PE20080281A1 - COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42 - Google Patents
COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42Info
- Publication number
- PE20080281A1 PE20080281A1 PE2007000966A PE2007000966A PE20080281A1 PE 20080281 A1 PE20080281 A1 PE 20080281A1 PE 2007000966 A PE2007000966 A PE 2007000966A PE 2007000966 A PE2007000966 A PE 2007000966A PE 20080281 A1 PE20080281 A1 PE 20080281A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- compounds
- methyl
- members
- trifluoroacetate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Abstract
SE REFIERE A COMPUESTOS CINAMIDA DE FORMULA (I) DONDE Ra Y Rb SON CADA UNO H O ALQUILO(C1-C6); Xa ES METOXI O F; Y ES -CO-(O)n-Rc.Ma-, DONDE Rc ES ALQUILO(C1-C6), ANILLO AROMATICO DE 6 A 14 MIEMBROS, HETEROCICLO DE 5 A 14 MIEMBROS, ENTRE OTROS; n ES 0 O 1; Ma- ES UN ANION; A ES UN COMPUESTO DE FORMULA (A-1), ENTRE OTROS, DONDE R1, R2, R3 Y R4 SON CADA UNO H O ALQUILO(C1-C6); X1 ES ALQUILENO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HIDROXILO O ALQUILO(C1-C6); X2 ES O U METILENO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6); Ar1 ES X1-a-Ar1-a, DONDE Ar1-a ES UN ANILLO AROMATICO DE 6 A 14 MIEMBROS O UN HETEROCICLO DE 5 A 14 MIEMBROS; X1-a ES UN ENLACE SIMPLE U O. SON COMPUESTOS PREFERIDOS: 3-{4-{1-[(S)-1-(4-FLUOROFENIL)ETIL]-2-OXOPIPERIDIN-(3E)-ILIDENOMETIL}-2-METOXIFENIL}-5-METIL-1-(FOSFONOXIMETIL)-3H-IMIDAZOL-1-IO TRIFLUOROACETATO, 3-{4-{1-[(1R,2R)-2-HIDROXI-1-(3,4,5-TRIFLUOROFENIL)PROPIL]-2-OXOPIPERIDIN-(3E)-ILIDENOMETIL}-2-METOXIFENIL}-5-METIL-1-(FOSFONOXIMETIL)-3H-IMIDAZOL-1-IO TRIFLUOROACETATO, 3-[2-FLUORO-4-[(S)-4-[(1R,2R)-2-HIDROXI-1-(3,4,5-TRIFLUOROFENIL)PROPIL]-6-METIL-3-OXOMORFOLINA-(2Z)-ILIDENOMETIL]FENIL]-5-METIL-1-FOSFONOXIMETIL-3H-IMIDAZOL-1-IO TRIFLUOROACETATO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS DEL B-AMILOIDE 40 Y 42 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DEMENCIA SENIL, AMILOIDOSIS
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82076106P | 2006-07-28 | 2006-07-28 | |
JP2006206007 | 2006-07-28 | ||
US86925906P | 2006-12-08 | 2006-12-08 | |
JP2006331274 | 2006-12-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20080281A1 true PE20080281A1 (es) | 2008-05-05 |
Family
ID=38981524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007000966A PE20080281A1 (es) | 2006-07-28 | 2007-07-26 | COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42 |
Country Status (25)
Country | Link |
---|---|
US (1) | US7737141B2 (es) |
EP (1) | EP2048143A4 (es) |
JP (1) | JPWO2008013213A1 (es) |
KR (1) | KR20090033910A (es) |
AR (1) | AR062095A1 (es) |
AU (1) | AU2007277729A1 (es) |
CA (1) | CA2658037A1 (es) |
CO (1) | CO6150153A2 (es) |
CR (1) | CR10499A (es) |
EA (1) | EA200970172A1 (es) |
EC (1) | ECSP099091A (es) |
GE (1) | GEP20115176B (es) |
HN (1) | HN2009000157A (es) |
IL (1) | IL196351A0 (es) |
MA (1) | MA30636B1 (es) |
MX (1) | MX2008015504A (es) |
MY (1) | MY144971A (es) |
NO (1) | NO20090541L (es) |
NZ (1) | NZ574102A (es) |
PE (1) | PE20080281A1 (es) |
SA (1) | SA07280403B1 (es) |
SV (1) | SV2009003157A (es) |
TN (1) | TN2009000024A1 (es) |
TW (1) | TW200821319A (es) |
WO (1) | WO2008013213A1 (es) |
Families Citing this family (30)
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KR101128065B1 (ko) | 2004-05-26 | 2012-04-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
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WO2007058305A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド誘導体の製造方法 |
WO2007058304A1 (ja) * | 2005-11-18 | 2007-05-24 | Eisai R & D Management Co., Ltd. | シンナミド化合物の塩またはそれらの溶媒和物 |
NZ568050A (en) * | 2005-11-24 | 2010-09-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
SA07280403B1 (ar) | 2006-07-28 | 2010-12-01 | إيساي أر أند دي منجمنت كو. ليمتد | ملح رباعي لمركب سيناميد |
TW200848054A (en) * | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
JPWO2008140111A1 (ja) * | 2007-05-16 | 2010-08-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド誘導体のワンポット製造方法 |
MX2010002098A (es) | 2007-08-31 | 2010-03-30 | Eisai R&D Man Co Ltd | Compuesto policiclico. |
US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
JP2011507909A (ja) | 2007-12-20 | 2011-03-10 | エンビボ ファーマシューティカルズ インコーポレイテッド | 四置換ベンゼン |
KR101204213B1 (ko) | 2007-12-21 | 2012-11-26 | 에프. 호프만-라 로슈 아게 | 오렉신 수용체 길항제로서의 헤테로아릴 유도체 |
KR101244517B1 (ko) | 2008-01-11 | 2013-03-18 | 에프. 호프만-라 로슈 아게 | 아밀로이드 베타에 대한 조절제 |
CA2712095A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R&D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
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KR101293421B1 (ko) | 2008-11-10 | 2013-08-05 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 감마 분비효소 조절제 |
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US9018253B2 (en) | 2010-07-02 | 2015-04-28 | Bio-Pharm Solutions Co., Ltd. | Phenylcarbamate compound and muscle relaxant containing the same |
BR112013000050B1 (pt) * | 2010-07-02 | 2021-10-19 | Bio-Pharm Solutions Co., Ltd | Compostos de carbamato de fenila e composição farmacêutica |
WO2012096458A2 (en) | 2011-01-13 | 2012-07-19 | Bio-Pharm Solutions Co., Ltd. | Process for preparation of phenyl carbamate derivatives |
US8901066B2 (en) | 2011-06-15 | 2014-12-02 | Basf Se | Branched polyesters with sulfonate groups |
EP2721090B1 (de) | 2011-06-15 | 2015-09-09 | Basf Se | Verzweigte polyester mit sulfonatgruppen |
CN104136413B (zh) * | 2011-12-27 | 2016-10-26 | 比皮艾思药物研发有限公司 | 用于预防或治疗癫痫症的苯基氨基甲酸酯化合物 |
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-
2007
- 2007-07-25 SA SA7280403A patent/SA07280403B1/ar unknown
- 2007-07-25 AR ARP070103296A patent/AR062095A1/es unknown
- 2007-07-25 US US11/878,556 patent/US7737141B2/en not_active Expired - Fee Related
- 2007-07-26 JP JP2008526796A patent/JPWO2008013213A1/ja not_active Abandoned
- 2007-07-26 TW TW096127264A patent/TW200821319A/zh unknown
- 2007-07-26 MY MYPI20090056A patent/MY144971A/en unknown
- 2007-07-26 PE PE2007000966A patent/PE20080281A1/es not_active Application Discontinuation
- 2007-07-26 EA EA200970172A patent/EA200970172A1/ru unknown
- 2007-07-26 KR KR1020097004007A patent/KR20090033910A/ko not_active Application Discontinuation
- 2007-07-26 MX MX2008015504A patent/MX2008015504A/es not_active Application Discontinuation
- 2007-07-26 CA CA002658037A patent/CA2658037A1/en not_active Abandoned
- 2007-07-26 EP EP07791337A patent/EP2048143A4/en not_active Withdrawn
- 2007-07-26 WO PCT/JP2007/064637 patent/WO2008013213A1/ja active Application Filing
- 2007-07-26 NZ NZ574102A patent/NZ574102A/en not_active IP Right Cessation
- 2007-07-26 AU AU2007277729A patent/AU2007277729A1/en not_active Abandoned
- 2007-07-26 GE GEAP200711078A patent/GEP20115176B/en unknown
-
2008
- 2008-12-11 CR CR10499A patent/CR10499A/es not_active Application Discontinuation
-
2009
- 2009-01-05 IL IL196351A patent/IL196351A0/en unknown
- 2009-01-06 CO CO09000699A patent/CO6150153A2/es unknown
- 2009-01-23 TN TN2009000024A patent/TN2009000024A1/fr unknown
- 2009-01-26 HN HN2009000157A patent/HN2009000157A/es unknown
- 2009-01-27 EC EC2009009091A patent/ECSP099091A/es unknown
- 2009-01-28 SV SV2009003157A patent/SV2009003157A/es unknown
- 2009-02-03 NO NO20090541A patent/NO20090541L/no not_active Application Discontinuation
- 2009-02-11 MA MA31628A patent/MA30636B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
JPWO2008013213A1 (ja) | 2009-12-17 |
EA200970172A1 (ru) | 2009-08-28 |
HN2009000157A (es) | 2011-01-24 |
WO2008013213A1 (fr) | 2008-01-31 |
SA07280403B1 (ar) | 2010-12-01 |
GEP20115176B (en) | 2011-03-10 |
EP2048143A1 (en) | 2009-04-15 |
MX2008015504A (es) | 2008-12-18 |
KR20090033910A (ko) | 2009-04-06 |
NO20090541L (no) | 2009-02-03 |
CO6150153A2 (es) | 2010-04-20 |
NZ574102A (en) | 2010-10-29 |
MY144971A (en) | 2011-11-30 |
US7737141B2 (en) | 2010-06-15 |
EP2048143A4 (en) | 2010-11-03 |
AR062095A1 (es) | 2008-10-15 |
IL196351A0 (en) | 2009-09-22 |
MA30636B1 (fr) | 2009-08-03 |
TW200821319A (en) | 2008-05-16 |
CR10499A (es) | 2009-03-20 |
SV2009003157A (es) | 2010-01-12 |
ECSP099091A (es) | 2009-02-27 |
TN2009000024A1 (en) | 2010-08-19 |
AU2007277729A1 (en) | 2008-01-31 |
US20090048213A1 (en) | 2009-02-19 |
CA2658037A1 (en) | 2008-01-31 |
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