T1/en unknown
- 2007-07-11 EP EP17179340.9A patent/EP3255141B1/en not_active Revoked
- 2007-07-11 US US11/827,301 patent/US8129145B2/en active Active
- 2007-07-11 EP EP12164058.5A patent/EP2495307B9/en not_active Revoked
- 2007-07-11 CA CA2657248A patent/CA2657248C/en active Active
- 2007-07-11 KR KR20097003040A patent/KR101495549B1/ko active IP Right Grant
- 2007-07-11 DK DK17179340.9T patent/DK3255141T3/da active
- 2007-07-11 PL PL07796784T patent/PL2041270T3/pl unknown
- 2007-07-11 DK DK07796784T patent/DK2041270T3/da active
- 2007-07-11 PL PL12164058T patent/PL2495307T3/pl unknown
- 2007-07-11 BR BRPI0714212A patent/BRPI0714212B8/pt not_active IP Right Cessation
- 2007-07-11 WO PCT/US2007/015767 patent/WO2008008360A1/en active Application Filing
- 2007-07-11 PT PT121640585T patent/PT2495307T/pt unknown
- 2007-07-11 JP JP2009519501A patent/JP5401310B2/ja active Active
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